I-TASSER results

I-TASSER results for job id Rv1191

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (304 residues)
MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLHGTPGARRQIPTEARVYAEHHN
IRLIGVDRPGIGASTPHQYETILAFADDLRTIADTLGIDKMAVVGLSGGGPYTLACAAGL
PDRVVAAGVLGGVAPTRGPDAISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVAS
PALDLYGLLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAPFADVIAFARDWGFRLDEV
KVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHLAGLGRGEEILSTLMQIWDR
DLRK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLHGTPGARRQIPTEARVYAEHHNIRLIGVDRPGIGASTPHQYETILAFADDLRTIADTLGIDKMAVVGLSGGGPYTLACAAGLPDRVVAAGVLGGVAPTRGPDAISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYGLLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAPFADVIAFARDWGFRLDEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHLAGLGRGEEILSTLMQIWDRDLRK
Prediction	CCCCCCCCCCCCEEHCCCCCEEEEEEHCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHCCHHHEEEEEEHCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHHCCCCEEEEHCCCCCCCCHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
Conf.Score	9999999986676886898599999977999988999889999987656888998865698899958999999999999999999999999999989998899987778999999999876554478898678887775456666666554455555456676788899999987456675567777657764567647957899999999999877578899999987576554566599888999758986579999999999899988999799998655565899999999999999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLHGTPGARRQIPTEARVYAEHHNIRLIGVDRPGIGASTPHQYETILAFADDLRTIADTLGIDKMAVVGLSGGGPYTLACAAGLPDRVVAAGVLGGVAPTRGPDAISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYGLLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAPFADVIAFARDWGFRLDEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHLAGLGRGEEILSTLMQIWDRDLRK
Prediction	7734354244434040542020001113367020000000000012003400430045330000000001201032456221220040022005206043000000000000000003311410100000000012333411342232124323222312321332133103322322232224112212452123105434124202400221133113010200111144134206502000000044433000140023005123604231154023001111054015200500452178
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCEEHCCCCCEEEEEEHCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHCCHHHEEEEEEHCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHHCCCCEEEEHCCCCCCCCHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLHGTPGARRQIPTEARVYAEHHNIRLIGVDRPGIGASTPHQYETILAFADDLRTIADTLGIDKMAVVGLSGGGPYTLACAAGLPDRVVAAGVLGGVAPTRGPDAISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYGLLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAPFADVIAFARDWGFRLDEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHLAGLGRGEEILSTLMQIWDRDLRK

1azwA

0.21

0.98

2.45

MUSTER

MLYPEITPYQQGSLKVDDRHTLYFEQCGNPHGKPVVMLHGGPGGGCN--DKMRRFHDPAKYRIVLFDQRGSGRSTPHVDNTTWDLVADIERLRTHLGVDRWQVFGGSWGSTLALAYAQTHPQQVTELVLRGIFLLRRFEEWFYQEGASRLFPDAWEHYLNAIPPVERADLMSAFHRRLTSDDEATRLAAAKAWSVWEGVDEDFVTGHEDAHFALAFARIENHYFVNGGFFEVEDQLLRDADIPGVIVHGRYDVVCPLQSAWDLHKAWPKAQLQISPASGHSAFE---PENVDALVRATDGFA--

1azwA

0.21

0.20

0.98

2.49

dPPAS

TLYPEITPYQQGSLKVDDRHTLYFEQCGNPHGKPVVMLHGGPGGGCN--DKMRRFHDPAKYRIVLFDQRGSGRSTPHADNTTWDLVADIERLRTHLGVDRWQVFGGSWGSTLALAYAQTHPQQVTELVLRGIFLLRRFEEWFYQEGASRLFPDAWEHYLNAIPPVERADLMSAFHRRLTSDDEATRLAAAKAWSVWEGVDEDFVTGHEDAHFALAFARIENHYFVNGGFFEVEDQLLRDADIPGVIVHGRYDVVCPLQSAWDLHKAWPKAQLQISPASGHSAFE---PENVDALVRATDGFA--

1qtrA

0.18

0.98

2.93

wdPPAS

LLYPPLAAYDSGWLDTGDGHRIYWELSGNPNGKPAVFIHGGPGGGISPHHRQ--LFDPERYKVLLFDQRGCGRSRPHASNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLALAYAQTHPERVSEMVLRGIFTLRKQRHWYYQDGASRFFPEKWERVLSILSDDERKDVIAAYRQRLTSADPQVQLEAAKLWSVWEGETSRESASFGEDDFALAFARIENHYFTHLGFLESDDQLLRNVHIPAVIVHGRYDMACQVQNAWDLAKAWPEAELHIVEGAGHSYDE---PGILHQLMIATDRFAGK

