I-TASSER results

I-TASSER results for job id Rv1167c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (201 residues)
MTVSAPAKANPYRRRGEVLERALYDATLAELESAGYGGLTMEGIAARAQTGKAALYRRWA
GKRELVLAAVQYALPPVPEPRADRSARENLLAVFTANCEILAGKTALPSMEIVSQLLHEP
ELRAIFINSVWAPRLRIVESILQAGVRSGEIDPATLTPMTARIGPALIHQHVLFTGSPPD
REQLTRIIDAMILTTGERRES

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MTVSAPAKANPYRRRGEVLERALYDATLAELESAGYGGLTMEGIAARAQTGKAALYRRWAGKRELVLAAVQYALPPVPEPRADRSARENLLAVFTANCEILAGKTALPSMEIVSQLLHEPELRAIFINSVWAPRLRIVESILQAGVRSGEIDPATLTPMTARIGPALIHQHVLFTGSPPDREQLTRIIDAMILTTGERRES
Prediction	CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
Conf.Score	999899999999998889999999999999999898888999999998998655455589999999999999766677889999999999999999999986875789999999987598999999999999999999999999999899999878999999999999999985799999999999999999987556889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MTVSAPAKANPYRRRGEVLERALYDATLAELESAGYGGLTMEGIAARAQTGKAALYRRWAGKRELVLAAVQYALPPVPEPRADRSARENLLAVFTANCEILAGKTALPSMEIVSQLLHEPELRAIFINSVWAPRLRIVESILQAGVRSGEIDPATLTPMTARIGPALIHQHVLFTGSPPDREQLTRIIDAMILTTGERRES
Prediction	864566675545344465244201400140036331340344320420434333233334345422041034205513534772401400120032004103543121021002103523400320252024301400230052026235044732142013012233311011344314442034137334222242378
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
MTVSAPAKANPYRRRGEVLERALYDATLAELESAGYGGLTMEGIAARAQTGKAALYRRWAGKRELVLAAVQYALPPVPEPRADRSARENLLAVFTANCEILAGKTALPSMEIVSQLLHEPELRAIFINSVWAPRLRIVESILQAGVRSGEIDPATLTPMTARIGPALIHQHVLFTGSPPDREQLTRIIDAMILTTGERRES

2zb9A

0.19

0.18

0.93

2.48

MUSTER

-----------GRRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

2fq4A

0.20

0.18

0.91

2.73

dPPAS

--------------RNIETQKAILSASYELLLESGFKAVTVDKIAERAKVSKATIYKWWPNKAAVVDGFLSAAAAR-LPVPDTGSALNDILIHATSLANFLISREGTIINELVGEGQFDSKLAEEYRVRYFQPRRLQAKQLLEKGIKRGELKENLDIELSIDLIYGPIFYRLLVTGEKLDDSYVHDLVINAFEGIRLR---

2zb9A

0.19

0.18

0.93

3.23

wdPPAS

-----------GRRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

2zb9A

0.19

0.18

0.93

2.98

wMUSTER

------------RRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

2zb9A

0.19

0.18

0.93

3.25

wPPAS

-----------GRRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

2zb9A

0.19

0.18

0.93

4.04

dPPAS2

-----------GRRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

2zb9A

0.19

0.18

0.93

2.89

PPAS

-----------GRRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

2zb9A

0.19

0.18

0.93

3.56

Env-PPAS

-----------GRRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

2fq4A

0.20

0.18

0.91

2.45

MUSTER

--------------RNIETQKAILSASYELLLESGFKAVTVDKIAERAKVSKATIYKWWPNKAAVVDGFLSAAAARL-PVPDTGSALNDILIHATSLANFLISREGTIINELVGEGQFDSKLAEEYRVRYFQPRRLQAKQLLEKGIKRGELKENLDIELSIDLIYGPIFYRLLVTGEKLDDSYVHDLVINAFEGIRLR---

2zb9A

0.19

0.18

0.93

2.71

dPPAS

-----------GRRPAEEVRAEVLHAVGELLLTEGTAQLTFERVARVSGVSKTTLYKWWPSKGALALDGYFHAVEDTLAFPDTGDVRADLLAQLRAFTHVMTRTPGRILTELIGAAQTDADLATAYRQLYSAQRRALAAERLRHARELGQIRPDVDVQVLVDQLWGAVYHRLLIPDEPVDDAFVTALVTNLLDGVCPR---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.54

Estimated TM-score = 0.79±0.09

Estimated RMSD = 4.3±2.8Å

Download Model 2

C-score=-2.23

Download Model 3

C-score=-3.28

Download Model 4

C-score=-1.77

Download Model 5

C-score=0.46

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2zb9A	0.907	0.88	0.193	0.930
2	2fq4A	0.724	2.96	0.174	0.886
3	3cwrA	0.688	3.40	0.130	0.881
4	2id3A	0.685	3.49	0.183	0.910
5	2f07A	0.684	3.48	0.109	0.910
6	3mnlA	0.678	3.18	0.136	0.876
7	1rktA	0.675	3.67	0.107	0.905
8	3lwjA	0.670	3.21	0.058	0.851
9	5d1wA	0.670	3.52	0.117	0.881
10	3angC	0.669	3.49	0.130	0.905

