I-TASSER results

I-TASSER results for job id Rv1075c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (314 residues)
MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFDAPPRADGVYTRGGGP
VQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAEQTGKRIRLSTKAIVGA
TSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQRLADCVRRLRTRGAVVVV
GTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVPVPLGHLLAPKFRAMPELM
FSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPSRPGTATLEPGHTRHSMMSR
LRRPRPARAVPTGG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFDAPPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAEQTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQRLADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVPVPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPSRPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG
Prediction	CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEHCCHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCHHHHHHCCCCCCCCCCCCCCCCCC
Conf.Score	98655788999998878888999999999999999987557888899988887678888765555678898699998676664788998877779999999999879987999956899768999999878776578998999995864655899999999999999999999899699985888655778776556899999999999999999998996655653445555568677557889999999999999999999999997656889888888765544544444554445545567777888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFDAPPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAEQTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQRLADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVPVPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPSRPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG
Prediction	65323310010001100101122122000100033024214424633353523324453344435564444032234131000000024554110210041027426350201010132410430151044322344401000000000001243315301510340052037440200000012122123123102420341031024014201520761301001000431343242000420001145003120420051026105644743346446434335344422233013202233434545648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEHCCHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCHHHHHHCCCCCCCCCCCCCCCCCC
MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFDAPPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAEQTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQRLADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVPVPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPSRPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG

4jggA

0.22

0.12

0.57

1.41

MUSTER

-----------------------------------------------------------------------QTLLVVGDSISAALGLDTSQG-WVALLQKRLADEG-YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQ----------LPPNYGPRYIEAFSRVYGAVAAQEK---TALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

4jggA

0.21

0.12

0.57

1.69

dPPAS

-----------------------------------------------------------------------QTLLVVGDSISAALGLDTSQG-WVALLQKRLADEG-YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQLP-------------PNYGPRYIEAFSRVYGAVAAQEKTALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

4jggA

0.22

0.12

0.57

2.36

wdPPAS

-----------------------------------------------------------------------QTLLVVGDSISAALGLDTSQG-WVALLQKRLADEG-YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQLP----------PNYGPRYIEAFSRVYGAVAAQEK---TALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

4jggA

0.22

0.12

0.57

1.80

wMUSTER

-----------------------------------------------------------------------QTLLVVGDSISAALGLDTSQG-WVALLQKRLADEG-YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQ----------LPPNYGPRYIEAFSRVYGAVAAQEK---TALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

4jggA

0.22

0.13

0.57

2.72

wPPAS

-----------------------------------------------------------------------QTLLVVGDSISAALGLDTSQG-WVALLQKRLADE--YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQLP--------PNYG--PRYIEAFSRVYGAVAAQEK---TALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

4jggA

0.21

0.12

0.57

3.77

dPPAS2

-----------------------------------------------------------------------QTLLVVGDSISAALGLDTSQG-WVALLQKRLADEG-YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQLP-------------PNYGPRYIEAFSRVYGAVAAQEKTALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

4jggA

0.21

0.12

0.57

2.27

PPAS

-----------------------------------------------------------------------QTLLVVGDSISAALGLDTSQG-WVALLQKRLADEG-YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQLP-------------PNYGPRYIEAFSRVYGAVAAQEKTALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

4jggA

0.22

0.12

0.57

3.33

Env-PPAS

-----------------------------------------------------------------------QTLLVVGDSISAALGLD-TSQGWVALLQKRLADEG-YDYRVVNASISGDTSAGGLARLPALLA-EEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQ----------LPPNYGPRYIEAFSRVYGAVAAQEK---TALVPFFLEGVGGVQG-MMQADGIHPALAAQPRLLENVWPTLKPLL----------------------------------------------

