I-TASSER results

I-TASSER results for job id Rv0923c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (354 residues)
MPDRRHPYFAYGSNLCAHQMASRCPDAGAPRPAVLSDHNWLINQRGVATVEPFAGNKVHG
VLWQLSERDLVRLDSAEGVPVRYRRERLTVHTDDTALPAWVYIDHRVMPGRPRPGYLPRV
IDGARHHGLPQRWIDYLHRWDPARWPLPVLPSSRSGPAPQSLSELLSQPGVIETSQLRSR
FGFLAIHGGGLEQVTDLIAERSAEAAGASVYLLRHPDNYPHHLPSARFDPAESARLAEFL
DHVDVAVSLHGYDRIGRSTQLLAGGRNRALAAHLARHIQLPGYRVVTDLAAIPEELRGLH
PDNPVNRVRDGGTQLELSIRVRGLGPRSTLPGVGGMSPVTATLVQGLVTAARSW

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPDRRHPYFAYGSNLCAHQMASRCPDAGAPRPAVLSDHNWLINQRGVATVEPFAGNKVHGVLWQLSERDLVRLDSAEGVPVRYRRERLTVHTDDTALPAWVYIDHRVMPGRPRPGYLPRVIDGARHHGLPQRWIDYLHRWDPARWPLPVLPSSRSGPAPQSLSELLSQPGVIETSQLRSRFGFLAIHGGGLEQVTDLIAERSAEAAGASVYLLRHPDNYPHHLPSARFDPAESARLAEFLDHVDVAVSLHGYDRIGRSTQLLAGGRNRALAAHLARHIQLPGYRVVTDLAAIPEELRGLHPDNPVNRVRDGGTQLELSIRVRGLGPRSTLPGVGGMSPVTATLVQGLVTAARSW
Prediction	CCCCCEEEEEEHCCCCHHHHHHHCCCCCCEEEEEHCCEEEEEHCCCCCEEEHCCCCEEEEEEEHCCHHHHHHHHHHHCCCCCCEEEEEEEEHCCEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEHCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCEEEHCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
Conf.Score	999868999974579989999988987545789988958998567766588669967999999879999999888758887757999999988967999999768888899998999999999999899999999987667777776666666555557788876467765787557886799975799877677999999998579679998679998656777779958999999998766679998567788998589985888899999999999859767655566876678899888777889986799858999998755788887778777569999999999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPDRRHPYFAYGSNLCAHQMASRCPDAGAPRPAVLSDHNWLINQRGVATVEPFAGNKVHGVLWQLSERDLVRLDSAEGVPVRYRRERLTVHTDDTALPAWVYIDHRVMPGRPRPGYLPRVIDGARHHGLPQRWIDYLHRWDPARWPLPVLPSSRSGPAPQSLSELLSQPGVIETSQLRSRFGFLAIHGGGLEQVTDLIAERSAEAAGASVYLLRHPDNYPHHLPSARFDPAESARLAEFLDHVDVAVSLHGYDRIGRSTQLLAGGRNRALAAHLARHIQLPGYRVVTDLAAIPEELRGLHPDNPVNRVRDGGTQLELSIRVRGLGPRSTLPGVGGMSPVTATLVQGLVTAARSW
Prediction	577532001000000226103620240420020202201000232000001235733010000203460052003112144204324030304533020000024535523026302410140046140265004202424334342423444343434433443465344242443433000000131301410140043007412000000224634410000240236203301522641310000001344463310000032550152026205734040334256345403042550000225510000001350063016444344643443334104201500464
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCEEEEEEHCCCCHHHHHHHCCCCCCEEEEEHCCEEEEEHCCCCCEEEHCCCCEEEEEEEHCCHHHHHHHHHHHCCCCCCEEEEEEEEHCCEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEHCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCEEEHCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
MPDRRHPYFAYGSNLCAHQMASRCPDAGAPRPAVLSDHNWLINQRGVATVEPFAGNKVHGVLWQLSERDLVRLDSAEGVPVRYRRERLTVHTDDTALPAWVYIDHRVMPGRPRPGYLPRVIDGARHHGLPQRWIDYLHRWDPARWPLPVLPSSRSGPAPQSLSELLSQPGVIETSQLRSRFGFLAIHGGGLEQVTDLIAERSAEAAGASVYLLRHPDNYPHHLPSARFDPAESARLAEFLDHVDVAVSLHGYDRIGRSTQLLAGGRNRALAAHLARHIQLPGYRVVTDLAAIPEELRGLHPDNPVNRVRDGGTQLELSIRVRGLGPRSTLPGVGGMSPVTATLVQGLVTAARSW

