I-TASSER results

I-TASSER results for job id Rv1158c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (227 residues)
MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLA
TALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITP
AAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQV
PQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLATALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITPAAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQVPQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP
Prediction	CCCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98766544554344456666788888889999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLATALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITPAAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQVPQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP
Prediction	64301230311000101122133332453544344544453454345344433633662554354444344464463435444444444444454344454454436446444444444544444445444443544544454443444544454344643543536454454343445434436446734444444446435446444364454444334346768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLATALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITPAAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQVPQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP

5gaoE

0.26

1.00

1.52

MUSTER

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAA

4nl6A

0.10

1.00

1.99

dPPAS

TALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSM

1mv3A

0.13

0.08

0.61

2.89

wdPPAS

----------------------------------------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPP

5gaoE

0.26

1.00

1.90

wMUSTER

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATT

1mv3A

0.13

0.08

0.61

3.52

wPPAS

----------------------------------------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPP

1mv3A

0.13

0.08

0.61

3.95

dPPAS2

----------------------------------------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPP

5gaoE

0.26

1.00

2.83

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

1tu7A

0.11

0.10

0.88

0.57

Env-PPAS

MSYKLTYIRGLAEPIRLFLVDQDIKFDRIAKDDFSSIKSQFQFGQLPCLYDGDQQIVQSGAILRARKYNLNGENEMETTYIDMFCEGVRDLHVKYTRMIYMAYETEKDPYIKSILPGELAKFEKLLATRGNGRNLILGDKISYALFEELDVHQILDPHCLDKFPLLKVFHQRMKDRPKLKEYCEKRDAAKVPVNGNGKQ----------------------------

2pffB

0.06

1.00

1.41

MUSTER

GTLDINPDDDYGFKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

3gv2A

0.10

0.96

1.97

dPPAS

----PIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNAATETLLVQNANPDCKTILKALGPGATLEEMMTACQ----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.64

Estimated TM-score = 0.32±0.10

Estimated RMSD = 14.4±3.8Å

Download Model 2

C-score=-3.66

Download Model 3

C-score=-4.03

Download Model 4

C-score=-4.17

Download Model 5

C-score=-4.43

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1tu7A	0.749	2.44	0.101	0.872
2	1pgtA	0.726	2.73	0.106	0.872
3	2fnoA	0.721	3.14	0.068	0.903
4	5an1A	0.701	3.33	0.055	0.881
5	1b8xA	0.700	3.63	0.071	0.916
6	4q5qA	0.700	3.26	0.080	0.877
7	2f3mA	0.694	3.29	0.085	0.877
8	4w66A	0.694	3.34	0.070	0.885
9	2on5A	0.688	2.75	0.090	0.833
10	4q5nA	0.688	3.52	0.069	0.894

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	7	1tu8A	GTX	Rep, Mult	6,7,11,37,39,45,46,47,58,59,89,100,196
2	0.11	5	3gssA	EAA	Rep, Mult	6,7,96,100,101,196
3	0.06	3	2e3bA	MAN	Rep, Mult	64,107,108,113,114
4	0.02	1	4a5wB	BMA	Rep, Mult	43,44,63,76
5	0.02	1	4zxgA	MES	Rep, Mult	21,22,176,177,178
6	0.02	1	2wsc3	CLA	Rep, Mult	70,73
7	0.02	1	2e84A	ZN	Rep, Mult	167,168,169
8	0.02	1	2civA	MAN	Rep, Mult	47,49
9	0.02	1	2qt6A	CA	Rep, Mult	169,195
10	0.02	1	2buqA	CAQ	Rep, Mult	174,175
11	0.02	1	1cq1B	CA	Rep, Mult	81,82
12	0.02	1	16gs0	III	Rep, Mult	53,56,57,61,64,66,67,71,75,78,79,82,83,86,87,90,122

