I-TASSER results

I-TASSER results for job id Rv1100

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (233 residues)
MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFWSLAPLVVGCILLAGLV
GMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPGGWTPNSGGRGGIENGRAD
PATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSIHPSMYPTGTVDVGGTRWVVY
EGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFRTLASATQSQPPLPAR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFWSLAPLVVGCILLAGLVGMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPGGWTPNSGGRGGIENGRADPATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSIHPSMYPTGTVDVGGTRWVVYEGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFRTLASATQSQPPLPAR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCEEEEEHCCCCHHHHHHHHHCCCCCCCEEEHCCEEEEEEHCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCHHHHHHHHHHHHHCCCCCCC
Conf.Score	98888888877678888887788888876444454688688999999999999999999965445789999999986685899999999789985688999997565788756788887776667788757899999689968999987998789999975788777579989989999986898876555688876578998899999789999999999999878999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFWSLAPLVVGCILLAGLVGMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPGGWTPNSGGRGGIENGRADPATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSIHPSMYPTGTVDVGGTRWVVYEGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFRTLASATQSQPPLPAR
Prediction	74361454442444554354446464565444444465111001001233121233133011011314468754245142533044117516121230723760421103244255444444445464331020000047532010202535355105522763455244515544033233666644343121230446543100000030437204400520472643478
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCEEEEEHCCCCHHHHHHHHHCCCCCCCEEEHCCEEEEEEHCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCHHHHHHHHHHHHHCCCCCCC
MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFWSLAPLVVGCILLAGLVGMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPGGWTPNSGGRGGIENGRADPATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSIHPSMYPTGTVDVGGTRWVVYEGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFRTLASATQSQPPLPAR

4b2nA

0.14

0.97

0.66

MUSTER

ANGAIPKPAGNGSGVYSPRHAADPNYLPDPRLKGVARTDPRRMRLMADERQRRAWNSGWWAYNNLSPSWTGYPSDNIVASELRRVPRAIYNGGPIYSPLGPNIWEEPTGYIAPPLYGAWATAPYFHNGSVPNLWGVLKPSDRPKLWKRPYTAAGI--GKNAGYDYSFASYDWQKLGWKYTAVACNNSIFTSPFLPCTHNMATIDIL----YSMWDNVAAQYLNLAYQSPPPIT

5gaoE

0.09

0.97

0.70

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

3j6vI

0.13

0.12

0.91

0.62

wdPPAS

MMGEDPETPSGLFEKRARPIMKHPE-FPKQRAVQWGEDGRSLMHEAYGKVLHAEERQDQLRAKGLFSEKSKSKDLIGSDYAQFIRLLERLSALPAAEEEFVGRFR-RTVTVQSKKHLIEPLQYDEQGMAFSTGQGKRKTANAEAVVYG----------------HGSGKIEINGVDYLLYFPVTQDREQFPFHFLDRLGK--DVTCTVSGGGRSSQAGAIRLAMSRA--LCSF

4on1A2

0.14

0.11

0.78

0.62

wMUSTER

L----PIKDYPTEATYPATLE--KEKDGGSLEHDITSQIQAVTTSLKFLIDSGFITVKYTIKDSSHKGGASDYEVSALEFQNYLRSWDEVKGQD-KKPYI-GTWDSGKT--GYASGIGVIHLNNPRGNFEVAAISTTSSSHPYT--------LAHEIGHLL------GAEHVD-----------NEQDLMYTWYSPQVTPN---------HLSADNWVRMLECIQK-------

4ol4A

0.16

0.11

0.65

0.63

wPPAS

-----------------------------PVTPAISGTLRDHLREKGV---------------KLEAQRPHGFKALDIT-----------------LP-MPPRWTQV-------PDPNVPDAFVDRLGNS----VY-TSN--QLVVYR-DFDPAEAITHGYIDSQKLAMANFDGFPSSIIEG-RENDMTLNTSRRHVIATSGADKYLVSLSVTLSQAVTDGPATDA---VVAH

