I-TASSER results

I-TASSER results for job id Rv0978c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (331 residues)
MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDEVSTAIAALFGSHGQH
YQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLDAINAPVQSLTGRPLIGDG
ANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIGNGGAGGTGGAVSLARAG
TAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNVYVTNFGSGT
VSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSPIT
VGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDEVSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLDAINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIGNGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCEEEEEHCCCCCEEEEEHCCCCCCEEEEHCCCCCEEEEHCCCCEEEEEHCCCCEEEEEEEHCCCCCEEEEHCCCCCEEEEEHCCCCEEEEEHCCCCEEEEEHCCCCCCCEEEEHCCCCCEEEEEHCCCCEEEEHC
Conf.Score	9756556599999999999988888876544566654555676654577888888877888877655555546776545667655555566776654444667777665556776666777666666666667766666677766655445677655555566666666777788776667788876555457777668887657775788875678986689976898589985799989999899996988876579986689987999999999789997999988999798755578999658998799998999977999799969
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDEVSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLDAINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIGNGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS
Prediction	4210203023021003204402210322202113301003123332010000101320320110023141224202332422032203233323323332333333332203232334333222333232322222222322323222222220222223224232232222222222220232222202202321220020232342223222422420120002443200000345320000105334114240421520100000144320000024421000010443412424031143010000014332000002463200006
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCEEEEEHCCCCCEEEEEHCCCCCCEEEEHCCCCCEEEEHCCCCEEEEEHCCCCEEEEEEEHCCCCCEEEEHCCCCCEEEEEHCCCCEEEEEHCCCCEEEEEHCCCCCCCEEEEHCCCCCEEEEEHCCCCEEEEHC
MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDEVSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLDAINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIGNGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS

3bwsA

0.12

0.97

1.29

MUSTER

IELKLSSPGFQNSSIRKPEELNEKLIALDKEGITFISRFKTGFQPKSVR----FIDNTRLA--IPLLEDEGDVLDINSGQTVRLSPPEKYKKKLGFVETISIPEHNESQQANAVHVFDLKTLAYKATVDLTGKWSKILLYDPIRDLVYCSNWISEDISVIDRKTKLEIRKTDKIGLPRGLLLSKDGKELYIAQFSAGGGRLGIYSDKEKLIDTIGPPGNKRHIVSGNTNKIYVSDC-CSKIEVYDLKEK-KVQKSIPVFDKPNTIALSPDGKYLYVSCRGPNKVYVIDTTTDTVKEFW-EAGNQPTGLDVSPDNRYLVISDFLDHQIRVYR

3vgzA

0.10

0.09

0.92

1.28

dPPAS

-------------------------ELRKAVGKGAYEAYSQQENALWLATSQSRKLDKGGVVYRLDPVTLEVTQAIHNDLKPFGATINNTTQTLWFGNTVNSAVTAIDAKTGEVKGRLVLDDRKRTEEVRPLQPRELVADDATNTVYISGIGKESVIWVVDGGNIKLKTAIQNTGKSTGLALDSEGKRLYTTNADGELITIDTADNKILSRKKLLDGKEHFFINISLDQRAFITDSKAAEVLVVDTRNGNILAKVAA--PESLAVLFNPARNEAYVTHRQAGKVSVIDAKSYKVVKTF-DTPTHPNSLALSADGKTLYVSVKQKSTKQQEA

3u4yA

0.09

0.07

0.82

2.26

wdPPAS

---------------------------------------------------------TTSNFGIVVEQHLRRISFFSTDTLEILNQITLGYDFVDTAITSDCSNVVVTSDFCQTLVQIETQLEPPVVAIQEGQSSADVDITPDDQFAVTVTGNHPFNQSYSFLKNKFISTIPIPYDAVGIAISPNGNGLILIDRSSANTVRRFKIDADTGQEFISGGTRPFNITFTPDGNAFVANLIGNSIGILETQNPETLLNAVGTNNLPGTIVVSRDGSTVYVLTESTVDVFNFNQLSGTLSFVK-PRPLFGANQALNKTETKLFISANISRELKVFT