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.164	1tu8D	0.749	2.44	0.101	0.872	2.5.1.18	NA
2	0.164	1tu7A	0.749	2.44	0.101	0.872	2.5.1.18	NA
3	0.136	13gsA	0.724	2.76	0.106	0.872	2.5.1.18	NA
4	0.119	1iyhA	0.668	3.06	0.096	0.828	5.3.99.2	NA
5	0.113	2pvqA	0.648	3.08	0.115	0.806	2.5.1.18	55,57
6	0.112	2ntoA	0.650	3.06	0.109	0.806	2.5.1.18	NA
7	0.110	2f3mA	0.694	3.29	0.085	0.877	2.5.1.18	NA
8	0.109	2dc5A	0.699	3.19	0.070	0.877	2.5.1.18	NA
9	0.108	1hnaA	0.695	3.21	0.086	0.872	2.5.1.18	NA
10	0.105	1gsqA	0.660	3.18	0.089	0.837	2.5.1.18	NA
11	0.104	1m0uA	0.656	3.26	0.085	0.828	2.5.1.18	NA
12	0.103	1zl9B	0.670	2.93	0.085	0.828	2.5.1.18	7,13
13	0.102	4gtuA	0.692	3.32	0.085	0.877	2.5.1.18	NA
14	0.100	1fheA	0.688	3.38	0.090	0.881	2.5.1.18	NA
15	0.098	1gsbA	0.688	3.36	0.090	0.877	2.5.1.18	NA
16	0.095	2aawC	0.674	2.95	0.122	0.828	2.5.1.18	14,56
17	0.094	1oktA	0.671	3.07	0.122	0.833	2.5.1.18	NA
18	0.092	2hnlA	0.663	3.02	0.065	0.819	2.5.1.18	93
19	0.060	1pd21	0.671	3.01	0.106	0.828	5.3.99.2	NA
20	0.060	2fheA	0.680	3.61	0.103	0.894	2.5.1.18	NA
21	0.060	2wb9A	0.675	2.90	0.090	0.833	2.5.1.18	NA
22	0.060	2vczC	0.605	2.96	0.101	0.740	5.3.99.2	NA
23	0.060	1gulA	0.673	3.31	0.070	0.855	2.5.1.18	NA
24	0.060	1bg5A	0.685	3.86	0.063	0.912	2.5.1.18	NA
25	0.060	2gsqA	0.657	3.22	0.089	0.837	2.5.1.18	NA
26	0.060	1glpA	0.725	2.73	0.106	0.872	2.5.1.18	NA
27	0.060	1zl9A	0.677	2.84	0.085	0.828	2.5.1.18	NA
28	0.060	1c72A	0.681	3.42	0.090	0.877	2.5.1.18	NA
29	0.060	2fheB	0.679	3.61	0.103	0.894	2.5.1.18	57,59
30	0.060	1b4pA	0.689	3.35	0.075	0.877	2.5.1.18	NA
31	0.060	2v6kA	0.669	3.12	0.100	0.833	5.2.1.2	NA
32	0.060	2c3nA	0.659	3.38	0.071	0.846	2.5.1.18	NA
33	0.060	3gtuB	0.703	3.34	0.069	0.890	2.5.1.18	NA
34	0.060	1b8xA	0.700	3.63	0.071	0.916	2.5.1.18	NA
35	0.060	1r5aA	0.664	3.39	0.098	0.855	2.5.1.18	NA
36	0.060	2cz3A	0.641	3.03	0.106	0.784	2.5.1.18,5.2.1.2	NA
37	0.060	1fw1A	0.668	3.11	0.101	0.828	2.5.1.18,5.2.1.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.724	2.76	0.11	0.87	13gsA	GO:0000302 GO:0002674 GO:0004364 GO:0005615 GO:0005622 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006469 GO:0006749 GO:0006805 GO:0007417 GO:0008144 GO:0008152 GO:0008432 GO:0009636 GO:0009890 GO:0010804 GO:0014003 GO:0016740 GO:0019207 GO:0031100 GO:0031667 GO:0031982 GO:0032355 GO:0032691 GO:0032720 GO:0032869 GO:0032872 GO:0032873 GO:0032930 GO:0033591 GO:0035726 GO:0035730 GO:0035731 GO:0035732 GO:0043066 GO:0043124 GO:0043200 GO:0043295 GO:0043407 GO:0043409 GO:0043508 GO:0045471 GO:0046689 GO:0048147 GO:0051771 GO:0070026 GO:0070062 GO:0070372 GO:0070373 GO:0070664 GO:0071222 GO:0071364 GO:0071385 GO:0071460 GO:0071638 GO:0097057 GO:1901687 GO:2001237
1	0.19	0.650	3.36	0.09	0.82	1yq1A	GO:0016740
2	0.15	0.749	2.44	0.10	0.87	1tu7A	GO:0004364 GO:0008152 GO:0016740
