I-TASSER results

I-TASSER results for job id Rv0941c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (257 residues)
MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDSLTRATLEQPSAVIVNV
TELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAVTRTGVARFMPVYPTEKAA
SKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQWSRPGLIPVALVVVNVFVENV
LKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPPKGIDVSGLAIVAALSRAWGSSP
TSSGKTVWAIIGPENQL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDSLTRATLEQPSAVIVNVTELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAVTRTGVARFMPVYPTEKAASKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQWSRPGLIPVALVVVNVFVENVLKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPPKGIDVSGLAIVAALSRAWGSSPTSSGKTVWAIIGPENQL
Prediction	CCCCCCCCCCCCEEEEEEHCCCCEEEEEHCCEHCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCHCCCCHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHCCEEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEHCCCCEEEEEEHCCCCCC
Conf.Score	98888888888758999875798689998556667765789999999987589858987577565776467877776654357888758886588886567777777775677887556777765578888758999978988569999999999999859964446899999999999998599984999999899899999879999998889999899997699999999886977679985899998589999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDSLTRATLEQPSAVIVNVTELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAVTRTGVARFMPVYPTEKAASKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQWSRPGLIPVALVVVNVFVENVLKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPPKGIDVSGLAIVAALSRAWGSSPTSSGKTVWAIIGPENQL
Prediction	72423743443440303144544010010313023320440151035003641420001034040225110100010022046245120000024442342123200220122213342033223332433322010303243200220131023103414145103200100010010013134330110021344100000004243123224345522101332444230432312435432144236326758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCEEEEEEHCCCCEEEEEHCCEHCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCHCCCCHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHCCEEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEHCCCCEEEEEEHCCCCCC
MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDSLTRATLEQPSAVIVNVTELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAVTRTGVARFMPVYPTEKAASKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQWSRPGLIPVALVVVNVFVENVLKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPPKGIDVSGLAIVAALSRAWGSSPTSSGKTVWAIIGPENQL

3ke6A

0.15

0.14

0.93

1.22

MUSTER

FHKQVPGSKSSGEFQYCTAGHPPPLLVTADASARYVEPTGAG-----PLGSGTG---FPVRSEVLNIGDAILFYTDGLIERPGRPLADLAASIASARPIDRLCSDTLELLLRTGYNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATDV------SKGIVVAAA---LAGDGNVRASVIDRGQWGLAMAEALVSEARIMHGAGGTTATLTHRVTDTM

3ke6A

0.15

0.14

0.93

1.16

dPPAS

FHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLADLAASIASARPIDRLCSDTLELLLRSTGNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATVVAAALAGDGNVRASVID---------------RGQWGLAMAEALVSEARIMHGAGGTTATLTHRLSRPA

3ke6A

0.15

0.14

0.94

2.38

wdPPAS

FHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASA----YVEPTGAGPLPVRSEVLNIGDAILFYTDGLIERPGRP-ADLAASIASARPIDRLCSDTLELLLRSTGNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATDVSKG---------IVVAAALAGDGNVRASVIDRGQWGLAMAEALVSEARIMHGAGGTTATLTHRLSDTM

3ke6A

0.17

0.15

0.88

1.48

wMUSTER

FHKQVPGSKSSGEFQYCTAGHPPPLLVTADASARYV--------------EPTGAGPLPVRSEVLNIGDAILFYTDGLIERPGRPLADLAASIASARPIDRLCSDTLELLLRTGYNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATVVAAALAGDGNVRASVID---------------RGQWGLAMAEALVSEARIMHGAGGTTATLTHRVTDTM

3ke6A

0.15

0.14

0.94

2.93

wPPAS

FHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASA----YVEPTGAGPLPVRSEVLNIGDAILFYTDGLIERPGRP-ADLAASIASARPIDRLCSDTLELLLRSTGNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATDVSKG---------IVVAAALAGDGNVRASVIDRGQWGLAMAEALVSEARIMHGAGGTTATLTHRLSDTM

3ke6A

0.17

0.14

0.84

2.89

dPPAS2

FHKQVPGSKSATMCVGSLDFTSGEFQYCTAG--------------------HPPPLLVTADAEVLNIGDAILFYTDGLIERPGRPLADLAASIASARPIDRLCSDTLELLLRSTGNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATVVAAALAGDGNVRASVID---------------RGQWGLAMAEALVSEARIMHGAGGTTATLTHR----L

