I-TASSER results

I-TASSER results for job id Rv0899

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (326 residues)
MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAIGYGAFERPQSVTGPT
GVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNV
IDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAAT
STWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEIL
NRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGL
GSVNPIASNATPEGRAKNRRVEIVVN

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAIGYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN
Prediction	CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCEEEEEEEHCCHHHHHHHHHHHHHHHCCCCEEEEEEEHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHCCEEEEEHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCEEHCCCCCHCCHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHCCCCCCCCCCCCHHHHHHCCEEEEEHC
Conf.Score	98888888898865455666778766776545666665555545666655554444566666677777766777778865466765797799999977868899999999999778876998677656777777545555555444457747999886899975567755566777776467887766555444455677777776665544457898779667678854479799999999999999889969999987699999999999999999999999999899866579997788999999999989887887999989
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAIGYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN
Prediction	74444445444245525434402522342111001101130211313423434442543434144244443443451323211033563302020302363114402520462134524021304136424534134234213331414513030444303130414466445413532544245352354254356336544575515624540341245503233431403560352044005103715714030001021403560325004400510151037340567203030214731113162660243101010418
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCEEEEEEEHCCHHHHHHHHHHHHHHHCCCCEEEEEEEHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHCCEEEEEHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCEEHCCCCCHCCHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHCCCCCCCCCCCCHHHHHHCCEEEEEHC
MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAIGYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

2.57

MUSTER

--------------------------------------------------------------------------SALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

2.91

dPPAS

--------------------------------------------------------------------------SALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

6.04

wdPPAS

--------------------------------------------------------------------------SALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

3.12

wMUSTER

---------------------------------------------------------------------------ALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

6.29

wPPAS

--------------------------------------------------------------------------SALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

6.76

dPPAS2

--------------------------------------------------------------------------SALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

5.06

PPAS

--------------------------------------------------------------------------SALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2l26A

1.00

0.77

5.46

Env-PPAS

--------------------------------------------------------------------------SALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2kgwA

1.00

0.40

1.41

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

2kgwA

1.00

0.40

1.58

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.18

Estimated TM-score = 0.46±0.15

Estimated RMSD = 11.5±4.5Å

Download Model 2

C-score=-2.72

Download Model 3

C-score=-2.75

Download Model 4

C-score=-3.09

Download Model 5

C-score=-3.18

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1l2aA	0.396	6.05	0.044	0.638
2	1ffyA2	0.380	6.67	0.038	0.647
3	1gjwA	0.369	6.95	0.063	0.666
4	1v5dA	0.366	5.77	0.036	0.568
5	1i8qA	0.366	6.61	0.053	0.626
6	1ivsA	0.364	6.60	0.044	0.617
7	1ksdA	0.362	6.77	0.057	0.626
8	1js4A1	0.362	6.55	0.036	0.617
9	1ga2B	0.361	6.39	0.044	0.595
10	1jzsA	0.360	6.52	0.037	0.601

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.20	7	1js4A	CA	Rep, Mult	261,315,318,319
2	0.10	4	2d2mD	OXY	Rep, Mult	277,281
3	0.10	4	5i50B	NUC	Rep, Mult	270,273,274,277
4	0.05	2	4zdrB	TME	Rep, Mult	280,283
5	0.02	1	3prqX	CLA	Rep, Mult	273,280
6	0.02	1	1ga2B	BGC	Rep, Mult	283,285,323
7	0.02	1	1mxdA	ACR	Rep, Mult	240,243,258