3	0.15	0.675	2.90	0.09	0.83	2wb9A	GO:0004364 GO:0016740
4	0.14	0.725	2.73	0.11	0.87	1glpA	GO:0000302 GO:0002674 GO:0004364 GO:0005615 GO:0005622 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006749 GO:0006805 GO:0008144 GO:0008152 GO:0008432 GO:0009636 GO:0009890 GO:0014003 GO:0016740 GO:0019207 GO:0031100 GO:0031667 GO:0031982 GO:0032355 GO:0032691 GO:0032720 GO:0032869 GO:0032872 GO:0032873 GO:0032930 GO:0033591 GO:0035726 GO:0035730 GO:0035731 GO:0043066 GO:0043124 GO:0043200 GO:0043234 GO:0043407 GO:0043508 GO:0045471 GO:0048147 GO:0051771 GO:0070062 GO:0070372 GO:0070373 GO:0070664 GO:0071222 GO:0071364 GO:0071385 GO:0071460 GO:0071638 GO:0097057 GO:2000429 GO:2000469 GO:2001237
5	0.13	0.742	2.55	0.08	0.87	5d73A	GO:0004364 GO:0008152 GO:0016740
6	0.12	0.723	2.76	0.10	0.87	2gsrA	GO:0004364 GO:0005634 GO:0005737 GO:0005739 GO:0008152 GO:0016740
7	0.12	0.612	3.99	0.08	0.84	4hz4A	GO:0016740
8	0.12	0.687	3.59	0.10	0.90	3isoA	GO:0016740 GO:0046872
9	0.12	0.685	3.86	0.06	0.91	1bg5A	GO:0004364 GO:0016740
10	0.11	0.688	2.75	0.09	0.83	2on5A	GO:0016740
11	0.11	0.703	3.34	0.07	0.89	3gtuB	GO:0004364 GO:0005634 GO:0005737 GO:0005829 GO:0006749 GO:0008065 GO:0008152 GO:0016740 GO:0018916 GO:0019899 GO:0035686 GO:0042178 GO:0042802 GO:0042803 GO:0043295 GO:0043627 GO:0070062 GO:0070458 GO:1901687
12	0.11	0.678	3.59	0.10	0.89	3h1nB	GO:0016740
13	0.11	0.700	3.63	0.07	0.92	1b8xA	GO:0004364 GO:0016740
14	0.11	0.661	3.43	0.06	0.86	1b48A	GO:0004364 GO:0005737 GO:0005739 GO:0006749 GO:0006805 GO:0008144 GO:0008152 GO:0009635 GO:0010043 GO:0016740 GO:0035094 GO:0043295 GO:0071285
15	0.11	0.694	3.29	0.09	0.88	2f3mA	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0016740 GO:0018916 GO:0019899 GO:0042178 GO:0042803 GO:0043295 GO:0070458 GO:1901687
16	0.11	0.699	3.19	0.07	0.88	2dc5A	GO:0004364 GO:0005102 GO:0005737 GO:0006749 GO:0008152 GO:0010880 GO:0016529 GO:0016740 GO:0018916 GO:0019899 GO:0042178 GO:0042803 GO:0043295 GO:0060315 GO:0060316 GO:0070062 GO:0070458 GO:0071313
17	0.11	0.669	3.00	0.09	0.83	3w8sA	GO:0016740
18	0.11	0.645	3.36	0.10	0.83	4q5rA	GO:0004364 GO:0016740
19	0.11	0.660	3.18	0.09	0.84	1gsqA	GO:0004364 GO:0005737 GO:0016740
20	0.11	0.700	3.26	0.08	0.88	4q5qA	GO:0004364 GO:0005737 GO:0008152 GO:0016740
21	0.11	0.677	2.84	0.09	0.83	1zl9A	GO:0004364 GO:0016740 GO:0045087
22	0.11	0.673	3.07	0.09	0.84	4ofmB	GO:0016740
23	0.11	0.671	3.01	0.11	0.83	1pd21	GO:0000287 GO:0001516 GO:0004364 GO:0004667 GO:0005509 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0016740 GO:0016853 GO:0042803 GO:2000255
24	0.11	0.666	3.05	0.10	0.83	4ec0B	GO:0000287 GO:0001516 GO:0004364 GO:0004667 GO:0005509 GO:0005737 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0007165 GO:0007626 GO:0016740 GO:0016853 GO:0019371 GO:0042803 GO:0046872 GO:1901687 GO:2000255
