I-TASSER results

I-TASSER results for job id Rv1051c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (251 residues)
MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADYPGLRVRVAMSVGPWQG
IAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAEKGVTILERGITSTRWRDY
VDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAGYGAVAQAKWATEHGRCQHCW
RHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHSDIGPASFTLGRRVVYRRDEVSR
WISKRESATRR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADYPGLRVRVAMSVGPWQGIAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAEKGVTILERGITSTRWRDYVDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAGYGAVAQAKWATEHGRCQHCWRHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHSDIGPASFTLGRRVVYRRDEVSRWISKRESATRR
Prediction	CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHCCCCCCCCEEEEEEEEHCCEEEEEEEEEHCCCCCCCCCEEEEHCCCCCCCCEEEEHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHCCEEEHCHHHHHHHHHHHHHHHCC
Conf.Score	99999999999999999988888996999976555654445789978999999988858889999877986678858998656678887688757889999999999997777887645556777776589999999999999999899887655556678999988887765889999888765555556554545899999988999999999986889975787766886799999999999866569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADYPGLRVRVAMSVGPWQGIAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAEKGVTILERGITSTRWRDYVDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAGYGAVAQAKWATEHGRCQHCWRHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHSDIGPASFTLGRRVVYRRDEVSRWISKRESATRR
Prediction	87361437303500440071437340303054251540365670421202020325514140301001324033453425042025760402002211010300200042334433022200011003440337202500340064275624444423431520342442443642453045244444324334234123004304132500430334543020120022010336204501562466568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHCCCCCCCCEEEEEEEEHCCEEEEEEEEEHCCCCCCCCCEEEEHCCCCCCCCEEEEHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHCCEEEHCHHHHHHHHHHHHHHHCC
MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADYPGLRVRVAMSVGPWQGIAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAEKGVTILERGITSTRWRDYVDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAGYGAVAQAKWATEHGRCQHCWRHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHSDIGPASFTLGRRVVYRRDEVSRWISKRESATRR

4ok0A

0.12

0.09

0.74

0.90

MUSTER

--LSEQALNHEKLMRAIVKNLADTPIPNGIILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHY--EEHFNLDLASRLKDFSKD---------------------PDKLVSDYLVDVKLDALLNQIMDLEETALELGVM--AQLIHKKLEKLEHH------------------------------

4ok0A

0.12

0.08

0.67

0.89

dPPAS

CHKKIN---LLGRVKSAIPNG--------IILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHY--EEHFNLDLASRLKDFSKDPDKLVSDYLVDVKLDLEETALELGVMAQLIHKKLEKLEHH-------------------------------------------------------------

4ok0A

0.12

0.08

0.69

1.57

wdPPAS

LDF-HKKINLLGRVKSAIPNG--------IILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHY-FNLDLASRLKDFSKDPDKLVSDYLVDVKLDALLDLEETALELGVMAQLIHKKLEKLEHH-------------------------------------------------------------

4ok0A

0.11

0.08

0.69

1.03

wMUSTER

CHKKIN---LLGRVKSAIPNG--------IILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHYEEHLDLASRLKDFSKDPDKLVSDYLVDVKLDALLNQMDLEETALELGVMAQLIHKKLEKLEHH----------------------------------------------------------

4ok0A

0.14

0.09

0.68

1.55

wPPAS

LDFDCHKKNLLGRVKSAIPNG--------IILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHY-FNLDLASRLKDFSKDPDKLV---SDYLVDVKLMDLEETALELGVMAQLIHKKLEKLEHH-------------------------------------------------------------

4ok0A

0.12

0.08

0.67

2.31

dPPAS2

CHKKIN---LLGRVKSAIPNG--------IILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHY--EEHFNLDLASRLKDFSKDPDKLVSDYLVDVKLDLEETALELGVMAQLIHKKLEKLEHH-------------------------------------------------------------

4ok0A

0.12

0.08

0.71

1.29

PPAS

CHKKIN---LLGRVKSAIPNG--------IILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHY--EEHFNLDLASRLKDFSKD---------------------PDKLVSDYLVDVKLDALLNQIMDLEETALELGVM--AQLIHKKLEKLEHH------------------------------

4ok0A

0.12

0.09

0.74

1.35

Env-PPAS

--LSEQALNHEKLMRAIVKNLADTPIPNGIILNDIHIKKDTDSVGRYMVRYATKDNKEEQTLKLEISYRDAPKESEVNVIEG--------MRIAKIERIIDNKLCACFDGEHTRTKARDLFDLHFLAKHY--EEHFNLDLASRLKDFSKD---------------------PDKLVSDYLVDVKLDALLNQIMDLEETALELGVM--AQLIHKKLEKLEHH------------------------------

