I-TASSER results

I-TASSER results for job id Rv0998

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (333 residues)
MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLI
SSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFAT
MVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGET
LYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTV
ADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVIT
TMIDVPGPGELSLGREMVDQINRVARQVIEAVG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG
Prediction	CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEHCCCEEEEHCCCCCCEEEEEEEEEEEEEEHCCCCEEEEEEHCCCCEEEHHHHHCCCCCEEEEEHCCCEEEEEHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHEEEEHCCCCCCCHHHHHHHHCCCCCCEEEEEEEHCCEEEEEEEEEEHCCCCCEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEHCCCCHHHHHHHHHHCCEEEHCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	987577679999999988566589999999999985467877997999688788868999987999999859957999998798466445654699865799985775899854456777776555556666666655555566666766654443346788655799999999778556565544788886999999876788995999999789589999999858999868999998645579888999999999999998995999998688589999999989957875898899999968986556899999999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG
Prediction	856446325511510371516660466104400510453606522100202140410000241403011427724330240452210000000264333020202340200011432332222222222322222222222222222222222322222422322342123014402540122222344423341032005022521000000146310000000214554410000000024133210023004200510273204201010132243013004514151454442102020304535633214412541341033125448
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEHCCCEEEEHCCCCCCEEEEEEEEEEEEEEHCCCCEEEEEEHCCCCEEEHHHHHCCCCCEEEEEHCCCEEEEEHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHEEEEHCCCCCCCHHHHHHHHCCCCCCEEEEEEEHCCEEEEEEEEEEHCCCCCEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEHCCCCHHHHHHHHHHCCEEEHCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.98

2.90

MUSTER

-DGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.98

3.76

dPPAS

-DGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.98

4.98

wdPPAS

-DGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.97

0.98

3.28

wMUSTER

I---AELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.98

5.09

wPPAS

-DGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.98

5.71

dPPAS2

-DGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.98

4.53

PPAS

-DGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4avaA

1.00

0.98

5.71

Env-PPAS

-DGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMS-----PALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG

4ollA

0.53

0.48

0.92

2.24

MUSTER

V---AELTEVRAADLAALEFFTGCRPSALEPLATQLRPLKAEPGQVLIRQGDPALT-FLIESGRVQVSHAVADGP--PIVLDIELIIGEIALLRDAPRTATVVAAEPVIGWVGDRDAFDTILHLPG-FDRLVRIARQRLAAFITPIPVQVRTGEWFYLRPVLPGDVERTYRR------------FQSVRKPTRALLEYLFEVDYADHFVWVTEGALGVIADARFVR-EGHNATAEVAFTVGDDYQGRG-IGSFLGALIVSANYVGVQRFNARVLTDNARKI---DRLGAVWVRE----VVTEVDVPPVDTVPFEPELIDQIRDATRKVIRAVS

4ollA

0.51

0.47

0.92

2.69

dPPAS

---VAELTEVRAADLAALEFFTGCRPSALEPLATQLRPLKAEPGQVLIRQGDPALT-FLIESGRVQVSHAVADGP--PIVLDIELIIGEIALLRDAPRTATVVAAEPVIGWVGDRDAFDTILHLPGFDRLVRIARQRL-AAFITPIPVQVRTGEWFYLRPVLPGDVERTY------------RRFQSVRKPTRALLEYLFEVDYADHFVWVTEGALPVIADARFVR-EGHNATAEVAFTVGDDYQGRG-IGSFLGALIVSANYVGVQRFNARVLTDNARKI---DRLGAVWVREV----VTEVDVPPVDTVPFEPELIDQIRDATRKVIRAVS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.74