1azwA

0.21

0.20

0.98

2.80

wMUSTER

TLYPEITPYQQGSLKVDDRHTLYFEQCGNPHGKPVVMLHGGPGGGCNDKMRR--FHDPAKYRIVLFDQRGSGRSTPHVDNTTWDLVADIERLRTHLGVDRWQVFGGSWGSTLALAYAQTHPQQVTELVLRGIFLLRRFEEWFYQEGASRLFPDAWEHYLNAIPPVERADLMSAFHRRLTSDDEATRLAAAKAWSVWEGVDEDFVTGHEDAHFALAFARIENHYFVNGGFFEVEDQLLRDADIPGVIVHGRYDVVCPLQSAWDLHKAWPKAQLQISPASGHSAFE---PENVDALVRATDGFA--

1qtrA

0.18

0.98

3.21

wPPAS

LLYPPLAAYDSGWLDTGDGHRIYWELSGNPNGKPAVFIHGGPGGGISPHHRQ--LFDPERYKVLLFDQRGCGRSRPHASNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLALAYAQTHPERVSEMVLRGIFTLRKQRHWYYQDGASRFFPEKWERVLSILSDDERKDVIAAYRQRLTSADPQVQLEAAKLWSVWEGETSRESASFGEDDFALAFARIENHYFTHLGFLESDDQLLRNVHIPAVIVHGRYDMACQVQNAWDLAKAWPEAELHIVEGAGHSYDE---PGILHQLMIATDRFAGK

1azwA

0.21

0.20

0.98

3.29

dPPAS2

TLYPEITPYQQGSLKVDDRHTLYFEQCGNPHGKPVVMLHGGPGGGCN--DKMRRFHDPAKYRIVLFDQRGSGRSTPHADNTTWDLVADIERLRTHLGVDRWQVFGGSWGSTLALAYAQTHPQQVTELVLRGIFLLRRFEEWFYQEGASRLFPDAWEHYLNAIPPVERADLMSAFHRRLTSDDEATRLAAAKAWSVWEGVDEDFVTGHEDAHFALAFARIENHYFVNGGFFEVEDQLLRDADIPGVIVHGRYDVVCPLQSAWDLHKAWPKAQLQISPASGHSAFE---PENVDALVRATDGFA--

1azwA

0.22

0.21

0.98

3.11

PPAS

MLYPEITPYQQGSLKVDDRHTLYFEQCGNPHGKPVVMLHGGPGGGCNDKMRR--FHDPAKYRIVLFDQRGSGRSTPHADNTTWDLVADIERLRTHLGVDRWQVFGGSWGSTLALAYAQTHPQQVTELVLRGIFLLRRFEEWFYQEGASRLFPDAWEHYLNAIPPVERADLMSAFHRRLTSDAAAKAWSVWEGATSFLHVDEDFVTGHEDAHFALAFARIENHYFVNGGFFEVEDQLLRDADIPGVIVHGRYDVVCPLQSAWDLHKAWPKAQLQISPASGHSAFE---PENVDALVRATDGFA--

1qtrA

0.19

0.98

2.85

Env-PPAS

LLYPPLAAYDSGWLDTGDGHRIYWELSGNPNGKPAVFIHGGPGGGISPHHRQ--LFDPERYKVLLFDQRGCGRSRPHASNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLALAYAQTHPERVSEMVLRGIFTLRKQRHWYYQDGASRFFPEKWERVLSILSDDERKDVIAAYRQRLTSAEAAKLWSVWEGETVTLLPSRES-ASFGEDDFALAFARIENHYFTHLGFLESDDQLLRNVHIPAVIVHGRYDMACQVQNAWDLAKAWPEAELHIVEGAGHSYDE---PGILHQLMIATDRFAGK

1qtrA

0.18

0.98

2.41

MUSTER

LLYPPLAAYDSGWLDTGDGHRIYWELSGNPNGKPAVFIHGGPGGGISPHHRQ--LFDPERYKVLLFDQRGCGRSRPHDNNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLALAYAQTHPERVSEMVLRGIFTLRKQRHWYYQDGASRFFPEKWERVLSILSDDERKDVIAAYRQRLTSADPQVQLEAAKLWSVWEGETVTLSASFGEDDFALAFARIENHYFTHLGFLESDDQLLRNVHIPAVIVHGRYDMACQVQNAWDLAKAWPEAELHIVEGAGHSYDE---PGILHQLMIATDRFAGK

