I-TASSER results

I-TASSER results for job id Rv1140

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (282 residues)
MPRDYTAPRWAHAWAGEPRPARWHPANQPAHPDHSNRESPACMSQSTTPYRSSVLAEFRR
AITNVAVPHHEPPGIVRRRRVVVGVTLVIGAVMLGFSLRRTPGESSFYWLTLALAAVWIA
GALMSGPLHLGGICWRGRNQRPVITGTTVGLLLAGIFGVGAMIVRAIPGAAEPIARVLQF
AHQGTLLPILLITLINGIAEEMFFRGALYTALGRRYPVTISTVLYVGATMASANLMLGFA
AIFVGTVCALERRASGGVLAPILTHFVWGLIMVFALPPLFAV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRDYTAPRWAHAWAGEPRPARWHPANQPAHPDHSNRESPACMSQSTTPYRSSVLAEFRRAITNVAVPHHEPPGIVRRRRVVVGVTLVIGAVMLGFSLRRTPGESSFYWLTLALAAVWIAGALMSGPLHLGGICWRGRNQRPVITGTTVGLLLAGIFGVGAMIVRAIPGAAEPIARVLQFAHQGTLLPILLITLINGIAEEMFFRGALYTALGRRYPVTISTVLYVGATMASANLMLGFAAIFVGTVCALERRASGGVLAPILTHFVWGLIMVFALPPLFAV
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	988778876544567888887667777888888877778766788888877656899999986578888888555333445788999999999999985588875799999999999999999864445565556677654689999999999999999999999856756799999998555759999999999877889998889999886556699999999999998756899999999999999999998984799999999999999999765589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRDYTAPRWAHAWAGEPRPARWHPANQPAHPDHSNRESPACMSQSTTPYRSSVLAEFRRAITNVAVPHHEPPGIVRRRRVVVGVTLVIGAVMLGFSLRRTPGESSFYWLTLALAAVWIAGALMSGPLHLGGICWRGRNQRPVITGTTVGLLLAGIFGVGAMIVRAIPGAAEPIARVLQFAHQGTLLPILLITLINGIAEEMFFRGALYTALGRRYPVTISTVLYVGATMASANLMLGFAAIFVGTVCALERRASGGVLAPILTHFVWGLIMVFALPPLFAV
Prediction	755624123102212354333544416445347455564334336354443333043024104514353654432132210000010332333112002042433200010333132233202212323122131444432100000011331222133113313203313520430252144210110111002313211200011014204632100000221111113333310232022002000000233410000000023113223323233346
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
MPRDYTAPRWAHAWAGEPRPARWHPANQPAHPDHSNRESPACMSQSTTPYRSSVLAEFRRAITNVAVPHHEPPGIVRRRRVVVGVTLVIGAVMLGFSLRRTPGESSFYWLTLALAAVWIAGALMSGPLHLGGICWRGRNQRPVITGTTVGLLLAGIFGVGAMIVRAIPGAAEPIARVLQFAHQGTLLPILLITLINGIAEEMFFRGALYTALGRRYPVTISTVLYVGATMASANLMLGFAAIFVGTVCALERRASGGVLAPILTHFVWGLIMVFALPPLFAV

4cadC

0.14

0.10

0.72

0.97

MUSTER

-------------------------------------------------------------------------NPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLINLKTIPVVFLLMPAVILLSILLSIPFGGSISQFQF-----SGGDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFYQYEIFNQSIWYGLNFF-SIILAIIFHFLINLNQELLAQDTKII

4cadC

0.14

0.10

0.72

0.86

dPPAS

---------------------------------------------------------------------------NPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLINLKTIPVVFLLMPAVILLSILLSIPFGGSIS---QFQFSGGDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFVNNSYQYEIFNQSIWYGLSIILAIIFHFLINLNQELLAITQDTK