Estimated TM-score = 0.96±0.05

Estimated RMSD = 2.9±2.1Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4avaA	0.974	0.63	1.000	0.982
2	4ollA	0.778	3.21	0.507	0.913
3	5f0eA	0.417	6.58	0.031	0.694
4	5fifA	0.417	6.18	0.066	0.664
5	1on3E	0.415	6.21	0.047	0.664
6	5by3A	0.414	6.26	0.041	0.673
7	1xnvA	0.414	6.35	0.043	0.676
8	1vrgA	0.411	6.37	0.048	0.670
9	3w5mA	0.411	6.39	0.067	0.685
10	4rcnA	0.409	6.02	0.081	0.637

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.38	6	4avaA	ACO	Rep, Mult	173,236,237,238,239,240,245,246,247,248,249,250,251,272,273,277,279,280,282,283,286
2	0.17	3	4avbA	CMP	Rep, Mult	48,67,79,80,87,88,89,90,91,98,99,100,102,138,142
3	0.04	1	3tdcA	0EU	Rep, Mult	176,180,181,183,184,185
4	0.04	1	3ff6B	RCP	Rep, Mult	256,257,260
5	0.04	1	3kllA	MAL	Rep, Mult	214,219,220,249
6	0.04	1	3ff6C	RCP	Rep, Mult	91,92,94,95

