I-TASSER results

I-TASSER results for job id Rv1097c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (293 residues)
MTVPPAGPYGNYPYGPNTYGQDPYWGGQPQGGSYPPAYPPQQYPPGWPAGPYPPGPPPPG
PGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPATSAPTSQPFSQQTATGCT
PNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNLIDAVGVGHEVAGADQWMMQA
EVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLGPTKTSSITVDGVRAARVDADIT
IADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSRATVERVIEALKVNKS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVPPAGPYGNYPYGPNTYGQDPYWGGQPQGGSYPPAYPPQQYPPGWPAGPYPPGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPATSAPTSQPFSQQTATGCTPNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNLIDAVGVGHEVAGADQWMMQAEVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLGPTKTSSITVDGVRAARVDADITIADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSRATVERVIEALKVNKS
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCHCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCEEEEEEEEEEEHCCCCCCCCCCEEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHCCCC
Conf.Score	99999999999999999999999999999999999999999999999999999999999999999865455544444445666555567899999999999999999999999999999999999999999887789888898899999999988998877777888888899988666567877788999987666666677778888888998777876665676885678999999985788888765799999977996688756788885788999999999744579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVPPAGPYGNYPYGPNTYGQDPYWGGQPQGGSYPPAYPPQQYPPGWPAGPYPPGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPATSAPTSQPFSQQTATGCTPNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNLIDAVGVGHEVAGADQWMMQAEVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLGPTKTSSITVDGVRAARVDADITIADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSRATVERVIEALKVNKS
Prediction	75334653344424444334463343241422323344433442234333443333235444442100000011110110110210102345444554544445444441445644452435455454546440443525143632451433433333423433334442444431111121241423453524530432041024142154353445434444140441400303040304456361411201000000433110001232436523440440154041558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCHCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCEEEEEEEEEEEHCCCCCCCCCCEEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHCCCC
MTVPPAGPYGNYPYGPNTYGQDPYWGGQPQGGSYPPAYPPQQYPPGWPAGPYPPGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPATSAPTSQPFSQQTATGCTPNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNLIDAVGVGHEVAGADQWMMQAEVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLGPTKTSSITVDGVRAARVDADITIADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSRATVERVIEALKVNKS

5c2vC

0.11

0.98

1.14

MUSTER

ISTIQTGATWEPLGREEPLTVPEVHFRVKHSPFKSEAAWSLQGSYSHYERGQTTGLIWDLGDEGWGSWKNTKYIRGGRYLPPFRHEGFTGHPDEIVGATSSLDRVCGRDPGFVFRSENFSPMRLEALICYIRALEFTGSPFRNADGSLTEAQKRGQEDPKVGCLECHPGDPMDPRALFSDAQTHDVGTGRVGVNGFRSTPGKVFNISALEAGEDPYGVESNTPIIGLDLVKEFDTPTLRDIYASGTFHDGGARTLMTINVNDKDMHGRTSHLKQQELQDLVE--LKAL-----

5gaoE

0.10

1.00

1.42

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-

1mv3A

0.16

0.11

0.67

1.23

wdPPAS

------------------------------------------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQADYTATDTD--KAGDVVLVIPFQNQDEGWLMGVK--SDWNQHKKLEK-ENFTEVP--

2pffB

0.12

0.95

1.27

wMUSTER

QGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG---------GGGGGGGGGGG-------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

1mv3A

0.15

0.10

0.67

1.64

wPPAS

-------------------------DGSPAATP-----EIRVNHEPEPAGGATPGATLPKSPSQLR---------------------------KGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETF--PATVNGTVEGGSGAGRLDLPPGFMFKVQA---H-DYTATDT---------D---------ELQLK------AGDVVLVIPFQNPDEGWLMGVK--SDWNQHKKLEK--------RG

