I-TASSER results

I-TASSER results for job id Rv1172c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (308 residues)
MSFVFAAPEALAAAAADMAGIGSTLNAANVVAAVPTTGVLAAAADEVSTQVAALLSAHAQ
GYQQLSRQMMTAFHDQFVQALRASADAYATAEASAAQTMVNAVNAPARALLGHPLISADA
STGGGSNALSRVQSMFLGTGGSSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRA
GAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLTAWAVGWLPYIGILAPQINFFYY
LGEPIVQAVLFNAIDFVDGTVTFSQALTNIETATAASINQFINTEINWIRGFLPPLPPIS
PPGFPSLP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVFAAPEALAAAAADMAGIGSTLNAANVVAAVPTTGVLAAAADEVSTQVAALLSAHAQGYQQLSRQMMTAFHDQFVQALRASADAYATAEASAAQTMVNAVNAPARALLGHPLISADASTGGGSNALSRVQSMFLGTGGSSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLTAWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALTNIETATAASINQFINTEINWIRGFLPPLPPISPPGFPSLP
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
Conf.Score	97676447999999999999988999998777777654456666568999999999999999999999999999999999999999888888889999987666888999889888888888888888888776444788888888887777777776666788877766667666677777777667766555467888889999999998776456665454557887665789999987654554434566545787557888899988888888899999999999866788888998888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVFAAPEALAAAAADMAGIGSTLNAANVVAAVPTTGVLAAAADEVSTQVAALLSAHAQGYQQLSRQMMTAFHDQFVQALRASADAYATAEASAAQTMVNAVNAPARALLGHPLISADASTGGGSNALSRVQSMFLGTGGSSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLTAWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALTNIETATAASINQFINTEINWIRGFLPPLPPISPPGFPSLP
Prediction	42104030330220032034032003202220011001112323220010000101300430120033203300410030022023121324332334013102110220042111142343341434423200001031232333334334333133132333333232322343244343423233323344322321320120132015221510310010101011004201001200221043020300221232231140022023202310242034203102311022221335425728
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MSFVFAAPEALAAAAADMAGIGSTLNAANVVAAVPTTGVLAAAADEVSTQVAALLSAHAQGYQQLSRQMMTAFHDQFVQALRASADAYATAEASAAQTMVNAVNAPARALLGHPLISADASTGGGSNALSRVQSMFLGTGGSSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLTAWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALTNIETATAASINQFINTEINWIRGFLPPLPPISPPGFPSLP

2g38C

0.28

0.07

0.25

1.10

wdPPAS

-------PEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38C

0.28

0.07

0.25

1.20

wPPAS

-------PEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.24

0.22

0.94

1.55

dPPAS2

-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAA

5gaoE

0.24

0.23

0.96

1.46

PPAS

-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAA

4wj1A

0.11

0.09

0.86

1.01

wPPAS

-EELQYELPGLERKAHECES----------RPEGPG----ATKPDELATTASVYSKLASAAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAAELSRQ--------------SDAPPPAAEAVVPDSGIPGPLAIPSEYPSAAAAADEDWEAAARIIHSGDTQALSKYFRDQQSTLEGHGRHFANPAEGGAAAETCAEAQRRLSTWWAD---GAECGRLAQEATTFVDAHDKLVAN---PTLEN-VREFEETEWASEWDRQNAWALQEQSEDALEAYANGSQ------IQEIRPGKPPSIGGLP

4wj1A

0.09

0.08

0.88

1.48

dPPAS2

-EELQYELPGLERKAHECES----------TRPEGPGDATKPDE--LATTASVYSKLASAAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAAELSRQN-----------GSDAPPPAAEAVVPDSGIPGPLAIPSEYPSAAAAADEDWEAAARIIHSGDTQALSKYFRDQSTLEGHGRHFANPAEGWAGAAAETCAEAQRRLSTWWAD---GAECGRLAQEATTFVDAHDKLVANH--PTLE--NVREFEETEWASEWDRQNAWALQEQSEDALEAYANGSQ-----IQEIRPGKPPSIGGLP

4wj1A

0.10

0.08

0.88

1.26

PPAS

-EELQYELPGLERKAHECES------------PEGPGD--ATKPDELATTASVYSKLASAAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAAELSRQN--------GSDAPPPAAEAVVPDSGIPGPLAIPSEYPSAAAAADEDWEAAARIIHSGDTQALSKYFRDQWRDYQSTLEGHGRHFANPAEGGAAAETCAEAQRRLSTWWAD---GAECGRLAQEATTFVDAHDKLVAN---PTLE--NVREFEETEWASEWDRQNAWALQEQSEDALEAYANGSQ-----IQEIRPGKPPSIGGLP

4ke2A

0.20

0.13

0.64

1.41

dPPAS2

-----MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAA--------ATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------------------------------------------------------------------

