I-TASSER results

I-TASSER results for job id Rv1072

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (278 residues)
MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAKATRPLTIDDVVTKTGL
TLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVATFGRKQDNPAIVLSYAALE
GLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGMLVVYKTGAIRVTPKFTRMVVA
ALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIFSLVCIGIAAFSFLIDFDAADQM
IRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQNE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAKATRPLTIDDVVTKTGLTLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVATFGRKQDNPAIVLSYAALEGLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGMLVVYKTGAIRVTPKFTRMVVAALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIFSLVCIGIAAFSFLIDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQNE
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	98888876678777778877788888888777777777777777788755634889999999999999999999875566899999999999999999999965787765899999999999999999999988765567764799999999999999999999886664766789999999999999999999998678887766556775789999999999999999997999999999899867778999999999999999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAKATRPLTIDDVVTKTGLTLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVATFGRKQDNPAIVLSYAALEGLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGMLVVYKTGAIRVTPKFTRMVVAALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIFSLVCIGIAAFSFLIDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQNE
Prediction	74533122033245544434434444444424453344444544553301041023101201211333133112213333211312132133313221101003344202000000022113200200110132234444110000002310320021013023222030153011001323313323333133311002333322313322121113113001310100001042025006451243100100010121311232110200230388
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAKATRPLTIDDVVTKTGLTLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVATFGRKQDNPAIVLSYAALEGLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGMLVVYKTGAIRVTPKFTRMVVAALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIFSLVCIGIAAFSFLIDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQNE

4pgrA

0.16

0.12

0.74

1.83

MUSTER

--------------------------------------------HESK---QSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLPLSILEVAMIILAFWMR-RRKAVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4pgrA

0.16

0.12

0.74

1.70

dPPAS

-----------------------------------------------HESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLPLSILEVAMIILAFWMR-RRKAVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4pgrA

0.16

0.12

0.74

3.57

wdPPAS

-----------------------------------------------HESKQSIMQRILTVFVFTLLIATVGLFIGQFVP-VALMLPLSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4pgrA

0.16

0.12

0.73

2.33

wMUSTER

---------------------------------------------------QSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLPLSILEVAMIILAFWMR-RRKAVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4pgrA

0.17

0.12

0.74

4.15

wPPAS

----------------------------------------------HESK-QSIMQRILTVFVFTLLIATVGLFIGQFVP---VALMLPLSILEVAMIILAFWMRRRVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4pgrA

0.16

0.12

0.74

4.56

dPPAS2

--------------------------------------------HESKQ---SIMQRILTVFVFTLLIATVGLFIGQFVPVALMLPLSILEVAMIILAFWMR-RRKAVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4pgrA

0.16

0.12

0.74

2.79

PPAS

----------------------------------------------HESK-QSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLPLSILEVAMIILAFWMR-RRKAVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4pgrA

0.16

0.12

0.74

2.74

Env-PPAS

----------------------------------------------HESK-QSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLPLSILEVAMIILAFWMRR-RKAVGYAFVYTFAFVSGITLFPIVSHYASIA-----GAYVVLEAFGSTFVIFAVLGTIGAK-MKKDLSFLWSFLLVAVLALAVVGIFNIFS-------------PLNSAAMMAYSVIGTIVFSLYILYDLNQIKHR---HITEDLIPVMALSLYLDFINLFINLLRFFGILSS-

4oo9A1

0.14

0.12

0.83

0.98

MUSTER

-------------------------------------SPVQYLRWGDPAPI-AAVVFACLGLLATLFVTVVFIIYRDTPVVKSSRELCYIILAGICLGYLCTIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTYRAARILAAAQLVIAFILICIQLGIIVALFIMEPPDIMVYLNLGVVAPLGYNGLLILACTFYAFKTRNVPANF----NEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITMCFSVSLSATVALGCMFVPKVYIILAKPER

3wxvA

0.07

0.06

0.94

0.89

dPPAS

-------------GSEGRWRVIPYDVLPDWLKDNDYMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVMGWFFLMAVMYITGAGLYAARIP---ERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLE

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.68

Estimated TM-score = 0.51±0.15

Estimated RMSD = 9.8±4.6Å

Download Model 2

C-score=-2.23

Download Model 3

C-score=-2.82

Download Model 4

C-score=-2.77

Download Model 5

C-score=-2.87

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4pgrA	0.715	1.31	0.159	0.745
2	4av3A	0.484	5.92	0.074	0.766
3	4l1fA	0.447	5.24	0.078	0.658
4	4a01A	0.447	6.20	0.058	0.752
5	1kpkA	0.444	5.70	0.053	0.676
6	3oibA	0.443	5.62	0.062	0.683
7	1ivhA	0.442	5.52	0.053	0.673
8	3swoA	0.442	5.08	0.073	0.651
9	3sf6A	0.442	5.13	0.073	0.655
10	1rx0A	0.441	5.62	0.067	0.683

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1oczB	HEA	Rep, Mult	185,225
2	0.04	2	2nr9A	PA6	Rep, Mult	268,272
3	0.04	2	3nwyA	GTP	Rep, Mult	269,270
4	0.04	2	2q8hA	TF4	Rep, Mult	95,182,221,260,263
5	0.02	1	2h2sA	SEK	Rep, Mult	54,58,250
6	0.02	1	3qbgA	22B	Rep, Mult	230,231,234,250,257,264
7	0.02	1	1pprM	PID	Rep, Mult	144,148
8	0.02	1	2h2sB	SEK	Rep, Mult	91,92,93,119
9	0.02	1	5c65A	37X	Rep, Mult	89,122
10	0.02	1	1y66B	DIO	Rep, Mult	262,265,269
11	0.02	1	3owaA	FAD	Rep, Mult	62,157,160,257
12	0.02	1	3swoC	UNX	Rep, Mult	93,94,119,120,121
13	0.02	1	3lw52	CLA	Rep, Mult	217,221
14	0.02	1	3pyrI	MG	Rep, Mult	261,264
15	0.02	1	1xmeC	HAS	Rep, Mult	253,257
16	0.02	1	4amiA	2CV	Rep, Mult	221,225
17	0.02	1	1fbmD	RTL	Rep, Mult	255,262
18	0.02	1	1vcrA	CLA	Rep, Mult	120,176
19	0.02	1	2h2sA	SEK	Rep, Mult	63,65,113
20	0.02	1	1kzuE	BCL	Rep, Mult	228,231

