I-TASSER results

I-TASSER results for job id Rv1111c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (327 residues)
MSAQRARSAVQASHRSIHPHIPGVPWWAAILIAVTATAIGYAIDAGSGHKALTLVFTGCY
IAGCVGAVLAVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIGKFKDLLINCGYSLIER
FPLMLGTAAGVLLIGLVRWYLGTALFDSIARKLSSLMTGDSDDDGGRRSAQRPARTRSRH
ARPPSEDNREPIAERRSRRRPRPQNDPHPRRNAHERPAPRSSRFDSYRSYQPSEPSGPAE
PVNRYERRGARYQPYARYEPTYEPQRRRARPSEPTNPTHHPISQVRYRGSATRDARRDNY
REEQRFDRRDRSRAPRRPPAESWEYDV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSAQRARSAVQASHRSIHPHIPGVPWWAAILIAVTATAIGYAIDAGSGHKALTLVFTGCYIAGCVGAVLAVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIGKFKDLLINCGYSLIERFPLMLGTAAGVLLIGLVRWYLGTALFDSIARKLSSLMTGDSDDDGGRRSAQRPARTRSRHARPPSEDNREPIAERRSRRRPRPQNDPHPRRNAHERPAPRSSRFDSYRSYQPSEPSGPAEPVNRYERRGARYQPYARYEPTYEPQRRRARPSEPTNPTHHPISQVRYRGSATRDARRDNYREEQRFDRRDRSRAPRRPPAESWEYDV
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	987656788888877777888887758999999999999999987478988648999999999999999864454567788899999999999998635888875689999999999999999999999999999998875677776666666667877777788888888888877788889888888888888888888888899999888889988888888888889998888899998888998888988889999899989999998999999999888999998889999988788998888889899999888887899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSAQRARSAVQASHRSIHPHIPGVPWWAAILIAVTATAIGYAIDAGSGHKALTLVFTGCYIAGCVGAVLAVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIGKFKDLLINCGYSLIERFPLMLGTAAGVLLIGLVRWYLGTALFDSIARKLSSLMTGDSDDDGGRRSAQRPARTRSRHARPPSEDNREPIAERRSRRRPRPQNDPHPRRNAHERPAPRSSRFDSYRSYQPSEPSGPAEPVNRYERRGARYQPYARYEPTYEPQRRRARPSEPTNPTHHPISQVRYRGSATRDARRDNYREEQRFDRRDRSRAPRRPPAESWEYDV
Prediction	746546646242564323452301201000000100121010001224343011001101120000000002342000000131322013111010002345444221200200120034111101101200000001011344456545554554554545545544556545554546653556656654665565555666865645566675455566656566656566666465466466456665646646656665656554466787466444665445578766664566666545665656654754657345257
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSAQRARSAVQASHRSIHPHIPGVPWWAAILIAVTATAIGYAIDAGSGHKALTLVFTGCYIAGCVGAVLAVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIGKFKDLLINCGYSLIERFPLMLGTAAGVLLIGLVRWYLGTALFDSIARKLSSLMTGDSDDDGGRRSAQRPARTRSRHARPPSEDNREPIAERRSRRRPRPQNDPHPRRNAHERPAPRSSRFDSYRSYQPSEPSGPAEPVNRYERRGARYQPYARYEPTYEPQRRRARPSEPTNPTHHPISQVRYRGSATRDARRDNYREEQRFDRRDRSRAPRRPPAESWEYDV

4nl6A

0.10

0.07

0.71

1.09

wPPAS

------------------------------------------MAMSSGGSG-----------GGVPE----QEDSLF---------------------RRGTGQSDDSDI------LIKAY-----------AVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQDFKRETGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADA-RQNQKEGRCSHSL

4zowA2

0.11

0.05

0.40

1.04

dPPAS2

QSP------------IIIITGEQLSGLLQVPIFGALIAGNLLLARLTSRRTIIMGGWPIMIGLLVAAAATVISSGLSIYAFGIGLANAGLVRLTLFASDMSKIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.11

0.09

0.88

1.26

PPAS

---------------------------AAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

