I-TASSER results

I-TASSER results for job id Rv1061

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (287 residues)
MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFDEHHQPRLHKQPIAAWQ
DADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRIFAHNGVVEGLDVLDERLR
EVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDALRWLAANVPIYAVNVLLSTAT
DVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHSTHLRERSSVVFATEPMDDNPRWR
LLDAGELVHVDAALRVNRSLVLPDPPRHPIRREDLSEPVLHAQHTSA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFDEHHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRIFAHNGVVEGLDVLDERLREVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDALRWLAANVPIYAVNVLLSTATDVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHSTHLRERSSVVFATEPMDDNPRWRLLDAGELVHVDAALRVNRSLVLPDPPRHPIRREDLSEPVLHAQHTSA
Prediction	CCEEEEEHCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCEEEEEHCCCEEEEHCCCCCCCCCCHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCCCEEHCCEEEEHCCCCCCHHHHHHHHHHHCCCCEEHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEHCCCEEEEEHCCCCCCCEEEEHCCCCCCEHCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCEEHCCCCEEEEEHCCEEEEEHCCCCCCCCCCCCHHHCCCCCCCCCCCCC
Conf.Score	98799998699854667776556556655567888865899995998799984777755775567876558888799987567899887545688566889999868889899999999998998656579879999999999999979997999999999999975666589999859989999879999856888779986544456555444434468885899995658899876886999899999998999755688888766445665665555667789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFDEHHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRIFAHNGVVEGLDVLDERLREVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDALRWLAANVPIYAVNVLLSTATDVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHSTHLRERSSVVFATEPMDDNPRWRLLDAGELVHVDAALRVNRSLVLPDPPRHPIRREDLSEPVLHAQHTSA
Prediction	73000000134400200110030231135243411100000002775211013442222442434541550412000000010141444340000022530000000105406501540375225321403000000000003204755553252024004302731430000000014420000010333000000324523232223323132443416623000000011363740350452000002573324342136744332033450456335466668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEHCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCEEEEEHCCCEEEEHCCCCCCCCCCHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCCCEEHCCEEEEHCCCCCCHHHHHHHHHHHCCCCEEHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEHCCCEEEEEHCCCCCCCEEEEHCCCCCCEHCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCEEHCCCCEEEEEHCCEEEEEHCCCCCCCCCCCCHHHCCCCCCCCCCCCC
MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFDEHHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRIFAHNGVVEGLDVLDERLREVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDALRWLAANVPIYAVNVLLSTATDVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHSTHLRERSSVVFATEPMDDNPRWRLLDAGELVHVDAALRVNRSLVLPDPPRHPIRREDLSEPVLHAQHTSA

1gph12

0.21

0.18

0.85

2.72

MUSTER

-CGVFGIWGHEEAPQITYYGLHSLQHRGQ------EGAGIVATDGEK-LTAHKG-QGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFGSLALAHNGNLVNATQLKQQLENQGS--IFQTSSDTEVLAHLIKRS---GHFTLKDQIKNSLSMLKG-----AYAFLIMTETEMIVALDPNGLRPLSIGMMGD-----------------------AYVVASETCVGATYLREVEPGEMLIINDEGMKSERFSMNINRPTEIYDTVLPHVKEAVLTK--

1te5A

0.21

0.18

0.86

5.14

dPPAS

-CELLGMSANVP--TDIVFSFTGLMQRGGGTGPHRDGWGIAFYEGRGVRLFQDPLASVDSEVARLVQRFPIKSETVIGHIRQANVGKVGLSNTHPFIREYWTFAHNGQLADFQPK-------PGFYRPVGETDSEAAFCDLLNRVRRAFPEPVEVLLPVLISACDEYRKKGFNALISDGDWLFTFC--SSKLAYITRRAPFGPARLKDADLTVDFHAETTPDDVVTVIATEPLTDNENWTLQQSGEWVLWWGGEVLAK-----------------------------

