I-TASSER results

I-TASSER results for job id Rv0950c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (332 residues)
MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDDLDLGDDCVFDYEAQL
LAAPELDDLDDADDLAPEWLVAPTVVLTPEVTPVSRRVGQHRKQPIGAARGRLLISAMAA
GAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPRGVQVIAAQPAASAAVHNAEF
ARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGIDLANAIGTPIYAVSD
GVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGERVMAGDQIATMGSRGFSTGP
HLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDDLDLGDDCVFDYEAQLLAAPELDDLDDADDLAPEWLVAPTVVLTPEVTPVSRRVGQHRKQPIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPRGVQVIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGIDLANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGERVMAGDQIATMGSRGFSTGPHLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG
Prediction	CCCCCCCCCCCCCCCHHHHHEEHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCCCCCCCCCCCCCEHCCCCCCCEEEHCCCCEEEEEHCCCCCCEEEEEEHCCCEEEEEEHCCEHCCCCCEEEHCCEEEEEHCCCCCCCCCCEEEEEEHCCCCCCCHHHHHHHHCCCCCCCCC
Conf.Score	99877667777778856643344567766654555556777776655555555454455555544556555545555444566544566666554444555455665544455666666655556666555555545555455555554455555566554445544554455566778887777777666666655688766777756875898888988997556888897589868979999766898755899995996898765446454799989968878998678888889865799985899889968999998987676789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDDLDLGDDCVFDYEAQLLAAPELDDLDDADDLAPEWLVAPTVVLTPEVTPVSRRVGQHRKQPIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPRGVQVIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGIDLANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGERVMAGDQIATMGSRGFSTGPHLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG
Prediction	74344444543362455322421224424534432436414413534235542253634324235346355445244542443545444744525454454365445443332122123343343345424445545645444544545255445554554453444544554544455355445335544555442651311220402000111114132020000103430003004612000002421000000020741210000000414053434054313003010013001000000014444420101410472405125248
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCHHHHHEEHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCCCCCCCCCCCCCEHCCCCCCCEEEHCCCCEEEEEHCCCCCCEEEEEEHCCCEEEEEEHCCEHCCCCCEEEHCCEEEEEHCCCCCCCCCCEEEEEEHCCCCCCCHHHHHHHHCCCCCCCCC
MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDDLDLGDDCVFDYEAQLLAAPELDDLDDADDLAPEWLVAPTVVLTPEVTPVSRRVGQHRKQPIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPRGVQVIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGIDLANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGERVMAGDQIATMGSRGFSTGPHLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG

3sluA

0.21

0.20

0.95

1.69

MUSTER

VQTAYWVQEAVQP---DSLADVLARSGMARDEIARITEKYRHLRADQSVH--LVGGDGGAREVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPVEIRESLSGIFAGRDGLKEGDAVRLIYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFYYRSDKGGNYYDE----DGRVLQGFNIEPLVYRISSPFGYRMHPLHTGIDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAQG-NVRGGEVIGFVGSTGRSTGPHLHYEARINGQ-PVNPVSVA----LPTPELTQ

2hsiB

0.21

0.14

0.67

1.33

dPPAS

------------------------------------------------------------------------------------------------SFIMRLLNKPVPGGVAVVDLGEEGPPPRAFYQGKPVLVVREEGRRWIAVVGIPLSTKPGAATGNHEERFSVGSKLPEDLKRIERELAEQTAAYRRFSPGLPSNLMLDKPVDGPLSSPFG-----PHSGLDFAVPAGTPIKAPAAGKVILIGDYFFNGKTVFVDHGQGFISMFCHLSKIDVKLGQQVPRGGVLGKVGATGRATGPHMHWNVSLNDA-RVDPAIFIGAF---------

2gu1A

0.21

0.19

0.92

2.32

wMUSTER

VKVGDTLSGAQLGVPYSILQKILSVDLDHLQLDMIQPGEELEL---------MMDDMGQLSRLHMSIVEKAIYTRENDGSFSYDFQEISGEWREILFSGEINGSFSVSARRVGLTSSQVANITQVMKDKIDFSRSL-RADRFDILVKQQYLGEHNTGNSEIKAISFKLAKGDVSAFLAEDGR-------YDRAGNSLERAFNRYPVDKQITSGFNPRKHPPHNGTDFATPIGAPVYSTGDGKVIVVRKHPYAGNYLVIEHNSVYKTRYLHLDKILVKKGQLVKRGQKIALAGATGRLTGPHLHFEVLVRN-RPVDAMK------ADLP----