4fsxA3

0.10

0.09

0.90

1.04

wPPAS

-S------SVAYSTFANISSTRGC---GSTGLCLGAALSGLKLETRWANSFACQSLKYNHICGC-------KQVTDIVAYLKPKYVL------VVDILKFADGYLGKYALSCLVAKYAGCYP--------VFLWGALSSVLPKYPLPTYDVVVRGGAPNAFSQCVAYDETQKPSLKKALLDLPKVQNHQPNDVEYGGSPKTEFQRYIRLSRKDLDWSFGEGAGPDEGKLLDHQPLRLNNDIPVKKGANFRDLKGVRVGANNIVEWDPEIERVKLSSGKPLVPDYASFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQVHPTQARV-L

4ke2A

0.12

0.05

0.45

1.01

dPPAS2

ASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4fsxA3

0.09

0.98

1.21

PPAS

------SYSVAYSTFANISSTRGCG--GSTGLCLGAALSGLKLETRWAVDFNSFACQSLKYNHPQTEVRNELPGDVDVICGGPPQVTFDIVAYLVVDILKFADGYLGKYALSCLVAKYQARLGVAGCYGLVFLWGALSSVLPKYPLPTYDVVVRGGAPNAFSQCVAYDETQKPSLKKALLSDLPKVQNHQPNDVEYGGSPKTEFQRYIRLSRKDLDWSFGEGAGPDEGKLLDHQPLRLNNDDYERVQQIPVKKGANFRDLKGVRVGANNIVEWDPEIERVKLSSGKPLVPDYASFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQVI

5tgzA

0.09

0.08

0.88

0.99

wPPAS

--------GGRGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVL-VFHRKDSLGGVTASFTASVGSLFLAA-RVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVPHIDKTYLMFWIGVVSVLLLFIVYAYMYILWKAHSHAVAKALIVYGSTTGNTEYTAETIARELADAGYEVDSRDAASVEAGGLFEGFDLVLLGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKVACFGCGDSSWEYFCGAVDAIEEKLKNLGAEIVQDGLRIDGDPRAA------------------------------RDDIVGWAHDVRGAIPDQARMDI

4nl6A

0.08

0.05

0.68

1.20

PPAS

----------------------------------------------------------------------------------------------MAMSSGGSGGGVPEQEDSVLF-LIKAY-----------AVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKPATIASIDFKRETGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADAL

1mv3A

0.11

0.05

0.46

0.96

wPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGTATDTDE-DV

5c2vC

0.10

0.09

0.87

1.19

PPAS

--GQPRVISTIQTGATWEPLGREEP--------LTVPEVHFRVKHSPFKSEL------------------VR-QFQF-----AAWSLQGSYSCASCHYERGQTTGLIWDLGDEGWGSWKNTKYIR--------GRYLPPFRHEGFTGHPDEIVGATSSLDRVCGRDPGFVFRSENFSPMRLEALICYIRALEFTGSPFRNADGSLTEAQKRGQKEDPKVGCLECHPGDPMDPRALFSDAQTHDVGTGRVGVNGFRSTPGKVFNISALEAGEDPYGVESNTPIIGLDLVKEFDTPTLRDIYASGT--NNTVNDKDMHGRTSHLKQQEL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.69

Estimated TM-score = 0.23±0.06

Estimated RMSD = 18.4±2.3Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4fsxA	0.755	4.10	0.046	0.951
2	4wxxA	0.634	4.85	0.076	0.872
3	3pt6A	0.631	4.99	0.072	0.878
4	3g7uA	0.471	5.00	0.068	0.667
5	3cmuA	0.451	6.57	0.049	0.764
6	2wjvA	0.424	7.09	0.042	0.768
7	1wygA	0.418	6.77	0.041	0.731
8	3zyvA	0.415	6.67	0.044	0.719
9	5a22A	0.412	6.30	0.037	0.676
10	3pyaA	0.411	6.73	0.053	0.713