3bwsA

0.13

0.97

1.73

wMUSTER

IELKLSSPGF-SYRIRKPEELNEKLIALDKEGITFISRFKTGFQPKSVR----FIDNTRLA--IPLLEDEGDVLDINSGQTVRLSPPEKYKKKLGFVETISHNELWVSQQ-ANAVHVFDLKTLAYKATVLTGKWSKILLYDPIRDLVYCSNWISEDISVIDRKTKLEIRKTDKIGLPRGLLLSKDGKELYIAQFSAGGGRLGIYSDKEKLIDTIGPPGNKRHIVSGNTENIYVSDC-CSKIEVYDLKEK-KVQKSIPVFDKPNTIALSPDGKYLYVSCRGPNKVYVIDTTTDTVKEFW-EAGNQPTGLDVSPDNRYLVISDFLDHQIRVYR

3vgzA

0.12

0.10

0.84

2.80

wPPAS

GAYEAYSQQLWLATSQSRKL-GGVVYRLDPVTLEVTQAIHNDLKPFGATI------------------------------------------------NNTTQTLWFGNTVNSAVTAIDAKTGEVKGRLVLDDRKRTEEVRPLQPRELVADDATNVIWVVDGGNIKLKTAIQNTGKSTGLALDSEGKRLYTTN-ADGELITIDTADNKILSRKKDDGKEHINISLDTARQAFITDSKAAEVLVVDTRNGN-ILAKVAAP-ESLAVLFNPARNEAYVTHRQAGKVSVIDAKSYKVVKTF-DTPTHPNSLALSADGKTLYVSVKQKSTKQQEA

3vgzA

0.12

0.11

0.85

2.07

dPPAS2

--------------------------------------------ELRKAVGAYSQQENALWLATSQSRKLDKGGVVYRLDPVTLEVTQAIHNDLKPFGATINNTTQTGNTVNSAVTAIDAKTGEVKGRLVLDDRKRTEEVRPLQPRELVADDATNTVWVVDGGNIKLKTAIQNTGKSTGLALDSEGKRLYTTN-ADGELITIDTADNKILSRKKDDGKEHFFINISLDQRAFITDSKAAEVLVVDTRNGNILAKVAA--PESLAVLFNPARNEAYVTHRQAGKVSVIDAKSYKVVKTF-DTPTHPNSLALSADGKTLYVSVKQKSTKQQEA

3vgzA

0.13

0.11

0.88

2.47

PPAS

GAYEAYSQQWLATSQSRKLDKGGVVYRLDPVTLEVTQAIHNDLKPFGATIN----------------------------------NTTQTLWFGNTVNSAVTAIDAKTGEVKGRLVLDDRKRTEEVRPLQPR---ELVADDATNTVYISGIGKESVIWVVDGGNIKLKTAIQNTGKSTGLALDSEGKRLYTTN-ADGELITIDTADNKILSRKKDDGKEHFFINISLDQRAFITDSKAAEVLVVDTRNGN-ILAKVAAP-ESLAVLFNPARNEAYVTHRQAGKVSVIDAKSYKVVKTF-DTPTHPNSLALSADGKTLYVSVKQKSTKQQEA

3vgzA

0.12

0.10

0.88

1.64

Env-PPAS

GAYEAYSQQWLATSQSRKLDKGGVVYRLDPVTLEVTQAIHNDLKPFGATIN-------------------NTTQTLWFGNTVNSAVTAIDAKTGEVKGRLVLDDRKRTEEVRPLQPR------------------ELVADDATNTVYISGIGKESVIWVVDGGNIKLKTAIQNTGKSTGLALDSEGKRLYTTN-ADGELITIDTADNKILSRKKLLDDGKINISLDTARQAFITDSKAAEVLVVDTRNGN-ILAKVAAP-ESLAVLFNPARNEAYVTHRQAGKVSVIDAKSYKVVKTF-DTPTHPNSLALSADGKTLYVSVKQKSTKQQEA

3vgzA

0.10

0.09

0.90

1.29

MUSTER

----------------ELRKVGKGAYEAYSQQENALWLATSQSRKLDKGGVVYR------------DPVTLEVTQAIHNDLKPFGATINNTTQTLWFGNTVNSAVTAIDAKTGEVKGRLVLDDRKRTEEVRPLQPRELVADDATNTVYISGIGKESVWVVDGGNIKLKTAIQNTGKSTGLALDSEGKRLYTTNADG-ELITIDTADNKILSRKKLLDDFFINISLDTARQAFITDSKAAEVLVVDTRNGN-ILAKVAAPE-SLAVLFNPARNEAYVTHRQAGKVSVIDAKSYKVVKTF-DTPTHPNSLALSADGKTLYVSVKQKSTKQQEA

