I-TASSER results

I-TASSER results for job id Rv1041c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (287 residues)
MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGSAITVGRWMVPATRCSP
TLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSPQGALSDYKKSADEPDDHA
IGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLDDYRHASTEYALGSTDFR
LLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAGGRPPAFDAALYGLRNTVE
RGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTPKLGDTP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGSAITVGRWMVPATRCSPTLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSPQGALSDYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLDDYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAGGRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTPKLGDTP
Prediction	CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
Conf.Score	98888876556658999875888887678888988898876899999999998758885549854699999779999999998877578888888865567665545666666677878776666777874677648899858999857887756899999998645577778887765898656777757899999986655566776544445566666777776664334555678888888887778876654775889999999999999997665568899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGSAITVGRWMVPATRCSPTLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSPQGALSDYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLDDYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAGGRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTPKLGDTP
Prediction	75434454340443214324624146415443244542544012001000110201020320064024334031003002202541332323341444343351323334424324444224333443323200222442202002213443222300220232033323334334322202022202122223222322022222223222333323434342233232323323320230012244022002212321410200000000000021135426748
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGSAITVGRWMVPATRCSPTLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSPQGALSDYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLDDYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAGGRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTPKLGDTP

3ja832

0.11

0.10

0.97

0.69

MUSTER

ARSTVAARQMLTDFDIRNINKLSKKKDIFDILSQSAPSIYGHDHIKKAILLMLMGGVE-KNLENGSHLRGDINILMVG----DPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMV-DRGVVCIDEFDKMTDVDRVAIHEVMEQIAKAGIHTTLNARCSVIAA-GQYDVNRDDSLLSRFDLLFVVTDDINSISEHVLRTHRVTIPFLRKYVQYAKERAINVIVKNYTDLRNDDNTKKSPIRTLETLIRLATAHAKVRL-SKTV--NK

3hotA

0.07

0.97

0.62

dPPAS

DKEHGKPPKRYEDAELQALLDEDDAQTQKQLAEQLEVSQQAVSNRLREMGKIQKVGRWVPHELNERQMERRKNTCEILLSRYKRKSFLHRIVTGDEKWIFFVNPKRKKSYVDPGQPATSTARPNRFGKKTMLCVWWDQSGVIYYELLKPGETVNAARYQQQLINLNRALQRKRPEYQHRVIFLHDNHTARAVRDTLETLNWEVLPHAAYSPDLAPSDYHLFASMGHALAEQRFDSYESVKKWLDEWFAAK---------DDEFYWRGIHKLPERWEKCVASDGKYFE

3hotA

0.11

0.09

0.89

0.63

wdPPAS

GEQVPTVKT----ERWFQRF---SGDFDVDDKEHGKPPKRYEDAELQALLDEDDA-QTQKQLAEQLEVSQ--QAVSNRLREERQMERRKNTCEILLSRYKRKSFVNPKRKKSYVDPGQPATSTARPNRFGKLCVWWDQSGVIYYELLKPGETVNAARYQQQLINLNRAQRKRPEYQHRVIFLHDNAHTARAVRDTLETLNWEVLHAAYSPDLAPASMGHALAEQRFDSYESV---KKWLDEWFAAKD-DEFYWRGIHKLPERWEKCVAS------------------

3ja832

0.12

0.11

0.94

0.68

wMUSTER

ARSTVAARQMLTDFDIRNINKL-------SKKKD-APSIYGHDHIKKAILLMLMGGVE-KNLENGSHLRGDINILMV-----DPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGELEAGAMVLAD-RGVVCIDEFDKMTDVDRVAIHEVMEQIAKAGIHTTLNARCSVIAAANQYDVNRDDSLLSRFDLLFVVTDDINSISEHVLRTHRVTIPFLRKYVQYAKERAINVIVKNYTDLRNDDNTKKSPARTLETLIRLATAHAKVRL-SKTV--NK

3hotA

0.11

0.09

0.83

0.71

wPPAS

FQRFKSGDFDVDD------------------KEHGKPPKRYEDAELQALLDEDDA-QTQKQLAEQLEVSQ--QAVSNRLREMERQ-RRKNTCEILLSRYKRKSFVNPKRKKSYVDPGQPATSTARPNRFGKLCVWWDQSGVIYYELLKPGETVNAARYQQQLINLNRALQRKRPEYQHRIFLHDNAHTARAVRDTLETLNWEVLHAAYS-------------------DL-----APSDYHLFASMGHALA--EQRFDSYESVKKWLDEWFAAKDDEFYWRGIHKLP

4z6gA

0.07

0.06

0.88

0.68

dPPAS2

VRKHINDYEDLRDSLLEVLSGIKLPRE------KGRMRFHRLQNVQIALDFLKQRQV--------KLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTN---------------FSSCWSDGKMFNALIHRYRPDLVDMERVQIQ-----SNRENLEQAFEVAERLGVTRLLDAEDVDVPSAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDNQAKEREKGRIEELYKLLEVWIEFGRIKL

