I-TASSER results

I-TASSER results for job id Rv0988

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (386 residues)
MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDENNAGYSLATVPGAVRFP
RDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPPGEGVAIADASSWRTTQVY
MAHFAISDISNRGFYPAEKFSRQALGLAGASSEPYAVWLDDWYARESNNNSVQLFARTQN
TVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLVRQESRGTVSVNGDTFMVSGLSW
KDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIRQADGSVTRFSSGTFVAGDGGVIPL
ESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIGLTLRGAALMANQELRLSRTYWEGAVA
LEGRYQGMPISGRGYVEMTGYVQRLS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDENNAGYSLATVPGAVRFPRDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPPGEGVAIADASSWRTTQVYMAHFAISDISNRGFYPAEKFSRQALGLAGASSEPYAVWLDDWYARESNNNSVQLFARTQNTVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLVRQESRGTVSVNGDTFMVSGLSWKDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIRQADGSVTRFSSGTFVAGDGGVIPLESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIGLTLRGAALMANQELRLSRTYWEGAVALEGRYQGMPISGRGYVEMTGYVQRLS
Prediction	CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCEEEEEEEHCCCCCCCCCCCCCCEEEEHCCEEEHCCCCCCEEEEEHCCCEEEEEEEHCCCCCEEHCCCCCEHCCCCCCCEEEEEEHCCEEEEEEEEHCCEEEEEEEEEEEEHCCCCCCCCCCCCCCEEEEEHCCCCCEEEEEEEHCCCCCCCCEEEEEEHCCCCCEEEHCCCCEEEEEEEEEHCCCCCCEEEEEEEEEHCCCCEEEEEEHCCCCCCCCCCCCCEEEEEEEEEEHCCEEEEEEEEEEEHCCCCCCC
Conf.Score	97579999999999999999856788777666555555557788888656789987568865578987775589999999789998689999999754688877777777787787656788878886789958886654456777776668987999957799858999589999758789999998689966658998566578889747999865579999999899999998789987555788888777885589999599988999999858998666589999969998899767758999966898577996774589999958886999998675554677887656779999865886788999999866776679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDENNAGYSLATVPGAVRFPRDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPPGEGVAIADASSWRTTQVYMAHFAISDISNRGFYPAEKFSRQALGLAGASSEPYAVWLDDWYARESNNNSVQLFARTQNTVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLVRQESRGTVSVNGDTFMVSGLSWKDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIRQADGSVTRFSSGTFVAGDGGVIPLESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIGLTLRGAALMANQELRLSRTYWEGAVALEGRYQGMPISGRGYVEMTGYVQRLS
Prediction	52221001000121100000001342435444444233323445453144136743040042133147142100100000417514300000000010143444545445433042310000000000245631221131214323213144540301012020324563303030317411020203353210111540112215534210000010203030102066541303130121100133314763110000000033421000000124744433101000114635334044540303124303134352400130102056460403031135422151321000000203132634402020000001125528
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCEEEEEEEHCCCCCCCCCCCCCCEEEEHCCEEEHCCCCCCEEEEEHCCCEEEEEEEHCCCCCEEHCCCCCEHCCCCCCCEEEEEEHCCEEEEEEEEHCCEEEEEEEEEEEEHCCCCCCCCCCCCCCEEEEEHCCCCCEEEEEEEHCCCCCCCCEEEEEEHCCCCCEEEHCCCCEEEEEEEEEHCCCCCCEEEEEEEEEHCCCCEEEEEEHCCCCCCCCCCCCCEEEEEEEEEEHCCEEEEEEEEEEEHCCCCCCC
MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDENNAGYSLATVPGAVRFPRDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPPGEGVAIADASSWRTTQVYMAHFAISDISNRGFYPAEKFSRQALGLAGASSEPYAVWLDDWYARESNNNSVQLFARTQNTVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLVRQESRGTVSVNGDTFMVSGLSWKDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIRQADGSVTRFSSGTFVAGDGGVIPLESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIGLTLRGAALMANQELRLSRTYWEGAVALEGRYQGMPISGRGYVEMTGYVQRLS

2ichB

0.30

0.24

0.82

2.97

MUSTER

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTA-----------NPSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRG-KDDSK-IWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRD--G--QPAGRGYELTGYVR---

2ichB

0.28

0.23

0.82

5.89

dPPAS

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTAN-----------PSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRGKD--DSKIWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRQPAGRGYELTGYVR---------

2ichB

0.30

0.24

0.82

6.98

wdPPAS

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTAN-----------PSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRGKDDSK--IWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRD--G-QPAGRGYELT--YVR---

2ichB

0.29

0.24

0.82

3.47

wMUSTER

------------------------------------------------APVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTA-----------NPSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRGKDDSK--IWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRD--G--QPAGRGYELTGYVR---

