I-TASSER results

I-TASSER results for job id Rv1043c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (341 residues)
MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVADFSRYLSTLGLPAAG
DAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGAISKGQRGGNLWLSEVFGAELI
IPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKHVVTGLAGTSAGLSVYPSSNH
AEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGGMAFRDPDWADEVYVFGYPRVPM
TAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARPGNSGGPIVAQDGRVIGLVVEDSAE
APSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTLP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVADFSRYLSTLGLPAAGDAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGAISKGQRGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKHVVTGLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGGMAFRDPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARPGNSGGPIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTLP
Prediction	CCCCHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEHCCCCCCCCEEEEHCCEEEEHCCEEHCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCEEEEEEEEHCCCCCCCCCCEEEEHCCCCCCCCCCCCCCHCCCCCEEEEEEEHCCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHCCEEHCCCCC
Conf.Score	98644545566756777657788888776667777665454444467887766588654446678888887776554456677776555555444567666566677766666677477787655546666577888864677755899979978857444689867799999869997899999985577788998878999985899887765688888888998789999769988776665798778997588888887455787457889998875544789988998864445678888877755676544599999999999985857767899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVADFSRYLSTLGLPAAGDAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGAISKGQRGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKHVVTGLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGGMAFRDPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARPGNSGGPIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTLP
Prediction	71033002213455025315524444244322232322021111230142047341532343222220021033011023233433243234322354434445544434145424274026204402140314555455330200000015400000000044065041203324565514020002234443125100000104368443103033245640412020000000213343321212120202044254464331000010011230000000035130000000201334543432202000000104203500530276251535628
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEHCCCCCCCCEEEEHCCEEEEHCCEEHCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCEEEEEEEEHCCCCCCCCCCEEEEHCCCCCCCCCCCCCCHCCCCCEEEEEEEHCCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHCCEEHCCCCC
MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVADFSRYLSTLGLPAAGDAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGAISKGQRGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKHVVTGLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGGMAFRDPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARPGNSGGPIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTLP

3qo6A1

0.23

0.15

0.63

2.21

MUSTER

------------------------------------------------------------------------------------------------------PKKLQTDELATVRLFQENTPSVVYITNLAVRTLDVLEVPQGSGSGFVWDQGHIVTNYHVIRGASDLRVTL---ADQTTFDAKVVGF------DQDKDVAVLRIDAPK-NKLRPIPVGVSADLLVGQKVFAIGNPFGDHTLTTGVISGLRREI-SSAATGRPIQDVIQTDAAINPGNSGGPLLDSSGTLIGINTAIYSPS------GASSGVGFSIPVDTVGGIVDQLVRFGK-------

3stjA1

0.19

0.11

0.58

2.87

dPPAS

----------------------------------------------------------------------------------------------------------------PLPSLAPMLEKVLPAVVSVRVEGTQP--FEGLGSGVIINKGYVLTNNHVINQAQKISIQL---NDGREFDAKLIGS------DDQSDIALLQIQNPS--KLTQIAIADSDKLRVGDFAVAVGNPFG-----LGQTATSGIVSALGRSGLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPG------GGSVGIGFAIPSNMARTLAQQLIDFGEI------

1l1jA

0.22

0.14

0.64

3.97

wdPPAS

-------------------------------------------------------------------------------------DYESPIVNVVEACAPAVVKIDVVKTTSFFDPYEQFFKKWFG-----ELPPGFERQVASLGSGFIFDEGYILTNYHVVGGADNITVTM---LDGSKYDAEYIGG------DEELDIAVIKIKASD-KKFPYLEFGDSDKVKIGEWAIAIGNPLG-----FQHTVTVGVVSATNRRGSGYYVGLIQTDAAINPGNSGGPLLNIHGEVIGINTAIVNPQ-------EAVNLGFAIPINTVKKFLDTILT----------

