I-TASSER results

I-TASSER results for job id Rv1048c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (371 residues)
MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSALEGAFRSEVRARRVNGP
HRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAPTMSPGARKAAHDAGVGWV
DESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRATLAVCEALLANIAGPTVASV
VEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLIVDRDALLDAYAEAADKLRSPIS
ISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSASLLAPMQTEIAPMEIYVPGRSWSD
LRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQNLQGFRSMLWPRVYADLRTAGVRGED
AAEHLREAMTK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSALEGAFRSEVRARRVNGPHRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAPTMSPGARKAAHDAGVGWVDESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRATLAVCEALLANIAGPTVASVVEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLIVDRDALLDAYAEAADKLRSPISISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSASLLAPMQTEIAPMEIYVPGRSWSDLRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQNLQGFRSMLWPRVYADLRTAGVRGEDAAEHLREAMTK
Prediction	CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHCCCEEEEEEEHCCCCCHHHHHHHHHHCCCCEEEEHCCCCHHHHHHHHHHCCCEEHCCCCEEEEHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEHCCCCCCCCEEEHCCHHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCCCCCCEEEEHCCCCCHHHHHHCCCCCCCHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
Conf.Score	98766544455554456556555676445566655666677776555555654456778765467768758999998588986999999975798589996679999999999989957747775899967887657898757888887666666776667899999985777888999999989989999999999999897665478887655898599999999999855555764567775688889999999997566787467734899999865556776699998787668999999998996567898799985787545444445788645568999999865898769999999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSALEGAFRSEVRARRVNGPHRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAPTMSPGARKAAHDAGVGWVDESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRATLAVCEALLANIAGPTVASVVEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLIVDRDALLDAYAEAADKLRSPISISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSASLLAPMQTEIAPMEIYVPGRSWSDLRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQNLQGFRSMLWPRVYADLRTAGVRGEDAAEHLREAMTK
Prediction	75364441454033111024016343124241422254311510342253424444373232301234620100010145131430241045371100000120045015204746020002000010214423210101033454455535444424521110010003325325033005206101110130053046451136346434544130541550042016415553454132202224304401430263157531200000000011002212434301010244226304401541614416503000001244311333345352021030000000003165114500430263048
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHCCCEEEEEEEHCCCCCHHHHHHHHHHCCCCEEEEHCCCCHHHHHHHHHHCCCEEHCCCCEEEEHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEHCCCCCCCCEEEHCCHHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCCCCCCEEEEHCCCCCHHHHHHCCCCCCCHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSALEGAFRSEVRARRVNGPHRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAPTMSPGARKAAHDAGVGWVDESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRATLAVCEALLANIAGPTVASVVEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLIVDRDALLDAYAEAADKLRSPISISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSASLLAPMQTEIAPMEIYVPGRSWSDLRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQNLQGFRSMLWPRVYADLRTAGVRGEDAAEHLREAMTK

5boxA

0.10

0.05

0.50

1.34

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------------------------SKDRMLNLYEARAYVALVAFGV-LTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKT--NKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLEVPKYGVERVWVVRGIKNSTLKTKEMLEQNEILLADDGFIAVNLEDDIIKA----VDRGVKTKILL--TKNLLPRLKAS---------------------------KIIDYAKE

5boxA1

0.13

0.04

0.29

1.06

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------------------------SKDRMLNLYEARAYVALVAFGV-LTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQP--GKTNKYRPVHPANVLEKFIQDWQERVKEELE---AKKKAKEELLELMAPLIETE-----------------------------------------------------------------------------------------------------------

1rrvA

0.11

0.95

0.64

MUSTER

MRV---VCGTRGDVEIGVALADR---LKALQTRMCAPPAAEERLAEVVPHVPVGLPQHMMLQEGMPPPPPEEELAAMTVEMQFDAVPGAAEGCAAVVAVGDLAAATGVRSVAEKLGLPFFYSVPSPVYLASPHLPPA---------YDEPTTPGVTDIRVLWEERAARFADRYGPTLNRRRAEIGLDVFGYGHGERPLLAADPVLAPLQPDVDAVQWLLSDERPLPPELEAFLAAGSPPVHIGFSSGRGIADAAKVAVEAIRAQGRRVILS----RGWTELVLPDDRDDCFAIDEVNFQALFRRVAGTEHVATRAGVPQLVIPRNTDQPYFAGRVAHDGPTPTFESLSAALTTLAPETRARAEAVAGMVLT