2ichB

0.30

0.24

0.82

5.76

wPPAS

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTAN-----------PSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRGKDDSK--IWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRD--G-QPAGRGYELT--YVR---

2ichB

0.29

0.24

0.82

12.70

dPPAS2

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTAN-----------PSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRG-KDDSK-IWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRQPAGRGYELTGYVR---------

2ichB

0.29

0.24

0.82

5.13

PPAS

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTAN-----------PSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRGKDDSK--IWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRD-----QPAGRGYELTGYVR---

2ichB

0.29

0.24

0.82

8.95

Env-PPAS

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTAN-----------PSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEYLDPNAAGWDWISANLDDGSALAFQIRGKDDSK--IWAYAALRDASGHTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPDDQELDSRASAGAVYWEGAVTFTRDG----QPAGRGYELTGYVR---

2ichB1

0.34

0.17

0.49

1.78

MUSTER

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTA-----------NPSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEY-----------------------------------------------------------------------------------------------------------------------------------------

2ichB1

0.34

0.17

0.49

3.91

dPPAS

-----------------------------------------------LAPVVPGKALEFPQDFGAHNDFRIEWWYVTGWLETPTGKPLGFQITFFRTAN-----------PSHFAPDQLIIAHVALSDPAIGKLQHDQKIARAGFDLAYARTGNTDVKLDDWIFVRETDGRYRTRIEAEDFTLTFILTPSQPL-LQGENGFSRKGPGAPQASYYYSEPHLQVSGIINRQGEDIPVTGTAWLDREWSSEY-----------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.31

Estimated TM-score = 0.55±0.15

Estimated RMSD = 9.7±4.6Å

Download Model 2

C-score=-1.43

Download Model 3

C-score=-2.04

Download Model 4

C-score=-1.79

Download Model 5

C-score=-2.34

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ichB	0.809	1.03	0.305	0.824
2	3v89A	0.396	7.11	0.082	0.676
3	4clfA	0.385	6.45	0.044	0.611
4	4bq2A	0.381	7.07	0.065	0.658
5	4f9iA	0.376	6.96	0.049	0.624
6	3eqnA	0.375	6.62	0.054	0.611
7	1fepA	0.373	7.17	0.024	0.632
8	4y23A	0.371	6.98	0.056	0.624
9	4xc6A	0.366	7.29	0.057	0.653
10	3pflA	0.366	7.05	0.048	0.624

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	3	1fo4A	FES	Rep, Mult	339,340,357,358,359,377
2	0.05	3	3hhwC	TAR	Rep, Mult	185,211,215
3	0.04	2	2alzA	MG	Rep, Mult	72,244,245
4	0.04	2	2ckjB	FES	Rep, Mult	185,186,187,222,224,235,237
5	0.04	2	3rg1C	MAN	Rep, Mult	75,242
6	0.02	1	1uw6M	NCT	Rep, Mult	240,300
7	0.02	1	5bshI	PRO	Rep, Mult	260,374
8	0.02	1	3eubS	FES	Rep, Mult	196,197,200,213,214,215
9	0.02	1	3sltA	C8E	Rep, Mult	78,240
10	0.02	1	2ffuA	MN	Rep, Mult	62,66,243
11	0.02	1	1lgcA	ASN	Rep, Mult	265,266
12	0.02	1	5c1oC	MG	Rep, Mult	93,377
13	0.02	1	2qtkA	C8E	Rep, Mult	74,92,123
14	0.02	1	4oicB	MN	Rep, Mult	79,263,372
15	0.02	1	2ckjA	FES	Rep, Mult	189,190,191,193,218,219,220,221
16	0.02	1	2vk6A	MG	Rep, Mult	304,354
17	0.02	1	2uyjA	EDO	Rep, Mult	354,363
18	0.02	1	1vdvA	CA	Rep, Mult	263,265,371,372
19	0.02	1	4ofgA	N2P	Rep, Mult	300,304
20	0.02	1	4gv9A	MN	Rep, Mult	91,92,93,356