3a9lA

0.24

0.13

0.55

1.55

MUSTER

------------------------------------------------------------------------------------------------------------------------------------------------------TDTYPNIEALENAETVGVAYNIEVKRQNPSMIYFSPHAGGIEVGTTELIYRVVELTGGSLYLFQGSGNSRLHVTSTHFDEPMAVCMLSKH---TDAVSFHGYKDD-YNKNTLVGGLNTELRNLIVSKLNSKGIAAEV----ATDRFTATDPDNIVNRCASGGVQLEISSAQRRAFFQNNDWSKANRGNVT-QEFLDYAEAIKEA

2rbhA

0.27

0.12

0.44

1.03

MUSTER

--EESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQAGVKGMYVVIEVKVATQEGEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEE-----IEDIIKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3a9lA

0.25

0.14

0.55

2.45

dPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------TDTYPNIEALENAETVGVAYNIEVKRQNPSMIYFSPHAGGIEVGTTELIYRVVELTGGSLYLFQGSGNSRLHVTSTHFDE---PMAVCMLSKHTDAVSFHGYKDDY-NKNTLVGGLNTELRNLIVSKLNSKGIAAEV----ATDRFTATDPDNIVNRCASGGVQLEISSAQRRAFFQNNDWSKANRGNVT-QEFLDYAEAIKEA

2rbhA

0.27

0.12

0.44

1.69

dPPAS

--EESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQAGVKSGYVVIEVKVATQEGEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3a9lA

0.24

0.13

0.55

3.28

wdPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------TDTYPNIEALENAETVGVAYNIEVKRQNPSMIYFSPHAGGIEVGTTELIYRVVELTGGSLYLFQGSGNSRLHVTSTHFDE---PMAVCMLSKHTDAVSFHGYKDD-YNKNTLVGGLNTELRNLIVSKLNSKGIAAEV----ATDRFTATDPDNIVNRCASGGVQLEISSAQRRAFFQNNDWS-KANRGNVTQEFLDYAEAIKEA

2rbhA

0.27

0.12

0.44

2.24

wdPPAS

--EESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQAGVKGMYVVIEVKVATQEGEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3a9lA

0.23

0.13

0.55

1.87

wMUSTER

-------------------------------------------------------------------------------------------------------------------------------------------------------DTYPNIEALENAETVGVAYNIEVKRQNPSMIYFSPHAGGIEVGTTELIYRVVELTGGSLYLFQGSGNSRLHVTSTHFDEPMAVCMLSKH---TDAVSFHGYKDD-YNKNTLVGGLNTELRNLIVSKLNSKGIAAEV----ATDRFTATDPDNIVNRCASGGVQLEISSAQRRAFFQNNDWSKANRGN-VTQEFLDYAEAIKEA

2rbhA

0.27

0.12

0.44

1.20

wMUSTER

---ESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQAGVKGMYVVIEVKVATQEGEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEE-----IEDIIKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3a9lA

0.23

0.13

0.55

3.36

wPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------TDTYPNIEALENAETVGVAYNIEVKRQNPSMIYFSPHAGGIEVGTTELIYRVVELTGGSLYLFQGSGNSRLHVTSTHFDEPMAVCMLSK----TDAVSFHGYKDD-YNKNTLVGGLNTELRNLIVSKLNSKGIAAEV----ATDRFTATDPDNIVNRCASGGVQLEISSAQRRAFFQNNDWS-KANRGNVTQEFLDYAEAIKEA

2rbhA

0.27

0.12

0.44

2.29

wPPAS

--EESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQAGVKGMYVVIEVKVATQEGEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.43

