I-TASSER results

I-TASSER results for job id Rv1021

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (325 residues)
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDP
NHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEET
YELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPG
VLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITE
QEWLAHWPTAVNDSRGGSKKRKGMR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR
Prediction	CEEEEHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
Conf.Score	9899976999865558999987566667766686544445555665666665578867898867777654566566777756899999999999998768997544898999999999999999999989999999999899999999999999768999999999999999999748887888889999999999999999997656657887768899999999999999799988757999999999899999999999999999999999999998887655766695778886799999999999999986565545789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR
Prediction	0000000032011001301430335040266140403230432344344542201012346344225314434422443455305303400510440475220336122610251016201100100465227302500001000000001003337633020220052005102222320146551547513530551155156654315612420100320330052036240517504500240054171401400250054026104300630463454453255141530451046204510550175155665646748
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEEHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR

3craA

0.31

0.19

0.62

1.71

MUSTER

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA

0.31

0.19

0.62

3.18

dPPAS

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA

0.31

0.19

0.62

3.92

wdPPAS

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA

0.31

0.19

0.62

2.13

wMUSTER

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA

0.31

0.19

0.62

3.53

wPPAS

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA

0.31

0.19

0.62

10.23

dPPAS2

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA

0.31

0.19

0.62

2.66

PPAS

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA

0.31

0.19

0.62

4.60

Env-PPAS

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMT---------------ETMEEVWQQVKRQE-----------

3craA1

0.38

0.13

0.33

1.00

MUSTER

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQ-----------------------------------------------------------------------------------------------------------------------

3craA1

0.38

0.13

0.33

2.11

dPPAS

---------------------------------------------------------------------------------NQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQE--EGRFDFNDICAAISDKLERRLAR---------------WEQIKTEERAQ-----------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.43

Estimated TM-score = 0.43±0.14

Estimated RMSD = 12.1±4.4Å

Download Model 2

C-score=-2.48

Download Model 3

C-score=-3.26

Download Model 4

C-score=-3.57

Download Model 5

C-score=-3.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3craA	0.582	1.86	0.308	0.619
2	3w0lB	0.420	6.46	0.057	0.699
3	4kxfK	0.411	6.50	0.052	0.692
4	4kf7A	0.407	6.52	0.048	0.692
5	2va8B	0.406	6.80	0.033	0.711
6	5agaA	0.406	7.16	0.042	0.757
7	4bedA	0.405	6.17	0.030	0.661
8	5a22A	0.405	6.32	0.066	0.671
9	4a01A	0.404	6.77	0.043	0.717
10	4bb9A	0.401	6.68	0.055	0.689

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.40	9	2p06A	MG	Rep, Mult	119,122,138,141
2	0.13	3	3crcA	ATP	Rep, Mult	265,266,269,307
3	0.06	2	2yxhA	MG	Rep, Mult	119,145
4	0.03	1	4qi1C	MPG	Rep, Mult	112,115,144,152
5	0.03	1	3tuvA	ATP	Rep, Mult	212,213,214,217,218,221,224
6	0.03	1	2zj5A	ADP	Rep, Mult	221,224,245,246,247,248
7	0.03	1	3j47V	III	Rep, Mult	143,147,150