3u4yA

0.11

0.09

0.80

1.15

dPPAS

------------------------------------------------------------------TTSNFHLRRISFFSTDTLEILNQITLGYDFVDTAITSDCSSDFCQTLVQIETQLEPPKVVAIQEGQSSADVDITPDDQFAVTVTGLNHPFNQSYSFLKNKFISTIPIPYDAVGIAISPNGNGLILIDSSANTVRRFKIDADGTGQEFISGGTRPFNITFTPDGNAFVANLIGNSIGILETQNPETLLNAVGTNNLPGTIVVSRDGSTVYVLTESTVDVFNFNQLSGTLSFVKSPRPLFGANQALNKTETKLFISANISRELKVFT

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.07

Estimated TM-score = 0.58±0.14

Estimated RMSD = 8.8±4.6Å

Download Model 2

C-score=-3.16

Download Model 3

C-score=-3.78

Download Model 4

C-score=-3.94

Download Model 5

C-score=-3.41

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3bwsA	0.849	2.65	0.123	0.961
2	3dm0A	0.786	3.30	0.116	0.927
3	4xyhA	0.779	3.21	0.100	0.906
4	2eidA	0.774	3.61	0.093	0.958
5	3fm0A	0.774	2.55	0.093	0.873
6	4pswB	0.772	3.20	0.081	0.906
7	1erjC	0.770	3.28	0.079	0.906
8	3vgzA	0.769	2.34	0.117	0.852
9	3fcsA1	0.769	3.20	0.096	0.906
10	4xfvA	0.768	3.25	0.075	0.903

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	8	3ur4A	0BW	Rep, Mult	46,47,68,93,94,95,136,178,195,306,322
2	0.07	4	2xl2A	III	Rep, Mult	184,227,228,230,254,267,269,290
3	0.05	3	2z2pA	III	Rep, Mult	46,68,95,136,151,176,178,221,236,261,263,279,305,322
4	0.03	2	3p4fA	III	Rep, Mult	45,47,68,93,110,136,152,322
5	0.02	1	2z2pA	MHT	Rep, Mult	236,237,259,261,280
6	0.02	1	2z2pA	MHT	Rep, Mult	184,227
7	0.02	1	3odtA	CA	Rep, Mult	44,322,325
8	0.02	1	1dbnB	NAG	Rep, Mult	294,312
9	0.02	1	1jmxB	HEC	Rep, Mult	282,283,284,285
10	0.02	1	1vyh4	III	Rep, Mult	68,93,152,178,218,236,260,261,279,303,304
11	0.02	1	1kj4B	III	Rep, Mult	305,327
12	0.02	1	2winE	UUU	Rep, Mult	246,278
13	0.02	1	2z2pA	III	Rep, Mult	183,225,227,267,271
14	0.02	1	2z2pA	DOL	Rep, Mult	314,331
15	0.02	1	2z2pA	UUU	Rep, Mult	227,267,269,310,314
16	0.02	1	2z2pA	DOL	Rep, Mult	69,279,303,305,324