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	2	3f1fQ	MG	Rep, Mult	114,115,117
2	0.05	2	1fbmD	RTL	Rep, Mult	103,110
3	0.02	1	2j62A	GSZ	Rep, Mult	123,125
4	0.02	1	4g51C	NO	Rep, Mult	85,131
5	0.02	1	3prqX	CLA	Rep, Mult	80,87
6	0.02	1	2wscI	CLA	Rep, Mult	77,81
7	0.02	1	1s5lk	CLA	Rep, Mult	25,34
8	0.02	1	3ggdA	CO	Rep, Mult	160,180
9	0.02	1	3cmvE	ANP	Rep, Mult	239,240,241,242,287
10	0.02	1	4natB	2W5	Rep, Mult	137,140
11	0.02	1	2g18D	CA	Rep, Mult	263,270
12	0.02	1	1xzwB	UUU	Rep, Mult	212,215
13	0.02	1	4fe1F	CLA	Rep, Mult	111,112,115
14	0.02	1	3zvwC	MG	Rep, Mult	281,282
15	0.02	1	2ramB	NUC	Rep, Mult	305,312
16	0.02	1	4rb62	MG	Rep, Mult	107,110
17	0.02	1	3k7tA	GP7	Rep, Mult	22,23
18	0.02	1	3k71G	UUU	Rep, Mult	224,243,246
19	0.02	1	1i40A	CA	Rep, Mult	160,162