25	0.11	0.656	3.26	0.09	0.83	1m0uA	GO:0004364 GO:0004602 GO:0005737 GO:0006749 GO:0006979 GO:0008152 GO:0009636 GO:0016740 GO:0098869
26	0.11	0.671	2.89	0.05	0.83	1u3iA	GO:0004364 GO:0016740
27	0.10	0.675	3.08	0.08	0.84	1tw9F	GO:0016740
28	0.10	0.688	3.52	0.07	0.89	4q5nA	GO:0016740
29	0.10	0.621	3.38	0.10	0.78	1e6bA	GO:0003824 GO:0004364 GO:0004601 GO:0005737 GO:0005829 GO:0006749 GO:0009072 GO:0009407 GO:0009636 GO:0016034 GO:0016491 GO:0016740 GO:0016853 GO:0055114 GO:0098869 GO:1902000
30	0.10	0.689	3.33	0.07	0.88	2ab6A	GO:0004364 GO:0005102 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0010880 GO:0010881 GO:0014809 GO:0016529 GO:0016740 GO:0018916 GO:0019899 GO:0042178 GO:0042803 GO:0043295 GO:0055119 GO:0060315 GO:0060316 GO:0070062 GO:0070458 GO:0071313 GO:1901687
31	0.10	0.688	3.38	0.09	0.88	1fheA	GO:0004364 GO:0005737 GO:0016740
32	0.10	0.681	3.42	0.09	0.88	1c72A	GO:0004364 GO:0005737 GO:0008152 GO:0016740
33	0.10	0.689	3.35	0.07	0.88	1b4pA	GO:0004364 GO:0005737 GO:0005829 GO:0005886 GO:0006805 GO:0007568 GO:0007608 GO:0008152 GO:0010038 GO:0014070 GO:0016740 GO:0033595 GO:0042803 GO:0043234 GO:0050896 GO:1902168
34	0.10	0.692	3.32	0.09	0.88	4gtuA	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0016740 GO:0018916 GO:0019899 GO:0042178 GO:0042803 GO:0043295 GO:1901687
35	0.10	0.688	3.36	0.09	0.88	1gsbA	GO:0004364 GO:0005496 GO:0005576 GO:0005737 GO:0006749 GO:0007608 GO:0008152 GO:0010038 GO:0010226 GO:0010288 GO:0016151 GO:0016740 GO:0019901 GO:0042493 GO:0042803 GO:0043200 GO:0043234 GO:0045471 GO:0046677 GO:0048678 GO:0050896
36	0.10	0.680	2.80	0.10	0.83	4q5fD	GO:0004364 GO:0004602 GO:0005737 GO:0005903 GO:0016740 GO:0055114 GO:0098869
37	0.10	0.629	3.57	0.08	0.83	3vpqA	GO:0016740
38	0.10	0.682	3.64	0.09	0.90	2wrtA	GO:0004364 GO:0005737 GO:0016740
39	0.10	0.680	3.61	0.10	0.89	2fheA	GO:0004364 GO:0008152 GO:0016740
40	0.10	0.677	3.37	0.07	0.86	3ik7A	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0006805 GO:0008152 GO:0016740 GO:0042803 GO:1901687
41	0.10	0.674	2.95	0.12	0.83	2aawC	GO:0004364 GO:0016740
42	0.10	0.673	3.49	0.09	0.87	4pngB	GO:0004364 GO:0004602 GO:0005737 GO:0006749 GO:0016740 GO:0098869
43	0.10	0.670	3.46	0.07	0.86	3i69B	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0016740 GO:0030855 GO:0070062 GO:1901687
44	0.09	0.663	3.02	0.07	0.82	2hnlA	GO:0004364 GO:0016740
45	0.09	0.661	3.50	0.07	0.86	1agsA	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0016740 GO:0030855 GO:0070062 GO:1901687
46	0.09	0.649	3.27	0.07	0.82	2caiB	GO:0004364 GO:0016740
47	0.09	0.662	3.48	0.07	0.86	2vcvA	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0016740 GO:0070062 GO:1901687