1qtrA

0.17

0.98

2.42

dPPAS

GLYPPLAAYDSGWLDTGDGHRIYWELSGNPNGKPAVFIHGGPGGGISPHHRQ--LFDPERYKVLLFDQRGCGRSRPLDNNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLALAYAQTHPERVSEMVLRGIFTLRKQRHWYYQDGASRFFPEKWERVLSILSDDERKDVIAAYRQRLTSADPQVQLEAAKLWSVWEGLPSRESASFGEDDFALAFARIENHYFTHLGFLESDDQLPLIRHIPAVIVHGRYDMACQVQNAWDLAKAWPEAELHIVEGAGHSYDE---PGILHQLMIATDRFAGK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.13

Estimated TM-score = 0.87±0.07

Estimated RMSD = 3.9±2.6Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1azwA	0.960	0.91	0.205	0.977
2	1qtrA	0.956	1.15	0.177	0.984
3	3vvlA	0.744	3.31	0.208	0.882
4	3wmrA	0.744	3.40	0.191	0.895
5	1ivyA	0.743	3.64	0.131	0.905
6	2pl5A	0.742	3.39	0.118	0.888
7	5e4yA	0.740	3.45	0.159	0.891
8	3kdaA	0.740	3.65	0.124	0.914
9	3wi7A	0.737	3.59	0.144	0.905
10	5d6oA	0.737	3.36	0.145	0.882

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.29	35	1a8uB	BEZ	Rep, Mult	40,41,106,107,108,197,254,255,280
2	0.20	28	1x2bA	STX	Rep, Mult	40,41,106,107,108,130,197,220,224
3	0.06	13	3hssB	MLA	Rep, Mult	42,107,108,139,143,280
4	0.06	12	1vj5A	CIU	Rep, Mult	41,107,108,111,155,156,176,185,223,280,281
5	0.01	3	3c6yA	ACN	Rep, Mult	40,107,189,198,280
6	0.01	2	1q0rA	AKT	Rep, Mult	107,108,111,131,132,133,139,140,165,225,226,228,230,254
7	0.01	2	3muoA	ZPR	Rep, Mult	37,63,104,106,107,131,280,294,298
8	0.01	2	1xrpA	PRO	Rep, Mult	41,42,107,108,214,218,221,222,225
9	0.01	3	4fwbA	3KP	Rep, Mult	107,133,146,165,173,253,254,280
10	0.01	2	3hi4A	ACT	Rep, Mult	41,107,108,133,137,229
11	0.01	2	1xqyA	III	Rep, Mult	183,184,187,197,205,214
12	0.01	3	3otqA	MZL	Rep, Mult	41,107,108,111,155,173,174,176,181,183,185,194,223,254,255,280,281
13	0.00	1	3a2mB	SUC	Rep, Mult	29,31,32,58
14	0.00	1	3v1nA	HPK	Rep, Mult	39,40,45,46,49,50,190,197,202,206,281,284
15	0.00	1	1xrpA	III	Rep, Mult	187,205,208,209,214
16	0.00	1	3a2mA	SUC	Rep, Mult	114,117,124,126,127
17	0.00	1	1uk8A	LEA	Rep, Mult	261,264,265,272
18	0.00	1	1cqwA	IOD	Rep, Mult	169,173,280
19	0.00	1	3bwxA	CA	Rep, Mult	222,225
20	0.00	1	1g42A	CP2	Rep, Mult	32,33