1gph12

0.21

0.18

0.85

6.56

wdPPAS

-CGVFGIWGHEEAPQITYYGLHSLQHRGQ------EGAGIVATDGEKLTAHK--GQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFGSLALAHNGNLVNATQLKQQLENQG--SIFQTSSDTEVLAHLIKRSG---HFTLKDQIKNSLSMLKG-----AYAFLIMTETEMIVALDPNGLRPLSIGMMGD-----------------------AYVVASETCAGATYLREVEPGEMLIINDEGMKSERFSMNINRPTEIY-QDTVLPHVKE-AVLT

1gph12

0.21

0.18

0.85

3.77

wMUSTER

--GVFGIWGHEEAPQITYYGLHSLQHRGQ------EGAGIVATDGEK-LTAHK-GQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFGSLALAHNGNLVNATQLKQQLENQGS--IFQTSSDTEVLAHLIKRS---GHFTLKDQIKNSLSMLKG-----AYAFLIMTETEMIVALDPNGLRPLSIGMMGD-----------------------AYVVASETCVGATYLREVEPGEMLIINDEGMKSERFSMNINRPTEIY-QDTVLPHVKEAVLTK

1gph12

0.21

0.18

0.84

5.31

wPPAS

-CGVFGIWGHEEAPQITYYGLHSLQHRGQ------EGAGIVATDGEK--LTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFGSLALAHNGNLVNATQLKQQLENQG--SIFQTSSDTEVLAHLIKRSG---HFTLKDQIKNSLSMLKG-----AYAFLIMTETEMIVALDPNGLRPLSIGMMGD-----------------------AYVVASETCAGATYLREVEPGEMLIINDEGMKSERFSMNINRPTEIY-QDTVLPHVKEA---T

1te5A

0.21

0.18

0.86

9.76

dPPAS2

-CELLGMSANVP--TDIVFSFTGLMQRGGGTGPHRDGWGIAFYEGRGVRLFQDPLASVDSEVARLVQRFPIKSETVIGHIRQANVGKVGLSNTHPFIREYWTFAHNGQLADFQPKP-------GFYRPVGETDSEAAFCDLLNRVRRAFPEPVEVLLPVLISACDEYRKKGFNALISDGDWLFTFC--SSKLAYITRRAPFGPARLKDADLTVDFHAETTPDDVVTVIATEPLTDNENWTLQQSGEWVLWWGGEVLAK-----------------------------

1te5A

0.22

0.18

0.86

3.99

PPAS

-CELLGMSANVP--TDIVFSFTGLMQRGGGTGPHRDGWGIAFYEGRGVRLFQDPLASVDSEVARLVQRFPIKSETVIGHIRQANVGKVGLSNTHPFIREYWTFAHNGQLADFQPKP-------GFYRPVGETDSEAAFCDLLNRVRRAFPEPVEVLLPVLISACDEYRKGVFNALISDGD--WLFTFCSSKLAYITRRAPFGPARLKDADLTVDFHAETTPDDVVTVIATEPLTDNENWTLQQSGEWVLWWGGEVLAK-----------------------------

1gph12

0.21

0.18

0.85

5.69

Env-PPAS

-CGVFGIWGHEEAPQITYYGLHSLQHRGQ------EGAGIVATDGEKLTAHKG--QGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFGSLALAHNGNLVNATQLKQQLENQG--SIFQTSSDTEVLAHLIKRSG---HFTLKDQIKNSLSMLKG-----AYAFLIMTETEMIVALDPNGLRPLSIGMMGD-----------------------AYVVASETCVGATYLREVEPGEMLIINDEGMKSERFSMNINRPTEIY-QDTVLPHVKEAVLTK

1te5A

0.21

0.18

0.86

2.72

MUSTER

-CELLGMSANVPTD--IVFSFTGLMQRGGGTGPHRDGWGIAFYEGRGVRLFQDPLASVDSEVARLVQRFPIKSETVIGHIRQANVGKVGLSNTHPFIREYWTFAHNGQLADFQPKP-------GFYRPVGETDSEAAFCDLLNRVRRAFPVPVEVLLPVLISACDEYRKGVFNALISDGDWLFTFCS--SKLAYITRRAPFGPARLKDADLTVDFHAETTPDDVVTVIATEPLTDNENWTLQQSGEWVLWWGGEVLAK-----------------------------