5kvpA

0.35

0.15

0.42

3.64

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHHHHHHGSATYTRPLDGNITTGFNGYP--GHVGVDYAVPVGTPVRAVANGTVKFAGNGANHGNAVLIQHADGMHTGYAHLSKISVSTDSTVKQGQIIGYTGATGQVTGPHLHFEMLPANSGRIDPTGYIANAPV-FNGTTP

2hsiB

0.22

0.15

0.69

3.27

Env-PPAS

-------------------------------------------SFIMRLLNKPVPGGVAVV---------DLGEEGPPPRAFYQGKPVLVVREEGRRWIAVVGIPLSTKPGPQKLEVR-------------------------------------AATGNHEERFSVGSKLPEDLKRIERELAEQTAAYRRFSPGLPSNLMLDKPVDGPLSSPFG-----PHSGLDFAVPAGTPIKAPAAGKVILIGDYFFNGKTVFVDHGQGFISMFCHLSKIDVKLGQQVPRGGVLGKVGATGRATGPHMHWNVSLNDA-RVDPAIFIGAF---------

4bh5A

0.35

0.14

0.39

3.16

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLGAPRGQAFWPVRGPTLHRYGEQLQGRWKGMVIGASEGTEVKAIADGRVILADWLQGYGLVVVVEHGKGDMSLYGYNQSALVSVGSQVRAGQPIALVGSSGGQGRPSLYFEIRRQGQ-AVNPQPWLGR----------

2gu1A

0.20

0.19

0.92

1.69

MUSTER

VKVGDTLSGAQLGVPYSILQKILSVDLDHLQLDMIQPGEELEL---------MMDDMGQLSRL--IYHMSIVEKAIYTRENDGSFSYDFQEISGEWREILFSGEINGSFSVSARRVGLTSSQVANITQVMKDKSRSLRADRFDILVKQQYLGEHNTGNSEIKAISFKLAKGDVSAFLAEDGRFY------DRAGNSLERAFNRYPVDRQITSGFNPRKHPPHNGTDFATPIGAPVYSTGDGKVIVVRKHPYAGNYLVIEHNSVYKTRYLHLDKILVKKGQLVKRGQKIALAGATGRLTGPHLHFEVLVRN-RPVDAMK------ADLP----

4bh5A

0.35

0.14

0.39

3.36

PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLGAPRGQAFWPVRGPTLHRYGEQLQGRWKGMVIGASEGTEVKAIADGRVILADWLQGYGLVVVVEHGKGDMSLYGYNQSALVSVGSQVRAGQPIALVGSSGGQGRPSLYFEIRRQG-QAVNPQPWLGR----------

2hsiB

0.21

0.14

0.69

2.27

wMUSTER

---------------------------------------------------------SFIMRLL--------NKPVPGGVAVVDLGEEGPPPRAFYQ-GKPVLVVREEGRRWIAVVGI---------------------PLSTKPGPQKLEVRAATGNHEERFSVGSKLPEDLKRIERELAEQTAAYRRFS--PGLPSNLMLDKPVDGPLSSPFG-----PHSGLDFAVPAGTPIKAPAAGKVILIGDYFFNGKTVFVDHGQGFISMFCHLSKIDVKLGQQVPRGGVLGKVGATGRATGPHMHWNVSLND-ARVDPAIFIG-------AF--

4bh5A

0.35

0.14

0.39

1.31

dPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLGAPRGQAFWPVRGPTLHRYGEQLQGRWKGMVIGASEGTEVKAIADGRVILADWLQGYGLVVVVEHGKGDMSLYGYNQSALVSVGSQVRAGQPIALVGSSGGQGRPSLYFEIRRQGQ-AVNPQPWLGR----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.82