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	10	1jt0C	QNA	Rep, Mult	19,50,51,52,53,54,57,58
2	0.07	11	4dw6A	0MN	Rep, Mult	78,89,90,93,94,97,101,126,131,137,138,141,165,168,169,172,173,188
3	0.06	10	2uxhB	QUE	Rep, Mult	90,93,94,109,113,138,164,168,169,172
4	0.06	7	2yvhD	NUC	Rep, Mult	15,40,41,52,56,61,62
5	0.05	9	3whbA	DCC	Rep, Mult	67,70,71,74,97,100,109,114,123,126,127,131,132,134,135,158,159,161,162,165,169
6	0.05	9	3anpD	DCC	Rep, Mult	166,169,170,174,175,178
7	0.04	6	3angA	DCC	Rep, Mult	73,111,115,125,126,129,134,156,159,162,166,169
8	0.03	5	2uxpB	CLM	Rep, Mult	75,78,80,90,97,134,137,138,168
9	0.02	3	1jt00	III	Rep, Mult	109,113,163,166,167,169,170,171,183,186,187,190,191,193,194
10	0.02	4	1jt6B	DEQ	Rep, Mult	108,173,174
11	0.02	4	3br5A	RHQ	Rep, Mult	67,70,71,74,77,100,101,104,109,134,168
12	0.01	2	5cw8B	55X	Rep, Mult	28,100,101,106,113,134,162,165,168,172
13	0.01	1	2i10B	NPO	Rep, Mult	131,132,162
14	0.01	2	3q0wA	LL5	Rep, Mult	77,81,89,90,93,94,97,137,138,141,145,165,191
15	0.01	1	2id3A	CA	Rep, Mult	82,144
16	0.01	1	3locA	URA	Rep, Mult	174
17	0.01	2	3angB	DCC	Rep, Mult	170,174,178,179,182,186
18	0.01	1	2uxiA	G50	Rep, Mult	115,173
19	0.01	1	3lsjB	COA	Rep, Mult	89,150,189,192,193
20	0.01	1	2id3B	CA	Rep, Mult	43,47