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.222	1v04A	0.608	4.11	0.088	0.770	3.1.1.2,3.1.8.1	221
2	0.192	1rwlA	0.591	3.41	0.210	0.719	2.7.11.1	232,267,310
3	0.182	2fpcA	0.593	4.02	0.090	0.755	4.3.3.2	NA
4	0.085	2gc7A	0.674	4.34	0.096	0.882	1.4.99.3	223,228,243,269,272
5	0.084	2h47H	0.691	3.72	0.104	0.849	1.4.99.4	226,232,243,312
6	0.074	1madH	0.674	4.28	0.098	0.876	1.4.99.3	224,228,244,289
7	0.067	1pjxA	0.599	3.93	0.109	0.767	3.1.8.2	NA
8	0.067	2f10A	0.621	3.69	0.062	0.782	3.2.1.18	NA
9	0.067	1simA	0.592	4.10	0.078	0.773	3.2.1.18	273
10	0.066	2uvkB	0.575	4.29	0.072	0.758	5.1.3.-	224,232,259,267,276,282
11	0.066	2ht8A	0.587	4.58	0.071	0.798	3.2.1.18	NA
12	0.066	2htrA	0.568	4.83	0.064	0.788	3.2.1.18	NA
13	0.066	2xcyA	0.588	4.06	0.080	0.764	3.2.1.18	281
14	0.060	1fwxA	0.636	4.07	0.056	0.788	1.7.99.6	NA
15	0.060	1k32A	0.630	4.09	0.071	0.816	3.4.21.-	NA
16	0.060	1w6sC	0.691	4.07	0.090	0.885	1.1.99.8	NA
17	0.060	1lrwC	0.671	4.39	0.071	0.888	1.1.99.8	227,290
18	0.060	1k3iA	0.779	3.56	0.081	0.958	1.1.3.9	NA
19	0.060	2d0vA	0.709	3.90	0.071	0.888	1.1.99.8	219
20	0.060	1kitA	0.631	4.83	0.073	0.870	3.2.1.18	NA
21	0.060	2madH	0.677	4.29	0.080	0.882	1.4.99.3	223,228,269
22	0.060	2agsA	0.615	4.05	0.078	0.795	3.2.1.18	NA
23	0.060	2vk6A	0.606	4.03	0.077	0.782	3.2.1.18	229
24	0.060	3elqB	0.609	4.51	0.075	0.813	2.8.2.22	227,269,309
25	0.060	3fw0A	0.632	3.75	0.090	0.785	4.3.2.5	229,267,312
26	0.060	3dr2A	0.611	3.86	0.092	0.761	3.1.1.17	NA
27	0.060	3c75J	0.681	4.19	0.087	0.879	1.4.99.3	223,228,243,246,269
28	0.060	1ri6A	0.729	3.05	0.122	0.843	3.1.1.31	221
29	0.060	1vcuB	0.626	3.74	0.076	0.791	3.2.1.18	NA
30	0.060	1gjqA	0.652	3.73	0.080	0.813	1.7.99.1,1.7.2.1	NA
31	0.060	1cvmA	0.611	3.82	0.086	0.773	3.1.3.8	NA
32	0.060	2bixA	0.650	4.04	0.061	0.840	1.14.99.-	48