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ofdA	0.391	6.97	0.052	0.694	1.4.7.1	NA
2	0.060	3ff6A	0.402	6.27	0.051	0.643	6.4.1.2,6.3.4.14	255
3	0.060	2vn4A	0.392	6.38	0.057	0.652	3.2.1.3	NA
4	0.060	1fo4A	0.384	6.31	0.085	0.619	1.17.1.4	NA
5	0.060	1z1wA	0.397	6.06	0.041	0.628	3.4.11.-	NA
6	0.060	2e1qA	0.387	6.16	0.073	0.616	1.17.3.2,1.17.1.4	NA
7	0.060	3b9jC	0.352	6.60	0.044	0.601	1.17.3.2,1.17.1.4	NA
8	0.060	2a7sA	0.400	6.25	0.058	0.658	6.4.1.3	116,117
9	0.060	3gpbA	0.319	6.73	0.059	0.549	2.4.1.1	NA
10	0.060	3hz3A	0.405	6.37	0.063	0.670	2.4.1.5	170
11	0.060	1fa9A	0.348	6.79	0.061	0.595	2.4.1.1	NA
12	0.060	1ojnA	0.354	7.04	0.046	0.634	4.2.2.1	NA
13	0.060	2j5wA	0.401	6.28	0.034	0.649	1.16.3.1	NA
14	0.060	1c7sA	0.394	6.53	0.048	0.670	3.2.1.52	241
15	0.060	1od2A	0.399	6.10	0.050	0.631	6.3.4.14,6.4.1.2	NA
16	0.060	2ckjA	0.351	6.70	0.047	0.604	1.17.1.4,1.17.3.2	NA
17	0.060	1ethA	0.385	6.51	0.069	0.655	3.1.1.3	NA
18	0.060	1llwA	0.385	7.04	0.053	0.685	1.4.7.1	NA
19	0.060	1ea0A	0.375	6.65	0.035	0.640	1.4.1.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.71	0.974	0.63	1.00	0.98	4avaA	GO:0008080 GO:0016407 GO:0016740 GO:0016746 GO:0030552 GO:0046872
1	0.50	0.833	2.87	0.54	0.95	4orfA	GO:0008080 GO:0016740 GO:0016746 GO:0046872
2	0.20	0.372	3.25	0.23	0.44	3gydB	GO:0000166
3	0.14	0.371	4.68	0.13	0.48	1cx4A	GO:0000166 GO:0001932 GO:0004862 GO:0005737 GO:0005743 GO:0005813 GO:0005886 GO:0005952 GO:0006631 GO:0007612 GO:0008603 GO:0016020 GO:0019901 GO:0019904 GO:0030425 GO:0030552 GO:0031625 GO:0034236 GO:0043025 GO:0043197 GO:0043198 GO:0045121 GO:0045859 GO:0048471 GO:0070062 GO:0097332 GO:0097338 GO:0097546 GO:2000480
4	0.12	0.393	4.53	0.13	0.50	3of1A	GO:0000166 GO:0000790 GO:0001932 GO:0004862 GO:0005634 GO:0005737 GO:0005886 GO:0005952 GO:0008603 GO:0030552 GO:0042802 GO:0045762 GO:0045859 GO:0046580 GO:0071901 GO:0097271
5	0.11	0.346	4.22	0.16	0.44	4ev0D	GO:0000166 GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0010628 GO:0030552 GO:0042803 GO:0043565 GO:0044212 GO:0045893
6	0.10	0.347	2.73	0.18	0.39	2vi7C	GO:0004596 GO:0008080 GO:0017189 GO:0031248
7	0.09	0.348	3.29	0.13	0.41	3i54D	GO:0000166 GO:0003677 GO:0003700 GO:0005618 GO:0005886 GO:0006351 GO:0006355 GO:0009405 GO:0030552 GO:0040007 GO:0045892 GO:0045893
8	0.09	0.382	3.28	0.29	0.44	4nxyA	GO:0008080 GO:0048037
9	0.08	0.339	4.18	0.12	0.42	3dkwA	GO:0003677 GO:0006351 GO:0006355 GO:0051173 GO:0051353 GO:0071731
10	0.08	0.361	3.22	0.21	0.42	5bv6A	GO:0000166 GO:0004672 GO:0004674 GO:0004692 GO:0005524 GO:0005829 GO:0005886 GO:0006468 GO:0007165 GO:0016020 GO:0016301 GO:0016310 GO:0016324 GO:0016740 GO:0030553 GO:0031965 GO:0036289 GO:0042803 GO:0050999 GO:0072661
11	0.07	0.343	4.08	0.12	0.42	4byyA	GO:0000166 GO:0003677 GO:0006351 GO:0006355 GO:0016301 GO:0016310 GO:0016740 GO:0030552 GO:2000874
12	0.07	0.354	2.90	0.16	0.40	2j8mA
13	0.06	0.351	2.85	0.19	0.40	1vhsA	GO:0004596 GO:0006474 GO:0008080 GO:0009635 GO:0016740 GO:0016746 GO:0031248 GO:0046677
14	0.06	0.341	3.12	0.21	0.39	4bmhA	GO:0008080 GO:0016740
15	0.06	0.355	3.69	0.12	0.42	3u10A	GO:0000166 GO:0005216 GO:0005222 GO:0005244 GO:0005248 GO:0005249 GO:0005267 GO:0005272 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0007267 GO:0008076 GO:0016020 GO:0016021 GO:0030552 GO:0034765 GO:0035725 GO:0042391 GO:0042802 GO:0055085 GO:0060078 GO:0071320 GO:0071321 GO:0071805
16	0.06	0.357	3.06	0.21	0.41	5j3uA	GO:0016301 GO:0016310
17	0.06	0.353	3.65	0.13	0.42	2q0aA	GO:0000166 GO:0005216 GO:0005222 GO:0005244 GO:0005248 GO:0005249 GO:0005267 GO:0005272 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0016020 GO:0016021 GO:0030552 GO:0034765 GO:0035725 GO:0042391 GO:0042802 GO:0055085 GO:0060078 GO:0071320 GO:0071321 GO:0071805
18	0.06	0.354	3.46	0.19	0.42	4d7sA	GO:0000166 GO:0016020 GO:0016021

Consensus prediction of GO terms

Molecular Function	GO:0008080	GO:0046872	GO:0030552	GO:0030291
GO-Score	0.85	0.85	0.78	0.48
Biological Processes	GO:0043549	GO:0031399	GO:0006468
GO-Score	0.48	0.48	0.48
Cellular Component	GO:0044424	GO:1902554	GO:0071944	GO:0016020
GO-Score	0.48	0.48	0.48	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.