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2cqsA	0.334	6.71	0.050	0.582	2.4.1.20	104
2	0.060	3l4uA	0.379	6.00	0.045	0.606	3.2.1.20,3.2.1.3	NA
3	0.060	1b0pA	0.374	6.70	0.043	0.643	1.2.7.1	NA
4	0.060	3hmjA	0.379	6.78	0.043	0.661	2.3.1.86	NA
5	0.060	3cxhL	0.375	5.91	0.051	0.582	1.10.2.2	NA
6	0.060	2qmiA	0.390	5.81	0.050	0.591	3.5.2.6	NA
7	0.060	3bnjA	0.355	6.80	0.049	0.622	1.7.2.2	75,165
8	0.060	1qdbA	0.378	6.53	0.044	0.631	1.7.2.2	75
9	0.060	3b9jJ	0.251	6.57	0.041	0.428	1.17.1.4,1.17.3.2	199,208
10	0.060	1hr9F	0.365	6.23	0.071	0.585	3.4.24.64	138
11	0.060	2cvpA	0.369	6.52	0.035	0.600	5.3.1.9	NA
12	0.060	2fgeA	0.391	6.73	0.027	0.677	3.4.24.-	NA
13	0.060	2zj7A	0.372	6.48	0.045	0.625	3.1.1.3	120,246
14	0.060	2pdaA	0.373	6.71	0.046	0.646	1.2.7.1	NA
15	0.060	1q50A	0.370	6.22	0.035	0.582	5.3.1.9	NA
16	0.060	2g49A	0.382	6.17	0.027	0.606	3.4.24.56	NA
17	0.060	1ygpA	0.392	6.72	0.051	0.674	2.4.1.1	NA
18	0.060	3b9jI	0.204	5.08	0.036	0.295	1.17.1.4,1.17.3.2	NA
19	0.060	1bxrA	0.371	6.32	0.035	0.622	6.3.5.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.50	0.582	1.86	0.31	0.62	3craA	GO:0000166 GO:0005524 GO:0006203 GO:0009267 GO:0016787 GO:0046047 GO:0046052 GO:0046061 GO:0046076 GO:0046081 GO:0046872 GO:0047429 GO:0047693
1	0.09	0.300	2.75	0.24	0.34	2yxhA	GO:0006203 GO:0046047 GO:0046052 GO:0046061 GO:0046076 GO:0046081 GO:0046872 GO:0047429
2	0.06	0.401	6.68	0.06	0.69	4bb9A	GO:0000060 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005975 GO:0009750 GO:0010827 GO:0030246 GO:0033132 GO:0046415 GO:0070095 GO:0070328
3	0.06	0.408	6.60	0.07	0.69	4lc9A	GO:0000060 GO:0001678 GO:0004857 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005975 GO:0006006 GO:0009750 GO:0019899 GO:0019904 GO:0030246 GO:0033132 GO:0033133 GO:0034504 GO:0043086 GO:0051594 GO:0070095
4	0.06	0.339	6.39	0.04	0.56	3jblA	GO:0000166 GO:0002218 GO:0002376 GO:0004842 GO:0004869 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0005876 GO:0006915 GO:0006919 GO:0006954 GO:0009966 GO:0016045 GO:0016567 GO:0042742 GO:0042802 GO:0042803 GO:0042981 GO:0043065 GO:0043281 GO:0045087 GO:0050702 GO:0051092 GO:0051260 GO:0070269 GO:0072557 GO:0090307 GO:1990001
5	0.06	0.393	6.46	0.03	0.66	4kxfP	GO:0000166 GO:0002218 GO:0002376 GO:0004842 GO:0004869 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0005876 GO:0006915 GO:0006919 GO:0006954 GO:0009966 GO:0016045 GO:0016567 GO:0042742 GO:0042802 GO:0042803 GO:0042981 GO:0043065 GO:0043281 GO:0045087 GO:0050702 GO:0051092 GO:0051260 GO:0070269 GO:0072557 GO:0090307 GO:1990001
6	0.06	0.296	6.57	0.03	0.50	1a4yA	GO:0005654 GO:0005737 GO:0006402 GO:0008428 GO:0032311 GO:0043086 GO:0045765 GO:0070062
7	0.06	0.304	6.39	0.04	0.50	2bnhA	GO:0005737
8	0.06	0.273	6.68	0.04	0.46	3tsrE	GO:0005654 GO:0005737 GO:0008428 GO:0032311 GO:0043086 GO:0045765 GO:0070062
9	0.06	0.276	7.28	0.05	0.51	4perA	GO:0005654 GO:0005737 GO:0008428 GO:0032311 GO:0043086 GO:0045765 GO:0070062
10	0.06	0.420	6.46	0.06	0.70	3w0lB	GO:0005634 GO:0005654 GO:0005737 GO:0005975 GO:0030246 GO:0033132 GO:0070095
11	0.06	0.355	7.11	0.02	0.65	3abzA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
12	0.06	0.217	6.85	0.04	0.37	3od1B	GO:0000105 GO:0004812 GO:0005737 GO:0006418 GO:0008652
13	0.06	0.337	6.93	0.02	0.60	3abzB	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
14	0.06	0.280	6.84	0.04	0.49	1e3eA	GO:0001523 GO:0003960 GO:0004022 GO:0004024 GO:0004032 GO:0004745 GO:0005503 GO:0005737 GO:0006066 GO:0006067 GO:0006069 GO:0006081 GO:0008270 GO:0016491 GO:0016620 GO:0019115 GO:0019841 GO:0035276 GO:0042572 GO:0046164 GO:0046872 GO:0051287 GO:0055114 GO:1901661
15	0.06	0.243	6.11	0.05	0.39	2zfuA	GO:0000183 GO:0005634 GO:0005654 GO:0005677 GO:0005730 GO:0005737 GO:0005886 GO:0006351 GO:0006355 GO:0006364 GO:0008168 GO:0008757 GO:0016568 GO:0016740 GO:0032259 GO:0033553 GO:0035064 GO:0042149 GO:0044822 GO:0046015 GO:0071158 GO:0072332
16	0.06	0.242	7.10	0.05	0.45	3n29A	GO:0003824 GO:0005737 GO:0006596 GO:0008295 GO:0016829 GO:0016831 GO:0030170 GO:0042803 GO:0045312
17	0.06	0.247	6.31	0.02	0.40	2qu7A	GO:0003677 GO:0003700 GO:0006351 GO:0006355
18	0.06	0.238	7.13	0.05	0.44	4lzjB	GO:0005975 GO:0006040 GO:0009254 GO:0016829 GO:0016835 GO:0030246 GO:0046348 GO:0097173 GO:0097175

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0005524	GO:0047693
GO-Score	0.55	0.54	0.50
Biological Processes	GO:0046076	GO:0046061	GO:0006203	GO:0046052	GO:0046047	GO:0046081	GO:0009267
GO-Score	0.55	0.55	0.55	0.55	0.55	0.55	0.50
Cellular Component	GO:0043231	GO:0044444
GO-Score	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.