1ecgB1

0.20

0.16

0.83

4.62

dPPAS

-CGIVGIAGVMPVNQSIYDALTVLQHRGQ------DAAGIITIDANNCFRLRK-ANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVYGITLAHNGNLTNAHELRKKLFEE-KRRHINTTSDSEILLNIFASELDNHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRT------------------EYMVASESVLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPV---------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.17

Estimated TM-score = 0.87±0.07

Estimated RMSD = 3.7±2.6Å

Download Model 2

C-score=-2.17

Download Model 3

C-score=-4.00

Download Model 4

C-score=-3.89

Download Model 5

C-score=-4.09

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1gph1	0.794	1.84	0.208	0.854
2	1ecgB	0.782	2.73	0.178	0.902
3	1te5A	0.720	2.89	0.198	0.833
4	2vdcA	0.719	3.61	0.137	0.878
5	1llwA	0.717	3.67	0.125	0.881
6	2j6hA	0.696	2.70	0.192	0.784
7	4zfjA	0.658	2.63	0.264	0.749
8	3mdnA	0.615	2.78	0.221	0.711
9	1ct9A	0.601	2.89	0.135	0.693
10	1jgtB	0.557	3.60	0.114	0.686

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.62	23	1ofeA	ONL	Rep, Mult	2,81,82,94,105,106,107,108,133,134
2	0.04	2	1ecfB	PIN	Rep, Mult	52,53,70,92
3	0.02	1	1te50	III	Rep, Mult	47,48,49,50,53,54,68,90,98,99,125,126,127,128,129,146

