I-TASSER results

I-TASSER results for job id Rv1118c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (286 residues)
MQSGPHLVGRVGTSFPLIARHQGATRDDAGDTGQPDPLPHVAHPDRLYPPMVHGVDPSTL
ALDRALNETRTGDLWLFRGRSRPDRAIQTLTNAPVNHVGMTVAIDDLPPLIWHAELGDKL
LDVWTGTNHRGVQLNDARQVVQQWAGRYRQRCWLRQLTPHANRDQEDKLLRVIARMNGTP
FPTTARLTGRWLRGRLPTLNDWLRGIPVLDRKVREQTQRRKQQQRTMGLATAYCAETVAI
TYEEMGLLVTDKDAHWFDPGKFWSGDSLPLAPGYRLGHEIAVDVGG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQSGPHLVGRVGTSFPLIARHQGATRDDAGDTGQPDPLPHVAHPDRLYPPMVHGVDPSTLALDRALNETRTGDLWLFRGRSRPDRAIQTLTNAPVNHVGMTVAIDDLPPLIWHAELGDKLLDVWTGTNHRGVQLNDARQVVQQWAGRYRQRCWLRQLTPHANRDQEDKLLRVIARMNGTPFPTTARLTGRWLRGRLPTLNDWLRGIPVLDRKVREQTQRRKQQQRTMGLATAYCAETVAITYEEMGLLVTDKDAHWFDPGKFWSGDSLPLAPGYRLGHEIAVDVGG
Prediction	CCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEHCCCCCHHHHHHHHHCCCCCEEEEEEHCCCCCEEEEEHCCCCCCCEEHCCCCCCCCEEHCHHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCC
Conf.Score	9988864455666554565456777787777788888877677765666656677887899999999888995999858985899999998899858999999589985899875898754444467777746665999999998765767999858988899999999999999969998745667788887666667766555666556788888765555666676643468999999999899888988887785545678875557898778758999679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQSGPHLVGRVGTSFPLIARHQGATRDDAGDTGQPDPLPHVAHPDRLYPPMVHGVDPSTLALDRALNETRTGDLWLFRGRSRPDRAIQTLTNAPVNHVGMTVAIDDLPPLIWHAELGDKLLDVWTGTNHRGVQLNDARQVVQQWAGRYRQRCWLRQLTPHANRDQEDKLLRVIARMNGTPFPTTARLTGRWLRGRLPTLNDWLRGIPVLDRKVREQTQRRKQQQRTMGLATAYCAETVAITYEEMGLLVTDKDAHWFDPGKFWSGDSLPLAPGYRLGHEIAVDVGG
Prediction	8543341022133001010325635454435345554134234343124303431754403154027304200000011542102002113604010000001067330000003356414433344544101014035104503741422000021436344612530240044137441443343234313421431432252242345414432545445555552410000100030043041137644133020330156650402531503410203178
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEHCCCCCHHHHHHHHHCCCCCEEEEEEHCCCCCEEEEEHCCCCCCCEEHCCCCCCCCEEHCHHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCC
MQSGPHLVGRVGTSFPLIARHQGATRDDAGDTGQPDPLPHVAHPDRLYPPMVHGVDPSTLALDRALNETRTGDLWLFRGRSRPDRAIQTLTNAPVNHVGMTVAIDDLPPLIWHAELGDKLLDVWTGTNHRGVQLNDARQVVQQWAGRYRQRCWLRQLTPHANRDQEDKLLRVIARMNGTPFPTTARLTGRWLRGRLPTLNDWLRGIPVLDRKVREQTQRRKQQQRTMGLATAYCAETVAITYEEMGLLVTDKDAHWFDPGKFWSGDSLPLAPGYRLGHEIAVDVGG

3kw0B

0.12

0.08

0.65

1.03

MUSTER

---------------------------------------------YFQGGTDKFNNIKIDKYENLINVLKTGDIFLCSGNYLVSKLIKKVSES-FSHTGIIVKWGE--HTLIESVE------------DDGVRIVPLEHYIKNYENRYNGSLFIARHQNVNDDSEIRNLIKVGFSLLNSGYDKNEIAQIVARIGL---------------------------IGRHEDNNEYICSEFVNECFKKIGVEF--LTDSFIFPEHIAADHHVLPIAQIE-----------

3kw0B

0.12

0.08

0.66

1.12

dPPAS

---------------------------------------------YFQGGTDKFNNIKIDKYENLINVLKTGDIFLCSGNYLVSKLIKKVSES-FSHTGIIVKWGE--HTLIESVEDD------------GVRIVPLEHYIKNYNNRYNGSLFIARH--------------ELLQNVNDDSE---------IRNLIKVGFSLLNSGYDKNEIAQIVARIGLGIGRHEDNNEYICSEFVNECFKKIGVE--FLTDSFIFPEHIAADHHVLPIAQIE-----------