1te0A

0.23

0.15

0.64

2.37

wMUSTER

-------------------------------------------------------------------------------------------------------DSTDETPASYNLAVRRAAPAVVNVYNRGLNTNSNQLEIRTLGSGVIMDRGYIITNKHVINDADQIIVAL---QDGRVFEALLVGS------DSLTDLAVLIIKATGG--LPTIPINARRVPHIGDVVLAIGNPYN-----LGQTITQGIISATGRIGPTGRQNFLQTDASINHGNSGGALVNSLGELMGINTLSFDKSNDGETP---EGIGFAIPFQLATKIMDKLIRDGRVIRGYIP

1l1jA

0.22

0.14

0.64

3.57

wPPAS

-------------------------------------------------------------------------------------DYESPIVNVVEACAPAVVKIDVVKTTSFFDPYEQFFKKWFG-----ELPPGFERQVASLGSGFIFDEGYILTNYHVVGGADNITVTM---LDGSKYDAEYIGG------DEELDIAVIKIKASD-KKFPYLEFGDSDKVKIGEWAIAIGNPLG-----FQHTVTVGVVSATNRRISGYYVGLIQTDAAINPGNSGGPLLNIHGEVIGINTAIVNP-------QEAVNLGFAIPINTVKKFLDTILT----------

3stjA1

0.19

0.11

0.58

4.40

dPPAS2

----------------------------------------------------------------------------------------------------------------PLPSLAPMLEKVLPAVVSVRVE--GTQPFEGLGSGVIINKGYVLTNNHVINQAQKISIQL---NDGREFDAKLIGS------DDQSDIALLQIQNPS--KLTQIAIADSDKLRVGDFAVAVGNPFG-----LGQTATSGIVSALGRSGLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPG------GGSVGIGFAIPSNMARTLAQQLIDFGEI------

5hmaA

0.20

0.11

0.55

3.27

PPAS

-----------------------------------------------------------------------------------------------------------------------LYHTVPPAVVGVGGGGVNAG---PVASGAIVGNGYVITTLHSVSKLPEISVQVATTGGIRRFPAQVVKT------IPGHDLALLKMQTTE--KFLHFRMADVQTVVPGQQVFAFGRNMA-----GAPLVRQGLVQSADAPLATQITHLLRSDAVYSWEQTGGPLVNAQGDLVGINIAAT---GPTGK-----VEGFTVPAQVIVSHLQDVV-----------

5hmaA

0.20

0.11

0.55

4.33

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------LYHTVPPAVVGVGGGGVNAG---PVASGAIVGNGYVITTLHSVSKLPEISVQVATTGGIRRFPAQVVKT------IPGHDLALLKMQTTE--KFLHFRMADVQTVVPGQQVFAFGRNMA-----GAPLVRQGLVQSADAPLATQITHLLRSDAVYSWEQTGGPLVNAQGDLVGINIAAT---GPTGK-----VEGFTVPAQVIVSHLQDVV-----------

3stjA1

0.21

0.12

0.58

2.14

MUSTER

------------------------------------------------------------------------------------------------------------PLPSLAPMLEKVLPAVVSVRVEG------TQPFEGLGSGVIINKGYVLTNNHVINQAQKISIQL---NDGREFDAKLIGS------DDQSDIALLQIQNPS--KLTQIAIADSDKLRVGDFAVAVGNPFG-----LGQTATSGIVSALGRSGLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPG------GGSVGIGFAIPSNMARTLAQQLIDFGEI------

3qo6A1

0.23

0.14

0.61

2.84

dPPAS

----------------------------------------------------------------------------------------------------------PKKLQTDELATVRLFQENTPAVRQDAFTLDVLEVPQGSGSGFVWDQGHIVTNYHVIRGASDLRVTL---ADQTTFDAKVVGF------DQDKDVAVLRIDAPK-NKLRPIPVGVSADLLVGQKVFAIGNPFG-----LDHTLTTGVISGLRRATGRPIQDVIQTDAAINPGNSGGPLLDSSGTLIGINTAIYSPS------GASSGVGFSIPVDTVGGIVDQLVRFGK-------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.84