3ke6A

0.15

0.14

0.94

2.01

PPAS

FHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPP-----VTADASARYVEPTGAGPLPVRSEVLNIGDAILFYTDGLIERPGRPLADLAASIASARPIDRLCSDTLELLLRSTGNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATDVSKG---------IVVAAALAGDGNVRASVIDRGQWGLAMAEALVSEARIMHGAGGTTATLTHRRPARF

3ke6A

0.16

0.15

0.95

2.36

Env-PPAS

FHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASA---RYVEPTGAGPLPVRSEVLNIGDAILFYTDGLIERPGRPLADLAASIASARPIDRLCSDTLELLLRSTGNDDVTLLAMQRRAPTPP--LHITLDATINAARTVRAQLREWLAEIGADHDIADIVHAISEFVENAVEHGYATDVSKG------IVVAAAL---AGDGNVRASVIDRGQWGLAMAEALVSEARIMHGAGGTTATLTHRPARFV

4r3aA

0.15

0.14

0.96

0.79

MUSTER

AW-----GRLPFSLTIADISQDDEPLIYVVGRLQGKTDPGAVERLAKAIRNCEEVEETIY--NYRADGEGFHLLMGPLEDQDEKCRYFVGIQVDMGQSVQHRVKNHLAMIVSMIRIQVGSQFDSLSRRVEALQLLYQEMDIKIIPLGAYLGRIASAINHIDGRETAGRIGLLVSEVLTNALQHAFSDVQLRSSVMGEQLRVTVEDDGRGIPEDCDWPNE--GNLGSRIVRQLVQGLGVTRGGTGTIVNIDIPLSQQL

4qtpA

0.17

0.08

0.45

0.88

dPPAS

--------SAPDSITTLVEDHDGVSVVSVSGEIDMVTAPALEQAIGAVVADSPPALVIDLSAVEFLGSVGLKILAATYEKLG--KETGFGVVARGPATRRPIHLTGLDKTFPLYPTLDDALTAVRD-----------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.91

Estimated TM-score = 0.60±0.14

Estimated RMSD = 7.9±4.4Å

Download Model 2

C-score=-3.41

Download Model 3

C-score=-3.65

Download Model 4

C-score=-4.16

Download Model 5

C-score=-3.82

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ke6A	0.854	2.18	0.160	0.946
2	2pffA3	0.449	5.48	0.068	0.700
3	4mt1A	0.445	5.42	0.075	0.693
4	4k0eA	0.444	5.40	0.066	0.693
5	3pu9A	0.443	2.79	0.044	0.525
6	3k07A	0.443	5.36	0.056	0.697
7	2j8sA	0.436	5.53	0.056	0.689
8	3zyvA	0.436	5.92	0.049	0.728
9	4kmqA	0.436	5.21	0.041	0.669
10	2y8nA	0.435	6.09	0.037	0.743

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	3ehbB	HEA	Rep, Mult	180,247
2	0.08	4	4x23F	III	Rep, Mult	175,178,179,182
3	0.06	3	1tilA	MG	Rep, Mult	175,179,225
4	0.04	2	1h74B	MG	Rep, Mult	145,178
5	0.04	2	5klgA	6UC	Rep, Mult	177,180
6	0.04	2	3t9qB	GL0	Rep, Mult	224,225,238,240,245
7	0.02	1	1l8tA	MG	Rep, Mult	5,205
8	0.02	1	4wfdD	III	Rep, Mult	146,153,154
9	0.02	1	2ckjD	PO4	Rep, Mult	171,207,214,216,252
10	0.02	1	2ckjA	FES	Rep, Mult	138,139,193,203,204,205
11	0.02	1	1uryB	XE	Rep, Mult	149,152,174,177
12	0.02	1	2fkwF	BCL	Rep, Mult	175,176
13	0.02	1	3ke6A	MN	Rep, Mult	76,117
14	0.02	1	3zxoA	ZN	Rep, Mult	183,205,213