5gaoE

0.10

0.08

0.76

1.13

dPPAS2

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------------AAAAAAAAAAAAAAAARAAA--------------AAAAAAAAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAAAAAAT----TKEAYKKLSQKFHGTKSNKK-----

5gaoE

0.09

0.98

0.81

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2otxA

0.09

0.06

0.70

0.68

Env-PPAS

---------------------------------GSPEEIRNLLADVETFVADTLK------GENLSKKAKEKRESLIKKIKDVKSVYLQEFQFPIAAQDLPAGYLEKRRKDHSFLGFE-------------WQKRWCALSKTVFYYYGSD-----------KDKQQKGEFAIDGYDVRMNNTLRKDGKKD--CCFEICAPDKRIYQFTA--ASPKDAEEWVQQLKFIQDLG--

4qqxA

0.12

0.11

0.96

0.64

MUSTER

ENTDLPRSSMAWLNPDYAPAHRDPFAATDWLMGRKRGLLAPWAVGTIDQALMNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWLGTLDVPVVLHHSIANSLVKAYLEGARGRRWNRSEPQPVSEVSYPGWLHVDARIG-------KVTRSSDVDPLPIATTPRKPLEVRLVDVPVKEGALNRSTVLAKELTPLVKQGGCAAIIC---TTVAEAQGVYDLLSQWFATLAP

2miiA

0.13

0.10

0.79

0.70

dPPAS

MVGQREPAPVEEVKPAPEQPAEPQQPVPTVPSVPTIPQQ-------------------PGPIEHEDQTAPPAPHIRHYDWNGAMQPMVSKM---LGADGVTAGSVLLVDSVNNRTNGSLNAAEATETLRNA-----LANNGKFTLV---SAQQLSMAKQQLGLSPQDSLGTNVGAHYVLYSSASGNVNAPTLQMQLMLVQTGEIIWSGKGAVSQQ------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.56

Estimated TM-score = 0.24±0.07

Estimated RMSD = 17.0±2.8Å

Download Model 2

C-score=-4.74

Download Model 3

C-score=-4.59

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3j6vI	0.555	4.88	0.078	0.828
2	2zt6A	0.424	5.84	0.023	0.717
3	2ivfA	0.420	5.85	0.043	0.725
4	3fvyA1	0.413	6.20	0.048	0.751
5	1wygA	0.410	5.81	0.048	0.704
6	3ir7A	0.408	5.80	0.024	0.691
7	2r72A	0.407	5.70	0.025	0.687
8	3zyvA	0.406	6.02	0.031	0.712
9	2yi8A	0.404	5.90	0.025	0.691
10	1clcA	0.403	5.79	0.048	0.700

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	6	4kanB	DZY	Rep, Mult	216,220
2	0.04	2	2ha7A	BCH	Rep, Mult	41,104
3	0.04	2	1fiqA	FES	Rep, Mult	144,145,206,207,208,218,220
4	0.04	2	4f8hD	LMD	Rep, Mult	217,221
5	0.02	1	2wieB	CVM	Rep, Mult	55,56,59
6	0.02	1	1o7lC	MOO	Rep, Mult	202,203,205
7	0.02	1	1nh0A	III	Rep, Mult	175,177
8	0.02	1	3sm4A	NUC	Rep, Mult	34,42
9	0.02	1	1cgpA	CMP	Rep, Mult	220,224
10	0.02	1	4ukiS	MG	Rep, Mult	142,215
11	0.02	1	2vn4A	MAN	Rep, Mult	105,106
12	0.02	1	2wieB	CVM	Rep, Mult	59,60
13	0.02	1	3ndvA	AIC	Rep, Mult	43,46
14	0.02	1	2idkA	C2F	Rep, Mult	143,147
15	0.02	1	2d4qB	POP	Rep, Mult	85,89
16	0.02	1	1bwuA	MAN	Rep, Mult	143,152,157,212
17	0.02	1	2ia5C	MG	Rep, Mult	152,154
18	0.02	1	2voyH	III	Rep, Mult	214,217
19	0.02	1	2ig9B	CA	Rep, Mult	184,185

