I-TASSER results

I-TASSER results for job id Rv1026

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (319 residues)
MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLGQGVDATGRFAPEAIA
RTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTADVLGAALPGSAAEVITG
AEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVASYSADIGCVRLTERCLH
SDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTMTTLSALAQSMTAYDAAAI
HLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGGGAIVVEELARELRERAGID
QLTVSEHDILDGIALSLAG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLGQGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTADVLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVASYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTMTTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGGGAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG
Prediction	CCCCEEEEEEHCCCCEEEEEEEEHCCCCCCCEEEEEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEHCCHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCEEEEEEHCCCEEEEEEEHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEHCHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCHHHHHHHHHHC
Conf.Score	9985799999589858999999958988875799886667654557865569999999999999999999999977997999988377877985999999999998998788774885889999999999999788888968999958985899998895778999857768999998588999999999999999999999999998868885999973589999999986667754578768779999999999997999999978899955766889999999999999998669988998687588999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLGQGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTADVLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVASYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTMTTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGGGAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG
Prediction	7724100000030100000001125644523033045333202004313764433460042014004302610671602200000010013052154015202730515045241400336200300020002104364220000000111010002464233122030102100430177450246205301510362025005304744232000002012000200442564317403123031620350054127143630371545476201000000000110041037315063010162000000011028
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEEHCCCCEEEEEEEEHCCCCCCCEEEEEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEHCCHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCEEEEEEHCCCEEEEEEEHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEHCHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCHHHHHHHHHHC
MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLGQGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTADVLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVASYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTMTTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGGGAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG

1t6cA

0.32

0.30

0.94

2.90

MUSTER

-PIMRVASIDIGSYSVRLTIAQIKD----GKLSIILERGRITSLGTKVKETGRLQEDRIEETIQVLKEYKKLIDEFKVERVKAVATEAIRRAKNAEEFLERVKREVGLVV-----EVITPEQEGRYAYLAVAYSLKPE-GEVCVVDQGGGSTEYVFGKGYVREVISLPIGIVNLTETFFKQDPPTEEEVKRFFEFLEKELSKV-----KKPVDTIVGLGGTITTLAALEYNVYPYDPQKVHGKVLTYGQIKKWFDTFKEIPSEERSKRRQVEDRRAKVILAGIGIFLKTLEIFE----KDCLIVSDWGLREGVLVSEVL

1t6cA

0.32

0.30

0.94

3.61

dPPAS

-PIMRVASIDIGSYSVRLTIAQIKD----GKLSIILERGRITSLGTKVKETGRLQEDRIEETIQVLKEYKKLIDEFKVERVKAVATEAIRRAKNAEEFLERVKREVGLVV-----EVITPEQEGRYAYLAVAYSLK-PEGEVCVVDQGGGSTEYVFGKGYVREVISLPIGIVNLTETFFKQDPPTEEEVKRFFEFLEKELSKVKK-----PVDTIVGLGGTITTLAALEYNVYPYDPQKVHGKVLTYGQIKKWFDTFKEIPSEERSKRRQVEDRRAKVILAGIGIFLKTLEIFE----KDCLIVSDWGLREGVLVSEVL

1t6cA

0.32

0.30

0.93

4.79

wdPPAS

-PIMRVASIDIGSYSVRLTIAQIKD----GKLSIILERGRITSLGTKVKETGRLQEDRIEETIQVLKEYKKLIDEFKVERVKAVATEAIRRAKNAEEFLERVKREVGLVV-----EVITPEQEGRYAYLAVAYSLK-PEGEVCVVDQGGGSTEYVFGKGYVREVISLPIGIVNLTETFFKQDPPTEEEVKRFFEFLEKELSKVKK-----PVDTIVGLGGTITTLAALEYNVYPYDPQKVHGKVLTYGQIKKWFDTFKEIPSEERSK-RQVEDRRAKVILAGIGIFLKTLEIFE----KDCLIVSDWGLREGVLVSEVL

1t6cA

0.32

0.30

0.93

3.57

wMUSTER

I--MRVASIDIGSYSVRLTIAQIKD----GKLSIILERGRITSLGTKVKETGRLQEDRIEETIQVLKEYKKLIDEFKVERVKAVATEAIRRAKNAEEFLERVKREVGLVV-----EVITPEQEGRYAYLAVAYSLKPE-GEVCVVDQGGGSTEYVFGKGYVREVISLPIGIVNLTETFFKQDPPTEEEVKRFFEFLEKELSKV-----KKPVDTIVGLGGTITTLAALEYNVYPYDPQKVHGKVLTYGQIKKWFDTFKEIPSEERSK-RQVEDRRAKVILAGIGIFLKTLEIFE----KDCLIVSDWGLREGVLVSEVL