3kw0B

0.13

0.08

0.65

2.52

wdPPAS

---------------------------------------------YFQGGTDKFNNIKIDKYENLINVLKTGDIFLCSGNYLVSKLIKKVSES-FSHTGIIVK--WGEHTLIESVEDD------------GVRIVPLEHYIKNYENRYNGSLFIARHQNVNDDSEIRNLIKVGFSLLNSGYDKNEIAQIVARIGL---------------------------IGRHEDNNEYICSEFVNECFKKIGVE--FLTDSFIFPEHIAADHHVLPIAQIE-----------

3kw0B

0.12

0.08

0.65

1.35

wMUSTER

----------------------------------------------FQGGTDKFNNIKIDKYENLINVLKTGDIFLCSGNYLVSKLIKKVSES-FSHTGIIVKWGE--HTLIESVE------------DDGVRIVPLEHYIKNYENRYNGSLFIARHQNVNDDSEIRNLIKVGFSLLNSGYDKNEIAQIVARIGL---------------------------IGRHEDNNEYICSEFVNECFKKIGVEF--LTDSFIFPEHIAADHHV----------LPIAQIE-

3kw0B

0.13

0.08

0.65

2.59

wPPAS

---------------------------------------------YFQGGTDKFNNIKIDKYENLINVLKTGDIFLCSGNYLVSKLIKKVSES-FSHTGIIVK--WGEHTLIESVEDD------------GVRIVPLEHYIKNYENRYNGSLFIARHQNVNDDSEIRNLIKVGFSLLNSGYDKNEIAQIVARIGL---------------------------IGRHEDNNEYICSEFVNECFKKIGVE--FLTDSFIFPEHIAADHHV----------LPIAQIE-

3kw0B

0.14

0.09

0.66

3.10

dPPAS2

---------------------------------------------YFQGGTDKFNNIKIDKYENLINVLKTGDIFLCSGNYLVSKLIKKVSES-FSHTGIIVKWGE--HTLIESVEDD------------GVRIVPLEHYIKNYNNRYNGSLFIARHELLQNVNDDSE-----------------------IRNLIKVGFSLLNSGYDKNEIAQIVARIGLGIGRHEDNNEYICSEFVNECFKKIGVE--FLTDSFIFPEHIAADHHLPIAQIE------------

3kw0B

0.15

0.09

0.65

1.70

PPAS

---------------------------------------------YFQGGTDKFNNIKIDKYENLINVLKTGDIFLCSGNYLVSKLIKKVSES-FSHTGIIVKWGE--HTLIESVEDD------------GVRIVPLEHYIKNYNNRYNGSLFIARHQNVNDDSEIRNLIKVGFSLLNSGYDKNEIAQIVARIGL---------------------------IGRHEDNNEYICSEFVNECFKKIGVE--FLTDSFIFPEHIAADHHLPIAQIE------------

2ivoA

0.14

0.12

0.90

0.56

Env-PPAS

IEGTAHIVDKV---LANVFDTLTT------EKGGIHPEAAEHHARLMKPLLRKALSEAGVSLDDI-------DVIAFSQGATAARALAVKYRKPIAHVEITKMFGVKDPVGLYVSGGNTQVLALEGGRYRGLG-FPGGPKVEKLAEKGEKYIELPYAVKGMDSGLLTEAIRKYRSGKYRVEDLAYSFQETAFAALVEVTERAVAHTEKDENRLREMLRIMTEDRGIKVPPYDLCGAMIAYTGLRM-----------YKAGISFRLEETIVKQKFRT-DEVEIVWH-

2if6A

0.18

0.11

0.62

0.98

MUSTER

------------------------------------------------------------------WQPQTGDIIFQISRSSQSKAIQLATHSDYSHTGMLVMRNKK-PYVFEAV--------------GPVKYTPLKQWIAHGEKG---KYVVRRVEGGLSVEQQQKLAQTAKRYLGKPYDFSFSWSRQYCSEVVWKVYQNALGMRVGEQQKLKEFDLSN-------------PLVQAKLKERYGKIPLEETV--VSPQAVFDAPQLTTVA-WPLF---------