2yo3A

0.06

0.05

0.71

1.01

dPPAS2

------------------------------------------------KQIEDKIEEILSKIYHIENEIARIKKLIKVTDAQVSRNTQSITNLNTQVSNLDTRVTNIENGIGDIVTTGSTKYFKTNTDGAEANTVSVGSSTQQRRITNVAAGVNNTDAVNSEAGSVRYETNADGSVNYSVLNLGDGSGGTTRIGNVSAAVN------------DTDAVN-----YAQLKRSVEEANTYTDQKMGEMNSKIKGVENKMK---QIEDKIEEILSKIYHIENEIARIKK----------------------

5cwiA

0.11

0.08

0.75

1.01

dPPAS2

----------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHQAARDAIK------------------------LASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKK-CIKAASEAAEEASKAAEEAQRHPDS-----------------QKARDEIKEASQKAEEVKERCER--------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.14

Estimated TM-score = 0.46±0.15

Estimated RMSD = 11.2±4.6Å

Download Model 2

C-score=-4.63

Download Model 3

C-score=-4.88

Download Model 4

C-score=-4.87

Download Model 5

C-score=-4.57

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4wj1A	0.769	2.91	0.099	0.873
2	4xwpA	0.639	2.79	0.093	0.734
3	5j1iA	0.459	5.49	0.090	0.682
4	4dylA	0.458	4.11	0.054	0.581
5	4f4cA	0.457	4.41	0.042	0.607
6	2eflA	0.457	4.02	0.042	0.575
7	3pltA	0.456	4.48	0.079	0.614
8	3qweA	0.454	4.15	0.091	0.578
9	5c1fA	0.453	4.39	0.035	0.591
10	4ui9I	0.451	4.35	0.081	0.604

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1vlgA	FE	Rep, Mult	25,67,70,212
2	0.04	2	3ffzA	NA	Rep, Mult	44,45,47,48,52,53
3	0.04	2	3c9iA	CA	Rep, Mult	60,63
4	0.04	2	1yv1A	FE2	Rep, Mult	18,74,77,208
5	0.04	2	3rbmD	B73	Rep, Mult	51,55
6	0.04	2	3m4bA	ZN	Rep, Mult	12,45
7	0.04	2	2vzbA	FE	Rep, Mult	22,71,74,207,211
8	0.02	1	1rkvB	MG	Rep, Mult	45,74
9	0.02	1	1w8qC	CO	Rep, Mult	54,58
10	0.02	1	2w6dB	CPL	Rep, Mult	26,27,71,72,75
11	0.02	1	1i4d1	III	Rep, Mult	12,15,16,19,20,22,23,24,26,27,75,78,82,85,86
12	0.02	1	4dr0B	MN	Rep, Mult	29,64,67,220
13	0.02	1	2dyrK	PGV	Rep, Mult	73,74
14	0.02	1	3r6nB	D1D	Rep, Mult	25,26,29,68,71
15	0.02	1	3f1eT	MG	Rep, Mult	2,15
16	0.02	1	1gsaA	MG	Rep, Mult	45,46
17	0.02	1	2w6dA	GDP	Rep, Mult	101,102,104,107,117

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3a1cB	0.209	6.55	0.058	0.364	3.6.3.-	72,131
2	0.060	3btaA	0.410	5.96	0.054	0.649	3.4.24.69	NA
3	0.060	1z0hB	0.230	6.30	0.010	0.370	3.4.24.69	NA
4	0.060	1bg7A	0.336	4.09	0.086	0.432	1.16.3.1	NA
5	0.060	3bvlF	0.386	4.17	0.041	0.497	1.16.3.1	NA
6	0.060	2np0A	0.361	5.85	0.022	0.555	3.4.24.69	NA
7	0.060	3b8eC	0.408	6.46	0.058	0.675	3.6.3.9	33,53,164,166
8	0.060	1mo7A	0.202	4.99	0.066	0.292	3.6.3.9	NA
9	0.060	1gpjA	0.358	5.95	0.071	0.558	1.2.1.70	NA
10	0.060	3g61A	0.431	5.98	0.073	0.698	3.6.3.44	NA
11	0.060	1mfrW	0.381	4.10	0.053	0.490	1.16.3.1	NA
12	0.060	1o9iA	0.365	4.07	0.041	0.464	1.11.1.6	78
13	0.060	1yisA	0.365	4.98	0.037	0.500	4.3.2.2	NA
14	0.060	2e9fB	0.362	5.32	0.071	0.503	4.3.2.1	58
15	0.060	1y2mB	0.409	4.93	0.095	0.578	4.3.1.24	NA
16	0.060	3ixzA	0.408	6.35	0.046	0.672	3.6.3.10	NA
17	0.060	3e6sF	0.368	3.40	0.096	0.448	1.16.3.1	24,65,183
18	0.060	3ffzA	0.437	5.50	0.046	0.656	3.4.24.69	82
19	0.060	3b8eA	0.409	6.43	0.065	0.682	3.6.3.9	45

