I-TASSER results

I-TASSER results for job id Rv1190

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (292 residues)
MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPAVLFVHVGSWSFVWRDV
LLRLANDFRCVAIDAPGCGLSDRLSTPPTLAQAADAITSVIDALQLRDLTLVAHDLGGPA
GFLAAARRGDRVAALAAVNCFAWRPTGPLFRGMLAAMGSAPVRELDAAINALARATSTRF
GAGRHWSRADRAAFRAGIDAPARRAWHAYFRDARRAHALYTDVDAALRGGLADRPLLTIF
GQFNDPLRFQPRWKELFPTARQLQVRRGNHFPMCDDPDLVAGALTSFVQRST

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPAVLFVHVGSWSFVWRDVLLRLANDFRCVAIDAPGCGLSDRLSTPPTLAQAADAITSVIDALQLRDLTLVAHDLGGPAGFLAAARRGDRVAALAAVNCFAWRPTGPLFRGMLAAMGSAPVRELDAAINALARATSTRFGAGRHWSRADRAAFRAGIDAPARRAWHAYFRDARRAHALYTDVDAALRGGLADRPLLTIFGQFNDPLRFQPRWKELFPTARQLQVRRGNHFPMCDDPDLVAGALTSFVQRST
Prediction	CCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCEEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHCHHHCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCHHHHHHHHHCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHC
Conf.Score	9854457888865567778998558999999899999857898689967999757888899998678789997899999998999999999999999999999899967999968789999999998766646689987998999866889999988765565677789999999988865778889789999998756655557999999998867776655677776679998899985789986799999998999889996998776444469999999999998759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPAVLFVHVGSWSFVWRDVLLRLANDFRCVAIDAPGCGLSDRLSTPPTLAQAADAITSVIDALQLRDLTLVAHDLGGPAGFLAAARRGDRVAALAAVNCFAWRPTGPLFRGMLAAMGSAPVRELDAAINALARATSTRFGAGRHWSRADRAAFRAGIDAPARRAWHAYFRDARRAHALYTDVDAALRGGLADRPLLTIFGQFNDPLRFQPRWKELFPTARQLQVRRGNHFPMCDDPDLVAGALTSFVQRST
Prediction	7427414435334424575122432304066133121223503042333331202132503222154140423232315443416441203200410262362260440130002010300011011103025201402000123324203300431242224314421320133103311254413542242024104432221023003102412421341323342440421362526762301520330262046041223560323022620322040215246528
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCEEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHCHHHCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCHHHHHHHHHCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHC
MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPAVLFVHVGSWSFVWRDVLLRLANDFRCVAIDAPGCGLSDRLSTPPTLAQAADAITSVIDALQLRDLTLVAHDLGGPAGFLAAARRGDRVAALAAVNCFAWRPTGPLFRGMLAAMGSAPVRELDAAINALARATSTRFGAGRHWSRADRAAFRAGIDAPARRAWHAYFRDARRAHALYTDVDAALRGGLADRPLLTIFGQFNDPLRFQPRWKELFPTARQLQVRRGNHFPMCDDPDLVAGALTSFVQRST

3wi7A

0.23

0.22

0.94

2.71

MUSTER

---------------PHSAFGAKAYDVPAFGLQIHTVEHGSGAPIVFLHGPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNIDSPEFVTRRAKLRQGEGEIFVQQENRFLTELFPWF-FLTPLAPEDLRQYQTPFPTPSRKAILAGPRNLASTVAFLEQAVNWLNT--SDTPKLLLTFKPGFLLAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIA

3wi7A

0.22

0.21

0.96

2.68

dPPAS

-------------PHSAFGDGAKAYDVPAFGLQIHTVEHGSGAPIVFLHGPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNIDSPEFVTRRAKLRQPGEGEIFVQQENRFLTELFPWFFLTPLAPEDLRQYQTPFPTPHRKAILAGPRNLEPASTVAFLEQAVNWLNTSDTPKLLLTFKPGFLLAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIA

1ehyA

0.16

0.15

0.93

2.94

wdPPAS

--------------AIRRPEDFKHYEVQLPDVKIHYVREGAGPTLLLLHGPGFWWEWSKVIGPLAEHYDVIVPDLRGFGDSEKPDLNYSLDKAADDQAALLDALGIEKAYVVGHDFAAIVLHKFIRKYSDRVIKAAIFDPIQPDFES--WYSQFHQLDMAVEVVGREVCKKYFKHFFDHWSYDELLTEEELEVHVDNCMKPD--NIHGGFNYYRANIRPDAALWTDLDHTMSDLPVTMIWGLGDTCVPLIEFVPKYYSNYTMETIEDCGHFLMVEKPEIAIDRIKTAFR---

