I-TASSER results

I-TASSER results for job id Rv0915c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (423 residues)
MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSYGSVVSTLIVEPWMGP
AAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSL
VAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPA
AAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQVGS
AQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYGNAGGLGPTQGHPLSS
ATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGA
DPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTDGQEDGRKPPVVVIREQPPPGN
PPR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTDGQEDGRKPPVVVIREQPPPGNPPR
Prediction	CCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHCCCCCCCCCHHCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	986558856666655579995899999999999999999999999999999875778888999999999999999999999999999999999999999998699999999999999999998766666889999999999998888999999999999988768888998888988876655555566677665554455554455677787766556677666544455456666677665555555565666665555556665544445555555556666666667667777777777777777777888775555677777677788988888888777777777888888888888888888888887777777888888888887777877888888877666678899888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTDGQEDGRKPPVVVIREQPPPGNPPR
Prediction	541001000100010100100000200020023003302200310110001010331111001001100320130012003304420320310000011012011323302301320010000001000000003011303523130020010112001112324323412532446333443443443232333322222232333223302331332222222322202332223223333333233323223333332333222312131222332322222221111223233232223223332121121110001112113003000012111232223321231222324333323334331212121111011211122223344444445445434423344355444676468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHCCCCCCCCCHHCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTDGQEDGRKPPVVVIREQPPPGNPPR

2g38B

0.34

0.14

0.41

1.48

MUSTER

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2d4yA

0.08

0.95

1.02

Env-PPAS

----------DAFITNQ---LRGAQNQSSGLTTRYEQMSKIDNLLADKSSSLSG-SLQSFFTSLQTLVSNAEPAARQALIGKAEGLVNQFKTTDQYLRDQDKQV--NIAIGSSVAQINNYAKQ--IANLNDQISRMTNDLLDQRDQLVSELNKIQGSTARQLAAVPSSADPTRTTVAYVDEAAGNIEIPEKLLNTGSLGGLLTFRSQDLDQTRNTLGQLALAFADAFNAQHTKGYDADGNKGKDFFSIGSPVVYSNSNNADKTVSLTAKVVDSTKVQATDYKIVFDGTDWQVTRTADNTTFTATKDADGKLEIDGLKVTVGTGAQKNDSFLLKPVSNAIVDMNVKVTNEAEIAMASESKLSDNRNGQALLDLQNSNVVGGNKTFNDAYATLVSDVGNKTSTLKTSSTTQANVVKQLYKQ---Q

2g38B

0.34

0.14

0.41

1.77

dPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.35

0.14

0.40

2.93

wdPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.35

0.14

0.40

1.95

wMUSTER

--FEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.35

0.14

0.40

4.39

wPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.34

0.14

0.41

3.80

dPPAS2

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.35

0.14

0.40

3.39

PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.34

0.14

0.41

4.01

Env-PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2d4yA

0.09

0.08

0.95

0.83

MUSTER

IT------QLRGAQNQ----SSGLTTRYEQMSKIDNLLADKSSSLSGSLQSFF------TSLQTLVSNAED-PAARQALIGKAEGLVNQFKTTDQYLRDQDKQV--NIAIGSSVAQINNYAKQ--IANLNDQISRMTNDLLDQRDQLVSELNKIQGSTARQLAAVPSSADPTRTTVAYVDEAAGNIEIPEKLLNTGSLGGLLTFRSQDLDQTRNTLGQLALAFADAFNAQHTKGYDADGNKGKDFFSIGSPVVYSNSNNADKTVSLTAKVVDSTKVQATDYKIVFDGTDWQVTRTADNTTFTATKDADGKLEIDGLKVTVGTGAQKNDSFLLKPVSNAIVDMNVKVTNEAEIAMASESKLSDNRNGQALLDLQNSNVVGGNKTFNDAYATVSDVGNKTSTLKTSSTTQANVVKQLYKQQQS--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.47