2if6A

0.16

0.10

0.64

1.05

dPPAS

------------------------------------------------------------------WQPQTGDIIFQISRSSQSKAIQLATHSDYSHTGMLVMRNKK-PYVFEAV--------------GPVKYTPLKQWIAHGEKG---KYVVRRVEGGLSVEQQQKLAQTAKRYLGKPYDFSFSWSDDRQYCSEVVWKVYQNALGMRVGEQQKLKEFDLSN-----------PLVQAKLKERYGKNIPLEETV-VSPQAVFDAPQLTTVAKEWPLF--------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.07

Estimated TM-score = 0.37±0.12

Estimated RMSD = 13.4±4.0Å

Download Model 2

C-score=-3.68

Download Model 3

C-score=-3.71

Download Model 4

C-score=-3.93

Download Model 5

C-score=-3.91

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3kw0B	0.613	1.73	0.144	0.654
2	2if6A	0.472	2.39	0.197	0.531
3	4a01A	0.410	6.24	0.030	0.689
4	1w7cA	0.396	6.37	0.047	0.682
5	4uniA	0.395	6.69	0.049	0.713
6	2e0wB	0.394	6.33	0.061	0.664
7	1kwgA	0.394	6.30	0.088	0.685
8	4uzsA	0.391	6.39	0.068	0.678
9	4he8L	0.390	6.47	0.075	0.692
10	4ofzA	0.390	6.64	0.060	0.682

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	6	3kw0B	LYS	Rep, Mult	81,83,84,87,96,97,116,118,144,148
2	0.06	3	1gw0B	MAN	Rep, Mult	80,84
3	0.06	3	2j0yC	BGC	Rep, Mult	84,86
4	0.04	2	1lshB	UPL	Rep, Mult	74,154
5	0.04	2	3e5uC	3C4	Rep, Mult	170,173,174
6	0.04	2	2hdrA	4A3	Rep, Mult	94,95,96
7	0.02	1	3btxA	MG	Rep, Mult	21,27,97
8	0.02	1	1n38A	CH1	Rep, Mult	88,89,91,92,258
9	0.02	1	4dv1J	MG	Rep, Mult	96,97
10	0.02	1	1jb0M	CLA	Rep, Mult	235,239
11	0.02	1	1zqqA	MN	Rep, Mult	131,162,165
12	0.02	1	2ouxA	MG	Rep, Mult	70,73
13	0.02	1	3sxvA	3TR	Rep, Mult	81,82,181