3wi7A

0.23

0.22

0.93

2.95

wMUSTER

----------------HSAFGAKAYDVPAFGLQIHTVEHGSGAPIVFLHGPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNIDSPEFVTRRAKLRQGEGEIFVQQENRFLTELFPWFF-LTPLAPEDLRQYQTPFPTPSRKAILAGPRNLASTVAFLEQAVNWLNT--SDTPKLLLTFKPGFLLAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIA

3wi7A

0.23

0.21

0.94

2.99

wPPAS

-----------PHSAFGD--GAKAYDVPAFGLQIHTVEHGSGAPIVFLHGPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNIDSPEFVTRRAKLRQEGEIFVQQE-NRFLTELFPWF-FLTPLAPEDLRQYQTPFPTPHRKAILAGPRNLASTVAFLEQAVNWLNT--SDTPKLLLTFKPGFLLAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIA

3wi7A

0.22

0.21

0.96

3.10

dPPAS2

-----------PHSAFGDG--AKAYDVPAFGLQIHTVEHGSGAPIVFLHGPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNIDSPEFVTRRAKLRQPGEGEIFVQQENRFLTELFPWFFLTPLAPEDLRQYQTPFPTPHRKAILAGPRNLEPASTVAFLEQAVNWLNTSDTPKLLLTFKPGFLLAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIA

3wi7A

0.22

0.21

0.96

2.94

PPAS

-----------PHSAFGD--GAKAYDVPAFGLQIHTVEHGSGAPIVFLHGPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNIDSPEFVTRRAKLRQPGEGEIFVQQENRFLTELFPWFFLTPLAPEDLRQYQTPFPTPHRKAILAGPRNLEPASTVAFLEQAVNWLNTSDTPKLLLTFKPGFLLAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIA

3wi7A

0.22

0.21

0.96

3.20

Env-PPAS

-----------PHSAFGD--GAKAYDVPAFGLQIHTVEHGSGAPIVFLHGPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNDLSPEFVTRRAKLRQPGEGEIFVQQENRFLTELFPWFFLTPLAPEDLRQYQTPFPTPHRKAILAGPRNLEPASTVAFLEQAVNWLNTSDTPKLLLTFKPGFLLAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIA

4lxgA

0.16

0.15

0.91

2.60

MUSTER

--------------MFEQ---FESKFIDCDGIRTHYIEMGEGDPLVLVHGADGRSNFADNFPIFARHMRVIAYDMVGFGQTDAPDPAYTQAARTDHLISFIKALGLSKICLIGNSMGGTTACGAALKAPELIDRLVLMGAAVNISPDDMVADDLAAVMSY------DGSEEGMRKIIAALTHSYQPTDDIVHYRHEASLR---PTTTAAYKATMGWAKQNGLYYSPEQLASLTMPVLVLGGKNDVPVRKVIDQILAIPQAIGHVFPNCGHWVMIEYPEEFCTQTLHFFGKL-

1ehyA

0.16

0.15

0.93

2.57

dPPAS

--------------AIRRPEDFKHYEVQLPDVKIHYVREGAGPTLLLLHGPGFWWEWSKVIGPLAEHYDVIVPDLRGFGDSEKPDLNYSLDKAADDQAALLDALGIEKAYVVGHDFAAIVLHKFIRKYSDRVIKAAIFDPIQPDFESWYSQFHQLDMAVEVVGSSREVCKKYFKHFFDHWSYRDELTEEELEVHVDNCMKPD--NIHGGFNYYRANIRPDAALWTDLDHTMSDLPVTMIWGLGDTCVPLIEFVPKYYSNYTMETIEDCGHFLMVEKPEIAIDRIKTAFR---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.24

Estimated TM-score = 0.75±0.11

Estimated RMSD = 5.6±3.5Å

Download Model 2

C-score=-2.66

Download Model 3

C-score=-2.80

Download Model 4

C-score=-2.41

Download Model 5

C-score=-0.73

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wi7A	0.877	1.96	0.209	0.949
2	2qvbB	0.838	2.37	0.247	0.935
3	1mj5A	0.837	2.42	0.255	0.935
4	4brzA	0.828	2.41	0.225	0.928
5	3r3uA	0.827	2.95	0.185	0.962
6	3kdaA	0.826	2.67	0.162	0.949
7	5esrA	0.823	2.80	0.194	0.945
8	2v9zA	0.822	2.67	0.214	0.938
9	3a2lA	0.821	2.46	0.193	0.925
10	4nvrA	0.820	2.83	0.194	0.952