5gaoE

0.10

0.98

2.51

dPPAS2

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAATTKEAYKKLSQKFHGTKSNKK-

5gaoE

0.10

1.00

2.37

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-

4ol4A

0.11

0.06

0.58

0.93

Env-PPAS

-------------------------------------------------------------------------------------------------------------PVTPAISGTLREKGVKLEAQRPHGFKALDITLP--MPPRWTQVPDPNVPDAFVVI---ADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMA-------NFDGFPSSIIEGTYRENDMTLNT---SRRHVIATSGADKYLVSLSVTTAVTDGPATDAIVNGFQVVAH

4nl6A

0.06

0.90

1.12

MUSTER

MAMSSGGSGGGVPEQEDSVLFRRGTGQSHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPD------------SLDDADALGSMLI-----SGYHTGYYMGFRQNQKEG-----------RCSHS

4nl6A

0.06

0.04

0.78

1.22

dPPAS

GDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMTGYYMGFRQNQKEGRCSHSLN-----------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.17

Estimated TM-score = 0.36±0.12

Estimated RMSD = 13.8±3.9Å

Download Model 2

C-score=-3.28

Download Model 3

C-score=-4.31

Download Model 4

C-score=-4.54

Download Model 5

C-score=-4.84

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5c2vC	0.879	2.41	0.094	0.956
2	3hq6A	0.556	4.55	0.069	0.734
3	3l4mA	0.553	4.57	0.066	0.730
4	4aalA	0.548	4.62	0.065	0.730
5	1nmlA	0.544	4.51	0.050	0.717
6	2vhdA	0.539	4.59	0.059	0.707
7	2c1vA	0.539	4.50	0.071	0.700
8	1iqcA	0.536	4.36	0.076	0.683
9	3o5cA	0.532	4.48	0.081	0.686
10	4b2nA	0.532	4.58	0.044	0.717

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	7	3hq9A	HEM	Rep, Mult	85,163,166,167,187,188,233,234,235,236,238,259,264,271,280
2	0.07	3	5c2wF	CA	Rep, Mult	80,82,83,234
3	0.04	2	1iqcD	HEM	Rep, Mult	69,71,72,74,80,83,84,85,98,102,105,106,109,127,131,234
4	0.04	2	5c2vC	CA	Rep, Mult	70,71,244,245
5	0.02	1	2zyqB	TAR	Rep, Mult	147,148
6	0.02	1	1wsgD	MN	Rep, Mult	228,229
7	0.02	1	3a1eA	MG	Rep, Mult	259,260
8	0.02	1	3f1f1	MG	Rep, Mult	229,235
9	0.02	1	2b92B	MG	Rep, Mult	198,226,259
10	0.02	1	1lajA	NUC	Rep, Mult	205,209
11	0.02	1	1a3uA	CA	Rep, Mult	236,259,260
12	0.02	1	1l8tA	MG	Rep, Mult	33,243
13	0.02	1	1g42A	CP2	Rep, Mult	250,251
14	0.02	1	3o52C	TAR	Rep, Mult	225,228

