I-TASSER results

I-TASSER results for job id Rv1085c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (242 residues)
MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSAGTAVLAGASLVAVSW
AVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKRADHSMIFVFIAGSYTP
FALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPLYLLLGWVAVWYTATILH
NAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFFHACTAVAAICHYIAMWFV
VF

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSAGTAVLAGASLVAVSWAVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKRADHSMIFVFIAGSYTPFALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPLYLLLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFFHACTAVAAICHYIAMWFVVF
Prediction	CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	99877776667788888755677666554456774578899999999999999999875468988899999999999999999999998646899999999999655778999999999866653488589999999999999999999875888845789999999999999999999986889999999999999998876643588878888875589999999999999999999988
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSAGTAVLAGASLVAVSWAVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKRADHSMIFVFIAGSYTPFALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPLYLLLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFFHACTAVAAICHYIAMWFVVF
Prediction	85555565446744433423433254224224433010200220132133112100011243442212100200231133013200200002043530230021011200031131010000000133330110012012200000001122363231010000231131021102100321222101103312311130020102423442452111101211201211320132133224
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSAGTAVLAGASLVAVSWAVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKRADHSMIFVFIAGSYTPFALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPLYLLLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFFHACTAVAAICHYIAMWFVVF

3wxvA

0.19

1.00

2.16

MUSTER

LPWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPRLIYLSIVCVLGISAIIVAQFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPERFFPWFQSHQIFHVLVVAAAFVHFYGVSNLQE

3wxvA

0.16

1.00

1.98

dPPAS

PDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFAQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQE

3wxvA

0.17

1.00

4.07

wdPPAS

LPWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPERFFPWFQSHQIFHVLVVAAAFVHFYGVSNLQE

3wxvA

0.19

1.00

2.83

wMUSTER

LPWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPRLIYLSIVCVLGISAIIVAQFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPERFFPWFQSHQIFHVLVVAAAFVHFYGVSNLQE

3wxvA

0.19

1.00

5.25

wPPAS

LPWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPRLIYLSIVCVLGISAIIVAQFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPERFFPWFQSHQIFHVLVVAAAFVHFYGVSNLQE

3wxvA

0.19

1.00

4.84

dPPAS2

LPWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPRLIYLSIVCVLGISAIIVAQFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPEKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQE

3wxvA

0.19

1.00

3.49

PPAS

LPWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPRLIYLSIVCVLGISAIIVAQFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPEKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQE

3wxvA

0.19

1.00

4.30

Env-PPAS

LPWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPRLIYLSIVCVLGISAIIVAQFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGTTVMGWFFLMAVMYITGAGLYAARIPERFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQE

4oo9A1

0.08

0.07

0.90

0.91

MUSTER

------------------------SPVQYLRWGDPAPIAAVVFACLGLLATLFVTVVFIIYRDTSSSRELCYIILAGICLGYLCTFLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTYRAARILAMSSAAQLVIAFILICIQLGIIVALFIMEPPDITNLGVVAPLGYNGLLILACTFYAFNFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIIL

3wdoA2

0.11

0.09

0.81

0.87

dPPAS

--------------RESGMVKGSFSKVLAEPRLLKLNFGIMCLHMLLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVV--GVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIGMFDGQGVFLAGAMLAAVWLAVASTMKEPPY-----------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.14

Estimated TM-score = 0.87±0.07

Estimated RMSD = 3.5±2.4Å

Download Model 2

C-score=-2.55

Download Model 3

C-score=-3.47

Download Model 4

C-score=-4.77

Download Model 5

C-score=-3.91

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wxvA	0.944	1.51	0.194	1.000
2	5b2nA	0.710	3.46	0.073	0.901
3	4xtlA	0.708	3.71	0.058	0.934
4	3ddlA	0.685	3.67	0.089	0.880
5	3a7kA	0.679	3.86	0.088	0.888
6	1uazA	0.678	3.95	0.093	0.876
7	5azdA	0.677	3.70	0.056	0.876
8	3capA	0.675	4.26	0.068	0.955
9	2z73A	0.674	4.04	0.068	0.917
10	1brrB	0.672	3.56	0.105	0.847