Estimated TM-score = 0.50±0.15

Estimated RMSD = 10.6±4.6Å

Download Model 2

C-score=-3.30

Download Model 3

C-score=-4.02

Download Model 4

C-score=-4.56

Download Model 5

C-score=-3.98

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2gu1A	0.859	1.84	0.194	0.916
2	4rnyA	0.643	4.58	0.128	0.868
3	3sluA	0.486	5.87	0.116	0.738
4	2vdcA	0.408	6.99	0.067	0.723
5	1qwyA	0.402	3.41	0.267	0.467
6	1llwA	0.401	6.56	0.060	0.669
7	4uhwA	0.400	6.37	0.038	0.654
8	3u1kA	0.399	6.15	0.057	0.632
9	3fahA	0.399	6.77	0.058	0.699
10	1wygA	0.397	6.31	0.035	0.642

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.55	12	2gu1A	ZN	Rep, Mult	222,226,303
2	0.07	2	5j1lA	ZN	Rep, Mult	226,270,301,303
3	0.03	1	1lm1A	F3S	Rep, Mult	227,228,229,230,231,233,291,292
4	0.03	1	1fiqA	FES	Rep, Mult	270,271,292,293,294,295,300,301
5	0.03	1	1qwyA	ZN	Rep, Mult	160,222,226,303
6	0.03	1	2ckjA	FES	Rep, Mult	252,253,254,270,292,294,295