4cadC

0.14

0.10

0.72

1.79

wdPPAS

-------------------------------------------------------------------------NPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLINLKTIPVVFLLMPAVILLSILLSIPFGGSI-----SQFQFSGGDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFYQYEIFNQSIWYGLNFF-SIILAIIFHFLINLNQELLAITQDTK

4cadC

0.14

0.10

0.72

1.33

wMUSTER

-------------------------------------------------------------------------NPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLINLKTIPVVFLLMPAVILLSILLSIPFGGSISQFQF-----SGGDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFYQYEIFNQSIWYGLNFF-SIILAIIFHFLINLNQELLAQDTKII

4cadC

0.14

0.10

0.72

2.55

wPPAS

-------------------------------------------------------------------------NPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLINLKTIPVVFLLMPAVILLSILLSIPFGGSISQFQ------SGGDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFYQYEIFNQSIWYGLNFF-SIILAIIFHFLINLNQELLAQDTKII

4cadC

0.13

0.10

0.72

1.94

dPPAS2

---------------------------------------------------------------------------NPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLILKTIPVVFLLMPAVILLSILLSIPFGGSIS----QFQFSGGDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFVNNSYQYEIFNQSIWYGLSIILAIIFHFLINLNQELLAITQDTK

4cadC

0.13

0.10

0.72

1.71

PPAS

---------------------------------------------------------------------------NPKLYFLSTFVVTYILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLILKTIPVVFLLMPAVILLSILLSIPFGGSISQFQF----SGGDFVPVLFLLLLAATFEELGWRGYAFDSLQSRYSLFKASILFGIFWSLWHFPLIFVNNSYQYEIFNQSIWYG-SIILAIIFHFLINLNQELLAQDTKII

1vw4T

0.14

0.10

0.72

0.68

Env-PPAS

ARTKFTKPK-----PKQPVLPKDKIRPPTQLTHHSNNLRTEPIPPTTSNLRCPPLWQFFSNKKFIRSADDLPPSSHIR-------------PWSIPELRHKSFNHSLWYNCLREQNVLARENHLLKNIVGSTHD-------------EFSELSNSIRTTMWQIRHVLNERELAYSASREFLQDESERKKFLDTLANDYFDDEVASMLTRFQLAIFGDINFIDGIKFLANLKLQR------------------------------------------------

3wxvA

0.11

0.09

0.87

0.86

MUSTER

-----------------------GSEGRWRV---PYDVLPDWLKDND-PPMPSFRACFKSI-------RIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTV--YCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVMGWFFLMAVMYITGAGLYAARIVVAAAFVHFYGVSNLQEFRYGLEGG

3wxvA

0.11

0.10

0.89

0.80

dPPAS

-----------------------GSEGRWRVIPYDVLPDWLKDNDYLLPPMPSFRACFKSIF-------RIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVMGWFFLMAVMYITGAGLYAARIVVAAAFVHFYGVSNLQEFRYGLEGG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.24

Estimated TM-score = 0.35±0.12

Estimated RMSD = 13.9±3.9Å

Download Model 2

C-score=-3.84

Download Model 3

C-score=-3.94

Download Model 4

C-score=-4.00

Download Model 5

C-score=-3.92

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4cadC	0.686	1.56	0.132	0.723
2	4av3A	0.467	5.96	0.062	0.773
3	2ww9A	0.432	5.77	0.061	0.674
4	1d0nA	0.428	6.16	0.046	0.734
5	3rkoM	0.420	5.12	0.052	0.617
6	3kbcA	0.418	6.25	0.060	0.716
7	2w02B	0.413	5.43	0.044	0.638
8	5jm7A	0.411	5.50	0.031	0.638
9	3rkoL	0.408	5.98	0.031	0.656
10	2pulA	0.406	6.36	0.052	0.702