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	40	1a8uA	BEZ	Rep, Mult	49,50,114,115,116,141,213,270
2	0.13	38	1k63A	BRP	Rep, Mult	115,146,154,180,213
3	0.12	29	1k6eA	1BP	Rep, Mult	115,146,154,172,176,180,270,271
4	0.07	19	4lyeA	HPK	Rep, Mult	49,50,51,52,56,114,115,116,151,180,194,270,271
5	0.02	7	2dhcA	DCE	Rep, Mult	115,116,119,158,161,210,211,214,246
6	0.01	2	1b6gA	GOL	Rep, Mult	5,7,31,82
7	0.01	2	1b6gA	GOL	Rep, Mult	59,276,277,278,279
8	0.01	3	1iupA	ALQ	Rep, Mult	55,56,194,271
9	0.01	2	1b6gA	GOL	Rep, Mult	179,180,184,245
10	0.01	2	3stvA	3HO	Rep, Mult	50,156,157,160,270
11	0.01	4	2wj4A	HQD	Rep, Mult	52,114,115,116,156,176,198,206,209,213,270
12	0.01	3	2o2hA	DCE	Rep, Mult	146,147,244,245,270
13	0.01	3	2psjB	CEI	Rep, Mult	147,153,156,165,171,172,180,245,246,270
14	0.01	2	1ukbA	BEZ	Rep, Mult	58,176,179,190,271
15	0.01	4	1y37A	MG	Rep, Mult	88,89,90,93,209,212,217
16	0.01	3	1q0rA	AKT	Rep, Mult	115,116,119,139,140,141,151,212,213,218,220,246
17	0.01	2	3b12B	FAH	Rep, Mult	122,221,225,256
18	0.01	3	1xqyA	III	Rep, Mult	169,172,173,176,186,194,203
19	0.01	2	3hssB	MLA	Rep, Mult	175,197,201,271,274
20	0.01	2	1cijA	BR	Rep, Mult	116,158,161,210,211,214

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.384	1b6gA	0.818	2.94	0.161	0.945	3.8.1.5	115,270
2	0.350	1mj5A	0.837	2.42	0.255	0.935	3.8.1.5	115,270
3	0.343	1a8qA	0.766	2.62	0.193	0.870	1.11.1.10	245,270
4	0.339	2qvbB	0.838	2.37	0.247	0.935	3.8.1.5	115,270
5	0.300	1iunB	0.782	2.76	0.186	0.901	3.7.1.9	270
6	0.291	2r11D	0.749	3.19	0.159	0.884	3.1.1.1	57,116,277
7	0.286	1j1iA	0.764	2.36	0.181	0.853	3.7.1.8	51
8	0.280	3e3aB	0.754	2.83	0.145	0.873	1.11.1.-	35,51,74
9	0.279	2ocgA	0.725	2.71	0.165	0.829	3.1.-.-	111,117,237,270
10	0.275	1a88B	0.766	2.80	0.196	0.873	1.11.1.10	NA
11	0.263	2vf2A	0.780	3.00	0.181	0.907	3.7.1.8	77,79,116
12	0.236	2pu5A	0.787	2.99	0.143	0.907	3.7.1.8	NA
13	0.190	1c4xA	0.780	2.74	0.160	0.901	3.7.1.8	NA
14	0.162	1ehyA	0.801	2.79	0.160	0.918	3.3.2.10	115,270
15	0.159	1u2eA	0.779	3.11	0.158	0.907	3.7.1.-	245,270
16	0.123	3bf7A	0.679	3.60	0.165	0.829	3.1.-.-	NA
17	0.067	1i6wB	0.476	2.80	0.152	0.541	3.1.1.3	NA
18	0.060	1y37A	0.806	2.80	0.206	0.931	3.8.1.3	205,207
19	0.060	2psfA	0.812	3.02	0.199	0.945	1.13.12.5	115,270
20	0.060	1k8qA	0.791	3.31	0.124	0.942	3.1.1.3	NA
21	0.060	2v9zA	0.822	2.67	0.214	0.938	3.8.1.5	NA
22	0.060	3a2lA	0.821	2.46	0.193	0.925	3.8.1.5	58
23	0.060	1vj5A	0.798	2.90	0.144	0.928	3.3.2.10,3.3.2.3	110
24	0.060	1va4A	0.771	2.75	0.196	0.873	3.1.1.2	NA
25	0.060	1zoiA	0.765	2.81	0.180	0.873	3.1.1.-	245,270
26	0.060	1mt3A	0.752	3.45	0.112	0.904	3.4.11.5	270
27	0.060	1ivyA	0.758	3.84	0.113	0.938	3.4.16.5	NA
28	0.060	2e3jA	0.784	2.75	0.169	0.904	3.3.2.3	NA
29	0.060	1hlgB	0.794	3.12	0.133	0.938	3.1.1.3	NA
30	0.060	3g0iA	0.798	3.19	0.119	0.952	3.3.2.3	240
31	0.060	2vavB	0.756	3.33	0.119	0.918	2.3.1.175	174
32	0.060	1a7uA	0.771	2.49	0.178	0.863	1.11.1.10	245,270
33	0.060	1a8sA	0.765	2.81	0.169	0.873	1.11.1.10	270
34	0.060	1a88A	0.766	2.80	0.196	0.873	1.11.1.10	245,270
35	0.060	2og1A	0.787	2.99	0.143	0.907	3.7.1.8	NA
36	0.060	2pl5A	0.754	3.27	0.091	0.901	2.3.1.31	270