4r04A5

0.10

0.09

0.95

0.60

dPPAS

IQNPQFDNMKFYKKRMEFIYDRQKRFINYYKSVPTIDDIIKSHLVSEYNRDETVLESYRTNSLRKINSNHGIDIRANSLFTEQELLNIYSQELLNRGNLAA--ASDIVRLLALKN-------FGGVYLDVDMLPG-----IHSDLFKTISRPSSIGLDRWEMIKLEAIMKYKKYINNYTSENFDKLDQQLKDNFKLIIESKSEKSEIFSKLENLNVSDLETNLVIEQVKNRYQFLNQHLNPAIESDNNFTDTTKIFHDSLFNSATAENSMFLTKIAPYLQVGFMPEARSTISLSGPGAYASAYYDFINLQENTIE------KTLKASDLIEFKFPENNLSQLTEQEINSLWSFDQASAKYQFEKYVRDYTG

5boxA

0.11

0.06

0.57

0.77

wdPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------SKDRMVLNLYEARAYVALVAFGV-LTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGK--TNKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLIETEYGVERVWVVRGIKNSTLKTKEMLEQNEILLADDGFIAVNLEDDIIKA----VDRGVKTKIL-KASKIIDYAKEGKLELRALDKF-LICDFALEDLKDHRVVALFKEKFNE

5fshA

0.11

0.94

0.62

wMUSTER

ME------DLDALWERYREAVRAGGNPQALYQEMVWPALLALWRE---KPRVYPFPQAFAVSVHTLGTERVYVLHTPESARFLPRLRQDTG-KDLYPVEIGKSIYREVKRLLEKHPEVALDLTSAGFFFQRFYPKVRVVYVDNEDYELRRPNPHEALAEVDALFAKELYGKGEFGQFRGMVGRTGNQYALLAEMYRAWRALDFGRKLNHPLNARREALEAQVALLEAVDRFLKARDFALKEGVYG----LARTLLHLAQEAKEEAAVLAALELLLQERLALLGRRPG-----LSPEEAEALRKALAELLPEEVRLPAKLGLLDLL-AFLRLKGDEALGRLSLAELRGLAGALKG--RNPKAVEGIARLAQG

5boxA

0.11

0.07

0.59

0.88

wPPAS

--------------------------------------------------------------------------------------------------------SDRMVELLQEH--------E--------------------------------LNLYEARAYVALVAFGV-LTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGK--TNKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLEVPKYGVERVWVVRGIKNSTLKTKEMLEQNEILLADDGFIAVNLEDDIIKA----VDRG-KILLTLKASKIIDYAKEGKLELRALDKF-LICDFALEDLKDHRVVALFKEKFNE

4nb5A

0.13

0.05

0.36

1.04

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------------------------DIMEFLTRLAGRLLGWLLVDPERQSSEELATALAASSGGISTNARMLIQFGFIERLAVAGDRRTYFRLRP----NAFAAGERERIR--------AMAELQDLADVGLRALGDAPPQRSRRLREMRDLLA---------------YMENVVSDALGRYSQ-------------------------------------------------------------

5gaoE

0.16

0.15

0.91

0.81

PPAS

-----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----

4ijaA1

0.08

0.03

0.42

0.89

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------PMNDNEKRVLREIYNHH-NISRTQISKNLEINKATISSILNKLKYKSLVNEVGGGRKPILLKVN-------------------HLYGYFISL------------DLTYSSVEVMYNY-FDGNVIK-------HESYDLPDEKVSSILSIIKKHIQEKLDTYNGLLGV---------------SV-SIHVV----DNEQHVTYGISIAKKIKEITVP

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.76

Estimated TM-score = 0.40±0.13

Estimated RMSD = 13.3±4.1Å

Download Model 2

C-score=-3.51

Download Model 3

C-score=-3.51

Download Model 4

C-score=-4.13

Download Model 5

C-score=-4.12

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5fshA	0.809	3.37	0.110	0.954
2	4xqkA	0.467	6.72	0.060	0.790
3	3s4wB	0.447	6.57	0.061	0.739
4	5t8vA	0.446	6.46	0.058	0.712
5	5i6fA	0.427	6.27	0.059	0.679
6	5dfzB	0.420	6.76	0.034	0.714
7	2zxqA	0.418	6.65	0.051	0.685
8	4r04A	0.418	7.17	0.048	0.741
9	4bujB	0.416	6.92	0.072	0.706
10	5fwkA	0.415	7.18	0.045	0.725