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.19	0.660	2.99	0.10	0.77	4xxxA	GO:0005576 GO:0009405 GO:0044315
1	0.12	0.744	2.84	0.10	0.85	3j83A	GO:0005576 GO:0009405 GO:0044315
2	0.06	0.458	4.11	0.05	0.58	4dylA	GO:0000166 GO:0001578 GO:0004672 GO:0004713 GO:0004715 GO:0005524 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0005925 GO:0006468 GO:0006935 GO:0007173 GO:0007275 GO:0008017 GO:0008283 GO:0008289 GO:0008360 GO:0010976 GO:0015630 GO:0016020 GO:0016023 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0030054 GO:0030155 GO:0031116 GO:0031234 GO:0031410 GO:0034987 GO:0035091 GO:0038083 GO:0042127 GO:0043304 GO:0045087 GO:0045595 GO:0045639 GO:0046777 GO:0051297 GO:0060627 GO:2000145 GO:2000251
3	0.06	0.433	6.03	0.08	0.70	4m1mA	GO:0000086 GO:0000166 GO:0002481 GO:0002485 GO:0002489 GO:0002591 GO:0005524 GO:0005886 GO:0006810 GO:0006855 GO:0008559 GO:0009986 GO:0015893 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0042623 GO:0042626 GO:0042908 GO:0046581 GO:0055085 GO:0070062 GO:0072089
4	0.06	0.357	5.96	0.04	0.56	4pl0B	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0016887 GO:0030153 GO:0042626 GO:0043213 GO:0055085
5	0.06	0.335	5.95	0.01	0.53	2r6fA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
6	0.06	0.457	4.41	0.04	0.61	4f4cA	GO:0000166 GO:0005524 GO:0006810 GO:0006855 GO:0008559 GO:0010038 GO:0015562 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0016887 GO:0042626 GO:0042908 GO:0045087 GO:0050829 GO:0055085 GO:0093002
7	0.06	0.341	6.11	0.02	0.55	2r6fB	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
8	0.06	0.374	6.02	0.04	0.60	3pihA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
9	0.06	0.360	5.15	0.04	0.53	4ux3A	GO:0000166 GO:0003682 GO:0005524 GO:0005634 GO:0005694 GO:0006281 GO:0007049 GO:0007064 GO:0007067 GO:0007130 GO:0007131 GO:0008280 GO:0016887 GO:0030437 GO:0034990 GO:0042802 GO:0051177 GO:0051276 GO:0051301 GO:1990414
10	0.06	0.363	6.01	0.03	0.58	5c73A	GO:0000166 GO:0005524 GO:0006810 GO:0016021 GO:0016887 GO:0042626 GO:0055085
11	0.06	0.326	6.75	0.02	0.56	5do7D	GO:0005524 GO:0005886 GO:0006810 GO:0007584 GO:0007588 GO:0010949 GO:0015248 GO:0015914 GO:0015918 GO:0016020 GO:0016021 GO:0016324 GO:0016887 GO:0017127 GO:0030299 GO:0033344 GO:0042493 GO:0042626 GO:0042632 GO:0043190 GO:0043235 GO:0045796 GO:0046982 GO:0055085 GO:0055092
12	0.06	0.357	5.80	0.07	0.55	3b5wA	GO:0000166 GO:0005319 GO:0005524 GO:0005886 GO:0006810 GO:0006869 GO:0008144 GO:0008289 GO:0015437 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0034040 GO:0042626 GO:0043190 GO:0055085 GO:1901264
13	0.06	0.379	5.89	0.07	0.58	4mrrA	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0046689 GO:0055085
14	0.06	0.333	5.65	0.04	0.51	4mycA	GO:0000166 GO:0005524 GO:0005739 GO:0005743 GO:0006810 GO:0006811 GO:0006879 GO:0016020 GO:0016021 GO:0016887 GO:0022857 GO:0042626 GO:0044281 GO:0055072 GO:0055085
15	0.06	0.343	6.08	0.03	0.55	3uwxA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
16	0.06	0.327	5.89	0.06	0.52	3wmgA	GO:0000166 GO:0005524 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0055085
17	0.06	0.354	5.61	0.04	0.54	3qf4B	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0055085
18	0.06	0.340	5.58	0.06	0.50	4ayxA	GO:0000166 GO:0005215 GO:0005524 GO:0005739 GO:0005743 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0032592 GO:0042626 GO:0042803 GO:0055085

Consensus prediction of GO terms

Molecular Function	GO:0032550	GO:0035639	GO:0032559
GO-Score	0.36	0.36	0.36
Biological Processes	GO:0051704	GO:0009306	GO:0071806
GO-Score	0.58	0.58	0.58
Cellular Component	GO:0071944
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.