I-TASSER results

I-TASSER results for job id Rv0963c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (266 residues)
MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSLILLDTASDPRKVLAA
VGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIA
WLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVSDQHITAFGHSYGSLVTSLAL
QQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGVNDHVANTIPEFGAFGSAPQDVP
GMTQLSVNTGLAPGPLLGDGQLHERA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSLILLDTASDPRKVLAAVGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVSDQHITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGVNDHVANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA
Prediction	CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCEEEEEEEHCCCCCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHCCHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCC
Conf.Score	86799999999998788888999999999999999997589977999958999975799999788545877999969999987767776545677899999999998768899987999996999999857757968999997999999999987667899758999986668999999966987678999868999999988859999858997579997555788888889998778996785688888888888888665679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSLILLDTASDPRKVLAAVGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVSDQHITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGVNDHVANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA
Prediction	63544254246424545542551452154154036317764402000001545644010000001133053000000011030443344344424323432342354444463530000000101115313301344205500540450152032337465130000000110100020244624011000000011206315406155410100305412033134421221310452541440424413233322341343358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCEEEEEEEHCCCCCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHCCHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCC
MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSLILLDTASDPRKVLAAVGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVSDQHITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGVNDHVANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA

4pscA

0.16

0.11

0.73

1.08

wdPPAS

SINEFLSELAKVMPIGDTITAACDLISDGEDAAASLFGISE--------TENDP--------------GDVTVLFARGTC---DPGNVGVLVGPWFFDSLQTAL--------SRTLGVKG--PY--PASVQDFLSG--SVQNGINMANQIKSVLQS---PNTKLVLGGYSQGSMVVHNAASNLDAISAVVLFGDPGKPVA-----NFDAAKTLVVCHDGDNI-----------------------GDIILLPHLTYAEDADT---A

4pscA

0.18

0.13

0.73

1.04

wPPAS

SINEFLSELAKVM---GDTITAACDLISDGEDAAASLFGISE-------TENDP--------------GDVTVLFARG--TCDPGNVGVL-----VGPWFFDSLQTAL---GSRTLGVKG--PY--PASVQDFLSG--SVQNGINMANQIKSVLQS---PNTKLVLGGYSQGSMVVHNAASNLDAISAVVLFGDPGKPVA-----NFDAAKTLVV-HDGDNI------------QG----GDIILLP-----HLTYAEDADT---A

3ajaA

0.11

0.07

0.64

1.62

dPPAS2

-----------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDR--LQVYTTPYNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDR--CPLTSYVIAGFSQGAVIAGDIASDRGPVDGVTLIADG---------------------------RRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGF

3ajaA

0.11

0.08

0.70

1.06

wdPPAS

-----------------------------------------------------------------ADCPDVMMVSIPGTWSPTDDPFNPTQFPLSLMSNISKPLAEQF----GPDRLQVYTTPY--TAQFHNPFANDSRAEGMRTTVKAMTDMNDR---PLTSYVIAGFSQGAVIAGDIASDPVDEDGVTLIADGGPNPAGLSALGLTDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETL------SGPVHALYNTPQFWVENG

3dcnA

0.19

0.12

0.65

0.96

wPPAS

------------------------------------------------DPQSSTRNELET---GSSSACPKVIYIFRA--STEPGNMGIS-----AGPIVADALERIYG---ANDVWVQGV-GG--PDLASNFLPDGTSSAAINEARRLFTLANTK---PNAAIVSGGYSQGTAVMAGSISGTTIKNGVVLFGYTLQNLGRIP--NFETSKTEVYCDIADAV------------YG---------TLFILPAHFLYQTDAAVA--A

1i6wB

0.14

0.08

0.58

1.53

dPPAS2

------------------------------------------------------------------------VVMVHG----IGGASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGT--------------------NYNNGPVLSRFVQKVLDETGAKK--VDIVAHSMGGANTLYYIKNGNKVANVVTLGGALTTGKALPGTDPNQKLYTSIYSSADMIVMNYL---------SRLDGARNVQI-HGVGHIGLL----YSSQV