1t6cA

0.32

0.30

0.93

4.73

wPPAS

-PIMRVASIDIGSYSVRLTIAQIKD----GKLSIILERGRITSLGTKVKETGRLQEDRIEETIQVLKEYKKLIDEFKVERVKAVATEAIRRAKNAEEFLERVKREVGLVV-----EVITPEQEGRYAYLAVAYSLK-PEGEVCVVDQGGGSTEYVFGKGKVREVISLPIGIVNLTETFFKQDPPTEEEVKRFFEFLEKELSKVKK-----PVDTIVGLGGTITTLAALEYNVYPYDPQKVHGKVLTYGQIKKWFDTFKEIPSEERSK-RQVEDRRAKVILAGIGIFLKTLEIFE----KDCLIVSDWGLREGVLVSEVL

3mdqA

0.28

0.26

0.92

7.49

dPPAS2

---QRIGVID--TNTFHLLITDIVN----DRPHTLVNEKSAVGLGKGGITKGFITEEA-DRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNID-----VEVIDGAREAELIFRGVQQAVP--EDHISLADIGGGSVEFIIGNKNILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR---PTQLIGCSGTFDTLAENIQHHRKIALEKQTSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLV----STNAITVSTYSLKEGVLYTLDG

3mdqA

0.28

0.26

0.92

4.37

PPAS

---QRIGVID--TNTFHLLITDIVN----DRPHTLVNEKSAVGLGKGGITKGFITEEA-DRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNID-----VEVIDGAREAELIFRGVQQAVP--EDHISLADIGGGSVEFIIGNKNILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR---PTQLIGCSGTFDTLAENIQHHEKIALEKQTSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLV----STNAITVSTYSLKEGVLYTLDG

3mdqA

0.28

0.26

0.92

6.55

Env-PPAS

---QRIGVIDG-TNTFHLLITDIVN----DRPHTLVNEKSAVGLGKGGITKGFITEEA-DRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNID-----VEVIDGAREAELIFRGVQQAVP--EDHISLADIGGGSVEFIIGNKEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR---PTQLIGCSGTFDTLAENIQHHEKIALEKQTSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLV----STNAITVSTYSLKEGVLYTLDG

3mdqA

0.28

0.26

0.92

2.88

MUSTER

---QRIGVID--TNTFHLLITDIVN----DRPHTLVNEKSAVGLGKGGITKGFITEEA-DRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNID-----VEVIDGAREAELIFRGVQQAVP--EDHISLADIGGGSVEFIIGNKEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR---PTQLIGCSGTFDTLAENIQHHRKIALEKQTSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLV----STNAITVSTYSLKEGVLYTLDG

3mdqA

0.28

0.26

0.92

3.59

dPPAS

---QRIGVIDG-TNTFHLLITDIVN----DRPHTLVNEKSAVGLGKGGITKGFITEEA-DRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNID-----VEVIDGAREAELIFRGVQQAVP--EDHISLADIGGGSVEFIIGNKNILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR---PTQLIGCSGTFDTLAENIQHHRKIALEKQTSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLV----STNAITVSTYSLKEGVLYTLDG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.46

Estimated TM-score = 0.92±0.06

Estimated RMSD = 3.4±2.3Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1t6cA	0.924	0.84	0.318	0.937
2	3cerC	0.794	3.31	0.421	0.953
3	3agrA	0.765	4.11	0.147	0.962
4	3mdqA	0.765	3.28	0.282	0.922
5	3cj9A	0.748	4.15	0.134	0.959
6	4a5bA	0.747	4.07	0.161	0.950
7	1u6zB	0.746	3.50	0.242	0.912
8	3aapA	0.737	3.92	0.146	0.922
9	3hi0A	0.730	3.55	0.253	0.893
10	3zx0A	0.723	3.89	0.143	0.915