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1j79B	NCD	Rep, Mult	354,357
2	0.06	3	3iasK	CA	Rep, Mult	360,363
3	0.04	2	4m9vC	MPD	Rep, Mult	228,231
4	0.04	2	2byoA	ZN	Rep, Mult	203,222
5	0.04	2	2aiyB	IPH	Rep, Mult	224,227
6	0.02	1	4wakB	BCT	Rep, Mult	155,158
7	0.02	1	3cmvG	ANP	Rep, Mult	182,190,191,192,193,194
8	0.02	1	3shfA	GBL	Rep, Mult	237,238,243,277,281
9	0.02	1	4a8fA	MG	Rep, Mult	69,124
10	0.02	1	3sfzA	GBL	Rep, Mult	169,170,188,191,210,215
11	0.02	1	1khrC	VIR	Rep, Mult	348,350
12	0.02	1	2wscK	CLA	Rep, Mult	163,167
13	0.02	1	1jwlA	NUC	Rep, Mult	276,280
14	0.02	1	1xbtA	MG	Rep, Mult	10,49
15	0.02	1	3t24A	C8E	Rep, Mult	124,137
16	0.02	1	1ldbD	SO4	Rep, Mult	201,203
17	0.02	1	1f31A	UUU	Rep, Mult	191,192,204,206,218
18	0.02	1	3iylA	MYR	Rep, Mult	124,141