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	9	1cwqB	TRD	Rep, Mult	46,49,53,72,75,76,79,82
2	0.04	6	1p8uA	LI1	Rep, Mult	218,223,224,227
3	0.04	5	1o0aA	LI1	Rep, Mult	45,46,49,76,79,80,86
4	0.04	5	3a7kD	22B	Rep, Mult	192,196,224,228,232,236
5	0.04	5	1o0aA	LI1	Rep, Mult	175,187,191,194,195,198,202
6	0.03	4	1brrB	ARC	Rep, Mult	83,84,112,116
7	0.03	3	3qbiB	22B	Rep, Mult	108,112,115,139,140,143
8	0.03	4	2i21A	LI1	Rep, Mult	221,224,227,228,231
9	0.02	3	2i1xA	LI1	Rep, Mult	226,230,231,233,234
10	0.02	3	1brrA	ARC	Rep, Mult	194,195,198,199,202,206
11	0.02	2	3wxwA	ZN	Rep, Mult	89,219,223
12	0.02	3	3mbvA	BXC	Rep, Mult	53,56,68,71,72,75,82
13	0.01	1	3h90A	ZN	Rep, Mult	210,219,223
14	0.01	1	1m0kA	SQU	Rep, Mult	47,231,232,234,235,238
15	0.01	1	3qbiD	22B	Rep, Mult	73,115,119,122,127
16	0.01	1	1c8sA	LI1	Rep, Mult	165,169,172,173,191,195
17	0.01	1	2h8pC	GOA	Rep, Mult	200,204
18	0.01	1	1jv6A	LI1	Rep, Mult	114,117,118,133,134,137,141
19	0.01	1	2oi2A	MG	Rep, Mult	44,106
20	0.01	1	3vh7E	MG	Rep, Mult	86,89