5cwqA

0.10

0.92

0.67

MUSTER

EELERESEEAERRLQEARK--------------RSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKV----SEEAREQGDDEVLALALIAIALAVLALAEVACCRG-NSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCR--GNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLE

5cr4A

0.06

0.05

0.86

0.65

dPPAS

LLQNRHKKARLRFATAHGDKDRTFWRNVLWSDETKIELFGHNDHRYVWRKKGEACKPKNT-------IPTVKHGGGSIMLWGCFAAGGTGALHKIDGIMDAVQYVDILKQHLKTSVRKLKLGRKWVFQHDNDPKHTSKVVAKWLKDNKVKVLEWPSQSPDLNPIENLWAELKKRVRARRPTNLTQLHQLCQEEWAKIHPNYCGKLVYPKRLTQVKQFKGNATKY---------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.42

Estimated TM-score = 0.34±0.11

Estimated RMSD = 14.0±3.9Å

Download Model 2

C-score=-3.52

Download Model 3

C-score=-4.17

Download Model 4

C-score=-4.45

Download Model 5

C-score=-4.58

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ok0A	0.633	2.24	0.108	0.701
2	3w5mA	0.481	5.36	0.057	0.745
3	3dhiA	0.462	5.73	0.048	0.753
4	3wajA	0.460	5.80	0.069	0.761
5	1t0rA	0.458	5.78	0.044	0.749
6	4zleA	0.456	5.19	0.066	0.689
7	1mhzD	0.450	5.65	0.031	0.725
8	2eabA	0.446	5.70	0.024	0.713
9	4ktpA	0.444	5.21	0.035	0.669
10	2rdyA	0.439	6.09	0.059	0.753

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	3	1fz9A	ETI	Rep, Mult	99,100,103,104,143
2	0.05	3	1xvgA	BRJ	Rep, Mult	100,101,136,139,140
3	0.04	2	2ql2A	NUC	Rep, Mult	171,172,175
4	0.04	2	2qapA	PO4	Rep, Mult	177,178,181
5	0.04	2	2yzeA	NOB	Rep, Mult	170,171
6	0.02	1	2z7cD	ARG	Rep, Mult	122,125
7	0.02	1	3qoqD	NUC	Rep, Mult	116,118
8	0.02	1	3ecnB	MG	Rep, Mult	65,97
9	0.02	1	2g9zA	MG	Rep, Mult	132,134
10	0.02	1	1cprA	ZN	Rep, Mult	120,177
11	0.02	1	1sl0A	MG	Rep, Mult	65,122
12	0.02	1	2w9nA	ZN	Rep, Mult	103,119
13	0.02	1	3n9vA	CA	Rep, Mult	68,69,119
14	0.02	1	2vrzA	ZN	Rep, Mult	181,184
15	0.02	1	1xvgA	BRJ	Rep, Mult	13,17,85
16	0.02	1	3mliD	CA	Rep, Mult	97,103
17	0.02	1	3cr3A	MG	Rep, Mult	24,65
18	0.02	1	1xveA	3BB	Rep, Mult	103,106,107,115,116,153
19	0.02	1	2iefB	NUC	Rep, Mult	228,229
20	0.02	1	3qu6A	ZN	Rep, Mult	123,127