3hotA

0.09

0.08

0.90

0.84

PPAS

VDDKEHGKPPKRYEDAELQALLDEDDAQTQKQ-QLEVSQQAVSNRLREMGKIQKVGRWVPHELNERQMERRKNTCEILLSRYKRKSFLHRIV---TGDEKWIFFVNPKRKKSYVDPGQPATSTARPNRFGKLCVWWDQSGVIYYELLKPGETVNAARYQQQLINLNRALQRKRPEYQHRVIFLHDNHTARAVRDTLETLNWEVLPHAAYSPDLA----------------------PSDYHLFASMGHALA--EQRFDSYESVKKWLDEWFAAKDDEFYWRGIHKLP

1c0mC1

0.22

0.11

0.52

0.75

Env-PPAS

-------------------------------------------------------GVN----PRGLGPLQIWQTLEPRMAPRSW-----------------------------------------------LAVTVDTSSAIVVTQHGRVTS--VAVQHHWATAIAVLGR-------PKAIKTDNGFTSKSTREWLARWGIAHTIPGNSQGQ------------------------AMVERANRLLKDRIRVLAEGDKRIPTSKQGELLAKAMYALNHKERENTKTP

3ja842

0.10

0.09

0.92

0.62

MUSTER

------------DQDLAKIREVAAREDLYSLLARSIAPSYELEDVKKGILLQLFGGTN-KTFTKGGRYRGDINILLCG----DPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDFDKMSDSTRSVLHEVMEQIAKAGIITTLNARSSILAS-SRYNPDLPPPLLSRFDLVYLVLDKVDHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHAKTELVRAYVGMTRQLESMIRLAEAHAKM-----KLKNEL

3ja832

0.09

0.98

0.59

dPPAS

RSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSAPSIYGHDHIKKAILLMLMGGVE-KNLENGSHLRGDINILMVG----DPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDFDKMTDVDRVAIHEVMEQIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.63

Estimated TM-score = 0.41±0.14

Estimated RMSD = 12.3±4.4Å

Download Model 2

C-score=-4.17

Download Model 3

C-score=-3.40

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.19

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ja83	0.804	3.51	0.093	0.969
2	3ja87	0.774	3.69	0.084	0.958
3	3ja85	0.771	3.64	0.055	0.955
4	3ja84	0.771	3.68	0.080	0.958
5	3ja86	0.762	3.78	0.066	0.944
6	3ja82	0.728	4.37	0.079	0.951
7	3f9vA	0.718	4.20	0.063	0.941
8	4r7zA	0.687	3.82	0.073	0.861
9	3f8tA	0.686	3.86	0.080	0.868
10	1g8pA	0.592	4.32	0.082	0.798

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.23	12	3ja85	ADP	Rep, Mult	36,37,38,84,85,86,87,88,89,90
2	0.04	2	1musA	MN	Rep, Mult	108,184
3	0.02	1	2aj4A	MG	Rep, Mult	67,169
4	0.02	1	4z90A	4LE	Rep, Mult	268,272
5	0.02	1	3tdvA	MG	Rep, Mult	133,154
6	0.02	1	1ofhC	PO4	Rep, Mult	233,234,237
7	0.02	1	1musA	MN	Rep, Mult	108,240
8	0.02	1	1brrB	ARC	Rep, Mult	243,278
9	0.02	1	1w77A	CU	Rep, Mult	148,154
10	0.02	1	3uufA	MAN	Rep, Mult	130,137
11	0.02	1	3e2vA	MG	Rep, Mult	133,184
12	0.02	1	1wppA	ZN	Rep, Mult	133,137,184
13	0.02	1	2qx6A	ML1	Rep, Mult	72,150
14	0.02	1	3ja84	ADP	Rep, Mult	163,199,260,261

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	1g8pA	0.592	4.32	0.082	0.798	6.6.1.1	236
2	0.060	1itzA	0.381	5.52	0.052	0.585	2.2.1.1	234
3	0.060	1gl9B	0.429	5.63	0.069	0.662	5.99.1.3	NA
4	0.060	1kqfA	0.392	6.23	0.043	0.679	1.2.1.2	NA
5	0.060	1hkiA	0.379	6.10	0.063	0.634	3.2.1.14	NA
6	0.060	2zrpA	0.382	4.85	0.040	0.533	3.4.99.37	NA
7	0.060	1njgA	0.390	3.75	0.049	0.498	2.7.7.7	88,91,94,203
8	0.060	1itzB	0.381	5.51	0.052	0.585	2.2.1.1	NA
9	0.060	3hhsB	0.382	6.30	0.038	0.658	1.14.18.1	NA
10	0.060	3ebgA	0.384	6.07	0.027	0.638	3.4.11.-	NA
11	0.060	3iceC	0.394	5.06	0.044	0.565	3.6.1.-	NA
12	0.060	1fx0B	0.385	5.06	0.046	0.550	3.6.3.14	NA
13	0.060	1fx0A	0.407	4.57	0.051	0.554	3.6.3.14	NA
14	0.060	1tueD	0.431	5.17	0.094	0.638	3.6.4.12	NA
15	0.060	3b2qA	0.389	5.42	0.059	0.578	3.6.3.14	NA
16	0.060	1ixsB	0.416	4.20	0.066	0.547	3.6.4.12	NA
17	0.060	2hldK	0.407	4.49	0.061	0.550	3.6.3.14	NA
18	0.060	1fuiA	0.386	6.05	0.047	0.627	5.3.1.25	NA
19	0.060	1jqoA	0.393	6.67	0.036	0.697	4.1.1.31	NA
20	0.060	1nsfA	0.431	3.74	0.069	0.544	3.6.4.6	200