Estimated TM-score = 0.43±0.14

Estimated RMSD = 12.9±4.2Å

Download Model 2

C-score=-0.95

Download Model 3

C-score=-1.23

Download Model 4

C-score=-1.39

Download Model 5

C-score=-1.61

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2g38B	0.403	0.70	0.349	0.407
2	4kf7A	0.400	7.05	0.036	0.650
3	3k07A	0.398	7.10	0.038	0.671
4	2rdyA	0.397	6.86	0.052	0.645
5	2eabA	0.393	6.94	0.039	0.638
6	4c2mA	0.393	6.59	0.032	0.596
7	2j5wA	0.392	6.50	0.059	0.617
8	4k0eA	0.390	7.17	0.059	0.657
9	2xsgA	0.386	7.08	0.060	0.648
10	5furI	0.385	7.33	0.041	0.657

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3iilA	MG	Rep, Mult	8,9
2	0.06	3	3bvxA	MPD	Rep, Mult	147,148,151
3	0.04	2	3c9iC	XE	Rep, Mult	110,113
4	0.04	2	4zzbA	XE	Rep, Mult	110,140,143,144
5	0.03	1	2g381	III	Rep, Mult	3,14,15,17,18,19,20,23,24,27,30,31,33,34,37,38,40,41,44,45,48,52,57,65,72,75,83,86,90,97,154,155,158,162,164,165,167,168,170,171,173
6	0.02	1	3pyoN	MG	Rep, Mult	108,112
7	0.02	1	2jstA	HLT	Rep, Mult	31,69
8	0.02	1	3sjqC	PHU	Rep, Mult	100,103
9	0.02	1	2a6hD	STD	Rep, Mult	87,90,91,95
10	0.02	1	3rk2B	CA	Rep, Mult	95,98
11	0.02	1	3k7tA	GP7	Rep, Mult	19,20
12	0.02	1	1cxpA	UUU	Rep, Mult	75,76
13	0.02	1	1vd5A	GLY	Rep, Mult	117,133
14	0.02	1	2g38B	MN	Rep, Mult	149,152,153
15	0.02	1	1zyrN	STD	Rep, Mult	84,87,88,92
16	0.02	1	2q67A	CA	Rep, Mult	104,105
17	0.02	1	1lghA	DET	Rep, Mult	35,42
18	0.02	1	1y66B	DIO	Rep, Mult	129,132,133
19	0.02	1	2p9i3	III	Rep, Mult	139,141,142,144,147,148,150,152
20	0.02	1	2ppbN	STD	Rep, Mult	64,67,68,69,72