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.359	1a8qA	0.711	3.11	0.202	0.832	1.11.1.10	107,252,280
2	0.336	1a7uA	0.707	3.35	0.191	0.845	1.11.1.10	107,252,280
3	0.304	1qj4A	0.611	3.49	0.141	0.743	4.1.2.37	107,252,280
4	0.286	2r11D	0.674	3.52	0.194	0.809	3.1.1.1	106,113
5	0.274	1va4A	0.706	3.23	0.203	0.842	3.1.1.2	107,282
6	0.258	1mj5A	0.722	3.74	0.128	0.901	3.8.1.5	280
7	0.247	2qvbB	0.717	3.81	0.146	0.901	3.8.1.5	280
8	0.198	2psfA	0.713	3.88	0.120	0.898	1.13.12.5	280
9	0.190	3hjuA	0.702	3.48	0.129	0.845	3.1.1.23	72,107,212
10	0.176	2og1A	0.709	3.63	0.214	0.868	3.7.1.8	NA
11	0.143	2vf2A	0.723	3.54	0.154	0.875	3.7.1.8	70,72
12	0.141	1u2eA	0.717	3.67	0.195	0.875	3.7.1.-	107,252,280
13	0.128	1y37A	0.731	3.62	0.161	0.898	3.8.1.3	NA
14	0.126	1j1iA	0.672	3.21	0.165	0.796	3.7.1.8	107,255
15	0.098	3bf7A	0.633	3.71	0.146	0.780	3.1.-.-	107,238
16	0.087	1dwoA	0.609	3.60	0.113	0.747	4.1.2.37	41,107,252,280
17	0.060	3e3aB	0.702	3.17	0.186	0.832	1.11.1.-	40,43,67,71,281
18	0.060	1iunB	0.698	3.54	0.151	0.842	3.7.1.9	252,280
19	0.060	1zoiA	0.708	3.36	0.200	0.852	3.1.1.-	107,252,280
20	0.060	3a2lA	0.728	3.69	0.123	0.908	3.8.1.5	NA
21	0.060	2ocgA	0.696	2.82	0.165	0.796	3.1.-.-	38,107,109,252,255,272,280
22	0.060	1a88B	0.710	3.41	0.177	0.855	1.11.1.10	284
23	0.060	1hlgB	0.741	3.72	0.125	0.911	3.1.1.3	NA
24	0.060	2v9zA	0.726	4.21	0.148	0.934	3.8.1.5	NA
25	0.060	2pu5A	0.707	3.60	0.214	0.865	3.7.1.8	43
26	0.060	1a88A	0.710	3.34	0.177	0.852	1.11.1.10	107,252,280
27	0.060	2vavB	0.728	3.55	0.138	0.882	2.3.1.175	192,197,278
28	0.060	1ivyA	0.743	3.64	0.131	0.905	3.4.16.5	NA
29	0.060	1ehyA	0.696	3.66	0.165	0.855	3.3.2.10	252,280
30	0.060	1azwA	0.960	0.91	0.205	0.977	3.4.11.5	107,252,280
31	0.060	1a8sA	0.704	3.22	0.177	0.832	1.11.1.10	107,252,280
32	0.060	1qtrA	0.956	1.15	0.177	0.984	3.4.11.5	107,252,280
33	0.060	2b61A	0.718	3.51	0.114	0.868	2.3.1.31	NA
34	0.060	3nwoA	0.712	3.83	0.193	0.885	3.4.11.5	107
35	0.060	1c4xA	0.718	3.21	0.195	0.845	3.7.1.8	284

