I-TASSER results

I-TASSER results for job id Rv1065

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (188 residues)
MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHLLPDGGVPQTQRWYTRI
HGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYRWDGRRLRRRRLDAGDQAG
FPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLTAMSYYEITERNTLRRQRTEL
TDQPEGSG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHLLPDGGVPQTQRWYTRIHGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYRWDGRRLRRRRLDAGDQAGFPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLTAMSYYEITERNTLRRQRTELTDQPEGSG
Prediction	CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEHCCCCCCEEEHCCCEEEEHCCCEEEEEHCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCEEHCCCCCEEEEEEEHCCCCCCCCC
Conf.Score	98887888888888888788879999999999998755875554665567888876898746898799999868998788777898679999997799999966888755665788678867985777656788777555678888878999997798755556765798578877787577887889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHLLPDGGVPQTQRWYTRIHGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYRWDGRRLRRRRLDAGDQAGFPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLTAMSYYEITERNTLRRQRTELTDQPEGSG
Prediction	66242433444444443462424400420351144235242431224342456411001024374010000002445514211133020001004130313316456355441546553525442012013144544234344455310000000001343043133577331434426335546778
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180

                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEHCCCCCCEEEHCCCEEEEHCCCEEEEEHCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCEEHCCCCCEEEEEEEHCCCCCCCCC
MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHLLPDGGVPQTQRWYTRIHGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYRWDGRRLRRRRLDAGDQAGFPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLTAMSYYEITERNTLRRQRTELTDQPEGSG

3elnA

0.17

0.15

0.91

2.17

MUSTER

--TELLKPRT-HELFAGDEVNVEEVQAVLEAY-----ESNPAEWALYAKFDQYRYTRNLVDQGGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENVSTEPAVSLHLYSPPFDTCHAFDQ---RTGHKNKVTMTF---KFG

3elnA

0.16

0.15

0.93

2.76

dPPAS

--TELLKPRTLHELFAGDEVNVEEVQAVLEAY-----ESNPAEWALYAKFDQYRYTRNLVDQNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENSHTEPAVSLHLYSPPFDTCHAFDQRTGH---KNKVTMT-FHSKFG

3elnA

0.17

0.15

0.91

4.17

wdPPAS

--TELLKPRT-HELFAGDEVNVEEVQAVLEAY-----ESNPAEWALYAKFDQYRYTRNLVDQNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENSHTEPAVSLHLYSPPFDTCHAFD---QRTGHKNKVTMT---SKFG

3elnA

0.16

0.14

0.90

2.63

wMUSTER

LLKPRT--RILHELFAGDEVNVEEVQAVLEAY-----ESNPAEWALYAKFDQYRYTRNLVDQNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENVSTEPAVSLHLYSPPFDTCHAFDQ---RTGHKNKVTMT-----FG

3elnA

0.18

0.15

0.88

3.95

wPPAS

--TELLKPRT-----AGDEVNVEEVQAVLEAYES-----NPAEWALYAKFDQYRYTRNLVDQNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENSHTEPAVSLHLYSPPFDTCHAFD---QRTGHKNKVTMT-----FG

3elnA

0.17

0.15

0.93

6.77

dPPAS2

--TELLKPRTLHELFAGDEVNVEEVQAVLEAY-----ESNPAEWALYAKFDQYRYTRNLVDQNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENSHTEPAVSLHLYSPPFDTCHAFDQ---RTGHKNKVTMT-FHSKFG

3elnA

0.17

0.15

0.91

3.21

PPAS

--TELLKPRT-HELFAGDEVNVEEVQAVLEAY-----ESNPAEWALYAKFDQYRYTRNLVDQNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENSHTEPAVSLHLYSPPFDTCHAFD---QRTGHKNKVTMTF---KFG

3elnA

0.15

0.14

0.94

3.71

Env-PPAS

LLKPRTLARILHELFAGDEVNVEEVQAVLEAYESNPA-----EWALYAKFDQYRYTRNLVDQNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLREN---QCAYINDSIGLHRVENSHTEPAVSLHLYSPPFDTCHAFDQ---RTGHKNKVTMTFHSK-FG

3ussA

0.17

0.16

0.95

2.00

MUSTER

---SILRLDGELATLLDSRPDESTLLAQAHPLLAELVH--QDDWLPEARPDPQRYQQYLLHVDQRFSVVSFVWGPGQITPVHDHR-VWGLIGMLRGAEYSQPYAFDAGG-RPHPSGARRRLEPGEVEALS--PRIGDVHQVSNFSDRTSISIHVYGANIGAVRRAVFSAEGEEKPFISGYSNSPNIWD

2atfA

0.16

0.14

0.91

2.54

dPPAS

---ELLKPRTLADLFAGDEVNVEEVQAVLEAY-----ESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKS-NEIKKSERTLREN---QCAYINDSIGLHRVENSHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVT-----TFHSKFG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.79