1yzfA

0.20

0.12

0.61

1.36

MUSTER

----------------------------------------------------------------------MRKIVLFGDSITAGYLDEAVSPVLVDLVKRDIAAMGLEEVAVINAGMPGDTTEDGLKRLNKEVL-IEKPDEVVIFFGANDASRNITVATFRENLETMIHEIGSEKVILITPPYADSGRRPERP-------QTRIKELVKVAQEVGAAHNLPVIDLYKAMTVY--PGTDEFLQADGLHFSQVGYELLGALIVREIKGRLKPKQA-----------------------------------------

1ivnA

0.20

0.11

0.57

1.65

dPPAS

----------------------------------------------------------------------ADTLLILGDSLSAGYRMSASAA-WPALLNDKWS-----KTSVVNASISGDTSQQGLARLPALLK-QHQPRWVLVELGGNDGLRGFQPQQTEQTLRQILQDVKAANAEPLLMQIRLP-------------ANYGRRYNEAFSAIYPKLAKEFDVPLLPFFMEEVYLKPQWM-QDDGIHPNRDAQPFIADWMAKQLQPLVN---------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.03

Estimated TM-score = 0.37±0.13

Estimated RMSD = 13.6±4.0Å

Download Model 2

C-score=-3.15

Download Model 3

C-score=-3.75

Download Model 4

C-score=-4.27

Download Model 5

C-score=-4.11

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4xvhA	0.563	3.59	0.204	0.672
2	1thgA	0.561	5.53	0.058	0.822
3	1lpsA	0.558	5.32	0.058	0.806
4	4be4A	0.555	5.45	0.069	0.812
5	2wabA	0.555	4.10	0.147	0.685
6	4jggA	0.554	1.27	0.217	0.573
7	3kvnX	0.553	3.81	0.165	0.672
8	2o14A	0.543	4.71	0.107	0.707
9	3skvA	0.543	4.59	0.128	0.713
10	3i6mA	0.542	5.22	0.064	0.777

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.30	6	3dt9A	GD7	Rep, Mult	79,80,118,119,148,149,246,247
2	0.09	2	1u8uA	OCA	Rep, Mult	79,80,148,149,184,186,247
3	0.08	2	1gz7A	GOL	Rep, Mult	149,154,156
4	0.04	1	1u65A	UUU	Rep, Mult	142,171,172
5	0.04	1	1gz7A	GOL	Rep, Mult	95,256,259,260,263

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.414	1vyhA	0.535	3.19	0.154	0.627	3.1.1.47	80,119,149,244,247
2	0.189	2q0sH	0.497	2.51	0.168	0.554	3.1.1.2	149,247
3	0.161	1vyhN	0.535	3.19	0.154	0.627	3.1.1.47	121,149
4	0.107	1ivnA	0.519	2.13	0.185	0.567	3.1.1.5,	80,119,149,244,247
5	0.081	1bwpA	0.522	3.09	0.144	0.608	3.1.1.47	80,119,149,244,247
6	0.077	1deoA	0.492	3.62	0.181	0.596	3.1.1.-	80,119,149,244,247
7	0.060	2o14A	0.543	4.71	0.107	0.707	3.1.-.-	124
8	0.060	3enkA	0.478	4.21	0.103	0.612	5.1.3.2	NA
9	0.060	1z45A	0.480	4.41	0.073	0.618	5.1.3.2,5.1.3.3	202
10	0.060	1mx9D	0.526	5.50	0.041	0.774	3.1.1.1	NA
11	0.060	2pffA	0.479	4.78	0.083	0.669	2.3.1.41,2.3.1.86	NA
12	0.060	1gy8C	0.483	4.62	0.085	0.637	5.1.3.2	NA
13	0.060	1lpsA	0.558	5.32	0.058	0.806	3.1.1.3	NA
14	0.060	3kvnX	0.553	3.81	0.165	0.672	3.1.1.1	185,229,248,255
15	0.060	2vptA	0.513	2.40	0.200	0.573	3.1.1.72	247
16	0.060	1wvgA	0.488	4.45	0.066	0.640	4.2.1.45	NA
17	0.060	3eifA	0.493	5.54	0.072	0.739	3.4.21.110	NA
18	0.060	1ga1A	0.476	5.42	0.069	0.704	3.4.21.100,3.4.23.37	NA
19	0.060	1cleA	0.560	5.45	0.054	0.815	3.1.1.3	NA
20	0.060	1gz7C	0.565	5.20	0.070	0.806	3.1.1.3	178,264
21	0.060	1rkxC	0.487	4.61	0.071	0.640	4.2.1.45	NA
22	0.060	3f98A	0.492	5.50	0.035	0.723	3.1.1.47	170,172,224