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1mswD	0.390	5.77	0.034	0.646	2.7.7.6	NA
2	0.060	1t3tA	0.404	6.04	0.044	0.693	6.3.5.3	NA
3	0.060	1vcmA	0.393	6.03	0.058	0.654	6.3.4.2	NA
4	0.060	1bglA	0.318	6.21	0.070	0.549	3.2.1.23	NA
5	0.060	2uv8G	0.433	5.58	0.057	0.697	2.3.1.86	NA
6	0.060	1ay0A	0.404	5.98	0.061	0.689	2.2.1.1	NA
7	0.060	1orvA	0.363	7.01	0.048	0.724	3.4.14.5	NA
8	0.060	2e9eA	0.393	6.36	0.037	0.677	1.11.1.7	NA
9	0.060	3b9jI	0.208	5.72	0.008	0.342	1.17.1.4,1.17.3.2	150,179
10	0.060	2pffB	0.421	5.90	0.053	0.700	2.3.1.86	NA
11	0.060	1e5tA	0.399	6.43	0.061	0.724	3.4.21.26	NA
12	0.060	1vcnA	0.399	6.04	0.053	0.673	6.3.4.2	NA
13	0.060	3eqlD	0.376	5.70	0.045	0.603	2.7.7.6	171
14	0.060	1jrpB	0.400	5.92	0.034	0.669	1.17.1.4	226
15	0.060	2rnpC	0.392	5.76	0.033	0.630	2.7.7.6	NA
16	0.060	2ow6A	0.397	6.25	0.036	0.697	3.2.1.114	222
17	0.060	1jroB	0.401	5.75	0.030	0.661	1.1.1.204	NA
18	0.060	1r9mB	0.383	6.82	0.054	0.732	3.4.14.5	NA
19	0.060	1trkA	0.405	5.97	0.056	0.693	2.2.1.1	139,152

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.854	2.18	0.16	0.95	3ke6A	GO:0000155 GO:0000160 GO:0000287 GO:0003824 GO:0004035 GO:0005622 GO:0006355 GO:0016311 GO:0016791 GO:0023014 GO:0030145
1	0.16	0.392	2.52	0.14	0.45	1l0oA	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0006468 GO:0010468 GO:0016301 GO:0016310 GO:0016740 GO:0016989 GO:0030435 GO:0030436 GO:0045892
2	0.06	0.352	5.50	0.06	0.56	3goaB	GO:0003824 GO:0003988 GO:0005737 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0016042 GO:0016740 GO:0016746 GO:0016747
3	0.06	0.342	5.94	0.07	0.58	2gp6A	GO:0001666 GO:0003824 GO:0004315 GO:0005618 GO:0005737 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0030497 GO:0040007 GO:0071768
4	0.06	0.296	6.35	0.05	0.53	4c6vA	GO:0003824 GO:0008152 GO:0016740 GO:0016746 GO:0033817
5	0.06	0.316	6.56	0.06	0.58	4f32B	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
6	0.06	0.348	5.66	0.04	0.56	3e60A	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
7	0.06	0.404	5.98	0.06	0.69	1ay0A	GO:0003824 GO:0004802 GO:0005737 GO:0006098 GO:0008152 GO:0016740 GO:0046872
8	0.06	0.346	5.64	0.06	0.56	3o04A	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
9	0.06	0.345	6.43	0.09	0.63	5e5nB	GO:0003824 GO:0005737 GO:0008152 GO:0016491 GO:0016740 GO:0016746 GO:0017000 GO:0031177 GO:0055114
10	0.06	0.278	6.80	0.04	0.53	4r8eA	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
11	0.06	0.295	6.51	0.06	0.55	2gqdA	GO:0003824 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
12	0.06	0.327	6.14	0.05	0.57	3kzuA	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
13	0.06	0.299	6.83	0.05	0.57	2ix4A	GO:0003824 GO:0004315 GO:0005739 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747
14	0.06	0.281	6.23	0.04	0.51	2buhA	GO:0003824 GO:0004315 GO:0005737 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0008610 GO:0016740 GO:0016746
15	0.06	0.343	5.70	0.06	0.56	4mz0B	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
16	0.06	0.345	5.58	0.06	0.56	4xoxA	GO:0003824 GO:0004315 GO:0008152 GO:0016740 GO:0016746
17	0.06	0.352	6.45	0.08	0.64	4qyrA	GO:0003824 GO:0008152 GO:0031177
18	0.06	0.349	5.48	0.04	0.56	3oytA	GO:0003824 GO:0004315 GO:0008152 GO:0016740 GO:0016746

Consensus prediction of GO terms

Molecular Function	GO:0004673	GO:0046914	GO:0038023	GO:0042578	GO:0035639	GO:0000989	GO:0032559	GO:0032550
GO-Score	0.39	0.39	0.39	0.39	0.31	0.31	0.31	0.31
Biological Processes	GO:0006351	GO:0035556	GO:0044710	GO:0006468	GO:0048646	GO:0043934	GO:2000113	GO:0010629	GO:0030154	GO:0019954	GO:1903507
GO-Score	0.39	0.39	0.39	0.39	0.31	0.31	0.31	0.31	0.31	0.31	0.31
Cellular Component	GO:0044464
GO-Score	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.