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jJ	0.235	6.27	0.018	0.388	1.17.1.4,1.17.3.2	250
2	0.060	2epoB	0.378	6.68	0.050	0.651	3.2.1.52	NA
3	0.060	1fo4A	0.381	6.65	0.031	0.661	1.17.1.4	NA
4	0.060	1yr2A	0.398	6.59	0.060	0.673	3.4.21.26	75
5	0.060	2qr5A	0.383	6.61	0.054	0.664	3.4.19.1	NA
6	0.060	1yiqA	0.401	6.78	0.043	0.697	1.1.99.-	NA
7	0.060	1l5jA	0.402	6.35	0.026	0.667	4.2.1.3	NA
8	0.060	2epoA	0.391	6.60	0.046	0.657	3.2.1.52	303
9	0.060	3b9jC	0.287	6.94	0.055	0.501	1.17.3.2,1.17.1.4	NA
10	0.060	2tmdA	0.389	6.85	0.048	0.676	1.5.8.2	NA
11	0.060	1ja1A	0.393	6.83	0.043	0.688	1.6.2.4	NA
12	0.060	3dt7A	0.388	6.48	0.032	0.636	4.1.1.32	NA
13	0.060	1ox4B	0.396	6.54	0.056	0.661	4.1.3.-	NA
14	0.060	1bxrA	0.394	6.59	0.031	0.670	6.3.5.5	NA
15	0.060	2ow6A	0.389	7.12	0.046	0.706	3.2.1.114	326
16	0.060	1kv9A	0.394	6.69	0.019	0.673	1.1.99.-	NA
17	0.060	1orvA	0.386	6.79	0.041	0.670	3.4.14.5	NA
18	0.060	2gbcA	0.383	6.71	0.034	0.661	3.4.14.5,3.4.15.5	NA
19	0.060	2ckjA	0.379	6.59	0.053	0.651	1.17.1.4,1.17.3.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.759	4.04	0.05	0.96	4ft4B	GO:0003677 GO:0003682 GO:0003886 GO:0005634 GO:0006351 GO:0006355 GO:0008168 GO:0016568 GO:0016740 GO:0032259 GO:0090116
1	0.08	0.635	4.99	0.08	0.88	4wxxB	GO:0000122 GO:0000792 GO:0003677 GO:0003682 GO:0003690 GO:0003723 GO:0003886 GO:0005634 GO:0005654 GO:0005657 GO:0005721 GO:0005737 GO:0006306 GO:0006351 GO:0006355 GO:0007265 GO:0007420 GO:0007568 GO:0008168 GO:0008270 GO:0008327 GO:0009008 GO:0009408 GO:0009636 GO:0010033 GO:0010212 GO:0010216 GO:0010288 GO:0010424 GO:0010468 GO:0010628 GO:0014823 GO:0016458 GO:0016568 GO:0016740 GO:0019904 GO:0030182 GO:0030331 GO:0031000 GO:0031667 GO:0032259 GO:0032355 GO:0032496 GO:0032776 GO:0033189 GO:0033574 GO:0036120 GO:0036276 GO:0042127 GO:0042493 GO:0042826 GO:0043025 GO:0043234 GO:0044026 GO:0045322 GO:0045471 GO:0045814 GO:0045892 GO:0046498 GO:0046499 GO:0046500 GO:0046872 GO:0051571 GO:0051573 GO:0051718 GO:0071230 GO:0071284 GO:0071560 GO:0090116 GO:0090309 GO:1990090 GO:1990841
2	0.07	0.635	4.87	0.07	0.87	3swrA	GO:0000122 GO:0000792 GO:0003677 GO:0003682 GO:0003690 GO:0003723 GO:0003886 GO:0005634 GO:0005654 GO:0005657 GO:0005721 GO:0005737 GO:0006306 GO:0006351 GO:0006355 GO:0007265 GO:0007420 GO:0007568 GO:0008168 GO:0008270 GO:0008327 GO:0009008 GO:0009408 GO:0009636 GO:0010033 GO:0010212 GO:0010216 GO:0010288 GO:0010424 GO:0010468 GO:0010628 GO:0014823 GO:0016458 GO:0016568 GO:0016740 GO:0019904 GO:0030182 GO:0030331 GO:0031000 GO:0031667 GO:0032259 GO:0032355 GO:0032496 GO:0032776 GO:0033189 GO:0033574 GO:0036120 GO:0036276 GO:0042127 GO:0042493 GO:0042826 GO:0043025 GO:0043234 GO:0044026 GO:0045322 GO:0045471 GO:0045814 GO:0045892 GO:0046498 GO:0046499 GO:0046500 GO:0046872 GO:0051571 GO:0051573 GO:0051718 GO:0071230 GO:0071284 GO:0071560 GO:0090116 GO:0090309 GO:1990090 GO:1990841
3	0.07	0.631	5.12	0.08	0.89	3pt6B	GO:0000122 GO:0000183 GO:0000792 GO:0003677 GO:0003682 GO:0003690 GO:0003723 GO:0003824 GO:0003886 GO:0005634 GO:0005654 GO:0005657 GO:0005721 GO:0005737 GO:0006306 GO:0006351 GO:0006355 GO:0007265 GO:0007420 GO:0007568 GO:0008152 GO:0008168 GO:0008270 GO:0008327 GO:0009008 GO:0009408 GO:0009636 GO:0010033 GO:0010212 GO:0010216 GO:0010288 GO:0010424 GO:0010468 GO:0010628 GO:0014823 GO:0016458 GO:0016568 GO:0016740 GO:0019904 GO:0030182 GO:0030331 GO:0031000 GO:0031667 GO:0032259 GO:0032355 GO:0032496 GO:0032776 GO:0033189 GO:0033574 GO:0036120 GO:0036276 GO:0042127 GO:0042493 GO:0042826 GO:0043025 GO:0043045 GO:0043234 GO:0044026 GO:0045322 GO:0045471 GO:0045892 GO:0046498 GO:0046499 GO:0046500 GO:0046872 GO:0051571 GO:0051573 GO:0051718 GO:0071230 GO:0071284 GO:0071560 GO:0090116 GO:0090309 GO:1990090 GO:1990841