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.38	0.554	1.27	0.22	0.57	4jggA	GO:0004064 GO:0004622 GO:0005576 GO:0016787 GO:0052689
1	0.35	0.519	2.13	0.18	0.57	1ivnA	GO:0004620 GO:0004622 GO:0006508 GO:0006629 GO:0008233 GO:0016290 GO:0016298 GO:0016787 GO:0030288 GO:0042597 GO:0042802 GO:0047617
2	0.33	0.527	2.20	0.19	0.58	3hp4A
3	0.31	0.521	3.03	0.20	0.60	1yzfA	GO:0016787
4	0.29	0.516	3.03	0.13	0.60	4hf7A	GO:0016787
5	0.29	0.512	2.37	0.15	0.57	3x0hA	GO:0004553 GO:0005576 GO:0005975 GO:0030248
6	0.28	0.517	3.16	0.15	0.60	4jhlA	GO:0000272 GO:0005737 GO:0005975 GO:0016787 GO:0045493 GO:0046555 GO:0052689
7	0.26	0.501	2.99	0.20	0.57	3rjtA
8	0.24	0.524	3.22	0.13	0.61	4ppyA	GO:0016787
9	0.21	0.494	2.26	0.15	0.54	4rshA	GO:0016020 GO:0016021
10	0.21	0.568	5.27	0.07	0.81	1gz7A	GO:0004806 GO:0006629 GO:0016042 GO:0016787
11	0.19	0.499	3.21	0.13	0.58	3p94A
12	0.17	0.542	3.83	0.15	0.66	2waaA	GO:0000272 GO:0005886 GO:0005975 GO:0008152 GO:0016020 GO:0016787 GO:0016798 GO:0045493 GO:0046555 GO:2000884
13	0.16	0.508	2.64	0.17	0.57	4tx1A	GO:0004064 GO:0016787
14	0.16	0.516	3.24	0.11	0.60	3milA	GO:0006083 GO:0006629 GO:0016042 GO:0016787 GO:0016788
15	0.14	0.521	2.98	0.16	0.61	1z8hA
16	0.14	0.536	5.32	0.07	0.77	3o9mA	GO:0001540 GO:0003824 GO:0003990 GO:0004104 GO:0005576 GO:0005615 GO:0005641 GO:0005783 GO:0005788 GO:0007584 GO:0007612 GO:0008285 GO:0014016 GO:0016020 GO:0016787 GO:0016788 GO:0019695 GO:0019899 GO:0033265 GO:0042493 GO:0042802 GO:0043279 GO:0050783 GO:0050805 GO:0051384 GO:0051593 GO:0052689 GO:0072562
17	0.07	0.560	5.45	0.05	0.82	1cleA	GO:0004806 GO:0006629 GO:0008202 GO:0008203 GO:0016042 GO:0016787
18	0.07	0.560	5.30	0.06	0.81	1crlA	GO:0004806 GO:0006629 GO:0016042 GO:0016787
19	0.07	0.561	5.53	0.06	0.82	1thgA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787
20	0.07	0.555	5.45	0.07	0.81	4be4A	GO:0016787
21	0.07	0.555	4.10	0.15	0.68	2wabA	GO:0000272 GO:0003824 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030248 GO:0045493 GO:0046555 GO:0046872 GO:2000884
22	0.07	0.542	5.24	0.06	0.78	1eveA	GO:0001507 GO:0003990 GO:0004104 GO:0005886 GO:0016020 GO:0016787 GO:0030054 GO:0031225 GO:0042135 GO:0043083 GO:0045202 GO:0052689
23	0.07	0.530	5.67	0.06	0.79	1ukcA	GO:0016787