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	8	3cj9A	PO4	Rep, Mult	12,13,86,87,148,149,150,151
2	0.14	13	3cjaA	ANP	Rep, Mult	12,14,15,86,87,123,147,148,149,150,151,171,172,219,220,275
3	0.09	3	2j4rA	G4P	Rep, Mult	12,13,14,15,41,86,220,274,275
4	0.09	8	4pkhF	CA	Rep, Mult	10,17,309
5	0.04	2	1t6cA	CA	Rep, Mult	146,147,148,151,153
6	0.03	3	1u6zA	SO4	Rep, Mult	219,220,275
7	0.03	3	4braB	ANP	Rep, Mult	12,17,86,87,123,147,148,149,150,151,171,172,219,220,223,224,275,279,282
8	0.03	2	1u6zB	SO4	Rep, Mult	14,15,219,220,275
9	0.03	2	1u6zA	SO4	Rep, Mult	39,41,272,275
10	0.03	2	1u6zA	SO4	Rep, Mult	212,299,300,301
11	0.02	2	5f7rE	GLC	Rep, Mult	10,12,13,86,123,146,147,148,150,220,309
12	0.01	1	4k42B	CA	Rep, Mult	10,123,146,309
13	0.01	1	1u6zA	SO4	Rep, Mult	167,168,199
14	0.01	1	2j4r0	III	Rep, Mult	230,231,239,241,242,243,244,246,248,249,252,300
15	0.01	1	1u6zB	SO4	Rep, Mult	46,47,55,57,61

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.290	3mdqA	0.765	3.28	0.282	0.922	3.6.1.11	12,146,148,173
2	0.131	3djcG	0.511	4.39	0.106	0.677	2.7.1.33	10,12,146
3	0.118	3eo3A	0.539	3.74	0.144	0.674	5.1.3.14,2.7.1.60	NA
4	0.115	3bf3A	0.499	4.44	0.088	0.665	2.7.1.33	10,12,146
5	0.067	1woqA	0.550	3.60	0.147	0.683	2.7.1.63	NA
6	0.067	2aa4B	0.574	3.93	0.164	0.727	2.7.1.60	86,150,308
7	0.066	1q18A	0.546	4.44	0.094	0.734	2.7.1.2	NA
8	0.066	2h3gX	0.498	4.41	0.099	0.655	2.7.1.33	10,12,152,220
9	0.066	1zc6B	0.518	4.26	0.159	0.690	2.7.1.59	10,151,168
10	0.066	2ewsA	0.488	4.15	0.096	0.655	2.7.1.33	10,124,169
11	0.066	2ap1A	0.527	4.50	0.121	0.724	2.7.1.59	NA
12	0.060	2nztA	0.574	4.08	0.125	0.743	2.7.1.1	151
13	0.060	2aa4A	0.576	3.78	0.165	0.724	2.7.1.60	NA
14	0.060	1ig8A	0.569	4.39	0.091	0.755	2.7.1.1	95
15	0.060	3ifrA	0.550	4.53	0.124	0.734	2.7.1.17	149,174
16	0.060	1hkgA	0.590	4.02	0.070	0.762	2.7.1.1	NA
17	0.060	2q2rA	0.583	4.39	0.085	0.774	2.7.1.2	NA
18	0.060	2vwbA	0.526	4.30	0.093	0.709	3.4.24.57	NA
19	0.060	1tuuA	0.549	4.68	0.087	0.752	2.7.2.1	NA
20	0.060	2e20A	0.562	4.49	0.112	0.759	2.7.2.15	12,173
21	0.060	3hz6A	0.561	4.55	0.120	0.755	2.7.1.17	121,275
22	0.060	3b8aX	0.595	4.04	0.118	0.768	2.7.1.1	NA
23	0.060	3ezwG	0.569	4.37	0.112	0.752	2.7.1.30	150
24	0.060	3ge1A	0.548	4.54	0.093	0.724	2.7.1.30	12
25	0.060	1xc3A	0.555	3.91	0.080	0.705	2.7.1.4	NA
26	0.060	1bdgA	0.581	4.28	0.130	0.768	2.7.1.1	151
27	0.060	2zf5Y	0.554	4.86	0.123	0.762	2.7.1.30	NA
28	0.060	3enhA	0.526	4.26	0.107	0.705	3.4.24.57	223
29	0.060	1nbwA	0.549	4.30	0.149	0.737	4.2.1.30	10,12,123,146,225
30	0.060	3htvA	0.544	4.21	0.122	0.715	2.7.1.55	126