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3ebgA	0.370	7.04	0.043	0.619	3.4.11.-	NA
2	0.060	2r72A	0.383	6.89	0.042	0.634	2.7.7.48	43
3	0.060	1n1hA	0.349	7.08	0.039	0.589	2.7.7.48	12
4	0.060	3iayA	0.354	7.32	0.069	0.586	2.7.7.7	NA
5	0.060	1ea0A	0.303	7.59	0.049	0.534	1.4.1.13	NA
6	0.060	1ynnD	0.356	6.58	0.046	0.551	2.7.7.6	38
7	0.060	3ffzA	0.380	6.62	0.039	0.601	3.4.24.69	NA
8	0.060	1mhsA	0.357	6.00	0.040	0.525	3.6.3.6	221
9	0.060	1ug9A	0.342	6.69	0.075	0.546	3.2.1.70	NA
10	0.060	2qnoA	0.339	7.15	0.055	0.567	3.2.1.4	NA
11	0.060	2zr3B	0.342	6.18	0.053	0.515	6.1.1.11	86
12	0.060	3btaA	0.373	7.00	0.011	0.608	3.4.24.69	85
13	0.060	3iydD	0.367	6.72	0.053	0.575	2.7.7.6	NA
14	0.060	2j5wA	0.392	6.50	0.059	0.617	1.16.3.1	NA
15	0.060	2jfdA	0.274	7.19	0.075	0.456	2.3.1.85	NA
16	0.060	3b8eC	0.297	7.63	0.034	0.527	3.6.3.9	42
17	0.060	3b8eA	0.310	7.64	0.035	0.558	3.6.3.9	NA
18	0.060	2np0A	0.368	6.65	0.057	0.579	3.4.24.69	85
19	0.060	2eabA	0.393	6.94	0.039	0.638	3.2.1.63	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.23	0.396	1.39	0.34	0.41	4kxrB	GO:0005576 GO:0009405 GO:0009986
1	0.06	0.400	7.05	0.04	0.65	4kf7A	GO:0005643 GO:0006406 GO:0006606 GO:0006999 GO:0017056 GO:0031990 GO:0044611
2	0.06	0.381	7.03	0.07	0.64	3d9bA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
3	0.06	0.390	7.17	0.06	0.66	4k0eA	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
4	0.06	0.406	6.58	0.06	0.65	4k0eC	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
5	0.06	0.379	7.16	0.06	0.64	2v50D	GO:0005215 GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0016020 GO:0016021 GO:0046677
6	0.06	0.389	6.99	0.05	0.64	3w9iF	GO:0005215 GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0016020 GO:0016021 GO:0046677
7	0.06	0.331	7.67	0.04	0.58	3nogA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
8	0.06	0.383	7.19	0.05	0.65	4dnrA	GO:0005215 GO:0005375 GO:0005507 GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0006825 GO:0006878 GO:0008324 GO:0010272 GO:0010273 GO:0015080 GO:0015673 GO:0015679 GO:0016020 GO:0016021 GO:0046688 GO:0060003 GO:1902601
9	0.06	0.383	7.11	0.06	0.64	4k0eB	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
10	0.06	0.380	7.19	0.06	0.64	4mt1A	GO:0005215 GO:0006810 GO:0016020 GO:0016021
11	0.06	0.256	7.24	0.09	0.44	3c7aA	GO:0000166 GO:0016491 GO:0047830 GO:0050662 GO:0055114
12	0.06	0.230	6.59	0.03	0.36	5en5C	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
13	0.06	0.273	6.45	0.04	0.43	4qdhA	GO:0001932 GO:0002224 GO:0002237 GO:0002376 GO:0002730 GO:0002755 GO:0004888 GO:0005149 GO:0005737 GO:0005764 GO:0005768 GO:0005783 GO:0005789 GO:0005886 GO:0006954 GO:0006955 GO:0007165 GO:0007252 GO:0007409 GO:0009615 GO:0010628 GO:0016020 GO:0016021 GO:0016323 GO:0016324 GO:0030277 GO:0031410 GO:0032009 GO:0032088 GO:0032640 GO:0032715 GO:0032717 GO:0032722 GO:0032725 GO:0032728 GO:0032733 GO:0032735 GO:0032741 GO:0032755 GO:0032757 GO:0032760 GO:0034122 GO:0034123 GO:0034162 GO:0035197 GO:0042346 GO:0043123 GO:0043507 GO:0045078 GO:0045087 GO:0045335 GO:0045356 GO:0045359 GO:0045944 GO:0050707 GO:0050727 GO:0050729 GO:0050829 GO:0050864 GO:0051092 GO:0051607 GO:0051770 GO:1901895 GO:1902350
14	0.06	0.239	7.16	0.08	0.40	1k9xA	GO:0004180 GO:0004181 GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872 GO:0050897
15	0.06	0.340	6.41	0.05	0.52	4moaA	GO:0005102 GO:0006952 GO:0009405 GO:0030435
16	0.06	0.294	7.27	0.06	0.50	4dozA	GO:0000166 GO:0003723 GO:0005737 GO:0046872 GO:0051607
17	0.06	0.232	6.63	0.05	0.36	4q0mA	GO:0004067 GO:0006520
18	0.06	0.207	7.16	0.02	0.35	4iixA	GO:0016787 GO:0030153

Consensus prediction of GO terms

Molecular Function	GO:0042802	GO:0017056	GO:0015307
GO-Score	0.07	0.07	0.07
Biological Processes	GO:0051704	GO:0051234
GO-Score	0.46	0.36
Cellular Component	GO:0044464
GO-Score	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.