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1v6yA	0.397	4.74	0.084	0.622	3.2.1.8	NA
2	0.060	2eqdA	0.469	5.16	0.083	0.766	3.2.1.151	NA
3	0.060	3c46B	0.492	5.33	0.053	0.831	2.7.7.6	144,190
4	0.060	2zuwC	0.455	4.37	0.050	0.677	2.4.1.211	63
5	0.060	2pziA	0.467	5.58	0.063	0.796	2.7.11.1	42
6	0.060	1uasA	0.451	4.83	0.067	0.702	3.2.1.22	NA
7	0.060	2i2xA	0.498	5.06	0.056	0.816	2.1.1.90	37
8	0.060	3l4uA	0.452	4.96	0.049	0.711	3.2.1.20,3.2.1.3	NA
9	0.060	2e8yA	0.483	4.45	0.067	0.741	3.2.1.41	21,25
10	0.060	1b1yA	0.459	4.76	0.043	0.716	3.2.1.2	NA
11	0.060	1m7xB	0.455	5.03	0.057	0.721	2.4.1.18	32
12	0.060	1txzA	0.465	4.37	0.048	0.677	3.1.3.-	69
13	0.060	2c8nA	0.453	5.19	0.054	0.716	3.2.1.55	NA
14	0.060	3gbdA	0.483	5.01	0.046	0.771	5.4.99.11	63
15	0.060	2aaaA	0.464	5.23	0.024	0.756	3.2.1.1	NA
16	0.060	2ze0A	0.491	5.10	0.045	0.786	3.2.1.20	NA
17	0.060	3k1dA	0.452	5.54	0.063	0.771	2.4.1.18	81,85,87
18	0.060	1s46A	0.461	5.17	0.077	0.751	2.4.1.4	NA
19	0.060	3czkA	0.468	5.11	0.044	0.766	3.2.1.48	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.40	0.907	0.88	0.19	0.93	2zb9A	GO:0003677 GO:0006351 GO:0006355
1	0.39	0.640	3.61	0.14	0.86	3vuqC	GO:0003677 GO:0006351 GO:0006355
2	0.29	0.729	2.95	0.17	0.89	2fq4A	GO:0003677 GO:0006351 GO:0006355
3	0.29	0.678	3.18	0.14	0.88	3mnlA	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355 GO:0042803
4	0.28	0.639	3.61	0.18	0.87	4jl3C	GO:0003677 GO:0006351 GO:0006355
5	0.26	0.600	3.91	0.17	0.82	3b81A	GO:0003677 GO:0006351 GO:0006355
6	0.25	0.687	3.48	0.18	0.92	2id3A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0046872
7	0.25	0.562	4.38	0.13	0.82	2oerB	GO:0003677 GO:0006351 GO:0006355
8	0.25	0.644	3.57	0.15	0.86	4za6A	GO:0003677
9	0.25	0.645	4.00	0.09	0.89	3qbmA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
10	0.24	0.697	3.07	0.17	0.86	2g3bA	GO:0003677 GO:0006351 GO:0006355
11	0.24	0.646	3.46	0.15	0.85	3whcA	GO:0003677 GO:0005737 GO:0006351 GO:0006355 GO:0006629 GO:0006631 GO:0016042
12	0.24	0.600	4.21	0.12	0.86	3c2bA	GO:0003677 GO:0006351 GO:0006355
13	0.22	0.679	3.14	0.06	0.86	3lwjA	GO:0003677 GO:0006351 GO:0006355
14	0.22	0.684	3.48	0.11	0.91	2f07A	GO:0003677 GO:0006351 GO:0006355
15	0.21	0.659	3.47	0.14	0.86	3bjbB	GO:0003677 GO:0006351 GO:0006355
16	0.21	0.641	3.63	0.12	0.88	2qibA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
17	0.20	0.679	3.44	0.13	0.92	3angC	GO:0003677 GO:0006351 GO:0006355
18	0.19	0.592	4.18	0.08	0.85	3he0C	GO:0003677 GO:0006351 GO:0006355
19	0.19	0.669	3.50	0.12	0.88	5d1wD	GO:0003677 GO:0006351 GO:0006355
20	0.18	0.544	4.40	0.11	0.80	2q24B	GO:0003677 GO:0006351 GO:0006355
21	0.18	0.539	4.21	0.17	0.79	2qwtA	GO:0003677 GO:0006351 GO:0006355
22	0.17	0.595	4.31	0.13	0.86	4jykA	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355 GO:0045892 GO:0045893
23	0.16	0.575	4.28	0.17	0.85	2oi8A	GO:0003677 GO:0006351 GO:0006355
24	0.15	0.558	4.27	0.05	0.81	3ppbA	GO:0003677 GO:0006351 GO:0006355
25	0.14	0.526	4.01	0.12	0.72	3vvxA	GO:0003677 GO:0006351 GO:0006355
26	0.13	0.561	4.00	0.08	0.80	3egqA	GO:0003677 GO:0006351 GO:0006355
27	0.13	0.571	4.17	0.12	0.86	5f1jA	GO:0003677 GO:0006351 GO:0006355
28	0.10	0.639	3.92	0.14	0.88	4cgrA	GO:0003677 GO:0006351 GO:0006355
29	0.09	0.518	4.67	0.06	0.80	2o7tA	GO:0003677 GO:0006351 GO:0006355
30	0.09	0.589	4.34	0.06	0.87	3g7rB	GO:0003677 GO:0003700 GO:0006351 GO:0006355
31	0.09	0.636	3.77	0.14	0.86	2hyjA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
32	0.08	0.646	3.62	0.10	0.89	3hggA	GO:0003677 GO:0006351 GO:0006355
33	0.08	0.614	3.86	0.08	0.84	1sgmA	GO:0003677 GO:0006351 GO:0006355
34	0.08	0.619	4.06	0.12	0.86	2uxhA	GO:0003677 GO:0006351 GO:0006355
35	0.07	0.563	4.07	0.12	0.79	2qkoB	GO:0003677 GO:0006351 GO:0006355
36	0.07	0.572	3.82	0.09	0.80	2raeA	GO:0003677 GO:0006351 GO:0006355
37	0.07	0.586	4.01	0.09	0.80	4gclB	GO:0003677 GO:0005737 GO:0007049 GO:0009295 GO:0010974 GO:0043565 GO:0043590 GO:0051301 GO:0051302
38	0.07	0.553	4.14	0.09	0.78	4pxiB	GO:0003677 GO:0006351 GO:0006355
39	0.07	0.566	3.81	0.08	0.77	4gctC	GO:0000976 GO:0003677 GO:0003700 GO:0005737 GO:0005829 GO:0006355 GO:0007049 GO:0009295 GO:0010974 GO:0043565 GO:0043590 GO:0051301 GO:0051302

Consensus prediction of GO terms

Molecular Function	GO:0044212	GO:0001071	GO:0042802	GO:0046983	GO:1990837
GO-Score	0.57	0.57	0.57	0.57	0.57
Biological Processes	GO:0006355
GO-Score	0.87
Cellular Component	GO:0044444
GO-Score	0.57

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.