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1bxrA	0.371	6.94	0.057	0.660	6.3.5.5	209,210
2	0.060	2vdcA	0.408	6.99	0.067	0.723	1.4.1.13	NA
3	0.060	1kasA	0.368	6.12	0.060	0.587	2.3.1.179	NA
4	0.060	3ebgA	0.379	6.58	0.032	0.635	3.4.11.-	NA
5	0.060	2vdcF	0.391	6.95	0.049	0.705	1.4.1.13	NA
6	0.060	1dgjA	0.384	6.76	0.063	0.654	1.2.-.-	8
7	0.060	3kzuA	0.369	6.30	0.058	0.596	2.3.1.41	257,270
8	0.060	1t3tA	0.392	6.49	0.057	0.648	6.3.5.3	229
9	0.060	2ckjA	0.395	6.22	0.048	0.632	1.17.1.4,1.17.3.2	NA
10	0.060	3b9jI	0.189	5.60	0.079	0.289	1.17.1.4,1.17.3.2	253,278
11	0.060	1b3nA	0.370	6.01	0.043	0.581	2.3.1.179,2.3.1.41	257,296
12	0.060	2pffD	0.379	6.32	0.022	0.615	2.3.1.86	208,288
13	0.060	1jroB	0.393	6.50	0.069	0.651	1.1.1.204	NA
14	0.060	1llwA	0.401	6.56	0.060	0.669	1.4.7.1	NA
15	0.060	2e1qA	0.399	6.46	0.052	0.657	1.17.3.2,1.17.1.4	NA
16	0.060	2fknB	0.395	6.73	0.070	0.687	4.2.1.49	295
17	0.060	2owoA	0.385	6.90	0.064	0.675	6.5.1.2	NA
18	0.060	2b44A	0.340	2.00	0.364	0.364	3.4.24.75	246,253,295
19	0.060	3b9jJ	0.252	6.88	0.038	0.440	1.17.1.4,1.17.3.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.35	0.643	4.58	0.13	0.87	4rnyA	GO:0016020 GO:0016021 GO:0046872
1	0.35	0.395	3.24	0.23	0.45	2hsiB	GO:0046872
2	0.30	0.492	6.12	0.12	0.78	3sluB	GO:0016020 GO:0016021
3	0.25	0.355	2.10	0.35	0.38	4bh5A	GO:0000920 GO:0001896 GO:0005886 GO:0007049 GO:0009273 GO:0016787 GO:0030288 GO:0032153 GO:0042493 GO:0042597 GO:0051301 GO:0051345
4	0.19	0.859	1.84	0.19	0.92	2gu1A	GO:0046872
5	0.16	0.402	3.41	0.27	0.47	1qwyA	GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0009405 GO:0016787 GO:0046872 GO:0071555
6	0.15	0.359	2.26	0.24	0.39	3tufB	GO:0016020 GO:0016021 GO:0030435 GO:0042601
7	0.14	0.333	3.30	0.21	0.38	3it5A	GO:0004175 GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0009405 GO:0016787 GO:0046872
8	0.11	0.369	3.73	0.15	0.44	3nyyA	GO:0016020 GO:0016021
9	0.10	0.356	2.89	0.30	0.39	4lxcA	GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872 GO:0071555
10	0.06	0.274	6.84	0.04	0.47	3k57A	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0006261 GO:0006281 GO:0006974 GO:0008296 GO:0008408 GO:0009432 GO:0016740 GO:0016779 GO:0045004 GO:0071897 GO:0090305
11	0.06	0.307	6.71	0.04	0.52	3k5nA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0006261 GO:0006281 GO:0006974 GO:0008296 GO:0008408 GO:0009432 GO:0016740 GO:0016779 GO:0045004 GO:0071897 GO:0090305
12	0.06	0.298	6.84	0.03	0.52	1jmoA	GO:0004866 GO:0004867 GO:0005576 GO:0005615 GO:0006935 GO:0007596 GO:0007599 GO:0008201 GO:0008218 GO:0010466 GO:0010951 GO:0030414 GO:0070062
13	0.06	0.277	6.78	0.03	0.47	3ihjA	GO:0003824 GO:0004021 GO:0005739 GO:0005759 GO:0006103 GO:0008483 GO:0008652 GO:0009058 GO:0016740 GO:0030170 GO:0042851 GO:0042853
14	0.06	0.289	6.60	0.04	0.50	4wl2A	GO:0016787 GO:0016811
15	0.06	0.242	5.84	0.02	0.38	1o7dD	GO:0003824 GO:0004553 GO:0004559 GO:0005764 GO:0005975 GO:0006013 GO:0006517 GO:0007611 GO:0008152 GO:0008270 GO:0015923 GO:0016787 GO:0016798 GO:0030246 GO:0046872
16	0.06	0.216	5.58	0.02	0.33	4p9tA	GO:0005198 GO:0005634 GO:0005737 GO:0005856 GO:0005886 GO:0005912 GO:0005913 GO:0007155 GO:0007275 GO:0007409 GO:0015629 GO:0016020 GO:0016323 GO:0016337 GO:0021942 GO:0030027 GO:0030054 GO:0030154 GO:0030424 GO:0042995 GO:0045296 GO:0048813 GO:0048854 GO:0051015 GO:0051823 GO:0060134 GO:0097481
17	0.06	0.200	5.65	0.08	0.30	3ezjG	GO:0006810 GO:0008565 GO:0009279 GO:0009306 GO:0015627 GO:0015628 GO:0019867
18	0.06	0.177	7.37	0.03	0.33	4pkiG	GO:0001726 GO:0002102 GO:0003779 GO:0005509 GO:0005523 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0005856 GO:0005865 GO:0005886 GO:0005925 GO:0006911 GO:0006915 GO:0006936 GO:0007015 GO:0007568 GO:0008154 GO:0008180 GO:0008344 GO:0010628 GO:0014003 GO:0014891 GO:0015629 GO:0016020 GO:0016192 GO:0016528 GO:0019904 GO:0022617 GO:0030016 GO:0030017 GO:0030027 GO:0030030 GO:0030041 GO:0030049 GO:0030155 GO:0030239 GO:0030478 GO:0030863 GO:0030864 GO:0031648 GO:0042060 GO:0042246 GO:0042989 GO:0043209 GO:0043234 GO:0044267 GO:0045010 GO:0045159 GO:0045471 GO:0046597 GO:0046872 GO:0048015 GO:0048471 GO:0051014 GO:0051015 GO:0051016 GO:0051127 GO:0051593 GO:0051693 GO:0051694 GO:0060271 GO:0070062 GO:0070307 GO:0071276 GO:0071801 GO:0072562 GO:0090527 GO:0097017 GO:0097284 GO:1902174 GO:1903689 GO:1903903 GO:1903906 GO:1903909 GO:1903923 GO:1990000 GO:2001269

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0003824
GO-Score	0.65	0.35
Biological Processes	GO:0042221	GO:0042546	GO:0051301	GO:0051336	GO:0043085	GO:0012501
GO-Score	0.49	0.49	0.49	0.49	0.49	0.49
Cellular Component	GO:0016021	GO:0030313	GO:0071944
GO-Score	0.54	0.49	0.49

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
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