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3fvyA	0.392	6.39	0.051	0.738	3.4.14.4	NA
2	0.060	2ebsB	0.385	5.58	0.074	0.639	3.2.1.150	30
3	0.060	2d09A	0.380	6.05	0.064	0.669	1.14.-.-	NA
4	0.060	2z36B	0.374	5.97	0.067	0.644	1.-.-.-	NA
5	0.060	1h0hA	0.386	5.75	0.043	0.631	1.2.1.2	NA
6	0.060	1ug9A	0.379	5.99	0.053	0.669	3.2.1.70	NA
7	0.060	1fo4A	0.391	5.92	0.044	0.669	1.17.1.4	NA
8	0.060	1tt0A	0.385	6.04	0.057	0.682	1.1.3.10	NA
9	0.060	3lssB	0.385	5.83	0.034	0.657	6.1.1.11	202
10	0.060	1wleB	0.376	5.56	0.050	0.614	6.1.1.11	NA
11	0.060	1f0iA	0.343	6.03	0.037	0.601	3.1.4.4	NA
12	0.060	2ze4A	0.384	5.72	0.069	0.657	3.1.4.4	NA
13	0.060	3g4dA	0.387	6.08	0.063	0.674	4.2.3.13	NA
14	0.060	3b9jI	0.223	5.20	0.044	0.352	1.17.1.4,1.17.3.2	204
15	0.060	3b9jC	0.338	6.21	0.047	0.609	1.17.3.2,1.17.1.4	NA
16	0.060	1j38A	0.378	5.66	0.034	0.635	3.4.15.1	NA
17	0.060	1hxgA	0.396	5.99	0.058	0.682	4.2.3.9,4.1.99.7	NA
18	0.060	1xc6A	0.378	6.50	0.068	0.712	3.2.1.23	225
19	0.060	1h2aL	0.369	5.96	0.049	0.648	1.12.2.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.555	4.88	0.08	0.83	3j6vI	GO:0000462 GO:0003735 GO:0005730 GO:0005739 GO:0005743 GO:0005763 GO:0005840 GO:0006412 GO:0030529 GO:0044822 GO:0070124 GO:0070125
1	0.06	0.410	5.84	0.02	0.70	4kqeA	GO:0000166 GO:0004081 GO:0004812 GO:0004820 GO:0005524 GO:0005654 GO:0005737 GO:0005739 GO:0005759 GO:0005829 GO:0006412 GO:0006418 GO:0006426 GO:0015966 GO:0016874 GO:0030141 GO:0030424 GO:0042995 GO:0046983 GO:0070062
2	0.06	0.371	5.79	0.03	0.63	4qeiA	GO:0000166 GO:0004081 GO:0004812 GO:0004820 GO:0005524 GO:0005654 GO:0005737 GO:0005739 GO:0005759 GO:0005829 GO:0006412 GO:0006418 GO:0006426 GO:0015966 GO:0016874 GO:0030141 GO:0030424 GO:0042995 GO:0046983 GO:0070062
3	0.06	0.366	5.87	0.05	0.63	1b76A	GO:0000166 GO:0004812 GO:0004820 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006426 GO:0016874 GO:0046983
4	0.06	0.369	5.48	0.07	0.61	4kr3A	GO:0000166 GO:0004081 GO:0004812 GO:0004820 GO:0005524 GO:0005654 GO:0005737 GO:0005739 GO:0005759 GO:0005829 GO:0006412 GO:0006418 GO:0006426 GO:0015966 GO:0016874 GO:0030141 GO:0030424 GO:0042995 GO:0046983 GO:0070062
5	0.06	0.393	5.64	0.05	0.64	1kqfA	GO:0008430 GO:0008863 GO:0009055 GO:0009061 GO:0009326 GO:0015944 GO:0016020 GO:0016491 GO:0030151 GO:0030288 GO:0036397 GO:0042597 GO:0043546 GO:0045333 GO:0046872 GO:0047111 GO:0051536 GO:0051539 GO:0055114
6	0.06	0.349	5.83	0.04	0.60	1g8kA	GO:0016491 GO:0030151 GO:0046872 GO:0050611 GO:0051536 GO:0051538 GO:0055114