1i6wB

0.16

0.09

0.58

1.03

wdPPAS

---------------------------------------------------------------------EH-VVMVHGIGGASFN------------FAGIKSYLVSQGW----SRDKLYAVDFWDKTG---------NYNNGPVLSRFVQKVLDETGAKK--VDIVAHSMGGANTLYYIKNGNKVANVVTLGGALTTGKALPGTDPNQKLYTSIYSSADMIVMNYL---------SRLDGARNVQI-HGVGHIGL-----YSSQV

1i6wB

0.15

0.08

0.56

0.96

wPPAS

---------------------------------------------------------------------EH-VVMVHGIGGA-----------SFNFAGIKSYLVSQ-------SRDKLYAVDFWDKTG---------NYNNGPVLSRFVQKVLDET--GAKKVDIVAHSMGGANTLYYIKNGNKVANVVTLGGALTTGKALPGTDPNQKLYTSIYSSADMI--VM---------NSRLDGARNV---HGVGHIG-YSSQV--NSL

2fukA

0.14

0.10

0.73

1.46

dPPAS2

-----------------------------------NPLFPTESAALTLD--GPVGPLDVAVDLPEPDVAPVTAIVCHP----LSTEGGSMHNKVVTMAARALREL-------GITVVRFNFRSVGTSAGSFDHG-----DGEQDDLRAVAEWVRAQR--PTDTLWLAGFSFGAYVSLRAAAA-LEPQVLISIAPPAGRWDFSD--VQPPAQWLVIQGDADEIVDPQA--------------VYDWLETLEQQPTLVRMPDTSHFFH

3visA

0.13

0.09

0.68

1.42

dPPAS2

--------------------------------------------------------------------------------QAANPYERGPNPTESMLEARSEERASRFGADGNNTYGAIAISGYTGTQSSIAWLGERIASHPDSRARQLNAALDYMLTDASSRLAVMGHSMGGGGTLRLASQRPDLKAAIPL-TPWHLNKSWRDITVP---TLIIGAEYDTIASVTLHSKPF-YNSIPSPTDKAYLELDGASHFAPNITNKTIGMY

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.55

Estimated TM-score = 0.42±0.14

Estimated RMSD = 11.9±4.4Å

Download Model 2

C-score=-4.04

Download Model 3

C-score=-4.51

Download Model 4

C-score=-4.95

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3doiA	0.679	4.19	0.091	0.906
2	3azoA	0.663	4.13	0.099	0.880
3	1ve6A	0.662	4.17	0.071	0.876
4	2zsiA	0.659	4.10	0.101	0.876
5	4wjlA	0.659	4.56	0.097	0.898
6	3qh4A	0.657	3.86	0.101	0.853
7	4j7aA	0.654	4.38	0.074	0.876
8	1jjiA	0.653	4.03	0.099	0.850
9	3eblA	0.653	4.18	0.094	0.868
10	1xfdA	0.652	4.48	0.069	0.895

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.21	10	3f98A	NTJ	Rep, Mult	78,79,169,170,171,195,220,253,254
2	0.04	2	2bgrB	UUU	Rep, Mult	144,171,173,177,179
3	0.04	2	2ckiA	CA	Rep, Mult	220,222,225
4	0.04	2	2ripA	UUU	Rep, Mult	46,47,48,60,61,62
5	0.02	1	3e2vA	MG	Rep, Mult	169,220
6	0.02	1	3ue8A	09M	Rep, Mult	64,124
7	0.02	1	2bgrA	UUU	Rep, Mult	191,216,242,244,245,246
8	0.02	1	2d0dA	CL	Rep, Mult	86,170,171
9	0.02	1	4dz4A	UNK	Rep, Mult	220,233
10	0.02	1	2bucA	NDG	Rep, Mult	137,139,140,178,201
11	0.02	1	1y10C	CA	Rep, Mult	123,132
12	0.02	1	3t5tA	MG	Rep, Mult	124,194
13	0.02	1	2bgnB	UUU	Rep, Mult	63,65,68,70,118
14	0.02	1	2g9zA	MG	Rep, Mult	65,67