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.55	0.924	0.84	0.32	0.94	1t6cA	GO:0046872
1	0.41	0.792	3.24	0.27	0.95	3mdqA	GO:0004309 GO:0016787
2	0.34	0.748	3.63	0.25	0.92	3hi0A	GO:0004309 GO:0006793
3	0.14	0.746	3.50	0.24	0.91	1u6zB	GO:0004309 GO:0005886 GO:0006793 GO:0006798 GO:0016020 GO:0016787
4	0.06	0.359	6.57	0.05	0.62	4dibA	GO:0004365 GO:0006006 GO:0006096 GO:0016491 GO:0016620 GO:0050661 GO:0051287 GO:0055114
5	0.06	0.337	5.61	0.04	0.50	3pdiB	GO:0006461 GO:0009399 GO:0016163 GO:0016491 GO:0046872 GO:0051536 GO:0051539 GO:0055114
6	0.06	0.300	6.62	0.06	0.52	2gmsA	GO:0003824 GO:0008483 GO:0016740
7	0.06	0.341	5.53	0.07	0.51	3uveA	GO:0016491 GO:0033702 GO:0055114
8	0.06	0.292	6.41	0.03	0.49	1lfwA	GO:0005737 GO:0006508 GO:0008152 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0016805 GO:0046872
9	0.06	0.298	6.82	0.06	0.53	5amvA	GO:0005576 GO:0016829 GO:0030570 GO:0045490 GO:0046872
10	0.06	0.262	6.80	0.06	0.46	2r5vA	GO:0003868 GO:0005506 GO:0009072 GO:0016491 GO:0016701 GO:0017000 GO:0033072 GO:0046872 GO:0050585 GO:0055114
11	0.06	0.261	6.49	0.04	0.43	4ekuA	GO:0000165 GO:0000166 GO:0000302 GO:0001525 GO:0001556 GO:0001666 GO:0001954 GO:0002040 GO:0002250 GO:0002315 GO:0002376 GO:0002688 GO:0004672 GO:0004683 GO:0004713 GO:0004715 GO:0004871 GO:0004972 GO:0005102 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005925 GO:0005938 GO:0006461 GO:0006468 GO:0006915 GO:0006950 GO:0006968 GO:0006970 GO:0007015 GO:0007155 GO:0007165 GO:0007166 GO:0007172 GO:0007173 GO:0007204 GO:0007229 GO:0008284 GO:0008285 GO:0008360 GO:0009612 GO:0009725 GO:0009749 GO:0010226 GO:0010243 GO:0010595 GO:0010656 GO:0010752 GO:0010758 GO:0010976 GO:0014009 GO:0014069 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0017146 GO:0018108 GO:0030027 GO:0030054 GO:0030154 GO:0030155 GO:0030279 GO:0030307 GO:0030334 GO:0030335 GO:0030424 GO:0030425 GO:0030426 GO:0030500 GO:0030502 GO:0030826 GO:0030838 GO:0031175 GO:0031234 GO:0032270 GO:0032403 GO:0032960 GO:0033209 GO:0035235 GO:0035902 GO:0038083 GO:0042127 GO:0042220 GO:0042493 GO:0042542 GO:0042976 GO:0042995 GO:0043025 GO:0043066 GO:0043149 GO:0043267 GO:0043423 GO:0043507 GO:0043524 GO:0043534 GO:0043552 GO:0044297 GO:0045087 GO:0045121 GO:0045428 GO:0045429 GO:0045453 GO:0045471 GO:0045638 GO:0045727 GO:0045765 GO:0045766 GO:0045860 GO:0046330 GO:0046777 GO:0048010 GO:0048041 GO:0048471 GO:0050731 GO:0050848 GO:0051000 GO:0051279 GO:0051591 GO:0051592 GO:0051968 GO:0060291 GO:0060292 GO:0070098 GO:0070374 GO:0071300 GO:0071498 GO:0090630 GO:0097440 GO:2000058 GO:2000060 GO:2000114 GO:2000249 GO:2000310 GO:2000379 GO:2000463 GO:2000538 GO:2000573
12	0.06	0.269	5.65	0.09	0.41	3ksuA
13	0.06	0.263	6.46	0.06	0.45	3bm3A	GO:0003677 GO:0004519 GO:0009036 GO:0009307 GO:0090305
14	0.06	0.261	5.61	0.04	0.40	3mlwL
15	0.06	0.261	5.74	0.03	0.41	5cqrA	GO:0000123 GO:0000993 GO:0002098 GO:0004871 GO:0005634 GO:0005730 GO:0005737 GO:0006351 GO:0006355 GO:0006357 GO:0006368 GO:0006461 GO:0006468 GO:0006955 GO:0007165 GO:0008023 GO:0008607 GO:0030335 GO:0033588 GO:0045859
16	0.06	0.260	5.08	0.07	0.37	1hzdA	GO:0003723 GO:0003730 GO:0003824 GO:0004300 GO:0004490 GO:0005739 GO:0005759 GO:0006552 GO:0006635 GO:0008152 GO:0009083 GO:0016829
17	0.06	0.201	6.16	0.04	0.33	1ynbA
18	0.06	0.218	5.22	0.04	0.32	3d6eB	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0042972

Consensus prediction of GO terms

Molecular Function	GO:0004309	GO:0046872
GO-Score	0.66	0.56
Biological Processes	GO:0006793
GO-Score	0.43
Cellular Component	GO:0005886
GO-Score	0.14

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.