I-TASSER results

I-TASSER results for job id Rv0891c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (285 residues)
MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARVRISALGSLDLRYHSLRCYAAPPD
VGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHLWQMCPEDMATAIAHLD
HTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQRTSLAPIRLRIGLHTGEV
QLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLPADAWLVDLGRHPLRGLPR
PEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRRAQIS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARVRISALGSLDLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHLWQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQRTSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLPADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRRAQIS
Prediction	CCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHCCEEEEEHCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHCCCEEHCCHHHHHHHHHHHCCCCEEEHCHHHHHHHHCHCCCCEEEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
Conf.Score	987765667887644566776656777548999999999999888777788888776566666657898999998757655555677658999998678847898859899999999999999999999999566677658889998599999999999999986879857788877645876876886567799999986899889988999999975567875899855578589888689999857876555555555555565568876666667647659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARVRISALGSLDLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHLWQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQRTSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLPADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRRAQIS
Prediction	431422434243424001001345532420330213010000022313434344342445234441024302520364445464526412000000201410200133462024004302510250046250233114120100000041022002001410442254030211021020224621010100000010022054110000330152047415451303412424036174113002023473654254144466435442345123012244238
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHCCEEEEEHCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHCCCEEHCCHHHHHHHHHHHCCCCEEEHCHHHHHHHHCHCCCCEEEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARVRISALGSLDLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHLWQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQRTSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLPADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRRAQIS

4yusA

0.18

0.17

0.93

1.81

MUSTER

IFFQILEGEAEKIDRIYERILADERHTDILWSMQTINLDENTDFLIRPIKVLLQTLTESHRILEKYTQPSIFKIISQGTNPLNIRPKAVEKIVFFSDIVSFSTFAEKPVEEVVSVVNSYFSVCTAIITRQGG--EVTKFIGDCVMAYFDGADQAIQASLDILMELERVLYSGIGLAKGKVIE-DYTILGDAVNVAARLEALTRSQALVFSSEVKNSATK----SWNFIWLTDSELKGKSESIDIYSIDNEMTRKSSGGLEIARN---------IGHYLERV----

4wp3A

0.26

0.16

0.61

2.86

dPPAS

-------------------------------------------------------------------VRSSIEELADWAEVERPDLARVTVVILFTDIEESTALNERIDRAWVKLISSHDKLVSDLVRRQSG--HVVKSQGDGFMVAFARPEQAVRCGIELQRALRREIRVRIGIHMGRSVRDD--LFGRNVAMAARVAAQAAGGEILVSQPVRDALSS---DGIRFDDGREVELKGFSGTYRLFAVLA------------------------------------

4wp3A

0.27

0.16

0.61

3.92

wdPPAS

------------------------------------------------------------------V-RSSIEELADWAEVERPDLARVTVVILFTDIEESTALNERIDRAWVKLISSHDKLVSDLVRRQSG--HVVKSQGDGFMVAFARPEQAVRCGIELQRALRREIRVRIGIHMGRSVRDD--LFGRNVAMAARVAAQAAGGEILVSQPVRDALSS---DGIRFDDGREVELKGFSGTYRLFAVLA------------------------------------

4yusA

0.18

0.16

0.93

2.47

wMUSTER

IFFQILEGEAEKIDRIYERILADERRMFPDWSMQTINLDENTDFLIRPIKVLLQTLTESHRILEKYTQPSIFKIISQGTNPLNIRPKAVEKIVFFSDIVSFSTFAEKPVEEVVSVVNSYFSVCTAIITRQGG--EVTKFIGDCVMAYFDGADQAIQASLDILMELERVLYSGIGLAKGKVIEGDYTILGDAVNVAARLEALTRSQALVFSSEVKNSATK----SWNFIWLTDSELKGKSESIDIYSIDNEMTRKSSGGLEIARN---------IGHYLERV----

4wp3A

0.27

0.16

0.61

4.25

wPPAS

------------------------------------------------------------------V--SSIEELADWAEVERPDLARVTVVILFTDIEESTALNERIDRAWVKLISSHDKLVSDLVRRQSG--HVVKSQGDGFMVAFARPEQAVRCGIELQRALRREIRVRIGIHMGRSVRDD--LFGRNVAMAARVAAQAAGGEILVSQPVRDALSS---DGIRFDDGREVELKGFSGTYRLFAVLA------------------------------------