7	0.06	0.336	5.87	0.03	0.56	2i4nB	GO:0000166 GO:0004812 GO:0004827 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006433 GO:0016874
8	0.06	0.326	6.07	0.07	0.59	1fohC	GO:0004497 GO:0005737 GO:0016491 GO:0018662 GO:0019336 GO:0019439 GO:0055114 GO:0071949
9	0.06	0.314	6.34	0.02	0.58	4aayA	GO:0016491 GO:0030151 GO:0046872 GO:0051536 GO:0051538 GO:0055114
10	0.06	0.344	5.90	0.07	0.60	1g5hD	GO:0001701 GO:0003677 GO:0003887 GO:0004820 GO:0005739 GO:0006260 GO:0006281 GO:0006426 GO:0016740 GO:0016779 GO:0022904 GO:0032042 GO:0042645 GO:0042802 GO:0070062 GO:0070584 GO:0071897
11	0.06	0.324	6.83	0.03	0.64	1ogyA	GO:0005506 GO:0006777 GO:0008940 GO:0009055 GO:0016491 GO:0030151 GO:0042128 GO:0042597 GO:0046872 GO:0051536 GO:0051539 GO:0055114
12	0.06	0.347	6.73	0.07	0.67	2nyaA	GO:0005506 GO:0006777 GO:0008940 GO:0009055 GO:0009061 GO:0016491 GO:0030151 GO:0030288 GO:0042128 GO:0042597 GO:0046872 GO:0051536 GO:0051539 GO:0055114
13	0.06	0.305	6.52	0.07	0.58	1eu1A	GO:0009055 GO:0016491 GO:0030151 GO:0042597 GO:0046872 GO:0050626 GO:0055114
14	0.06	0.350	5.88	0.06	0.60	2g4cA	GO:0000262 GO:0001701 GO:0003677 GO:0003887 GO:0004820 GO:0005739 GO:0005759 GO:0006260 GO:0006261 GO:0006281 GO:0006426 GO:0007005 GO:0016740 GO:0016779 GO:0022904 GO:0032042 GO:0042645 GO:0042802 GO:0070062 GO:0070584 GO:0071897
15	0.06	0.337	6.12	0.03	0.58	2j3lB	GO:0000166 GO:0002161 GO:0004812 GO:0004827 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006433 GO:0006450 GO:0016874
16	0.06	0.347	6.23	0.05	0.63	3egwA	GO:0005886 GO:0008940 GO:0009055 GO:0009061 GO:0009325 GO:0016020 GO:0016491 GO:0030151 GO:0031224 GO:0031235 GO:0042126 GO:0042128 GO:0043546 GO:0044799 GO:0046872 GO:0051536 GO:0051539 GO:0055114
17	0.06	0.334	6.15	0.04	0.60	2v45A	GO:0005506 GO:0006777 GO:0008940 GO:0009055 GO:0016491 GO:0030151 GO:0042128 GO:0042597 GO:0046872 GO:0051536 GO:0051539 GO:0055114
18	0.06	0.385	5.75	0.04	0.63	1h0hA	GO:0008863 GO:0009055 GO:0016491 GO:0030151 GO:0042597 GO:0043546 GO:0045333 GO:0046872 GO:0047111 GO:0051536 GO:0051539 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0005515	GO:0035639	GO:0032550	GO:0032559	GO:0004812	GO:0008796
GO-Score	0.47	0.47	0.47	0.47	0.47	0.36
Biological Processes	GO:0043039	GO:0015965	GO:0015960	GO:0006412
GO-Score	0.47	0.36	0.36	0.34
Cellular Component	GO:0043005	GO:0044429	GO:0099503	GO:0012505	GO:1903561	GO:0031981
GO-Score	0.36	0.36	0.36	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.