Estimated TM-score = 0.82±0.08

Estimated RMSD = 3.6±2.5Å

Download Model 2

C-score=-1.55

Download Model 3

C-score=0.79

Download Model 4

C-score=-4.56

Download Model 5

C-score=-1.98

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3elnA	0.893	1.26	0.148	0.936
2	3ussA	0.804	1.96	0.126	0.899
3	2gm6A	0.794	1.99	0.150	0.888
4	3eqeA	0.676	2.22	0.208	0.761
5	4nhxA	0.601	4.28	0.066	0.814
6	3kt4A	0.597	4.22	0.055	0.803
7	1lr5A	0.595	2.84	0.130	0.707
8	4lejA	0.594	4.07	0.069	0.771
9	3bu7B	0.592	3.77	0.109	0.761
10	5cadA	0.583	4.17	0.069	0.771

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.43	36	3elnA	2CO	Rep, Mult	55,57,71,82,84,89,91,139,141,153,155,180
2	0.25	20	3eqeA	FE	Rep, Mult	82,84,139,155
3	0.09	13	2cgoA	FUM	Rep, Mult	55,71,79,82,91,98,139,141,153
4	0.03	4	2ic1A	CYS	Rep, Mult	26,119,128,129,130,131

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	1yfxA	0.559	2.75	0.085	0.681	1.13.11.6	75,79,181
2	0.060	1upiA	0.488	4.24	0.080	0.654	5.1.3.13	NA
3	0.060	1wltA	0.482	3.76	0.079	0.644	5.1.3.13	NA
4	0.060	1gp6A	0.519	4.29	0.063	0.729	1.14.11.19	NA
5	0.060	1ep0A	0.480	3.86	0.078	0.628	5.1.3.13	NA
6	0.060	2a1xA	0.527	4.61	0.087	0.761	1.14.11.18	NA
7	0.060	1epzA	0.480	3.98	0.079	0.633	5.1.3.13	NA
8	0.060	2qnkA	0.530	3.48	0.112	0.675	1.13.11.6	71,94
9	0.060	1uw8A	0.577	4.29	0.102	0.771	4.1.1.2	NA
10	0.060	3kv4A	0.563	4.07	0.084	0.750	1.14.11.27	130
11	0.060	2et6A	0.464	5.05	0.012	0.766	1.1.1.-	NA
12	0.060	3balD	0.503	3.36	0.059	0.638	1.13.11.50	NA
13	0.060	3elnA	0.893	1.26	0.148	0.936	1.13.11.20	82,91,156,158
14	0.060	1uofA	0.476	3.96	0.081	0.675	1.14.20.1	NA
15	0.060	1pmiA	0.497	4.10	0.025	0.654	5.3.1.8	NA
16	0.060	1ywkA	0.489	3.95	0.079	0.654	5.3.1.17	61
17	0.060	3eqeA	0.676	2.22	0.208	0.761	1.13.11.20	71,82,93
18	0.060	2ixhA	0.483	3.73	0.065	0.622	5.1.3.13	82,131,133
19	0.060	1fi2A	0.528	3.53	0.086	0.660	1.2.3.4	134
20	0.060	3h1mA	0.487	3.97	0.052	0.638	5.3.1.8	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.48	0.893	1.26	0.15	0.94	3elnA	GO:0000097 GO:0005506 GO:0005829 GO:0006534 GO:0007595 GO:0008198 GO:0010243 GO:0016491 GO:0016702 GO:0017172 GO:0019448 GO:0019451 GO:0033762 GO:0042412 GO:0043200 GO:0045471 GO:0046439 GO:0046872 GO:0051213 GO:0051384 GO:0051591 GO:0055114
1	0.35	0.697	2.05	0.21	0.78	3eqeA	GO:0000097 GO:0005506 GO:0005829 GO:0016491 GO:0016702 GO:0017172 GO:0019451 GO:0042412 GO:0046872 GO:0051213 GO:0055114
2	0.30	0.805	1.98	0.15	0.90	4qmaA	GO:0005506 GO:0016702 GO:0046872 GO:0051213 GO:0055114
3	0.22	0.595	2.84	0.13	0.71	1lr5A	GO:0004872 GO:0005783 GO:0005788 GO:0008270 GO:0009734 GO:0010011 GO:0046872
4	0.18	0.521	2.83	0.09	0.62	3ht2A	GO:0016301 GO:0016310 GO:0046872
5	0.18	0.565	3.48	0.12	0.70	4b29A	GO:0046872 GO:0047869
6	0.07	0.604	4.26	0.07	0.82	4nhyA	GO:0005506 GO:0005634 GO:0005737 GO:0006449 GO:0008283 GO:0010494 GO:0016491 GO:0016705 GO:0016706 GO:0018126 GO:0019511 GO:0031418 GO:0031543 GO:0031544 GO:0034063 GO:0046872 GO:0051213 GO:0055114
7	0.07	0.605	4.23	0.05	0.81	3kt4A	GO:0000288 GO:0005506 GO:0005634 GO:0005737 GO:0006307 GO:0006415 GO:0006449 GO:0008143 GO:0008198 GO:0016491 GO:0016705 GO:0016706 GO:0018188 GO:0031418 GO:0031543 GO:0035511 GO:0035516 GO:0046872 GO:0051213 GO:0055114 GO:0070989