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.776	3.16	0.07	0.90	2ybaB	GO:0000122 GO:0000281 GO:0003682 GO:0005634 GO:0005667 GO:0005700 GO:0006281 GO:0006334 GO:0006335 GO:0006342 GO:0006351 GO:0006355 GO:0007307 GO:0007346 GO:0007379 GO:0007517 GO:0008284 GO:0016568 GO:0016571 GO:0016573 GO:0016581 GO:0016584 GO:0016589 GO:0016590 GO:0031491 GO:0031497 GO:0031523 GO:0033186 GO:0035035 GO:0035097 GO:0035098 GO:0042054 GO:0042393 GO:0042766 GO:0042803 GO:0042826 GO:0046974 GO:0046976 GO:0048666 GO:0048812 GO:0048813 GO:0051567 GO:0061085 GO:0070615 GO:0070734 GO:0070822
1	0.29	0.777	2.42	0.12	0.86	3vgzC	GO:0003677 GO:0030288
2	0.28	0.779	3.21	0.10	0.91	4xyhA	GO:0000070 GO:0000778 GO:0000790 GO:0005634 GO:0005829 GO:0051382 GO:0061638 GO:0061641 GO:0070317 GO:0098654
3	0.28	0.849	2.65	0.12	0.96	3bwsA
4	0.28	0.770	3.28	0.08	0.91	1erjC	GO:0000122 GO:0000123 GO:0000433 GO:0001191 GO:0001198 GO:0005634 GO:0006351 GO:0006355 GO:0007070 GO:0008023 GO:0016584 GO:0017053 GO:0033588 GO:0035955 GO:0036033 GO:0042393 GO:0042826 GO:0043486 GO:0080025 GO:2000217 GO:2000531 GO:2001020
5	0.26	0.775	3.19	0.07	0.91	4pc0B	GO:0000790 GO:0000978 GO:0000980 GO:0004407 GO:0005634 GO:0005654 GO:0006260 GO:0006335 GO:0006336 GO:0006338 GO:0006351 GO:0006355 GO:0007049 GO:0008094 GO:0008285 GO:0016568 GO:0016575 GO:0016580 GO:0016581 GO:0016589 GO:0031492 GO:0031497 GO:0033186 GO:0034080 GO:0035098 GO:0042393 GO:0042826 GO:0043044 GO:0043234 GO:0045814 GO:0051726 GO:1901796
6	0.19	0.778	2.93	0.07	0.90	3gfcA	GO:0000790 GO:0000978 GO:0000980 GO:0004407 GO:0005634 GO:0005654 GO:0006260 GO:0006335 GO:0006336 GO:0006338 GO:0006351 GO:0006355 GO:0007049 GO:0008094 GO:0008285 GO:0016568 GO:0016575 GO:0016580 GO:0016581 GO:0016589 GO:0031492 GO:0031497 GO:0033186 GO:0034080 GO:0035098 GO:0042393 GO:0042826 GO:0043044 GO:0043234 GO:0045814 GO:0051726 GO:1901796
7	0.16	0.786	3.30	0.12	0.93	3dm0A	GO:0004871 GO:0005078 GO:0005215 GO:0005363 GO:0005634 GO:0005737 GO:0005829 GO:0006417 GO:0006810 GO:0006974 GO:0007165 GO:0008643 GO:0009507 GO:0009739 GO:0009749 GO:0009845 GO:0009967 GO:0010228 GO:0010476 GO:0015768 GO:0022626 GO:0030288 GO:0032947 GO:0034289 GO:0042254 GO:0042597 GO:0042956 GO:0043190 GO:0046686 GO:0055052 GO:0060326 GO:0071215 GO:1901982 GO:1990060
8	0.15	0.768	3.25	0.07	0.90	4xfvA	GO:0002098 GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0006357 GO:0006810 GO:0008017 GO:0015031 GO:0032447 GO:0033588
9	0.15	0.775	3.33	0.07	0.92	3cfvB	GO:0000122 GO:0003723 GO:0004407 GO:0005634 GO:0005654 GO:0006260 GO:0006351 GO:0006355 GO:0007275 GO:0008283 GO:0016568 GO:0016575 GO:0016581 GO:0030308 GO:0034080 GO:0035098 GO:0045814 GO:0045892 GO:0048545 GO:0070370 GO:1901796
10	0.15	0.760	2.97	0.12	0.88	4btsAR	GO:0005840
11	0.14	0.737	3.17	0.17	0.85	1l0qA	GO:0016020 GO:0016021
12	0.14	0.763	2.82	0.11	0.87	2h9lA	GO:0000123 GO:0001501 GO:0005622 GO:0005634 GO:0005654 GO:0005671 GO:0006351 GO:0006355 GO:0016568 GO:0018024 GO:0031175 GO:0035064 GO:0035097 GO:0035948 GO:0042800 GO:0043966 GO:0043981 GO:0043982 GO:0043984 GO:0043995 GO:0043996 GO:0044666 GO:0046972 GO:0048188 GO:0051568 GO:0071339
13	0.14	0.751	2.90	0.08	0.87	3jcrL	GO:0000375 GO:0000398 GO:0005634 GO:0005654 GO:0005681 GO:0006396 GO:0006397 GO:0008380 GO:0015030 GO:0016607 GO:0017070 GO:0030621 GO:0046540 GO:0071001 GO:0097525
14	0.14	0.757	2.97	0.09	0.88	4a11B	GO:0000109 GO:0000209 GO:0003678 GO:0004842 GO:0005634 GO:0005654 GO:0006281 GO:0006283 GO:0006289 GO:0006974 GO:0006979 GO:0008094 GO:0009411 GO:0010165 GO:0016363 GO:0016567 GO:0031464 GO:0032403 GO:0043161 GO:0043234 GO:0045739 GO:0051865
15	0.14	0.765	2.79	0.08	0.87	3jcmB	GO:0000398 GO:0005634 GO:0005681 GO:0006397 GO:0008380 GO:0017070 GO:0030621 GO:0034247 GO:0046540
16	0.14	0.757	2.90	0.11	0.87	3ow8C	GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0016055 GO:0016593 GO:0032968 GO:0035327 GO:0045638 GO:0045944 GO:0051571 GO:0055087 GO:0080182 GO:2001162
17	0.14	0.761	2.66	0.07	0.86	3jb9K	GO:0000974 GO:0005634 GO:0005662 GO:0005681 GO:0006397 GO:0008380 GO:0045292 GO:0071011 GO:0071013 GO:0080008
18	0.14	0.757	2.83	0.11	0.87	4aezA	GO:0000070 GO:0005634 GO:0007049 GO:0007067 GO:0010997 GO:0032153 GO:0033597 GO:0034613 GO:0044732 GO:0051301 GO:0072686 GO:0097027 GO:1904668
19	0.14	0.749	3.11	0.13	0.87	2ymuA	GO:0016020 GO:0016021
20	0.12	0.737	2.87	0.07	0.85	4d0kA	GO:0000288 GO:0000289 GO:0003676 GO:0004518 GO:0004527 GO:0004535 GO:0005737 GO:0006397 GO:0016787 GO:0031251 GO:0090305 GO:0090503
21	0.12	0.732	3.42	0.09	0.88	4lg9A	GO:0000118 GO:0000122 GO:0002021 GO:0003677 GO:0003714 GO:0005634 GO:0005654 GO:0005876 GO:0006351 GO:0006355 GO:0008013 GO:0010468 GO:0016042 GO:0016568 GO:0016575 GO:0017053 GO:0030814 GO:0035264 GO:0042393 GO:0043161 GO:0044212 GO:0044255 GO:0045892 GO:0045893 GO:0045944 GO:0047485 GO:0050872 GO:0060070 GO:0060612 GO:0060613 GO:0090207
22	0.12	0.716	3.09	0.12	0.84	3fgbA	GO:0005829 GO:0017057
23	0.11	0.690	3.36	0.10	0.81	3dsmA
24	0.07	0.691	3.90	0.10	0.87	4v7fq	GO:0000027 GO:0005634 GO:0005730 GO:0042254
25	0.07	0.721	3.68	0.10	0.89	3jctx	GO:0000027 GO:0005634 GO:0005730 GO:0042254
26	0.07	0.731	3.52	0.10	0.89	5fl8q	GO:0000027 GO:0005634 GO:0005730 GO:0042254
27	0.07	0.626	4.29	0.09	0.82	1jmxB
28	0.07	0.758	3.39	0.09	0.89	1nr0A	GO:0003779 GO:0005737 GO:0005856 GO:0016528 GO:0030016 GO:0030240 GO:0030836 GO:0030837 GO:0040011 GO:0040012 GO:0042643 GO:0051015 GO:0071689
29	0.07	0.652	3.73	0.08	0.81	1gjqA	GO:0009055 GO:0016491 GO:0020037 GO:0042597 GO:0046872 GO:0050418 GO:0050421 GO:0055114
30	0.07	0.713	3.78	0.11	0.88	4nsxA	GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0030529 GO:0031167 GO:0032040 GO:0034388 GO:0042254 GO:0042274