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1tnzL	0.336	6.89	0.072	0.598	2.5.1.59	NA
2	0.060	1ffuB	0.345	6.08	0.062	0.552	1.2.99.2	NA
3	0.060	1mhyD	0.332	6.68	0.070	0.577	1.14.13.25	NA
4	0.060	1lwhA	0.344	7.18	0.049	0.623	2.4.1.25	NA
5	0.060	1ileA	0.354	6.82	0.055	0.598	6.1.1.5	NA
6	0.060	1fziA	0.327	6.38	0.021	0.528	1.14.13.25	NA
7	0.060	1nj1A	0.338	6.40	0.021	0.568	6.1.1.15	NA
8	0.060	1g59A	0.337	6.41	0.067	0.558	6.1.1.17	NA
9	0.060	1k32A	0.311	6.73	0.067	0.528	3.4.21.-	NA
10	0.060	1lj8A	0.335	6.80	0.049	0.583	1.1.1.67	273
11	0.060	1gz3A	0.342	6.58	0.047	0.586	1.1.1.38	NA
12	0.060	3c8yA	0.339	6.70	0.033	0.574	1.12.7.2	250,253
13	0.060	1g87B	0.361	6.37	0.044	0.598	3.2.1.4	NA
14	0.060	2tmdA	0.333	6.99	0.031	0.592	1.5.8.2	227
15	0.060	1nj6A	0.334	6.47	0.008	0.568	6.1.1.15	260,273
16	0.060	1kqfA	0.341	7.09	0.036	0.620	1.2.1.2	NA
17	0.060	1px8A	0.341	6.54	0.059	0.580	3.2.1.37	NA
18	0.060	1ksdA	0.362	6.77	0.057	0.626	3.2.1.4	275
19	0.060	1f1sA	0.368	6.74	0.066	0.638	4.2.2.1	288

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.394	6.49	0.05	0.66	4jjjA	GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016162 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030247 GO:0046872
1	0.06	0.354	6.82	0.06	0.60	1ileA	GO:0000166 GO:0002161 GO:0004812 GO:0004822 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006428 GO:0006450 GO:0008270 GO:0016874 GO:0046872
2	0.06	0.378	6.39	0.07	0.64	5bv9A	GO:0003824 GO:0004553 GO:0008810 GO:0016787 GO:0030245
3	0.06	0.303	7.43	0.05	0.57	4fusA	GO:0003824 GO:0004553 GO:0005975 GO:0008810 GO:0030245 GO:0030246 GO:0030247
4	0.06	0.395	6.40	0.06	0.65	4xwlA	GO:0000272 GO:0003824 GO:0004553 GO:0008152 GO:0008810 GO:0016162 GO:0016787 GO:0016798 GO:0030245
5	0.06	0.349	6.69	0.03	0.60	1f9dA	GO:0000272 GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245
6	0.06	0.349	6.44	0.04	0.58	3zgzD	GO:0000166 GO:0002161 GO:0004812 GO:0004823 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006429 GO:0006450 GO:0016874
7	0.06	0.339	6.71	0.06	0.58	4l0gA	GO:0000272 GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030248 GO:0046872
8	0.06	0.330	6.85	0.05	0.58	1a47A	GO:0003824 GO:0005576 GO:0005975 GO:0016740 GO:0016757 GO:0030246 GO:0043169 GO:0043895 GO:0046872 GO:2001070
9	0.06	0.370	6.54	0.03	0.62	1gaxA	GO:0000166 GO:0002161 GO:0004812 GO:0004832 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006438 GO:0006450 GO:0016874 GO:0046872
10	0.06	0.290	7.10	0.04	0.53	2bteA	GO:0000166 GO:0002161 GO:0004812 GO:0004823 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006429 GO:0006450 GO:0016874 GO:0046872
11	0.06	0.396	6.34	0.03	0.66	1l1yA	GO:0000272 GO:0003824 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0046872
12	0.06	0.337	6.96	0.05	0.60	3kflA	GO:0000166 GO:0000287 GO:0004812 GO:0004825 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006431 GO:0016874
13	0.06	0.363	6.93	0.03	0.63	3ziuA	GO:0000166 GO:0004812 GO:0004823 GO:0005524 GO:0006418 GO:0006429 GO:0016874
14	0.06	0.323	6.44	0.04	0.54	1u0bB	GO:0000166 GO:0004812 GO:0004817 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006423 GO:0008270 GO:0016874 GO:0046872
15	0.06	0.295	6.91	0.03	0.51	1obhA	GO:0000166 GO:0002161 GO:0004812 GO:0004823 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006429 GO:0006450 GO:0016874 GO:0046872
16	0.06	0.333	6.30	0.04	0.53	2x1lA	GO:0000166 GO:0004812 GO:0004825 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006431 GO:0016874
17	0.06	0.310	6.65	0.05	0.52	4mw1B	GO:0000166 GO:0004812 GO:0004825 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006431 GO:0016874
18	0.06	0.337	6.62	0.07	0.56	1a8hA	GO:0000049 GO:0000166 GO:0003723 GO:0004812 GO:0004825 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006431 GO:0016874 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0016798
GO-Score	0.47
Biological Processes	GO:0051275	GO:0030243
GO-Score	0.47	0.47
Cellular Component	GO:0005737
GO-Score	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.