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.47	0.833	2.78	0.20	0.96	4nvrA	GO:0016740 GO:0016746 GO:0016787 GO:0046872
1	0.44	0.823	2.80	0.19	0.95	5esrA	GO:0003824 GO:0016787 GO:0018786
2	0.42	0.835	2.58	0.23	0.95	3u1tB	GO:0003824
3	0.41	0.775	2.39	0.15	0.87	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
4	0.41	0.824	2.44	0.21	0.93	4k2aC	GO:0003824 GO:0016787 GO:0018786
5	0.40	0.823	2.70	0.22	0.94	3sk0A	GO:0003824 GO:0009636 GO:0016787 GO:0018786
6	0.37	0.833	2.56	0.20	0.94	4kajA	GO:0003824 GO:0009636 GO:0016787 GO:0018786
7	0.35	0.800	2.96	0.17	0.92	4ccyB	GO:0005737 GO:0016787 GO:0052689
8	0.33	0.779	2.42	0.20	0.88	4x00A	GO:0016787
9	0.33	0.797	2.95	0.19	0.92	5bovB	GO:0003824 GO:0016787
10	0.33	0.759	2.54	0.17	0.86	3wzlA	GO:0016787
11	0.33	0.832	2.73	0.22	0.95	4mj3B	GO:0003824 GO:0016787 GO:0018786
12	0.33	0.816	2.83	0.20	0.94	4b9aA	GO:0003824 GO:0009062 GO:0016298 GO:0016787
13	0.32	0.877	1.96	0.21	0.95	3wi7A	GO:0016787 GO:0018786
14	0.32	0.783	3.18	0.16	0.92	4psuA	GO:0016787
15	0.31	0.801	2.79	0.16	0.92	1ehyA	GO:0003824 GO:0016787
16	0.30	0.747	2.94	0.18	0.86	1womA	GO:0016787
17	0.30	0.756	2.90	0.20	0.88	4rncA	GO:0016787 GO:0052689
18	0.30	0.810	2.66	0.19	0.93	3qyjA	GO:0003824
19	0.30	0.785	3.07	0.20	0.92	4io0A	GO:0003824 GO:0008152 GO:0016787 GO:0016798 GO:0047405
20	0.30	0.766	2.80	0.20	0.87	1a88A	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
21	0.30	0.744	3.30	0.22	0.89	3kxpA	GO:0016787 GO:0042803 GO:0042820 GO:0047411
22	0.29	0.738	3.41	0.17	0.89	3p2mA	GO:0052689
23	0.29	0.824	2.69	0.16	0.95	4dlnB	GO:0016787
24	0.29	0.770	2.78	0.15	0.89	4ns4A	GO:0016787 GO:0016788
25	0.28	0.799	2.89	0.14	0.93	4haiA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
26	0.28	0.780	3.00	0.18	0.91	2vf2A	GO:0005618 GO:0005886 GO:0006629 GO:0006694 GO:0016042 GO:0016787 GO:0018774 GO:0019439 GO:0034820 GO:0044117 GO:0102296
27	0.28	0.727	2.63	0.17	0.83	4nmwA	GO:0005737 GO:0009102 GO:0016787 GO:0052689
28	0.28	0.782	2.76	0.19	0.90	1iunB	GO:0003824 GO:0016787
29	0.28	0.810	2.70	0.20	0.93	3b12A	GO:0003824 GO:0016787 GO:0018785
30	0.28	0.766	2.62	0.19	0.87	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
31	0.28	0.778	2.80	0.17	0.89	4lxhA	GO:0016787
32	0.27	0.816	2.58	0.19	0.93	3afiB	GO:0003824 GO:0016787 GO:0018786 GO:0042206 GO:0042802
33	0.27	0.757	2.59	0.16	0.86	4g8bA	GO:0003824 GO:0016787 GO:0016788