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	1v54B	HEA	Rep, Mult	86,200,203,204
2	0.06	3	3rkoL	LFA	Rep, Mult	193,196,197,262
3	0.04	2	2xkpA	AKG	Rep, Mult	198,201
4	0.04	2	2b2jA	XE	Rep, Mult	208,221,224
5	0.04	2	4fbyZ	CLA	Rep, Mult	272,273,277
6	0.04	2	2nwwC	TB1	Rep, Mult	207,208,225,228,229,232
7	0.04	2	1sijA	FES	Rep, Mult	242,243,245,248,252,253,254
8	0.04	2	4ro2B	GLY	Rep, Mult	192,195
9	0.02	1	2xquB	CVM	Rep, Mult	256,259
10	0.02	1	2voyH	III	Rep, Mult	271,274
11	0.02	1	3a0bJ	MGE	Rep, Mult	203,204,206,207,211,212,213
12	0.02	1	1fbmD	RTL	Rep, Mult	187,194
13	0.02	1	5klgA	6UC	Rep, Mult	89,92
14	0.02	1	3d1lB	MPR	Rep, Mult	110,145,146
15	0.02	1	4ub8h	CLA	Rep, Mult	81,84

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2cb1A	0.384	6.40	0.029	0.663	4.2.99.10	204
2	0.060	1gph1	0.381	5.87	0.009	0.614	2.4.2.14	169
3	0.060	1u0uA	0.383	6.18	0.058	0.642	2.3.1.-	NA
4	0.060	1e5eA	0.380	6.59	0.040	0.670	4.4.1.11	NA
5	0.060	1kqfA	0.382	6.03	0.066	0.642	1.2.1.2	NA
6	0.060	2iukB	0.367	6.94	0.044	0.695	1.13.11.12	NA
7	0.060	1cs1A	0.379	6.39	0.053	0.656	2.5.1.48	225
8	0.060	2pywA	0.403	6.40	0.060	0.699	2.7.1.100	NA
9	0.060	2pnrF	0.358	6.03	0.053	0.596	2.7.11.2	NA
10	0.060	1vlbA	0.394	6.50	0.065	0.699	1.2.99.7	NA
11	0.060	3dwbA	0.384	6.67	0.048	0.670	3.4.24.71	265
12	0.060	2o2dB	0.376	6.31	0.038	0.635	5.3.1.9	NA
13	0.060	1q50A	0.322	6.34	0.056	0.550	5.3.1.9	200
14	0.060	1z1eA	0.383	6.20	0.040	0.642	2.3.1.95	NA
15	0.060	1a26A	0.396	5.54	0.059	0.606	2.4.2.30	NA
16	0.060	2c7tA	0.381	5.88	0.026	0.621	2.6.1.-	118
17	0.060	3crlB	0.397	6.16	0.074	0.670	2.7.11.2	NA
18	0.060	3d2rB	0.387	6.37	0.067	0.660	2.7.11.2	201
19	0.060	1cl2B	0.381	6.31	0.024	0.649	4.4.1.8	91,231