24	0.07	0.539	5.32	0.09	0.78	4bdtA	GO:0001507 GO:0001540 GO:0001919 GO:0002076 GO:0003990 GO:0004104 GO:0005518 GO:0005576 GO:0005605 GO:0005615 GO:0005634 GO:0005794 GO:0005886 GO:0006260 GO:0006581 GO:0006656 GO:0007155 GO:0007399 GO:0007416 GO:0007517 GO:0008283 GO:0009611 GO:0009986 GO:0016020 GO:0016787 GO:0017171 GO:0030054 GO:0031225 GO:0031594 GO:0031623 GO:0032223 GO:0042135 GO:0042136 GO:0042166 GO:0042803 GO:0042982 GO:0043083 GO:0043236 GO:0043621 GO:0045202 GO:0045212 GO:0048471 GO:0050714 GO:0051262 GO:0052689 GO:0060041
25	0.07	0.526	5.55	0.04	0.78	3k9bB	GO:0005615 GO:0005783 GO:0005788 GO:0006805 GO:0008152 GO:0009636 GO:0016787 GO:0030855 GO:0047374 GO:0052689
26	0.07	0.530	5.55	0.07	0.78	3vkfA	GO:0002087 GO:0004872 GO:0005615 GO:0005794 GO:0005829 GO:0005886 GO:0005887 GO:0006605 GO:0007155 GO:0007157 GO:0007158 GO:0007399 GO:0007416 GO:0009897 GO:0009986 GO:0010841 GO:0014069 GO:0016020 GO:0016021 GO:0016080 GO:0016339 GO:0017146 GO:0030054 GO:0030165 GO:0030425 GO:0031175 GO:0032230 GO:0032433 GO:0035418 GO:0042043 GO:0043197 GO:0043198 GO:0045161 GO:0045184 GO:0045202 GO:0045211 GO:0045664 GO:0046983 GO:0048489 GO:0048511 GO:0048789 GO:0050804 GO:0050808 GO:0050839 GO:0051260 GO:0051290 GO:0051491 GO:0051965 GO:0051968 GO:0052689 GO:0060076 GO:0060080 GO:0060291 GO:0060999 GO:0061002 GO:0072553 GO:0097091 GO:0097104 GO:0097105 GO:0097110 GO:0097113 GO:0097114 GO:0097115 GO:0097119 GO:0097120 GO:0098793 GO:1900029 GO:1900244 GO:1902474 GO:1902533 GO:2000302 GO:2000310 GO:2000311 GO:2000463 GO:2000809
27	0.07	0.537	5.31	0.06	0.78	1qo9A	GO:0001507 GO:0003990 GO:0004104 GO:0005615 GO:0005737 GO:0005886 GO:0006581 GO:0007268 GO:0016020 GO:0016787 GO:0030054 GO:0031225 GO:0042135 GO:0042331 GO:0042426 GO:0042803 GO:0043083 GO:0045202 GO:0052689
28	0.07	0.527	5.54	0.06	0.78	3bixA	GO:0002087 GO:0004872 GO:0005615 GO:0005794 GO:0005829 GO:0005886 GO:0005887 GO:0006605 GO:0007155 GO:0007157 GO:0007158 GO:0007399 GO:0007416 GO:0009897 GO:0009986 GO:0010841 GO:0014069 GO:0016020 GO:0016021 GO:0016080 GO:0016339 GO:0017146 GO:0030054 GO:0030165 GO:0030425 GO:0031175 GO:0032230 GO:0032433 GO:0035418 GO:0042043 GO:0043197 GO:0043198 GO:0045161 GO:0045184 GO:0045202 GO:0045211 GO:0045664 GO:0046983 GO:0048489 GO:0048511 GO:0048789 GO:0050804 GO:0050808 GO:0050839 GO:0051260 GO:0051290 GO:0051491 GO:0051965 GO:0051968 GO:0052689 GO:0060076 GO:0060080 GO:0060291 GO:0060999 GO:0061002 GO:0072553 GO:0097091 GO:0097104 GO:0097105 GO:0097110 GO:0097113 GO:0097114 GO:0097115 GO:0097119 GO:0097120 GO:0098793 GO:1900029 GO:1900244 GO:1902474 GO:1902533 GO:2000302 GO:2000310 GO:2000311 GO:2000463 GO:2000809