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1yqyA	0.258	7.40	0.028	0.466	3.4.24.83	272,320
2	0.060	3gtgB	0.353	6.78	0.069	0.596	2.7.7.6	NA
3	0.060	3a2kA	0.380	6.54	0.057	0.601	6.3.4.-	NA
4	0.060	1ob2A	0.216	6.00	0.037	0.332	3.6.1.48	NA
5	0.060	2x0sA	0.343	7.11	0.058	0.596	2.7.9.1	NA
6	0.060	3btaA	0.370	6.92	0.030	0.636	3.4.24.69	NA
7	0.060	1ej6A	0.350	7.06	0.048	0.609	2.7.7.50	NA
8	0.060	2w68C	0.158	6.20	0.079	0.251	3.2.1.18	NA
9	0.060	2qf7B	0.343	7.17	0.054	0.601	6.4.1.1	NA
10	0.060	2hg4C	0.368	6.58	0.055	0.607	2.3.1.94	166,210
11	0.060	2q3zA	0.361	7.25	0.037	0.639	2.3.2.13	NA
12	0.060	2vumB	0.343	6.62	0.054	0.571	2.7.7.6	325
13	0.060	2vz9B	0.368	7.12	0.072	0.644	2.3.1.85	NA
14	0.060	2zxqA	0.418	6.65	0.051	0.685	3.2.1.97	346,362
15	0.060	1z0hB	0.237	7.21	0.029	0.418	3.4.24.69	NA
16	0.060	1etuA	0.161	5.56	0.057	0.234	3.6.5.3	NA
17	0.060	1hn0A	0.408	6.71	0.052	0.676	4.2.2.20	NA
18	0.060	1p4rA	0.358	6.79	0.039	0.588	2.1.2.3,3.5.4.10	NA
19	0.060	2vkzG	0.377	7.13	0.053	0.668	2.3.1.38,3.1.2.14	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.400	6.63	0.03	0.66	5ffjA	GO:0000166 GO:0003676 GO:0003677 GO:0004518 GO:0004519 GO:0005524 GO:0006306 GO:0008168 GO:0008170 GO:0016787 GO:0032259 GO:0090305
1	0.06	0.264	6.59	0.05	0.43	4a2wA	GO:0000166 GO:0003677 GO:0005524 GO:0005737 GO:0016787 GO:0016817 GO:0046872
2	0.06	0.307	6.81	0.05	0.51	4p0dA	GO:0005576 GO:0005618
3	0.06	0.270	7.23	0.03	0.48	2wjyA	GO:0000166 GO:0000184 GO:0000294 GO:0000723 GO:0000784 GO:0000785 GO:0000932 GO:0000956 GO:0003677 GO:0003682 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006260 GO:0006281 GO:0006406 GO:0006449 GO:0008270 GO:0009048 GO:0016787 GO:0032201 GO:0035145 GO:0042162 GO:0044530 GO:0044822 GO:0046872 GO:0061014 GO:0061158 GO:0071044 GO:0071222 GO:0071347
4	0.06	0.298	6.18	0.08	0.46	3ufbA	GO:0003676 GO:0003677 GO:0006306 GO:0008168 GO:0008170 GO:0016740 GO:0032259
5	0.06	0.247	6.89	0.05	0.42	2zooA	GO:0005507 GO:0006807 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0050421 GO:0055114
6	0.06	0.364	7.16	0.05	0.64	5ffjB	GO:0000166 GO:0003676 GO:0003677 GO:0004518 GO:0004519 GO:0005524 GO:0006306 GO:0008168 GO:0008170 GO:0016787 GO:0032259 GO:0090305
7	0.06	0.213	6.59	0.03	0.34	2ocaA	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0016787
8	0.06	0.237	6.82	0.02	0.39	2xzlA	GO:0000166 GO:0000184 GO:0000956 GO:0003677 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005844 GO:0006310 GO:0006449 GO:0006452 GO:0008270 GO:0008298 GO:0016567 GO:0016787 GO:0016887 GO:0030466 GO:0043024 GO:0046872 GO:0070478
9	0.06	0.263	6.78	0.04	0.43	3h1tA	GO:0000166 GO:0003677 GO:0003824 GO:0005524 GO:0006304 GO:0016787
10	0.06	0.276	7.08	0.03	0.48	1larA	GO:0004721 GO:0004725 GO:0005001 GO:0005886 GO:0005887 GO:0006470 GO:0007155 GO:0007185 GO:0007268 GO:0008201 GO:0010975 GO:0016020 GO:0016021 GO:0016311 GO:0016477 GO:0016787 GO:0016791 GO:0031102 GO:0032403 GO:0035335 GO:0035373 GO:0043005 GO:0043025 GO:0048679 GO:0070062 GO:1900121
11	0.06	0.229	6.71	0.04	0.37	4rxoD	GO:0002376 GO:0003676 GO:0003723 GO:0003824 GO:0005622 GO:0005634 GO:0005654 GO:0005886 GO:0006203 GO:0006955 GO:0008152 GO:0008270 GO:0008832 GO:0016787 GO:0032567 GO:0045087 GO:0045088 GO:0046061 GO:0046872 GO:0051289 GO:0051607 GO:0060337
12	0.06	0.275	5.95	0.05	0.43	4a36A	GO:0000166 GO:0003677 GO:0005524 GO:0005737 GO:0016787 GO:0016817 GO:0046872
13	0.06	0.238	5.84	0.06	0.36	4cbhA	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0004175 GO:0004197 GO:0004252 GO:0004386 GO:0005216 GO:0005524 GO:0006508 GO:0006810 GO:0006811 GO:0008026 GO:0008233 GO:0008234 GO:0008236 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016817 GO:0017111 GO:0019012 GO:0019062 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0033897 GO:0034220 GO:0039503 GO:0039520 GO:0039548 GO:0039654 GO:0039663 GO:0039694 GO:0039707 GO:0042025 GO:0044228 GO:0044385 GO:0046718 GO:0051259 GO:0055036 GO:0070008 GO:0090502 GO:1903608 GO:1990219
14	0.06	0.236	6.96	0.04	0.42	1vj7A	GO:0000166 GO:0005524 GO:0005525 GO:0008152 GO:0008728 GO:0008893 GO:0015969 GO:0015970 GO:0016301 GO:0016310 GO:0016597 GO:0016740 GO:0016787 GO:0046872
15	0.06	0.239	6.47	0.05	0.38	4nmnA	GO:0000166 GO:0003677 GO:0003678 GO:0004386 GO:0005524 GO:0005829 GO:0006260 GO:0006268 GO:0006269 GO:0016787 GO:0046872 GO:1990077
16	0.06	0.248	6.26	0.06	0.40	2vq2A
17	0.06	0.230	6.63	0.04	0.38	2fdcA	GO:0000166 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009381 GO:0009432 GO:0016787 GO:0090305
18	0.06	0.226	7.04	0.10	0.38	2d7dA	GO:0000166 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009381 GO:0009432 GO:0016787 GO:0090305

Consensus prediction of GO terms

Molecular Function	GO:0003676	GO:0032550	GO:0032559	GO:0035639
GO-Score	0.46	0.36	0.36	0.36
Biological Processes	GO:0006306	GO:0090305	GO:0061158	GO:0006281	GO:0006449	GO:0032201	GO:0071044	GO:0071222	GO:0006406	GO:0000294	GO:0071347	GO:0061014	GO:0000184	GO:0009048
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0005576	GO:0005618	GO:0035145	GO:0005654	GO:0000932	GO:0000784	GO:0044530	GO:0005829	GO:0000785
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.