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.283	3cn7A	0.573	3.18	0.114	0.692	3.1.1.1	79,170,220
2	0.269	1auoA	0.574	3.26	0.129	0.699	3.1.1.1	79,170,220
3	0.185	3dcnA	0.531	3.75	0.133	0.669	3.1.1.74	170,220
4	0.177	1vkhA	0.554	4.09	0.082	0.729	3.5.1.9	NA
5	0.175	3esbA	0.524	3.84	0.106	0.665	3.1.1.74	170,220
6	0.158	1bs9A	0.489	3.51	0.087	0.602	3.1.1.72	170,220
7	0.152	1i6wB	0.503	3.08	0.125	0.602	3.1.1.3	170
8	0.129	3gbsA	0.523	3.48	0.131	0.647	3.1.1.74	170
9	0.067	1fj2A	0.578	3.48	0.116	0.714	3.1.4.39	79
10	0.067	2h1iA	0.548	3.46	0.128	0.684	3.1.1.1	170,195
11	0.067	1dinA	0.566	3.51	0.109	0.707	3.1.1.45	132
12	0.066	1jjfA	0.579	4.40	0.095	0.782	3.2.1.8	NA
13	0.060	1mx9D	0.589	4.60	0.092	0.804	3.1.1.1	NA
14	0.060	2jbwD	0.621	4.29	0.112	0.842	3.7.1.-	170
15	0.060	2bklB	0.639	4.68	0.082	0.887	3.4.21.26	NA
16	0.060	3c6bA	0.584	4.18	0.070	0.774	3.1.2.12	NA
17	0.060	2qr5A	0.662	4.11	0.075	0.872	3.4.19.1	NA
18	0.060	1hlgB	0.589	4.10	0.107	0.767	3.1.1.3	NA
19	0.060	1k8qA	0.601	4.08	0.109	0.778	3.1.1.3	NA
20	0.060	3k2iA	0.610	3.98	0.101	0.801	3.1.2.2	221
21	0.060	3fakA	0.637	4.22	0.101	0.838	3.1.1.-	NA
22	0.060	1orvA	0.645	4.54	0.081	0.883	3.4.14.5	NA
23	0.060	2o7rA	0.622	4.15	0.107	0.835	3.1.1.1	NA
24	0.060	2c7bA	0.623	4.08	0.121	0.820	3.1.1.1	NA
25	0.060	2gbcA	0.641	4.61	0.081	0.880	3.4.14.5,3.4.15.5	NA
26	0.060	2d5lA	0.638	4.67	0.117	0.883	3.4.14.-	NA
27	0.060	3fcxB	0.593	4.01	0.089	0.778	3.1.2.12	NA
28	0.060	1qz3A	0.642	4.30	0.121	0.853	3.1.1.1	NA
29	0.060	1gz7A	0.607	4.32	0.091	0.812	3.1.1.3	NA
30	0.060	1f6wA	0.588	4.28	0.064	0.793	3.1.1.13,3.1.1.3	NA
31	0.060	3g0bB	0.641	4.54	0.085	0.880	3.4.14.5	122