29	0.07	0.526	5.53	0.06	0.78	2wqzA	GO:0003360 GO:0004872 GO:0005615 GO:0005886 GO:0005887 GO:0007155 GO:0007158 GO:0007612 GO:0009986 GO:0014069 GO:0016020 GO:0016021 GO:0021549 GO:0030054 GO:0030182 GO:0030425 GO:0030534 GO:0031404 GO:0035176 GO:0035265 GO:0042043 GO:0042803 GO:0045202 GO:0045211 GO:0045216 GO:0050808 GO:0050839 GO:0052689 GO:0060076 GO:0071625 GO:0090394 GO:0097105 GO:0097110
30	0.07	0.537	5.51	0.06	0.79	1f6wA	GO:0003824 GO:0004771 GO:0004806 GO:0004872 GO:0005576 GO:0005615 GO:0005737 GO:0005887 GO:0006629 GO:0006641 GO:0006707 GO:0007158 GO:0007416 GO:0008201 GO:0009062 GO:0009986 GO:0016042 GO:0016787 GO:0018350 GO:0030157 GO:0030299 GO:0042043 GO:0044241 GO:0044258 GO:0045202 GO:0047372 GO:0050804 GO:0052689 GO:0070062
31	0.07	0.521	5.70	0.08	0.79	3biwA	GO:0002087 GO:0004872 GO:0005615 GO:0005794 GO:0005829 GO:0005886 GO:0005887 GO:0006605 GO:0007155 GO:0007157 GO:0007158 GO:0007399 GO:0007416 GO:0009897 GO:0009986 GO:0010841 GO:0014069 GO:0016020 GO:0016021 GO:0016080 GO:0016339 GO:0017146 GO:0030054 GO:0030165 GO:0030425 GO:0031175 GO:0032230 GO:0032433 GO:0035418 GO:0042043 GO:0043197 GO:0043198 GO:0045161 GO:0045184 GO:0045202 GO:0045211 GO:0045664 GO:0046983 GO:0048489 GO:0048511 GO:0048789 GO:0050804 GO:0050808 GO:0050839 GO:0051260 GO:0051290 GO:0051491 GO:0051965 GO:0051968 GO:0052689 GO:0060076 GO:0060080 GO:0060291 GO:0060999 GO:0061002 GO:0072553 GO:0097091 GO:0097104 GO:0097105 GO:0097110 GO:0097113 GO:0097114 GO:0097115 GO:0097119 GO:0097120 GO:0098793 GO:1900029 GO:1900244 GO:1902474 GO:1902533 GO:2000302 GO:2000310 GO:2000311 GO:2000463 GO:2000809
32	0.07	0.536	5.54	0.05	0.80	4fnmA	GO:0016787

Consensus prediction of GO terms

Molecular Function	GO:0004622	GO:0004064	GO:0008233	GO:0016290	GO:0042802
GO-Score	0.59	0.38	0.35	0.35	0.35
Biological Processes	GO:0006508	GO:0006629
GO-Score	0.35	0.35
Cellular Component	GO:0005576	GO:0030288
GO-Score	0.38	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.