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.956	1.15	0.18	0.98	1qtrA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0016787
1	0.35	0.725	3.62	0.13	0.88	4opmA	GO:0004806 GO:0016787
2	0.34	0.731	3.89	0.16	0.91	4haiA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
3	0.33	0.710	3.62	0.19	0.85	2yysA	GO:0006508 GO:0008233
4	0.32	0.698	3.54	0.15	0.84	1iunB	GO:0003824 GO:0016787
5	0.32	0.702	3.17	0.19	0.83	3e3aB	GO:0003824 GO:0004601 GO:0009062 GO:0016298 GO:0016491 GO:0055114 GO:0098869
6	0.31	0.724	3.78	0.17	0.89	5aljA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
7	0.30	0.711	3.04	0.20	0.83	1hkhA	GO:0003824 GO:0004601 GO:0098869
8	0.30	0.702	2.77	0.16	0.81	3v48A	GO:0006212 GO:0016787 GO:0016811 GO:0019740
9	0.30	0.705	3.28	0.20	0.84	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
10	0.29	0.717	3.34	0.19	0.86	4qesA	GO:0003723 GO:0003824 GO:0004601 GO:0005198 GO:0005576 GO:0005654 GO:0005829 GO:0005886 GO:0016020 GO:0016032 GO:0016491 GO:0017000 GO:0019012 GO:0019061 GO:0019062 GO:0019064 GO:0019065 GO:0019068 GO:0019070 GO:0019072 GO:0019076 GO:0019083 GO:0030666 GO:0030683 GO:0031904 GO:0039573 GO:0039660 GO:0042025 GO:0046761 GO:0055036 GO:0055114 GO:0075733 GO:0098869
11	0.29	0.691	3.34	0.17	0.82	4ns4A	GO:0016787 GO:0016788
12	0.29	0.671	3.87	0.14	0.82	3qitB	GO:0003824 GO:0008152 GO:0016740 GO:0031177
13	0.29	0.711	3.11	0.20	0.83	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
14	0.28	0.685	3.59	0.17	0.83	3oosA	GO:0004177 GO:0006508 GO:0016787
15	0.28	0.723	3.79	0.14	0.91	4kajA	GO:0003824 GO:0009636 GO:0016787 GO:0018786
16	0.28	0.710	3.34	0.18	0.85	1a88A	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
17	0.26	0.709	3.24	0.18	0.84	1womA	GO:0016787
18	0.26	0.960	0.91	0.20	0.98	1azwA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0016787
19	0.25	0.665	3.35	0.15	0.81	4nmwA	GO:0005737 GO:0009102 GO:0016787 GO:0052689
20	0.25	0.714	3.01	0.20	0.84	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
21	0.25	0.696	3.45	0.20	0.83	1q0rA	GO:0016787 GO:0017000 GO:0052689
22	0.25	0.737	3.62	0.17	0.90	1mt3A	GO:0004177 GO:0006508 GO:0008233 GO:0016787
23	0.23	0.725	4.31	0.14	0.95	3sk0A	GO:0003824 GO:0009636 GO:0016787 GO:0018786
24	0.23	0.705	3.38	0.17	0.85	4lxhA	GO:0016787
25	0.23	0.722	3.06	0.18	0.85	4rncA	GO:0016787 GO:0052689
26	0.23	0.704	3.22	0.18	0.83	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
27	0.22	0.672	3.21	0.17	0.80	1j1iA	GO:0016787
28	0.18	0.712	3.83	0.19	0.88	3nwoA	GO:0006508 GO:0008233 GO:0016787
29	0.15	0.744	3.40	0.19	0.89	3wmrA	GO:0006508 GO:0008233 GO:0016787
30	0.14	0.721	3.01	0.18	0.85	4x00A	GO:0016787
31	0.13	0.723	3.54	0.15	0.88	2vf2A	GO:0005618 GO:0005886 GO:0006629 GO:0006694 GO:0016042 GO:0016787 GO:0018774 GO:0019439 GO:0034820 GO:0044117 GO:0102296
32	0.13	0.716	3.39	0.16	0.86	4f0jA	GO:0003824 GO:0016787
33	0.13	0.737	3.36	0.14	0.88	5d6oA	GO:0004414 GO:0005737 GO:0008652 GO:0009086 GO:0016740 GO:0016746
34	0.13	0.713	4.10	0.11	0.91	4qlaA	GO:0003824 GO:0005783 GO:0005789 GO:0016020 GO:0016021 GO:0016787 GO:0019439 GO:0031090 GO:0033961 GO:0043231
35	0.13	0.709	3.63	0.21	0.87	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
36	0.12	0.715	3.31	0.18	0.85	4i3fA	GO:0016787
37	0.12	0.719	3.92	0.15	0.89	5bovB	GO:0003824 GO:0016787
38	0.12	0.666	3.42	0.17	0.81	1m33A	GO:0005737 GO:0009102 GO:0016787 GO:0052689 GO:0090499
39	0.12	0.718	3.82	0.13	0.90	3u1tB	GO:0003824
40	0.12	0.703	3.92	0.14	0.87	4io0A	GO:0003824 GO:0008152 GO:0016787 GO:0016798 GO:0047405
41	0.10	0.709	3.76	0.15	0.88	2e3jA	GO:0003824 GO:0016787
42	0.08	0.709	4.24	0.09	0.92	4qa9A	GO:0003824 GO:0016787 GO:0033961

Consensus prediction of GO terms

Molecular Function	GO:0004177	GO:0004806	GO:0042577	GO:0033885	GO:0005102	GO:0042803	GO:0004301	GO:0000287	GO:0015643
GO-Score	0.37	0.35	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Biological Processes	GO:0006508	GO:0008217	GO:0046272	GO:0006954	GO:0009636	GO:0006874	GO:0045909	GO:0010628	GO:0019373	GO:0006805	GO:0046839	GO:0072593	GO:0017144	GO:0090181	GO:0042632
GO-Score	0.58	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Cellular Component	GO:0005777	GO:0005829	GO:0070062
GO-Score	0.34	0.34	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.