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3ikmD	0.372	6.57	0.055	0.652	2.7.7.7	181
2	0.060	2g25A	0.337	6.12	0.055	0.553	1.2.4.1	NA
3	0.060	1k3iA	0.339	6.51	0.039	0.597	1.1.3.9	NA
4	0.060	2vhdB	0.540	4.59	0.059	0.707	1.11.1.5	71,105
5	0.060	3cskA	0.388	6.72	0.050	0.707	3.4.14.4	77
6	0.060	3dt7A	0.380	5.98	0.050	0.628	4.1.1.32	64
7	0.060	1iqcA	0.536	4.36	0.076	0.683	1.11.1.5	NA
8	0.060	2fahA	0.381	6.12	0.053	0.635	4.1.1.32	NA
9	0.060	1nmlA	0.544	4.51	0.050	0.717	1.11.1.5	NA
10	0.060	2uv8G	0.394	6.37	0.033	0.679	2.3.1.86	NA
11	0.060	1iqcD	0.537	4.33	0.076	0.683	1.11.1.5	71
12	0.060	1mswD	0.332	6.79	0.043	0.590	2.7.7.6	NA
13	0.060	3bznA	0.412	6.36	0.074	0.703	5.4.4.2	NA
14	0.060	2fuvA	0.372	6.41	0.032	0.642	5.4.2.2	NA
15	0.060	1l8aA	0.307	6.72	0.012	0.543	1.2.4.1	NA
16	0.060	2pmgB	0.392	6.45	0.062	0.676	5.4.2.2	NA
17	0.060	2vycA	0.385	6.38	0.062	0.669	4.1.1.19	NA
18	0.060	2cseW	0.402	5.93	0.034	0.652	3.6.4.13	NA
19	0.060	3hq7A	0.511	4.32	0.082	0.659	1.11.1.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.879	2.41	0.09	0.96	5c2vC	GO:0009055 GO:0020037 GO:0044222
1	0.07	0.556	4.55	0.07	0.73	3hq6A	GO:0004130 GO:0004601 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0098869
2	0.07	0.545	4.41	0.08	0.70	4aamA	GO:0004130 GO:0004601 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0098869
3	0.07	0.544	4.51	0.05	0.72	1nmlA	GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0055114
4	0.07	0.554	4.62	0.07	0.73	4fa4B	GO:0009055 GO:0016491 GO:0020037 GO:0042597 GO:0046872 GO:0055114
5	0.07	0.539	4.59	0.06	0.71	2vhdA	GO:0004130 GO:0004601 GO:0009055 GO:0016491 GO:0020037 GO:0042597 GO:0046872 GO:0055114 GO:0098869
6	0.07	0.532	4.48	0.08	0.69	3o5cA	GO:0004130 GO:0004601 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0098869
7	0.07	0.539	4.50	0.07	0.70	2c1vA
8	0.07	0.530	4.43	0.08	0.69	4aaoA	GO:0004130 GO:0004601 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0098869
9	0.07	0.536	4.36	0.08	0.68	1iqcA	GO:0004130 GO:0004601 GO:0009055 GO:0016491 GO:0020037 GO:0042597 GO:0046872 GO:0055114 GO:0098869
10	0.07	0.505	4.83	0.08	0.69	1zzhB
11	0.07	0.511	4.32	0.08	0.66	3hq7A	GO:0004130 GO:0004601 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0098869
12	0.06	0.271	6.21	0.04	0.45	3ooxA	GO:0016491 GO:0046872 GO:0055114
13	0.06	0.279	5.94	0.03	0.45	2pyxA	GO:0000166 GO:0016491 GO:0055114
14	0.06	0.224	6.18	0.04	0.38	4ij3A	GO:0000139 GO:0002576 GO:0003756 GO:0005576 GO:0005615 GO:0005794 GO:0016020 GO:0016021 GO:0016242 GO:0016491 GO:0016971 GO:0016972 GO:0030173 GO:0031093 GO:0043231 GO:0045171 GO:0045454 GO:0055114 GO:0070062
15	0.06	0.209	5.67	0.03	0.33	2dypD	GO:0002250 GO:0002376 GO:0002578 GO:0002645 GO:0002666 GO:0002767 GO:0002774 GO:0004872 GO:0005615 GO:0005737 GO:0005886 GO:0005887 GO:0006955 GO:0006968 GO:0007165 GO:0007166 GO:0007267 GO:0008157 GO:0009986 GO:0016020 GO:0016021 GO:0023029 GO:0032396 GO:0032755 GO:0034113 GO:0042102 GO:0042130 GO:0042288 GO:0045591 GO:0050776 GO:0050777 GO:0050839 GO:0051926 GO:0071222 GO:2001198
16	0.06	0.203	5.28	0.04	0.30	3i5fC	GO:0005509 GO:0016459
17	0.06	0.135	4.86	0.10	0.20	1cchA	GO:0005506 GO:0009055 GO:0020037 GO:0042597 GO:0046872 GO:0055114
18	0.06	0.167	3.14	0.01	0.20	351cA	GO:0005506 GO:0009055 GO:0020037 GO:0042597 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0009055	GO:0020037	GO:0003824
GO-Score	0.49	0.40	0.40	0.34
Biological Processes	GO:0044710
GO-Score	0.49
Cellular Component	GO:0044444	GO:0043231
GO-Score	0.41	0.41

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.