8	0.07	0.536	3.85	0.09	0.71	4bqxA	GO:0001666 GO:0005506 GO:0005634 GO:0005737 GO:0005829 GO:0016491 GO:0016705 GO:0016706 GO:0018401 GO:0019899 GO:0030821 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043433 GO:0045765 GO:0046872 GO:0051213 GO:0051344 GO:0055008 GO:0055114 GO:0060347 GO:0060412 GO:0060711 GO:0061418 GO:0071731
9	0.07	0.549	3.34	0.08	0.69	1zvfA	GO:0000334 GO:0005506 GO:0005634 GO:0005737 GO:0006569 GO:0008198 GO:0009435 GO:0016491 GO:0019363 GO:0019805 GO:0034354 GO:0043420 GO:0046872 GO:0046874 GO:0051213 GO:0055114
10	0.07	0.527	3.87	0.12	0.70	4iw3A	GO:0005506 GO:0016491 GO:0016705 GO:0031418 GO:0046872 GO:0055114
11	0.07	0.530	4.12	0.08	0.72	4kbzA	GO:0001666 GO:0005506 GO:0005634 GO:0005737 GO:0005829 GO:0016491 GO:0016705 GO:0016706 GO:0018401 GO:0019899 GO:0030821 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043433 GO:0045765 GO:0046872 GO:0051213 GO:0051344 GO:0055008 GO:0055114 GO:0060347 GO:0060412 GO:0060711 GO:0061418 GO:0071731
12	0.07	0.510	4.10	0.11	0.68	4j25A	GO:0005506 GO:0016491 GO:0016705 GO:0031418 GO:0046872 GO:0055114
13	0.07	0.515	4.23	0.09	0.70	5a3uA	GO:0001666 GO:0005506 GO:0005634 GO:0005737 GO:0005829 GO:0016491 GO:0016705 GO:0016706 GO:0018401 GO:0019899 GO:0030821 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043433 GO:0045765 GO:0046872 GO:0051213 GO:0051344 GO:0055008 GO:0055114 GO:0060347 GO:0060412 GO:0060711 GO:0061418 GO:0071731
14	0.07	0.563	3.43	0.08	0.71	2h0vA	GO:0008127 GO:0016491 GO:0046872 GO:0051213 GO:0055114
15	0.07	0.478	2.09	0.14	0.53	3h50A	GO:0046872
16	0.06	0.343	5.64	0.05	0.63	1fgxB	GO:0000138 GO:0002064 GO:0002526 GO:0003831 GO:0003945 GO:0004461 GO:0005576 GO:0005615 GO:0005794 GO:0005886 GO:0005975 GO:0005989 GO:0006012 GO:0006486 GO:0006487 GO:0007155 GO:0007339 GO:0007341 GO:0008092 GO:0008285 GO:0008378 GO:0009101 GO:0009312 GO:0009897 GO:0009986 GO:0016020 GO:0016021 GO:0016323 GO:0016740 GO:0016757 GO:0030057 GO:0030112 GO:0030145 GO:0030175 GO:0030198 GO:0030879 GO:0031526 GO:0032580 GO:0035250 GO:0042060 GO:0042127 GO:0042803 GO:0042995 GO:0043014 GO:0043065 GO:0045136 GO:0046872 GO:0048487 GO:0048754 GO:0050900 GO:0051270 GO:0060046 GO:0060054 GO:0060055 GO:0060058 GO:0070062
17	0.06	0.336	5.79	0.05	0.62	4f7kA	GO:0005507 GO:0016491 GO:0052716 GO:0055114
18	0.06	0.601	4.14	0.05	0.80	4nhkA	GO:0000288 GO:0005506 GO:0005634 GO:0005737 GO:0006307 GO:0006415 GO:0006449 GO:0008143 GO:0008198 GO:0016491 GO:0016705 GO:0016706 GO:0018188 GO:0031418 GO:0031543 GO:0035511 GO:0035516 GO:0046872 GO:0051213 GO:0055114 GO:0070989
19	0.06	0.361	5.51	0.07	0.64	1wp9A	GO:0000166 GO:0003676 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0006259 GO:0006281 GO:0046872 GO:0090305
20	0.06	0.314	5.67	0.03	0.57	1sdjA	GO:0003824 GO:0009058 GO:0016853
21	0.06	0.266	5.44	0.03	0.46	1xm7A

Consensus prediction of GO terms

Molecular Function	GO:0017172	GO:0008198	GO:0060089	GO:0042562	GO:0016772
GO-Score	0.66	0.48	0.44	0.44	0.36
Biological Processes	GO:0055114	GO:0019451	GO:0042412	GO:0000097	GO:0043200	GO:0006534	GO:0051384	GO:0007595	GO:0051591	GO:0045471	GO:0033762	GO:0071365	GO:0009755	GO:0006796
GO-Score	0.77	0.66	0.66	0.66	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.44	0.44	0.36
Cellular Component	GO:0005829	GO:0070013	GO:0044432
GO-Score	0.66	0.44	0.44

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.