Consensus prediction of GO terms

Molecular Function	GO:0003676	GO:0043168	GO:0001076	GO:0042393	GO:0042826	GO:0070615	GO:0046976	GO:0031491	GO:0046974	GO:0042803	GO:0035035
GO-Score	0.57	0.55	0.55	0.50	0.50	0.30	0.30	0.30	0.30	0.30	0.30
Biological Processes	GO:0070925	GO:0043623	GO:0000819	GO:0034508	GO:0010948	GO:0051383	GO:0070316	GO:0035953	GO:0100070	GO:0035952	GO:2000879	GO:0043044	GO:0000430	GO:0000437	GO:0045894	GO:0070784	GO:0045014	GO:0080135	GO:0001196	GO:0046021	GO:0007068	GO:0001403	GO:0016584	GO:0007346	GO:0008284	GO:0007379	GO:0016568	GO:0006335	GO:0042766	GO:0007307	GO:0016573	GO:0007517	GO:0051567	GO:0048813	GO:0061085	GO:0006281	GO:0000281	GO:0006342
GO-Score	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.50	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30
Cellular Component	GO:0030313	GO:0042597	GO:0044444	GO:0000777	GO:0000780	GO:0034506	GO:0031248	GO:0005667	GO:0033186	GO:0016590	GO:0005700	GO:0035098	GO:0031523	GO:0070822	GO:0016589	GO:0016581
GO-Score	0.57	0.57	0.56	0.56	0.56	0.56	0.55	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.