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1jtnA	0.296	5.39	0.055	0.479	3.2.1.17	NA
2	0.060	1qleA	0.541	4.81	0.044	0.781	1.9.3.1	NA
3	0.060	1k7wD	0.470	4.81	0.059	0.698	4.3.2.1	205
4	0.060	1k62B	0.459	4.48	0.065	0.653	4.3.2.1	NA
5	0.060	3e04D	0.477	5.20	0.043	0.731	4.2.1.2	NA
6	0.060	2ohyB	0.454	5.36	0.046	0.723	5.4.3.6	NA
7	0.060	1dcnB	0.464	4.40	0.069	0.674	4.3.2.1	NA
8	0.060	2pfmA	0.474	4.63	0.025	0.665	4.3.2.2	NA
9	0.060	1yisA	0.464	5.04	0.043	0.719	4.3.2.2	NA
10	0.060	1b8fA	0.455	5.13	0.052	0.719	4.3.1.3	NA
11	0.060	3b8cB	0.452	5.08	0.044	0.682	3.6.3.6	120,123
12	0.060	1fftA	0.475	5.30	0.058	0.727	1.10.3.-	107
13	0.060	1w27A	0.489	5.34	0.061	0.785	4.3.1.24	NA
14	0.060	1tj7A	0.472	4.99	0.019	0.719	4.3.2.1	NA
15	0.060	1f1oA	0.487	4.35	0.055	0.669	4.3.2.2	NA
16	0.060	3d4sA	0.593	4.15	0.080	0.831	3.2.1.17	112,119
17	0.060	1c3cA	0.469	4.47	0.070	0.661	4.3.2.2	NA
18	0.060	3no9A	0.470	4.62	0.059	0.674	4.2.1.2	168,227
19	0.060	1jswB	0.520	4.53	0.059	0.756	4.3.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.45	0.944	1.51	0.19	1.00	3wxvA	GO:0004872 GO:0005886 GO:0006629 GO:0006631 GO:0007186 GO:0009755 GO:0010633 GO:0010719 GO:0010906 GO:0016020 GO:0016021 GO:0019216 GO:0019395 GO:0019901 GO:0030308 GO:0031226 GO:0033210 GO:0033211 GO:0042593 GO:0042802 GO:0046426 GO:0046427 GO:0046628 GO:0046872 GO:0046982 GO:0055100 GO:0097003 GO:1901223
1	0.45	0.946	1.47	0.19	1.00	3wxwA	GO:0004872 GO:0005886 GO:0006629 GO:0006631 GO:0007186 GO:0007507 GO:0007565 GO:0007584 GO:0009755 GO:0016020 GO:0016021 GO:0019395 GO:0030308 GO:0031226 GO:0033211 GO:0042593 GO:0042802 GO:0046326 GO:0046872 GO:0046982 GO:0055100 GO:0061042 GO:0097003
2	0.36	0.682	3.67	0.09	0.88	3qbgA	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
3	0.33	0.664	3.78	0.10	0.85	1cwqA	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
4	0.22	0.672	3.90	0.09	0.87	2z55A	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
5	0.21	0.650	3.75	0.10	0.85	4qi1A	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
6	0.20	0.706	3.81	0.06	0.94	4xtnA	GO:0005216 GO:0006811 GO:0016020 GO:0016021 GO:0034220
7	0.20	0.660	3.81	0.10	0.86	5ahzA	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
8	0.19	0.659	3.76	0.10	0.85	4hyjA	GO:0005216 GO:0006811 GO:0007602 GO:0010461 GO:0016020 GO:0016021 GO:0018298 GO:0034220
9	0.18	0.677	3.70	0.06	0.88	5azdA	GO:0005216 GO:0006811 GO:0016020 GO:0016021 GO:0034220
10	0.17	0.667	3.75	0.10	0.85	4l35A	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
11	0.16	0.664	3.69	0.11	0.85	4fbzA	GO:0005216 GO:0006811 GO:0016020 GO:0016021 GO:0034220
12	0.15	0.605	4.34	0.07	0.86	2l6xA	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0010461 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
13	0.15	0.640	3.78	0.10	0.84	3am6A	GO:0005216 GO:0006811 GO:0016020 GO:0016021 GO:0034220
14	0.13	0.639	3.96	0.10	0.86	4klyB	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0010461 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
15	0.12	0.632	3.90	0.10	0.85	4knfC	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0010461 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
16	0.10	0.635	3.84	0.08	0.83	2ksyA	GO:0005216 GO:0006811 GO:0016020 GO:0016021 GO:0034220
17	0.10	0.678	3.95	0.09	0.88	1uazA	GO:0005216 GO:0005886 GO:0006810 GO:0006811 GO:0007602 GO:0009881 GO:0015992 GO:0016020 GO:0016021 GO:0018298 GO:0034220 GO:0050896
18	0.09	0.685	3.67	0.09	0.88	3ddlA	GO:0005216 GO:0006811 GO:0007602 GO:0010461 GO:0016020 GO:0016021 GO:0018298 GO:0034220

Consensus prediction of GO terms

Molecular Function	GO:0042802	GO:0046982	GO:0046872	GO:0055100	GO:0097003	GO:0005216	GO:0009881	GO:0019901
GO-Score	0.70	0.70	0.70	0.70	0.70	0.66	0.66	0.45
Biological Processes	GO:0030308	GO:0033211	GO:0007186	GO:0019395	GO:0042593	GO:0034220	GO:0018298	GO:0007602	GO:0015992	GO:0046426	GO:0010719	GO:1901223	GO:0010906	GO:0046628	GO:0019216	GO:0033210	GO:0046427	GO:0010633	GO:0007584	GO:0007565	GO:0046326	GO:0007507	GO:0061042
GO-Score	0.70	0.70	0.70	0.70	0.70	0.66	0.66	0.66	0.47	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45
Cellular Component	GO:0016021	GO:0031226
GO-Score	0.90	0.70

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.