Estimated TM-score = 0.39±0.13

Estimated RMSD = 13.3±4.1Å

Download Model 2

C-score=-3.11

Download Model 3

C-score=-2.93

Download Model 4

C-score=-3.47

Download Model 5

C-score=-3.14

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3qo6A	0.598	2.04	0.225	0.639
2	3stjA	0.573	1.65	0.205	0.601
3	4ic6A	0.567	2.54	0.202	0.628
4	2ok5A	0.563	4.88	0.100	0.745
5	1te0A	0.554	3.36	0.227	0.636
6	3k6yA	0.547	2.72	0.207	0.601
7	2z9iA	0.542	1.83	0.219	0.575
8	4xzyA2	0.540	4.24	0.166	0.660
9	1l1jA	0.536	2.40	0.238	0.584
10	2zleB	0.534	2.85	0.221	0.589

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.53	77	3qo6A	III	Rep, Mult	160,275,276,277,279,295,296,297,298,299,300
2	0.13	15	3pv3C	III	Rep, Mult	144,160,161,276,277,279
3	0.09	20	3stjI	III	Rep, Mult	339,340,341
4	0.03	7	2r3yA	III	Rep, Mult	197,262,263,264,265,339,340,341
5	0.02	4	3mh5B	DFP	Rep, Mult	232,236,247,249,273,274,277,278
6	0.01	2	3otpA	III	Rep, Mult	160,261,276,277,279,295,296,297,298,299,339,340,341
7	0.01	2	1c1uH	ZN	Rep, Mult	160,279
8	0.00	1	2z9iB	III	Rep, Mult	160,199,260,261,276,277,279,295,296,297,302,304,305,315
9	0.00	1	3lgyA	MG	Rep, Mult	250,271
10	0.00	1	1sozB	III	Rep, Mult	262
11	0.00	1	3e3tA	I3C	Rep, Mult	219,220,320,321,324