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1z68A	0.357	6.69	0.043	0.583	3.4.21.-	NA
2	0.060	1orvA	0.352	6.81	0.063	0.583	3.4.14.5	184
3	0.060	3b9jJ	0.276	5.87	0.048	0.409	1.17.1.4,1.17.3.2	297
4	0.060	2ecfA	0.350	6.87	0.069	0.591	3.4.14.5	184
5	0.060	1l1lA	0.353	7.02	0.025	0.601	1.17.4.2	301
6	0.060	2e1qA	0.367	7.06	0.045	0.627	1.17.3.2,1.17.1.4	NA
7	0.060	3fsnB	0.354	6.92	0.041	0.596	5.2.1.7	NA
8	0.060	2cfmA	0.363	7.01	0.048	0.617	6.5.1.1	NA
9	0.060	3b9jC	0.293	7.12	0.043	0.503	1.17.3.2,1.17.1.4	NA
10	0.060	1l2aE	0.349	6.96	0.043	0.578	3.2.1.4	76,90
11	0.060	3b9jI	0.185	5.64	0.044	0.275	1.17.1.4,1.17.3.2	288,372
12	0.060	2qr5A	0.367	7.03	0.055	0.624	3.4.19.1	NA
13	0.060	3gdeA	0.344	6.62	0.045	0.567	6.5.1.1	NA
14	0.060	1c7sA	0.351	7.71	0.040	0.658	3.2.1.52	358
15	0.060	2gbcA	0.334	7.13	0.039	0.580	3.4.14.5,3.4.15.5	NA
16	0.060	2w41B	0.347	6.93	0.024	0.578	2.7.1.30	216
17	0.060	1qbaA	0.353	7.72	0.040	0.661	3.2.1.52	NA
18	0.060	1h16A	0.368	7.06	0.048	0.627	2.3.1.54	NA
19	0.060	2qnoA	0.356	6.85	0.039	0.588	3.2.1.4	158

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.44	0.809	1.03	0.30	0.82	2ichB
1	0.06	0.396	7.11	0.08	0.68	3v89A	GO:0004872 GO:0005215 GO:0006810 GO:0009279 GO:0016020 GO:0016021 GO:0019867
2	0.06	0.359	7.32	0.04	0.64	4aipB	GO:0004872 GO:0005506 GO:0006810 GO:0009279 GO:0015891 GO:0016020
3	0.06	0.313	7.22	0.03	0.54	2gskA	GO:0004872 GO:0006810 GO:0006811 GO:0009279 GO:0015235 GO:0015288 GO:0015889 GO:0016020 GO:0016021 GO:0046872 GO:0046930 GO:0055085
4	0.06	0.315	7.16	0.03	0.54	5fp2B	GO:0004872 GO:0005506 GO:0006810 GO:0009279 GO:0015891 GO:0016020
5	0.06	0.331	6.98	0.05	0.56	1kmoA	GO:0004872 GO:0005506 GO:0006810 GO:0006811 GO:0009279 GO:0015091 GO:0015682 GO:0015891 GO:0016020 GO:0016021 GO:0019867 GO:0055072
6	0.06	0.318	6.89	0.06	0.52	3fhhA	GO:0004872 GO:0005215 GO:0006810 GO:0009279 GO:0016020 GO:0019867
7	0.06	0.316	7.25	0.04	0.54	2hdiA	GO:0004872 GO:0006810 GO:0006811 GO:0009279 GO:0015343 GO:0016020 GO:0016021 GO:0033212 GO:0042912 GO:0043213 GO:0044718 GO:0055072
8	0.06	0.357	7.33	0.05	0.62	1fepA	GO:0004872 GO:0005506 GO:0006810 GO:0006811 GO:0009279 GO:0015620 GO:0015685 GO:0015891 GO:0016020 GO:0016021 GO:0022834 GO:0033214 GO:0042912 GO:0042914 GO:0045203 GO:0055072 GO:0055085
9	0.06	0.303	7.22	0.05	0.52	5fp2A	GO:0004872 GO:0005506 GO:0006810 GO:0009279 GO:0015891 GO:0016020
10	0.06	0.325	7.18	0.04	0.55	5fr8A	GO:0004872 GO:0005506 GO:0006810 GO:0009279 GO:0015891 GO:0016020
11	0.06	0.274	7.17	0.03	0.47	5e7qA	GO:0003824 GO:0008152
12	0.06	0.254	7.75	0.03	0.47	4c2lA	GO:0000272 GO:0004650 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0071555
13	0.06	0.291	6.49	0.05	0.46	1x87A	GO:0005737 GO:0006547 GO:0006548 GO:0016153 GO:0016829 GO:0019556 GO:0019557
14	0.06	0.257	6.64	0.04	0.42	2yg3B	GO:0000166 GO:0016491 GO:0055114
15	0.06	0.288	6.82	0.05	0.48	3dwkC	GO:0008658 GO:0016020 GO:0016021
16	0.06	0.245	6.41	0.05	0.39	5ifyA	GO:0008879 GO:0009058 GO:0016740 GO:0016779 GO:0045226 GO:0046872
17	0.06	0.255	7.28	0.06	0.45	3ih8A	GO:0004359 GO:0006541 GO:0016787
18	0.06	0.251	6.84	0.05	0.41	3if5A	GO:0004359 GO:0006541 GO:0016787

Consensus prediction of GO terms

Molecular Function	GO:0060089
GO-Score	0.47
Biological Processes	GO:0051234
GO-Score	0.47
Cellular Component	GO:0019867	GO:0030313	GO:0044462
GO-Score	0.47	0.47	0.47

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.