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.746	4.07	0.10	0.95	4r7yA	GO:0000166 GO:0003677 GO:0004386 GO:0004519 GO:0005524 GO:0006260 GO:0016539 GO:0016787 GO:0046872 GO:0051301 GO:0090305
1	0.17	0.804	3.51	0.09	0.97	3ja83	GO:0000166 GO:0000727 GO:0000781 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006348 GO:0016787 GO:0016887 GO:0017116 GO:0030466 GO:0031261 GO:0031298 GO:0032508 GO:0033260 GO:0042555
2	0.16	0.661	3.65	0.09	0.82	4r7zA	GO:0000166 GO:0003677 GO:0004519 GO:0005524 GO:0006260 GO:0016539 GO:0046872 GO:0051301 GO:0090305
3	0.16	0.770	3.64	0.07	0.94	3jc56	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003688 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0097373 GO:1990163
4	0.14	0.771	3.68	0.08	0.96	3ja84	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0043596 GO:0097373 GO:1990163
5	0.14	0.774	3.69	0.08	0.96	3ja87	GO:0000166 GO:0000727 GO:0000781 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0006348 GO:0007049 GO:0016787 GO:0017116 GO:0030466 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0097373 GO:1990163
6	0.13	0.754	3.63	0.06	0.93	3jc75	GO:0000166 GO:0000727 GO:0000784 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006343 GO:0006348 GO:0007049 GO:0016787 GO:0017116 GO:0030174 GO:0031261 GO:0031298 GO:0031939 GO:0032508 GO:0033260 GO:0042555
7	0.13	0.744	3.68	0.08	0.92	3jc77	GO:0000166 GO:0000727 GO:0000781 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0006348 GO:0007049 GO:0016787 GO:0017116 GO:0030466 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0097373 GO:1990163
8	0.12	0.728	4.37	0.08	0.95	3ja82	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006974 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0032508 GO:0033260 GO:0042555 GO:0046872 GO:1902450
9	0.12	0.718	4.20	0.06	0.94	3f9vA	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006260 GO:0016787
10	0.12	0.720	3.85	0.08	0.91	3jc72	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006974 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0032508 GO:0033260 GO:0042555 GO:0046872 GO:1902450
11	0.12	0.686	3.86	0.08	0.87	3f8tA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
12	0.07	0.592	4.32	0.08	0.80	1g8pA	GO:0000166 GO:0005524 GO:0015979 GO:0015995 GO:0016851 GO:0016874 GO:0030494
13	0.06	0.427	4.31	0.07	0.58	3hteE	GO:0000166 GO:0004176 GO:0005524 GO:0005759 GO:0005829 GO:0006457 GO:0006508 GO:0008270 GO:0016032 GO:0016887 GO:0030163 GO:0042802 GO:0043335 GO:0046872 GO:0046983 GO:0051082 GO:0051301 GO:0051704
14	0.06	0.329	5.26	0.05	0.49	3crvA	GO:0000166 GO:0003676 GO:0003677 GO:0004003 GO:0004386 GO:0005524 GO:0006139 GO:0006281 GO:0006351 GO:0006974 GO:0008026 GO:0016787 GO:0016818 GO:0032508 GO:0043139 GO:0046872 GO:0051536 GO:0051539
15	0.06	0.278	5.31	0.06	0.43	1x6vA	GO:0000103 GO:0000166 GO:0001501 GO:0003824 GO:0004020 GO:0004781 GO:0005524 GO:0005829 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0016779 GO:0050428
16	0.06	0.293	5.38	0.06	0.45	2ax4A	GO:0000103 GO:0000166 GO:0001501 GO:0003824 GO:0004020 GO:0004781 GO:0005524 GO:0005829 GO:0007596 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0016779 GO:0050428 GO:0060348
17	0.06	0.305	5.61	0.03	0.47	5dn8A	GO:0000027 GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0042254 GO:0043022
18	0.06	0.255	6.85	0.02	0.46	2o1oA	GO:0008299 GO:0016740

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0043138	GO:0009378	GO:0017116	GO:0003688	GO:0044877	GO:0046872	GO:0004519
GO-Score	0.61	0.55	0.55	0.40	0.40	0.35	0.34	0.34
Biological Processes	GO:0032508	GO:0000727	GO:0006271	GO:0006270	GO:0006267	GO:0006342	GO:0016539	GO:0051301	GO:0090305
GO-Score	0.55	0.40	0.40	0.40	0.40	0.35	0.34	0.34	0.34
Cellular Component	GO:0031298	GO:0031261	GO:0005656	GO:0005737	GO:0042555	GO:0098687
GO-Score	0.40	0.40	0.40	0.40	0.40	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.