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.531	3.75	0.13	0.67	3dcnA	GO:0005576 GO:0008152 GO:0009405 GO:0016787 GO:0050525 GO:0052689
1	0.19	0.644	3.05	0.13	0.76	4psdA	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
2	0.17	0.524	3.84	0.11	0.67	3esbA	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
3	0.16	0.585	3.91	0.10	0.75	1l7aA	GO:0000272 GO:0005737 GO:0005975 GO:0016787 GO:0030245 GO:0046555 GO:0047739 GO:0052689
4	0.15	0.536	3.73	0.10	0.68	3qitB	GO:0003824 GO:0008152 GO:0016740 GO:0031177
5	0.15	0.652	4.48	0.07	0.89	1xfdA	GO:0005886 GO:0006508 GO:0008076 GO:0008236 GO:0008239 GO:0009986 GO:0015459 GO:0016020 GO:0016021 GO:0043025 GO:0043268 GO:0070062 GO:0072659 GO:1901379
6	0.14	0.489	3.51	0.09	0.60	1bs9A	GO:0000272 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0030245 GO:0045493 GO:0046555 GO:0052689
7	0.11	0.661	4.12	0.06	0.87	3o4jC	GO:0005737 GO:0006508 GO:0008236 GO:0016787
8	0.10	0.652	4.54	0.09	0.89	2ecfA	GO:0006508 GO:0008236
9	0.10	0.677	4.14	0.10	0.90	3dohA	GO:0002084 GO:0005737 GO:0008474 GO:0016787 GO:0052689
10	0.09	0.651	4.51	0.09	0.89	1z68A	GO:0001525 GO:0002020 GO:0004175 GO:0004222 GO:0004252 GO:0005178 GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0005925 GO:0006508 GO:0006915 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0009986 GO:0010710 GO:0010716 GO:0016020 GO:0016021 GO:0016787 GO:0030027 GO:0030054 GO:0031258 GO:0032587 GO:0042803 GO:0042995 GO:0043542 GO:0045177 GO:0045178 GO:0046983 GO:0051603 GO:0051917 GO:0060244 GO:0071158 GO:0071438 GO:0071850 GO:0097325 GO:1900119 GO:1902362 GO:1903054
11	0.09	0.669	4.08	0.10	0.88	3azoA	GO:0004177 GO:0006508 GO:0008236
12	0.09	0.639	4.68	0.08	0.89	2bklB	GO:0004252 GO:0006508 GO:0008236 GO:0070008
13	0.09	0.650	4.49	0.07	0.88	4hxgF	GO:0006508 GO:0008236 GO:0046872
14	0.09	0.641	4.61	0.08	0.88	2gbcA	GO:0002020 GO:0002709 GO:0004177 GO:0004252 GO:0005102 GO:0005518 GO:0005576 GO:0005783 GO:0005794 GO:0005886 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0042277 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0051234 GO:0071438
15	0.09	0.649	4.39	0.10	0.88	4v2iA	GO:0008152 GO:0016787 GO:0052689
16	0.08	0.638	4.67	0.12	0.88	2d5lA	GO:0004177 GO:0006508 GO:0008233 GO:0008236 GO:0016787
17	0.08	0.642	4.75	0.07	0.89	3munA	GO:0004252 GO:0006508 GO:0008236 GO:0070008
18	0.08	0.648	4.70	0.08	0.90	4amyA	GO:0004252 GO:0005737 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0070008
19	0.08	0.636	4.67	0.09	0.88	4q1vA	GO:0006508 GO:0008236 GO:0016787 GO:0046872
20	0.08	0.659	4.56	0.10	0.90	4wjlB	GO:0005886 GO:0006508 GO:0008236 GO:0008239 GO:0015459 GO:0016020 GO:0016021 GO:0072659 GO:0090004 GO:1901379
21	0.07	0.642	4.46	0.09	0.88	2aj8A	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
22	0.07	0.637	4.49	0.09	0.87	4n8eB	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
23	0.07	0.573	3.37	0.06	0.70	4f21B	GO:0016787
24	0.07	0.523	3.48	0.13	0.65	3gbsA	GO:0005576 GO:0008152 GO:0016042 GO:0016787 GO:0050525 GO:0052689
25	0.07	0.521	3.72	0.10	0.66	5ajhA	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
26	0.07	0.530	3.70	0.11	0.66	4oyyC	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
27	0.07	0.584	3.40	0.13	0.71	4fhzA	GO:0016787
28	0.07	0.578	3.48	0.12	0.71	1fj2A	GO:0002084 GO:0004622 GO:0005737 GO:0005739 GO:0005829 GO:0006629 GO:0006631 GO:0008474 GO:0016298 GO:0016787 GO:0042997 GO:0050999 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0050525	GO:0019213
GO-Score	0.47	0.32
Biological Processes	GO:0051704	GO:0051275	GO:0030243
GO-Score	0.40	0.32	0.32
Cellular Component	GO:0005576	GO:0044424
GO-Score	0.47	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.