4	0.07	0.471	5.00	0.07	0.67	3g7uA	GO:0003886 GO:0008168 GO:0009307 GO:0016740 GO:0032259 GO:0090116
5	0.06	0.368	5.43	0.06	0.55	3ubtA	GO:0003886 GO:0008168 GO:0009307 GO:0016740 GO:0032259 GO:0090116
6	0.06	0.378	5.26	0.05	0.55	1svuA	GO:0003886 GO:0008168 GO:0009307 GO:0016740 GO:0032259 GO:0090116
7	0.06	0.381	5.07	0.05	0.54	4h0nA	GO:0008168 GO:0032259 GO:0046872
8	0.06	0.349	6.11	0.06	0.55	1g55A	GO:0001975 GO:0003723 GO:0003886 GO:0005634 GO:0005654 GO:0005737 GO:0006400 GO:0008033 GO:0008168 GO:0008175 GO:0016428 GO:0016740 GO:0030488 GO:0032259 GO:0090116
9	0.06	0.379	5.46	0.05	0.56	10mhA	GO:0003886 GO:0008168 GO:0009307 GO:0016740 GO:0032259 GO:0090116
10	0.06	0.361	5.43	0.04	0.54	3me5A	GO:0003886 GO:0008168 GO:0009307 GO:0016740 GO:0032259 GO:0090116
11	0.06	0.309	6.95	0.05	0.55	2fiqA	GO:0003824 GO:0019402 GO:0019404 GO:2001059
12	0.06	0.312	6.65	0.03	0.54	3cghA	GO:0046872
13	0.06	0.292	6.99	0.03	0.53	5awvA	GO:0003824 GO:0004497 GO:0016491 GO:0016614 GO:0016746 GO:0016757 GO:0050660 GO:0055114
14	0.06	0.630	5.12	0.07	0.89	3av4A	GO:0000122 GO:0000183 GO:0000792 GO:0003677 GO:0003682 GO:0003690 GO:0003723 GO:0003824 GO:0003886 GO:0005634 GO:0005654 GO:0005657 GO:0005721 GO:0005737 GO:0006306 GO:0006351 GO:0006355 GO:0007265 GO:0007420 GO:0007568 GO:0008152 GO:0008168 GO:0008270 GO:0008327 GO:0009008 GO:0009408 GO:0009636 GO:0010033 GO:0010212 GO:0010216 GO:0010288 GO:0010424 GO:0010468 GO:0010628 GO:0014823 GO:0016458 GO:0016568 GO:0016740 GO:0019904 GO:0030182 GO:0030331 GO:0031000 GO:0031667 GO:0032259 GO:0032355 GO:0032496 GO:0032776 GO:0033189 GO:0033574 GO:0036120 GO:0036276 GO:0042127 GO:0042493 GO:0042826 GO:0043025 GO:0043045 GO:0043234 GO:0044026 GO:0045322 GO:0045471 GO:0045892 GO:0046498 GO:0046499 GO:0046500 GO:0046872 GO:0051571 GO:0051573 GO:0051718 GO:0071230 GO:0071284 GO:0071560 GO:0090116 GO:0090309 GO:1990090 GO:1990841
15	0.06	0.247	6.58	0.03	0.42	4r7oC	GO:0006629 GO:0008081 GO:0008889 GO:0046872
16	0.06	0.238	5.93	0.04	0.38	2r2aA	GO:0016020 GO:0016021
17	0.06	0.207	6.15	0.02	0.33	4bb7A	GO:0000724 GO:0003682 GO:0005634 GO:0006276 GO:0006303 GO:0006337 GO:0006351 GO:0006355 GO:0006368 GO:0007059 GO:0007062 GO:0015616 GO:0016568 GO:0016586 GO:0030435 GO:0042173 GO:0043044 GO:0070914
18	0.06	0.186	6.15	0.02	0.29	5hh7A	GO:0000166 GO:0000808 GO:0003677 GO:0003682 GO:0005524 GO:0005634 GO:0006260 GO:0006351 GO:0006355 GO:0008270 GO:0009567 GO:0010385 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0019899	GO:0043565	GO:0000166	GO:0035258	GO:0046914	GO:0003886	GO:0003682
GO-Score	0.40	0.40	0.40	0.40	0.40	0.35	0.30
Biological Processes	GO:0008283	GO:0042493	GO:0033993	GO:1901701	GO:0071229	GO:0071248	GO:0031062	GO:0006357	GO:0046128	GO:0071363	GO:0007417	GO:0033273	GO:1990089	GO:0090308	GO:0048513	GO:0051054	GO:0006950	GO:1901605	GO:0048699	GO:0071417	GO:0006732	GO:0060322	GO:0044030	GO:0043279	GO:0051570	GO:0009266	GO:0007264	GO:0036119	GO:0010288	GO:1901654	GO:0006790	GO:0043200	GO:0097305	GO:0031937	GO:0009314	GO:0051569	GO:0031061	GO:0002237	GO:0071559	GO:0014074	GO:0090116	GO:0016568
GO-Score	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.35	0.30
Cellular Component	GO:0036477	GO:0044297	GO:0031981	GO:0000785	GO:0000775
GO-Score	0.40	0.40	0.40	0.40	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.