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.445	1qy6A	0.510	2.89	0.173	0.575	3.4.21.19	160,199,277
2	0.425	2as9A	0.486	2.93	0.167	0.551	3.4.21.-	160,199,277,279
3	0.233	2vidB	0.484	2.75	0.190	0.540	3.4.21.-	160,199,235,279
4	0.230	2j92A	0.459	2.97	0.124	0.525	3.4.22.28	160
5	0.151	3gdvA	0.572	2.62	0.243	0.625	3.4.21.-	160,199,277
6	0.140	2wv4A	0.459	2.89	0.129	0.525	3.4.22.28	NA
7	0.070	1eufA	0.505	3.26	0.129	0.587	3.4.21.-	157
8	0.069	1jwtA	0.514	3.93	0.104	0.625	3.4.21.5	160,199,277,279,280
9	0.069	1gj5H	0.495	3.54	0.132	0.589	3.4.21.5	160,199,277,279,280
10	0.067	3rp2A	0.503	3.35	0.118	0.587	3.4.21.-	157,288
11	0.067	1fq3A	0.509	3.32	0.132	0.592	3.4.21.79	NA
12	0.067	1kltA	0.508	3.39	0.151	0.595	3.4.21.39	157,274
13	0.067	1fi8B	0.506	3.35	0.118	0.589	3.4.21.-	274
14	0.060	2ok5A	0.563	4.88	0.100	0.745	3.4.21.47	160,199,277,279,280
15	0.060	1pjpA	0.512	3.36	0.141	0.595	3.4.21.39	124,237,279
16	0.060	2qf3A	0.535	2.09	0.241	0.572	3.4.21.-	160,247,279
17	0.060	1esbA	0.513	3.48	0.123	0.607	3.4.21.36	160,199,277,279,280
18	0.060	1ky9B	0.534	2.85	0.221	0.589	3.4.21.-	160,199,277
19	0.060	1rs0A	0.509	4.39	0.106	0.642	3.4.21.47	NA
20	0.060	1op0A	0.511	3.41	0.139	0.601	3.4.21.-	160
21	0.060	8gchF	0.288	3.44	0.119	0.340	3.4.21.1	122,157,160
22	0.060	1lcyA	0.510	2.79	0.220	0.566	3.4.21.108	NA
23	0.060	1a5iA	0.522	3.54	0.090	0.622	3.4.21.68	NA
24	0.060	1l1jA	0.536	2.40	0.238	0.584	3.4.21.-	160,199,277,279
25	0.060	1kdqB	0.197	3.44	0.085	0.237	3.4.21.1	NA
26	0.060	1pytD	0.518	3.72	0.138	0.628	3.4.21.2	157
27	0.060	1ab9B	0.290	3.62	0.110	0.346	3.4.21.1	160
28	0.060	1o5fH	0.508	3.56	0.153	0.604	3.4.21.106	NA
29	0.060	1bbrH	0.299	3.41	0.121	0.355	3.4.21.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.33	0.459	2.97	0.12	0.52	2j92A	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006351 GO:0006417 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019030 GO:0019062 GO:0019082 GO:0030430 GO:0033644 GO:0034220 GO:0039520 GO:0039525 GO:0039544 GO:0039611 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0046718 GO:0051259 GO:0075509 GO:0075512
1	0.29	0.486	2.33	0.22	0.52	3stiA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0042597 GO:0042802 GO:0051603 GO:0071575
2	0.29	0.487	2.20	0.26	0.52	3nwuB	GO:0001558 GO:0001890 GO:0004252 GO:0005520 GO:0005576 GO:0005615 GO:0005737 GO:0005829 GO:0005886 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016787 GO:0019838 GO:0022617 GO:0030512 GO:0030514 GO:0031012 GO:0050679 GO:0050687 GO:0060718 GO:0070062 GO:0097187
3	0.29	0.492	2.74	0.17	0.55	4mvnD	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
4	0.28	0.507	3.71	0.20	0.61	5c2zA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787
5	0.27	0.497	2.40	0.24	0.54	3lgwA	GO:0004252 GO:0005886 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016021 GO:0016787 GO:0030288 GO:0031226 GO:0071218 GO:0071575
6	0.27	0.487	3.01	0.19	0.55	4k1tC	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
7	0.26	0.500	2.66	0.19	0.55	4inkA	GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
8	0.26	0.598	2.00	0.23	0.64	3qo6B	GO:0004252 GO:0005634 GO:0006508 GO:0008233 GO:0008236 GO:0009507 GO:0009534 GO:0009535 GO:0009536 GO:0009579 GO:0009735 GO:0010206 GO:0016020 GO:0016787 GO:0030163 GO:0031977
9	0.25	0.535	2.10	0.21	0.57	5jd8A	GO:0004252 GO:0006508 GO:0008233 GO:0016020 GO:0016021 GO:0016787
10	0.23	0.493	2.47	0.20	0.54	5hmaA	GO:0004252 GO:0005886 GO:0006508 GO:0008233 GO:0016020 GO:0016021
11	0.23	0.517	1.99	0.23	0.55	3mh5A	GO:0004252 GO:0005886 GO:0006457 GO:0006508 GO:0006515 GO:0006979 GO:0008233 GO:0008236 GO:0009266 GO:0016020 GO:0016787 GO:0030288 GO:0042802
12	0.22	0.509	2.80	0.28	0.57	4ri0A	GO:0001558 GO:0004175 GO:0004252 GO:0005520 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0030512 GO:0030514
13	0.22	0.576	2.58	0.24	0.63	1sozC	GO:0004252 GO:0005886 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016021 GO:0016787 GO:0030288 GO:0031226 GO:0071218 GO:0071575