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2eabA	0.446	5.70	0.024	0.713	3.2.1.63	NA
2	0.060	1fziA	0.446	5.74	0.038	0.717	1.14.13.25	90
3	0.060	1htoA	0.439	5.81	0.044	0.733	6.3.1.2	NA
4	0.060	2dgaA	0.412	6.33	0.051	0.729	3.2.1.21	98
5	0.060	1mhyD	0.452	5.65	0.031	0.725	1.14.13.25	NA
6	0.060	1xnvA	0.409	5.84	0.034	0.689	6.4.1.3	NA
7	0.060	2e1qA	0.435	6.26	0.066	0.765	1.17.3.2,1.17.1.4	NA
8	0.060	1fo4A	0.440	5.94	0.058	0.737	1.17.1.4	NA
9	0.060	1oqzB	0.413	6.24	0.064	0.737	3.5.1.93	201
10	0.060	2zzgA	0.425	5.72	0.035	0.681	6.1.1.7	124,202
11	0.060	1f1hA	0.432	5.81	0.058	0.725	6.3.1.2	NA
12	0.060	1z8lA	0.407	6.08	0.040	0.697	3.4.17.21	NA
13	0.060	1lf6A	0.417	6.01	0.063	0.717	3.2.1.3	NA
14	0.060	2jg0A	0.417	5.42	0.038	0.649	3.2.1.28	146
15	0.060	2je8B	0.414	6.32	0.047	0.749	3.2.1.25	246
16	0.060	2e9lA	0.414	6.38	0.056	0.741	3.2.1.21	NA
17	0.060	1f1hL	0.432	5.77	0.063	0.721	6.3.1.2	NA
18	0.060	1jqnA	0.435	5.35	0.035	0.677	4.1.1.31	213
19	0.060	1lgrA	0.411	5.93	0.062	0.689	6.3.1.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.424	6.05	0.04	0.72	2okxA	GO:0003824
1	0.07	0.460	5.82	0.08	0.76	3wakA	GO:0004576 GO:0006486 GO:0016020 GO:0016021 GO:0016740 GO:0046872
2	0.07	0.460	5.80	0.07	0.76	3wajA	GO:0004576 GO:0006486 GO:0016020 GO:0016021 GO:0016740 GO:0046872
3	0.07	0.481	5.36	0.06	0.74	3w5mA	GO:0003824 GO:0046872
4	0.07	0.457	5.71	0.04	0.74	2incA	GO:0004497 GO:0006725 GO:0016491 GO:0046872 GO:0055114
5	0.07	0.462	5.73	0.05	0.75	3dhiA	GO:0004497 GO:0006725 GO:0016491 GO:0019439 GO:0042203 GO:0046872 GO:0055114
6	0.07	0.452	5.65	0.03	0.73	1mhyD	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0016491 GO:0046872 GO:0055114
7	0.06	0.446	5.74	0.04	0.72	1fziA	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0015050 GO:0015947 GO:0016491 GO:0046872 GO:0055114
8	0.06	0.463	5.51	0.04	0.73	3cihA	GO:0003824
9	0.06	0.330	6.59	0.08	0.60	3eddA	GO:0003824 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046872 GO:0047798
10	0.06	0.374	5.79	0.02	0.63	2amxA	GO:0009168 GO:0019239
11	0.06	0.322	6.67	0.04	0.61	5azaA	GO:0004576 GO:0005215 GO:0005363 GO:0006486 GO:0006810 GO:0006974 GO:0008643 GO:0015768 GO:0016020 GO:0016021 GO:0016740 GO:0030288 GO:0034289 GO:0042597 GO:0042956 GO:0043190 GO:0055052 GO:0060326 GO:1901982 GO:1990060
12	0.06	0.379	6.15	0.04	0.67	1lshA	GO:0005319 GO:0006869 GO:0045735
13	0.06	0.360	6.22	0.04	0.63	4j6rG	GO:0005198 GO:0016020 GO:0016021 GO:0016032 GO:0019012 GO:0019031 GO:0019062 GO:0039663 GO:0044174 GO:0044175 GO:0046718 GO:0055036
14	0.06	0.299	6.25	0.05	0.53	4xmpG	GO:0005198 GO:0016020 GO:0016021 GO:0016032 GO:0019012 GO:0019031 GO:0019062 GO:0020002 GO:0033644 GO:0039663 GO:0044174 GO:0044175 GO:0046718 GO:0055036
15	0.06	0.322	6.23	0.04	0.58	2y27B	GO:0000166 GO:0003824 GO:0005524 GO:0008152 GO:0010124 GO:0016874 GO:0046872 GO:0047475
16	0.06	0.311	6.36	0.03	0.55	3waiA	GO:0004576 GO:0005215 GO:0005363 GO:0006486 GO:0006810 GO:0006974 GO:0008643 GO:0015768 GO:0016020 GO:0016021 GO:0016740 GO:0030288 GO:0034289 GO:0042597 GO:0042956 GO:0043190 GO:0046872 GO:0055052 GO:0060326 GO:1901982 GO:1990060
17	0.06	0.326	6.34	0.03	0.58	1p8jA	GO:0002020 GO:0004175 GO:0004252 GO:0004867 GO:0005576 GO:0005615 GO:0005769 GO:0005783 GO:0005788 GO:0005789 GO:0005794 GO:0005802 GO:0005886 GO:0006465 GO:0006508 GO:0007568 GO:0008233 GO:0008236 GO:0008283 GO:0009966 GO:0009986 GO:0010951 GO:0012510 GO:0016020 GO:0016021 GO:0016485 GO:0016486 GO:0016787 GO:0019058 GO:0030140 GO:0030335 GO:0030511 GO:0030574 GO:0031985 GO:0032455 GO:0032804 GO:0032902 GO:0032911 GO:0032940 GO:0042176 GO:0042277 GO:0043043 GO:0045121 GO:0045714 GO:0046872 GO:0048406 GO:0052548 GO:0070062
18	0.06	0.288	6.56	0.04	0.54	1mhyB	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0016491 GO:0016709 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0043169
GO-Score	0.47
Biological Processes	GO:0006486	GO:0006725	GO:0055114
GO-Score	0.13	0.07	0.07
Cellular Component	GO:0016021
GO-Score	0.13

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.