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1jxaA	0.405	6.02	0.052	0.662	2.6.1.16	NA
2	0.060	3djlA	0.423	6.09	0.078	0.694	1.3.99.-	NA
3	0.060	2ix6E	0.443	5.39	0.053	0.669	1.3.3.6	97
4	0.060	3mddA	0.407	5.71	0.073	0.637	1.3.99.3	126,128,130
5	0.060	2fonB	0.415	5.34	0.039	0.604	1.3.3.6	NA
6	0.060	2g3mF	0.401	5.89	0.054	0.633	3.2.1.20	NA
7	0.060	1ivhA	0.442	5.52	0.053	0.673	1.3.99.10	NA
8	0.060	1frvB	0.402	4.98	0.056	0.565	1.12.2.1	NA
9	0.060	1h2aL	0.401	4.93	0.055	0.561	1.12.2.1	NA
10	0.060	2r0nA	0.438	5.32	0.077	0.658	1.3.99.7	NA
11	0.060	1j36A	0.421	6.04	0.030	0.719	3.4.15.1	69
12	0.060	2frvD	0.403	5.07	0.056	0.568	1.12.2.1	62,254
13	0.060	1h2rL	0.403	4.96	0.056	0.565	1.12.2.1	261
14	0.060	3d9dA	0.439	5.50	0.065	0.669	1.7.3.1	NA
15	0.060	1u8vA	0.414	5.34	0.032	0.633	5.3.3.3	NA
16	0.060	2jifA	0.410	5.73	0.055	0.640	1.3.99.-	NA
17	0.060	1bucA	0.441	5.27	0.087	0.655	1.3.99.2	94
18	0.060	1j38A	0.423	5.94	0.030	0.709	3.4.15.1	NA
19	0.060	1ukwA	0.419	5.65	0.108	0.691	1.3.99.3	267

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.26	0.715	1.31	0.16	0.74	4pgrA	GO:0005886 GO:0016020 GO:0016021
1	0.07	0.405	6.02	0.07	0.65	4o5mC	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
2	0.07	0.419	5.65	0.11	0.69	1ukwA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
3	0.07	0.439	5.53	0.10	0.67	4u83A	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
4	0.07	0.443	5.67	0.07	0.69	4m9aB	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
5	0.07	0.445	5.33	0.06	0.66	3pfdC	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
6	0.07	0.436	5.74	0.05	0.68	2ix6A	GO:0000062 GO:0003995 GO:0003997 GO:0005777 GO:0005829 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0009514 GO:0009793 GO:0016491 GO:0016627 GO:0033539 GO:0046459 GO:0050660 GO:0052890 GO:0055088 GO:0055114
7	0.07	0.443	5.62	0.06	0.68	3oibA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
8	0.07	0.439	5.50	0.07	0.67	3d9dA	GO:0000166 GO:0003995 GO:0006807 GO:0008152 GO:0016491 GO:0016627 GO:0050141 GO:0050660 GO:0052664 GO:0055114 GO:0071949
9	0.07	0.423	5.82	0.05	0.67	2wbiB	GO:0000062 GO:0003995 GO:0004466 GO:0005634 GO:0005739 GO:0005743 GO:0005777 GO:0006635 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0017099 GO:0031966 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114 GO:0070991
10	0.07	0.442	5.13	0.07	0.65	3sf6A	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
11	0.07	0.442	5.34	0.09	0.67	2a1tC	GO:0000062 GO:0003995 GO:0005634 GO:0005739 GO:0005759 GO:0005777 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0019254 GO:0030424 GO:0033539 GO:0042802 GO:0045329 GO:0050660 GO:0051791 GO:0051793 GO:0052890 GO:0055088 GO:0055114 GO:0070062 GO:0070991
12	0.07	0.431	5.35	0.04	0.65	5jscA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
13	0.07	0.437	5.35	0.08	0.66	2r0mA	GO:0000062 GO:0003995 GO:0004361 GO:0005739 GO:0005759 GO:0006554 GO:0006568 GO:0006637 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0019395 GO:0033539 GO:0046949 GO:0050660 GO:0052890 GO:0055088 GO:0055114
14	0.07	0.442	5.08	0.07	0.65	3swoA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
15	0.07	0.430	5.64	0.05	0.66	4x28C	GO:0000062 GO:0003995 GO:0008152 GO:0009055 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
16	0.07	0.426	5.64	0.05	0.66	2dvlA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
17	0.07	0.442	5.52	0.05	0.67	1ivhA	GO:0000062 GO:0003995 GO:0005739 GO:0005759 GO:0006552 GO:0008152 GO:0008470 GO:0009055 GO:0009083 GO:0016491 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
18	0.07	0.447	5.24	0.08	0.66	4l1fA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0016627	GO:0000166	GO:0050662
GO-Score	0.47	0.47	0.47
Biological Processes	GO:0044710
GO-Score	0.47
Cellular Component	GO:0071944	GO:0031224
GO-Score	0.53	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.