14	0.22	0.549	2.26	0.24	0.59	3nziA	GO:0001558 GO:0001890 GO:0004252 GO:0005520 GO:0005576 GO:0005615 GO:0005737 GO:0005829 GO:0005886 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016787 GO:0019838 GO:0022617 GO:0030512 GO:0030514 GO:0031012 GO:0050679 GO:0050687 GO:0060718 GO:0070062 GO:0097187
15	0.22	0.569	2.10	0.21	0.60	4ynnA	GO:0004252 GO:0006508 GO:0008233 GO:0016787
16	0.22	0.457	3.03	0.11	0.52	5hm2A	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005524 GO:0006351 GO:0006508 GO:0008233 GO:0008234 GO:0016740 GO:0016779 GO:0016787 GO:0039694
17	0.21	0.510	2.88	0.17	0.57	4jcnA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0009405 GO:0016787
18	0.21	0.548	1.83	0.22	0.58	2z9iA	GO:0004252 GO:0005576 GO:0006508 GO:0006950 GO:0008233 GO:0008236 GO:0009405 GO:0016020 GO:0016021 GO:0030163
19	0.21	0.534	2.85	0.22	0.59	1ky9B	GO:0004252 GO:0005886 GO:0006457 GO:0006508 GO:0006515 GO:0006979 GO:0008233 GO:0008236 GO:0009266 GO:0016020 GO:0016787 GO:0030288 GO:0042802
20	0.20	0.496	3.28	0.18	0.58	1fn8A	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
21	0.19	0.528	2.33	0.20	0.57	4flnB	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0009507 GO:0009533 GO:0009535 GO:0009536 GO:0009570 GO:0009579 GO:0009658 GO:0009941 GO:0010206 GO:0016020 GO:0016787 GO:0030163
22	0.18	0.529	2.52	0.23	0.58	4ic5A	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0009507 GO:0009536 GO:0009543 GO:0009579 GO:0010206 GO:0016787 GO:0031977
23	0.18	0.536	2.40	0.24	0.58	1l1jA	GO:0004252 GO:0006508 GO:0008233
24	0.17	0.530	3.36	0.17	0.62	1agjA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787
25	0.16	0.503	3.55	0.20	0.60	1qtfA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787
26	0.16	0.554	3.36	0.23	0.64	1te0A	GO:0004252 GO:0005886 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016021 GO:0016787 GO:0030288 GO:0031226 GO:0071218 GO:0071575
27	0.13	0.510	2.79	0.22	0.57	1lcyA	GO:0000785 GO:0004252 GO:0005634 GO:0005739 GO:0005758 GO:0005783 GO:0005789 GO:0005829 GO:0005856 GO:0006508 GO:0006672 GO:0006915 GO:0007005 GO:0007628 GO:0008233 GO:0008236 GO:0008344 GO:0008630 GO:0009635 GO:0009898 GO:0010942 GO:0016020 GO:0016021 GO:0016540 GO:0016787 GO:0019742 GO:0030900 GO:0031966 GO:0034599 GO:0034605 GO:0035458 GO:0035631 GO:0040014 GO:0043065 GO:0043280 GO:0044257 GO:0045786 GO:0048666 GO:0051082 GO:0060548 GO:0071300 GO:0071363 GO:0097193 GO:0097194 GO:1901215 GO:1902176 GO:1903146 GO:1903955 GO:2001241 GO:2001269
28	0.12	0.567	2.54	0.20	0.63	4ic6A	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0009507 GO:0009534 GO:0009536 GO:0009543 GO:0009579 GO:0010206 GO:0016787 GO:0031977
29	0.07	0.573	1.78	0.20	0.60	4a8cA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0042597 GO:0042802 GO:0051603 GO:0071575
30	0.07	0.547	2.72	0.21	0.60	3k6yA	GO:0001101 GO:0004252 GO:0005576 GO:0005618 GO:0005886 GO:0005887 GO:0006508 GO:0008233 GO:0009403 GO:0009405 GO:0016020 GO:0016021 GO:0016787

Consensus prediction of GO terms

Molecular Function	GO:0004252	GO:0005515	GO:0003724	GO:0005198	GO:0003723	GO:0004197	GO:0005524	GO:0003968	GO:0005216
GO-Score	0.74	0.59	0.33	0.33	0.33	0.33	0.33	0.33	0.33
Biological Processes	GO:0044257	GO:0030154	GO:0017015	GO:0044702	GO:0040008	GO:0016049	GO:0030198	GO:0030510	GO:0050678	GO:0048646	GO:0090101	GO:1903845	GO:0060717	GO:0051128	GO:0022411	GO:0042475	GO:0008284	GO:0048608	GO:0019062	GO:0001172	GO:0051259	GO:0075512	GO:0039611	GO:0019082	GO:0039690	GO:0039707	GO:0039520	GO:0018144	GO:0039544	GO:0039525	GO:0034220
GO-Score	0.59	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.58	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33
Cellular Component	GO:0005887	GO:0031233	GO:1903561	GO:0044444	GO:0031988	GO:0044385	GO:0044162	GO:0019030
GO-Score	0.59	0.59	0.58	0.58	0.58	0.33	0.33	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.