Estimated TM-score = 0.43±0.14

Estimated RMSD = 12.3±4.3Å

Download Model 2

C-score=-2.44

Download Model 3

C-score=-2.61

Download Model 4

C-score=-3.54

Download Model 5

C-score=-2.96

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3a9lA	0.514	1.79	0.254	0.545
2	1suvA	0.488	5.53	0.063	0.703
3	4tweA	0.480	5.78	0.058	0.703
4	1z8lA	0.478	5.68	0.052	0.695
5	1ayeA	0.478	4.80	0.072	0.638
6	1jqgA	0.477	4.77	0.053	0.633
7	2boaA	0.475	4.85	0.077	0.638
8	1pcaA	0.472	4.90	0.082	0.638
9	1kwmA	0.464	5.23	0.059	0.641
10	3d67A	0.458	5.15	0.087	0.638

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.25	8	4wcmA	ZN	Rep, Mult	187,192,250
2	0.12	4	2bo9A	VAL	Rep, Mult	188,225,226,263,314,316
3	0.03	1	3rbhA	C8E	Rep, Mult	10,63
4	0.03	1	2c6pA	UUU	Rep, Mult	120,123,124,127
5	0.03	1	2c41G	CL	Rep, Mult	113,117
6	0.03	1	3jucA	PCA	Rep, Mult	10,11,12,13,14,48,77,83
7	0.03	1	3dgvB	UUU	Rep, Mult	4,26,66,67,68