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.685	1.81	0.13	0.73	4cadI	GO:0004175 GO:0004662 GO:0005886 GO:0005887 GO:0006508 GO:0008233 GO:0016020 GO:0016021 GO:0016787 GO:0071586
1	0.07	0.470	5.62	0.07	0.74	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
2	0.07	0.404	6.44	0.06	0.71	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
3	0.06	0.420	5.99	0.07	0.68	2yxrA	GO:0005622 GO:0005886 GO:0006605 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0065002
4	0.06	0.428	6.16	0.05	0.73	1d0nA	GO:0003779 GO:0005509 GO:0005737 GO:0005856 GO:0030030 GO:0045010 GO:0046872 GO:0051014 GO:0051016 GO:0051693 GO:0060271
5	0.06	0.326	6.27	0.05	0.55	2wwbA	GO:0005783 GO:0005789 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0030176 GO:0045047
6	0.06	0.381	6.23	0.06	0.63	3jc21	GO:0005783 GO:0005789 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0030176 GO:0045047
7	0.06	0.424	6.10	0.07	0.71	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
8	0.06	0.330	5.79	0.06	0.52	3mp7A	GO:0005622 GO:0005886 GO:0006605 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0065002
9	0.06	0.432	5.77	0.06	0.67	2ww9A	GO:0005048 GO:0005783 GO:0005789 GO:0006614 GO:0006810 GO:0008320 GO:0015031 GO:0016020 GO:0016021 GO:0071261 GO:0071806
10	0.06	0.316	6.13	0.06	0.53	1de5A	GO:0005737 GO:0008740 GO:0016853 GO:0019299 GO:0019301 GO:0019324 GO:0030145 GO:0042802 GO:0046872
11	0.06	0.320	6.40	0.07	0.56	3bo0A	GO:0005622 GO:0005886 GO:0006605 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0065002
12	0.06	0.261	6.86	0.07	0.48	5bv7A	GO:0004607 GO:0004623 GO:0005576 GO:0005615 GO:0006629 GO:0006644 GO:0006656 GO:0008202 GO:0008203 GO:0008374 GO:0016740 GO:0016746 GO:0030301 GO:0034186 GO:0034364 GO:0034372 GO:0034375 GO:0034435 GO:0042157 GO:0042158 GO:0042632 GO:0043691 GO:0046470 GO:0046688 GO:0051384 GO:0070062 GO:0090107
13	0.06	0.302	4.94	0.04	0.43	5ahzA	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
14	0.06	0.263	6.33	0.09	0.46	5ez7A	GO:0016491 GO:0055114
15	0.06	0.282	6.24	0.05	0.49	5a1kA	GO:0001786 GO:0003779 GO:0005509 GO:0005545 GO:0005546 GO:0005737 GO:0005856 GO:0005903 GO:0005938 GO:0008285 GO:0017156 GO:0032330 GO:0042989 GO:0043065 GO:0045010 GO:0045654 GO:0051014 GO:0051015 GO:0051047 GO:0051127 GO:0051693 GO:0070062
16	0.06	0.235	7.07	0.04	0.45	2fh4A	GO:0001726 GO:0002102 GO:0003779 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005925 GO:0006911 GO:0006915 GO:0007568 GO:0008154 GO:0010628 GO:0014003 GO:0014891 GO:0015629 GO:0016192 GO:0016528 GO:0019904 GO:0022617 GO:0030027 GO:0030030 GO:0030041 GO:0030155 GO:0030478 GO:0030864 GO:0031648 GO:0042060 GO:0042246 GO:0042989 GO:0043209 GO:0043234 GO:0044267 GO:0045010 GO:0045159 GO:0045471 GO:0046597 GO:0046872 GO:0048015 GO:0048471 GO:0051014 GO:0051016 GO:0051127 GO:0051593 GO:0051693 GO:0060271 GO:0070062 GO:0071276 GO:0071801 GO:0072562 GO:0090527 GO:0097017 GO:0097284 GO:1902174 GO:1903689 GO:1903903 GO:1903906 GO:1903909 GO:1903923 GO:1990000 GO:2001269
17	0.06	0.248	7.26	0.04	0.48	4rapE	GO:0008152 GO:0016740 GO:0016757
18	0.06	0.278	6.35	0.06	0.47	3l0mA	GO:0000166 GO:0003824 GO:0005085 GO:0005524 GO:0005576 GO:0005622 GO:0006612 GO:0008152 GO:0008289 GO:0009405 GO:0016020 GO:0016740 GO:0016779 GO:0017137 GO:0018117 GO:0018260 GO:0033644 GO:0043087 GO:0043547 GO:0044161 GO:0044162 GO:0044600 GO:0070273 GO:0070733

Consensus prediction of GO terms

Molecular Function	GO:0070011	GO:0004661	GO:0043169
GO-Score	0.44	0.44	0.37
Biological Processes	GO:0016485	GO:0080120	GO:0051234
GO-Score	0.44	0.44	0.37
Cellular Component	GO:0031226	GO:0016021
GO-Score	0.55	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.