34	0.27	0.777	2.48	0.18	0.87	4qesA	GO:0003723 GO:0003824 GO:0004601 GO:0005198 GO:0005576 GO:0005654 GO:0005829 GO:0005886 GO:0016020 GO:0016032 GO:0016491 GO:0017000 GO:0019012 GO:0019061 GO:0019062 GO:0019064 GO:0019065 GO:0019068 GO:0019070 GO:0019072 GO:0019076 GO:0019083 GO:0030666 GO:0030683 GO:0031904 GO:0039573 GO:0039660 GO:0042025 GO:0046761 GO:0055036 GO:0055114 GO:0075733 GO:0098869
35	0.27	0.707	3.22	0.14	0.84	4gdmC	GO:0005829 GO:0009234 GO:0016787 GO:0016829 GO:0070205
36	0.25	0.757	2.60	0.17	0.86	2xuaH	GO:0016787 GO:0042952 GO:0047570
37	0.24	0.764	2.36	0.18	0.85	1j1iA	GO:0016787
38	0.24	0.773	2.74	0.20	0.88	1hkhA	GO:0003824 GO:0004601 GO:0098869
39	0.24	0.770	2.77	0.20	0.87	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
40	0.20	0.685	2.99	0.15	0.80	1r3dA	GO:0005829 GO:0009234 GO:0016787 GO:0016829 GO:0070205
41	0.19	0.776	3.21	0.15	0.91	2r11D	GO:0016787 GO:0052689
42	0.18	0.837	2.42	0.26	0.93	1mj5A	GO:0003824 GO:0009636 GO:0016787 GO:0018786 GO:0042597
43	0.18	0.817	2.95	0.16	0.95	1be0A	GO:0003824 GO:0009636 GO:0016787 GO:0018786 GO:0019260
44	0.18	0.838	2.37	0.25	0.93	2qvbB	GO:0003824 GO:0005618 GO:0005886 GO:0016787 GO:0018786 GO:0042206
45	0.18	0.793	2.95	0.14	0.92	5aljA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
46	0.17	0.799	2.82	0.19	0.93	2xt0A	GO:0003824
47	0.17	0.812	3.02	0.20	0.95	2psfA	GO:0003824 GO:0004497 GO:0008218 GO:0016491 GO:0016829 GO:0016831 GO:0050248 GO:0055114
48	0.16	0.765	2.81	0.17	0.87	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
49	0.16	0.787	2.99	0.14	0.91	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
50	0.15	0.744	2.88	0.14	0.86	4htaA	GO:0005634 GO:0005737 GO:0005829 GO:0009640 GO:0009704 GO:0016787 GO:0080167
51	0.14	0.724	2.59	0.20	0.83	1m33A	GO:0005737 GO:0009102 GO:0016787 GO:0052689 GO:0090499
52	0.14	0.789	3.12	0.17	0.92	4ufoA	GO:0003824 GO:0016787
53	0.13	0.772	3.10	0.15	0.91	4f0jA	GO:0003824 GO:0016787
54	0.13	0.723	2.97	0.13	0.84	2xmzA	GO:0009234 GO:0016787 GO:0016829 GO:0070205
55	0.13	0.784	2.75	0.17	0.90	2e3jA	GO:0003824 GO:0016787

Consensus prediction of GO terms

Molecular Function	GO:0018786	GO:0046872	GO:0016746	GO:0016691	GO:0019806
GO-Score	0.67	0.47	0.47	0.41	0.41
Biological Processes	GO:0055114	GO:0098869
GO-Score	0.41	0.41
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.