48	0.09	0.660	3.52	0.08	0.86	1ev4A	GO:0004364 GO:0005634 GO:0005640 GO:0005737 GO:0005829 GO:0007568 GO:0008144 GO:0008152 GO:0016740 GO:0031667 GO:0042178 GO:0042493 GO:0043295
49	0.09	0.605	2.96	0.10	0.74	2vczC	GO:0000287 GO:0001516 GO:0004364 GO:0004667 GO:0005509 GO:0005737 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0007165 GO:0007626 GO:0016740 GO:0016853 GO:0019371 GO:0042803 GO:0046872 GO:1901687 GO:2000255
50	0.09	0.668	3.47	0.08	0.86	4mdcB	GO:0004364 GO:0016740
51	0.09	0.664	3.44	0.06	0.86	1vf4A	GO:0004364 GO:0005737 GO:0006749 GO:0008152 GO:0016740
52	0.08	0.640	3.44	0.09	0.83	1byeA	GO:0004364 GO:0016740
53	0.08	0.659	3.38	0.07	0.85	2c3nA	GO:0004364 GO:0004602 GO:0005737 GO:0005829 GO:0006749 GO:0016740 GO:0070062 GO:0098869 GO:1901687
54	0.08	0.646	3.45	0.10	0.84	2ws2A	GO:0016740
55	0.08	0.638	3.51	0.12	0.83	1aw9A	GO:0004364 GO:0016740
56	0.08	0.643	3.75	0.07	0.86	3qagA	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0006805 GO:0008152 GO:0016491 GO:0016740 GO:0019852 GO:0045174 GO:0050610 GO:0055114 GO:0070062 GO:0071243 GO:0098869 GO:1901687
57	0.08	0.600	3.97	0.12	0.83	3lszA	GO:0004364 GO:0016740
58	0.07	0.638	3.84	0.05	0.85	3qavA	GO:0016740
59	0.07	0.619	3.52	0.06	0.82	4ri6A	GO:0004364 GO:0005737 GO:0006749 GO:0016740
60	0.07	0.661	3.45	0.07	0.85	4mpgB	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0016740 GO:0070062 GO:1901687
61	0.07	0.619	3.43	0.09	0.80	4f0bA	GO:0016740
62	0.07	0.601	3.75	0.08	0.81	2ycdA	GO:0016740
63	0.07	0.593	3.51	0.06	0.78	3erfA	GO:0004364 GO:0006749 GO:0016740
64	0.07	0.642	3.71	0.09	0.85	3vlnA	GO:0004364 GO:0005604 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0010880 GO:0010881 GO:0014810 GO:0016491 GO:0016740 GO:0019852 GO:0019853 GO:0030424 GO:0031965 GO:0032259 GO:0042178 GO:0043209 GO:0044297 GO:0045174 GO:0050610 GO:0055114 GO:0060315 GO:0060316 GO:0070062 GO:0071243 GO:0098869 GO:1901687

Consensus prediction of GO terms

Molecular Function	GO:0004364	GO:1900750	GO:0072341	GO:0008432	GO:0035731	GO:0035730	GO:0008144	GO:0019207
GO-Score	0.50	0.39	0.39	0.31	0.31	0.31	0.31	0.31
Biological Processes	GO:0051179	GO:1901685	GO:0010038	GO:0044272	GO:0033484	GO:1901566	GO:1990267	GO:0001960	GO:0044711	GO:0010803	GO:0051771	GO:0032869	GO:0048147	GO:0031100	GO:0071638	GO:0071385	GO:0070664	GO:0043124	GO:0009636	GO:0035726	GO:0000302	GO:0045471	GO:0014003	GO:0032720	GO:0033591	GO:0006749	GO:0071460	GO:0043508	GO:2001237	GO:0032930	GO:0006805	GO:0032355	GO:0070373	GO:0043200	GO:0032691	GO:0071364	GO:0002674	GO:0071222
GO-Score	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31
Cellular Component	GO:0070062	GO:0005829	GO:0005886	GO:0005739	GO:0097057	GO:0005634	GO:0005615
GO-Score	0.31	0.31	0.31	0.31	0.31	0.31	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.