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2fknB	0.373	6.79	0.051	0.692	4.2.1.49	99
2	0.060	1gthA	0.369	6.69	0.051	0.668	1.3.1.2	91
3	0.060	1qlaD	0.370	6.02	0.051	0.612	1.3.99.1	138
4	0.060	1av4A	0.375	6.91	0.027	0.689	1.4.3.21,1.4.3.6	27
5	0.060	1kwgA	0.394	6.30	0.088	0.685	3.2.1.23	NA
6	0.060	1ui7A	0.379	6.52	0.032	0.661	1.4.3.21	145,283
7	0.060	2e0wB	0.394	6.33	0.061	0.664	2.3.2.2	237,248,260
8	0.060	3btaA	0.373	6.24	0.042	0.622	3.4.24.69	NA
9	0.060	1jdwA	0.381	6.13	0.077	0.640	2.1.4.1	NA
10	0.060	2vuaA	0.286	6.62	0.038	0.493	3.4.24.69	NA
11	0.060	1xmeA	0.370	5.71	0.025	0.573	1.9.3.1	NA
12	0.060	2z8kC	0.287	5.91	0.049	0.465	2.3.2.2	NA
13	0.060	1hlgA	0.325	6.69	0.047	0.587	3.1.1.3	NA
14	0.060	1yq3A	0.351	6.38	0.066	0.605	1.3.5.1	NA
15	0.060	1izjA	0.384	6.10	0.045	0.629	3.2.1.135,3.2.1.1	NA
16	0.060	1w7cA	0.396	6.37	0.047	0.682	1.4.3.13	27
17	0.060	2oqeB	0.310	6.06	0.096	0.503	1.4.3.21,1.4.3.6	27
18	0.060	2etfB	0.295	6.66	0.031	0.528	3.4.24.69	NA
19	0.060	3debA	0.367	6.13	0.080	0.594	3.4.24.69	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.406	6.44	0.04	0.69	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
1	0.06	0.410	6.24	0.03	0.69	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
2	0.06	0.310	6.70	0.02	0.55	1ksiA	GO:0005507 GO:0008131 GO:0009308 GO:0016491 GO:0046872 GO:0048038 GO:0052593 GO:0052594 GO:0052595 GO:0052596 GO:0052597 GO:0055114 GO:0097185
3	0.06	0.362	6.19	0.07	0.62	1obbA	GO:0000023 GO:0003824 GO:0004553 GO:0004558 GO:0005975 GO:0008152 GO:0016616 GO:0016787 GO:0016798 GO:0032450 GO:0046872 GO:0055114
4	0.06	0.314	6.94	0.04	0.57	3hi7A	GO:0004872 GO:0005507 GO:0005509 GO:0005576 GO:0005615 GO:0005777 GO:0005886 GO:0005923 GO:0006805 GO:0008131 GO:0008144 GO:0008201 GO:0008270 GO:0009308 GO:0016491 GO:0032403 GO:0035874 GO:0042493 GO:0042803 GO:0046677 GO:0046872 GO:0048038 GO:0052597 GO:0052598 GO:0052599 GO:0052600 GO:0055114 GO:0070062 GO:0071280 GO:0071420 GO:0071504 GO:0097185
5	0.06	0.369	7.01	0.03	0.69	3loyA
6	0.06	0.391	6.61	0.02	0.69	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
7	0.06	0.385	6.74	0.05	0.70	1tu5A	GO:0005507 GO:0005576 GO:0005615 GO:0008131 GO:0009308 GO:0016491 GO:0046872 GO:0048038 GO:0052593 GO:0052594 GO:0052595 GO:0052596 GO:0055114
8	0.06	0.380	6.69	0.04	0.69	3alaD	GO:0005507 GO:0005509 GO:0005737 GO:0005769 GO:0005783 GO:0005794 GO:0005886 GO:0005902 GO:0006805 GO:0006954 GO:0007155 GO:0008131 GO:0009308 GO:0009986 GO:0016020 GO:0016021 GO:0016491 GO:0042803 GO:0046677 GO:0046872 GO:0046982 GO:0048038 GO:0052593 GO:0052594 GO:0052595 GO:0052596 GO:0055114
9	0.06	0.306	6.23	0.06	0.52	1j6uA	GO:0000166 GO:0005524 GO:0005737 GO:0007049 GO:0008360 GO:0008763 GO:0009058 GO:0009252 GO:0016874 GO:0051301 GO:0071555
10	0.06	0.288	7.31	0.04	0.56	1avkA	GO:0005507 GO:0008131 GO:0009308 GO:0016491 GO:0046872 GO:0048038 GO:0052593 GO:0052594 GO:0052595 GO:0052596 GO:0055114
11	0.06	0.377	6.62	0.04	0.66	3nbbA	GO:0005507 GO:0005777 GO:0008131 GO:0009308 GO:0016491 GO:0046872 GO:0048038 GO:0052593 GO:0052594 GO:0052595 GO:0052596 GO:0055114
12	0.06	0.322	6.51	0.04	0.57	2wgqB	GO:0005507 GO:0005509 GO:0006559 GO:0008131 GO:0009308 GO:0016491 GO:0019607 GO:0042597 GO:0046872 GO:0048038 GO:0052593 GO:0052594 GO:0052595 GO:0052596 GO:0055114
13	0.06	0.384	6.36	0.04	0.66	3t0uB	GO:0005507 GO:0005777 GO:0008131 GO:0009308 GO:0016491 GO:0046872 GO:0048038 GO:0052593 GO:0052594 GO:0052595 GO:0052596 GO:0055114
14	0.06	0.396	6.37	0.05	0.68	1w7cA	GO:0005507 GO:0008131 GO:0009308 GO:0016491 GO:0046872 GO:0048038 GO:0052597 GO:0055114 GO:0071241
15	0.06	0.298	6.87	0.03	0.54	1smsA	GO:0004748 GO:0005634 GO:0005737 GO:0005971 GO:0006260 GO:0009186 GO:0009263 GO:0016491 GO:0051188 GO:0055114
16	0.06	0.392	6.47	0.04	0.68	3pgbA	GO:0005507 GO:0008131 GO:0009308 GO:0016491 GO:0018057 GO:0018149 GO:0046872 GO:0048038 GO:0055114
17	0.06	0.280	6.50	0.10	0.49	3r5xC	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
18	0.06	0.251	6.78	0.04	0.45	3optA	GO:0000122 GO:0001078 GO:0003676 GO:0003677 GO:0005634 GO:0006351 GO:0006355 GO:0010507 GO:0016577 GO:0032454 GO:0032968 GO:0033169 GO:0043565 GO:0046872 GO:0051864 GO:0070544

Consensus prediction of GO terms

Molecular Function	GO:0043169
GO-Score	0.57
Biological Processes	GO:0044710
GO-Score	0.36
Cellular Component	GO:0005774	GO:0005615	GO:0005777	GO:0070062	GO:0005923	GO:0005887
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.