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.391	1ecfB	0.782	2.74	0.178	0.902	2.4.2.14	106,107
2	0.288	1gmsG	0.690	2.37	0.197	0.767	2.6.1.16	171,186,245
3	0.060	2pnqB	0.392	5.47	0.071	0.582	3.1.3.43	NA
4	0.060	1w7cA	0.394	6.23	0.043	0.676	1.4.3.13	25
5	0.060	1gph1	0.794	1.84	0.208	0.854	2.4.2.14	123
6	0.060	1ct9A	0.601	2.89	0.135	0.693	6.3.5.4	NA
7	0.060	1rf4B	0.389	5.91	0.074	0.631	2.5.1.19	98,180
8	0.060	1ayyD	0.342	3.83	0.094	0.443	3.5.1.26	NA
9	0.060	1ofdA	0.721	3.68	0.125	0.881	1.4.7.1	NA
10	0.060	1iq8A	0.412	6.45	0.046	0.714	2.4.2.29	NA
11	0.060	1vncA	0.396	6.45	0.055	0.672	1.11.1.10	NA
12	0.060	1moqA	0.277	6.48	0.037	0.484	2.6.1.16	56
13	0.060	2d0vA	0.391	6.11	0.039	0.645	1.1.99.8	NA
14	0.060	3gbdA	0.388	6.26	0.047	0.655	5.4.99.11	186
15	0.060	1llwA	0.717	3.67	0.125	0.881	1.4.7.1	NA
16	0.060	1jxaA	0.694	2.57	0.188	0.780	2.6.1.16	NA
17	0.060	3c17B	0.462	4.43	0.060	0.634	3.4.19.5	10
18	0.060	1pg3B	0.390	6.13	0.047	0.641	6.2.1.1	6,59
19	0.060	1ea0A	0.719	3.61	0.137	0.878	1.4.1.13	NA
20	0.060	2a8iA	0.477	4.62	0.068	0.665	3.4.25.-	NA
21	0.060	1w6sC	0.385	6.30	0.031	0.652	1.1.99.8	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.38	0.782	2.74	0.18	0.90	1ecfB	GO:0000287 GO:0004044 GO:0005737 GO:0005829 GO:0006164 GO:0006189 GO:0006541 GO:0009113 GO:0009116 GO:0016740 GO:0016757 GO:0042802 GO:0046872
1	0.31	0.661	2.79	0.28	0.76	4zfkB	GO:0006541 GO:0016787 GO:0016811 GO:0052699 GO:0052704
2	0.30	0.632	2.77	0.20	0.72	3mdnD	GO:0006541 GO:0016740
3	0.20	0.601	2.89	0.14	0.69	1ct9A	GO:0000166 GO:0004066 GO:0004071 GO:0005524 GO:0005737 GO:0005829 GO:0006529 GO:0006541 GO:0008652 GO:0009063 GO:0016597 GO:0016874 GO:0042802 GO:0042803 GO:0070981
4	0.18	0.720	2.89	0.20	0.83	1te5A
5	0.15	0.794	1.84	0.21	0.85	1gph1	GO:0000287 GO:0003824 GO:0004044 GO:0006164 GO:0006189 GO:0006541 GO:0008152 GO:0009113 GO:0009116 GO:0016740 GO:0016757 GO:0046872 GO:0051536 GO:0051539
6	0.10	0.698	2.59	0.19	0.78	4amvA	GO:0004360 GO:0005737 GO:0005829 GO:0005975 GO:0006002 GO:0006048 GO:0006541 GO:0008483 GO:0016740 GO:0030246 GO:1901137
7	0.06	0.331	6.32	0.07	0.56	2hdwA	GO:0016787
8	0.06	0.316	6.37	0.06	0.55	2ekcB	GO:0000162 GO:0003824 GO:0004834 GO:0005737 GO:0006568 GO:0008152 GO:0008652 GO:0009073 GO:0009507 GO:0016829 GO:0030170
9	0.06	0.295	6.71	0.06	0.52	3dahC	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0044249 GO:0046872
10	0.06	0.300	6.05	0.04	0.50	2avnA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
11	0.06	0.221	6.09	0.06	0.37	4gsnB	GO:0016740
12	0.06	0.285	6.29	0.09	0.48	3zmkB	GO:0016740
13	0.06	0.357	6.09	0.07	0.59	4dozA	GO:0000166 GO:0003723 GO:0005737 GO:0046872 GO:0051607
14	0.06	0.274	6.48	0.07	0.49	4ohcD	GO:0000287 GO:0004588 GO:0006221 GO:0009116 GO:0016740 GO:0016757 GO:0044205
15	0.06	0.275	6.74	0.04	0.50	3mbiA	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009116 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0046872
16	0.06	0.282	6.42	0.04	0.48	4ojqB	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0004197 GO:0004252 GO:0004386 GO:0005198 GO:0005524 GO:0006508 GO:0008026 GO:0008236 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0019012 GO:0019028 GO:0019031 GO:0019079 GO:0019087 GO:0039694 GO:0046872
17	0.06	0.293	6.43	0.05	0.51	2e4gA	GO:0000166 GO:0016491 GO:0055114
18	0.06	0.272	6.52	0.02	0.48	4tz7A	GO:0016301 GO:0016307 GO:0016310 GO:0046488 GO:0046854
19	0.06	0.272	6.39	0.05	0.48	1lh0A	GO:0000287 GO:0004588 GO:0006221 GO:0009116 GO:0016740 GO:0016757 GO:0044205
20	0.06	0.243	6.22	0.07	0.42	1u9yA	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009116 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0042802	GO:0031406	GO:0032559	GO:0035639	GO:0046983	GO:0016211	GO:0032550	GO:0016884	GO:0000287	GO:0004044	GO:0016811
GO-Score	0.50	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.38	0.38	0.31
Biological Processes	GO:0006541	GO:0070982	GO:0008652	GO:0009067	GO:0006189	GO:0009116	GO:0009113	GO:0052704
GO-Score	0.76	0.39	0.39	0.39	0.38	0.38	0.38	0.31
Cellular Component	GO:0005829
GO-Score	0.50

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.