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2hb6B	0.408	4.30	0.051	0.520	3.4.11.1	NA
2	0.060	1cpbA	0.117	3.99	0.095	0.147	3.4.17.2	63,102
3	0.060	1z8lA	0.478	5.68	0.052	0.695	3.4.17.21	NA
4	0.060	1gytJ	0.406	4.27	0.041	0.520	3.4.11.1	76
5	0.060	2boaA	0.475	4.85	0.077	0.638	3.4.17.-	NA
6	0.060	3fedA	0.474	5.57	0.044	0.684	3.4.17.21	NA
7	0.060	3kzwA	0.410	4.31	0.039	0.523	3.4.11.1	79
8	0.060	1pcaA	0.472	4.90	0.082	0.638	3.4.17.1	NA
9	0.060	1pytA	0.118	4.35	0.043	0.152	3.4.17.1	87
10	0.060	2ecfA	0.412	6.64	0.062	0.678	3.4.14.5	NA
11	0.060	1ayeA	0.478	4.80	0.072	0.638	3.4.17.15	NA
12	0.060	1pytB	0.383	4.59	0.068	0.514	3.4.17.1	NA
13	0.060	3h8eA	0.402	4.33	0.053	0.511	3.4.11.1	59
14	0.060	1cpbB	0.286	4.47	0.127	0.376	3.4.17.2	NA
15	0.060	1jqgA	0.477	4.77	0.053	0.633	3.4.17.1	NA
16	0.060	3dgvA	0.458	5.14	0.076	0.638	3.4.17.20	NA
17	0.060	1gytA	0.405	4.21	0.044	0.517	3.4.11.1	NA
18	0.060	3gpbA	0.397	6.24	0.042	0.630	2.4.1.1	NA
19	0.060	1ob2A	0.291	6.98	0.031	0.508	3.6.1.48	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.362	4.66	0.04	0.48	1ampA	GO:0004177 GO:0005576 GO:0006508 GO:0008233 GO:0016787 GO:0046872
1	0.07	0.514	1.79	0.25	0.55	3a9lA	GO:0016787 GO:0046872
2	0.07	0.488	5.53	0.06	0.70	1cx8A	GO:0001558 GO:0001618 GO:0001666 GO:0001948 GO:0003725 GO:0004998 GO:0005576 GO:0005615 GO:0005739 GO:0005768 GO:0005886 GO:0005887 GO:0005905 GO:0006879 GO:0006897 GO:0006898 GO:0006953 GO:0007568 GO:0007584 GO:0009897 GO:0009986 GO:0010033 GO:0010035 GO:0010039 GO:0010042 GO:0016020 GO:0016021 GO:0016023 GO:0016032 GO:0016323 GO:0030316 GO:0030544 GO:0032526 GO:0033570 GO:0033572 GO:0035690 GO:0042127 GO:0042470 GO:0042802 GO:0042803 GO:0043231 GO:0044822 GO:0045780 GO:0046688 GO:0046718 GO:0048471 GO:0051087 GO:0055037 GO:0055038 GO:0070062 GO:0072562 GO:0097286 GO:1903561 GO:1990712
3	0.07	0.479	5.72	0.05	0.70	5f09A	GO:0003824 GO:0004180 GO:0004181 GO:0005737 GO:0005886 GO:0005887 GO:0006508 GO:0006760 GO:0008152 GO:0008233 GO:0008237 GO:0008652 GO:0009986 GO:0016020 GO:0016021 GO:0016787 GO:0016805 GO:0035609 GO:0046872 GO:0070062 GO:1904492 GO:1904493
4	0.07	0.480	5.78	0.06	0.70	4tweA	GO:0003824 GO:0004180 GO:0005886 GO:0006508 GO:0008152 GO:0008233 GO:0008237 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0016805 GO:0046872
5	0.07	0.474	5.57	0.04	0.68	3fedA	GO:0003824 GO:0004180 GO:0005886 GO:0006508 GO:0008152 GO:0008233 GO:0008236 GO:0008237 GO:0008239 GO:0008652 GO:0016020 GO:0016021 GO:0016787 GO:0016805 GO:0042135 GO:0046872 GO:0050129
6	0.07	0.435	5.67	0.04	0.63	2ek8A	GO:0004177 GO:0006508 GO:0046872
7	0.06	0.436	5.86	0.03	0.66	4r12A	GO:0016020 GO:0016021 GO:0016485 GO:0046872
8	0.06	0.432	5.71	0.04	0.64	3iibA	GO:0046872
9	0.06	0.322	6.85	0.07	0.56	1mabB	GO:0000166 GO:0000275 GO:0005509 GO:0005524 GO:0005739 GO:0005743 GO:0005753 GO:0006754 GO:0006810 GO:0006811 GO:0006898 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016787 GO:0016820 GO:0016887 GO:0030228 GO:0033178 GO:0045261 GO:0046034 GO:0046933
10	0.06	0.274	7.11	0.02	0.49	3eifA	GO:0004252 GO:0005618 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016787
11	0.06	0.278	7.05	0.02	0.49	2g50D	GO:0000166 GO:0000287 GO:0003824 GO:0004743 GO:0005524 GO:0005634 GO:0005737 GO:0006096 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0030955 GO:0046872
12	0.06	0.271	6.85	0.03	0.46	3itgB	GO:0000986 GO:0001141 GO:0003677 GO:0003700 GO:0003824 GO:0003842 GO:0004029 GO:0004657 GO:0006351 GO:0006355 GO:0006560 GO:0006561 GO:0008152 GO:0009898 GO:0010133 GO:0016491 GO:0016620 GO:0043565 GO:0045892 GO:0050660 GO:0055114
13	0.06	0.253	6.46	0.04	0.42	3qedB	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046872
14	0.06	0.369	4.56	0.05	0.48	1f2oA	GO:0004177 GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0016787 GO:0046872
15	0.06	0.289	5.66	0.07	0.43	3nrgA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
16	0.06	0.248	6.88	0.04	0.42	2rduA	GO:0001561 GO:0003824 GO:0003973 GO:0005102 GO:0005777 GO:0005782 GO:0006979 GO:0008891 GO:0010181 GO:0016491 GO:0046296 GO:0046487 GO:0047969 GO:0052852 GO:0052853 GO:0052854 GO:0055114
17	0.06	0.261	6.26	0.04	0.42	4j4wA	GO:0003723 GO:0019013
18	0.06	0.262	6.12	0.08	0.42	3ov9A	GO:0003723 GO:0019012 GO:0019013 GO:0019028 GO:0019029

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0003824
GO-Score	0.56	0.39
Biological Processes	GO:0019538
GO-Score	0.46
Cellular Component	GO:0071944
GO-Score	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.