4wp3A

0.26

0.16

0.61

5.89

dPPAS2

-------------------------------------------------------------------VRSSIEELADWAEVERPDLARVTVVILFTDIEESTALNERIDRAWVKLISSHDKLVSDLVRRQSG--HVVKSQGDGFMVAFARPEQAVRCGIELQRALRREIRVRIGIHMGRSVRDD--LFGRNVAMAARVAAQAAGGEILVSQPVRDALSS---DGIRFDDGREVELKGFSGTYRLFAVLA------------------------------------

4wp3A

0.26

0.16

0.61

3.54

PPAS

-------------------------------------------------------------------VRSSIEELADWAEVERPDLARVTVVILFTDIEESTALNERIDRAWVKLISSHDKLVSDLVRRQSG--HVVKSQGDGFMVAFARPEQAVRCGIELQRALRREIRVRIGIHMGRSVR--DDLFGRNVAMAARVAAQAAGGEILVSQPVRDALSS---DGIRFDDGREVELKGFSGTYRLFAVLA------------------------------------

4wp3A

0.26

0.16

0.61

4.75

Env-PPAS

-------------------------------------------------------------------VRSSIEELADWAEVERPDLARVTVVILFTDIEESTALNERIDRAWVKLISSHDKLVSDLVRRQSG--HVVKSQGDGFMVAFARPEQAVRCGIELQRALRREIRVRIGIHMGRSVR--DDLFGRNVAMAARVAAQAAGGEILVSQPVRDALS---SDGIRFDDGREVELKGFSGTYRLFAVLA------------------------------------

1y11A

0.15

0.13

0.86

1.71

MUSTER

RAQRFVELGLNPDQVVLVVRVLAEMRYTALEAIELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERA-AGKPLPGARQVTVAFADLVGFTQLGEVVAEELGHLAGRLAGLARDLT-APPV--WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEDGFQWSFAGPRRLRGIRGDVRLFRVRRG-----------------------------------

1y11A2

0.19

0.12

0.63

2.56

dPPAS

---------------------------------------------------------------METEAVNAGERAAGKP-----LPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPV--WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADFQWSFAGPRRLRGIRGDVRLFRVRRG-----------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.60

Estimated TM-score = 0.64±0.13

Estimated RMSD = 7.4±4.3Å

Download Model 2

C-score=-2.33

Download Model 3

C-score=-0.98

Download Model 4

C-score=-2.41

Download Model 5

C-score=-4.70

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4yusA	0.698	3.05	0.142	0.821
2	1fx2A	0.555	2.80	0.290	0.621
3	1y11A	0.554	3.58	0.134	0.660
4	2wz1A	0.533	2.55	0.181	0.597
5	2w01A	0.532	2.15	0.214	0.579
6	3r5gA	0.523	1.99	0.182	0.565
7	1ybtB	0.521	2.06	0.288	0.565
8	4wp3A	0.519	2.70	0.251	0.579
9	3uvjA	0.517	2.68	0.204	0.583
10	3et6A	0.516	2.42	0.188	0.575

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.38	49	4wp8B	ZDA	Rep, Mult	97,98,100,101,102,140,141,142,172
2	0.19	31	1wc0A	APC	Rep, Mult	95,138,145,186,187,188,192,193,196,197,236
3	0.09	10	2bw7A	ECS	Rep, Mult	95,97,140,143,193,196,197,199,200
4	0.08	12	1cs4B	FOK	Rep, Mult	101,102,105,140,141,142
5	0.02	4	1wc6A	MG	Rep, Mult	97,140,142,143
6	0.01	1	1y10D	CA	Rep, Mult	70,193
7	0.01	2	2gvdB	128	Rep, Mult	95,188,189,190,193,196,237
8	0.00	1	1fx2A	DTT	Rep, Mult	162,165,166,167,169,170,171,205,253

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.432	1wc4A	0.504	2.86	0.189	0.575	4.6.1.1	197
2	0.421	2wz1A	0.533	2.55	0.181	0.597	4.6.1.2	197
3	0.383	1cjkB	0.507	2.50	0.117	0.572	4.6.1.1	197
4	0.368	1fx4A	0.553	2.87	0.313	0.621	4.6.1.1	197
5	0.348	1fx2A	0.555	2.80	0.290	0.621	4.6.1.1	197
6	0.060	2pdaA	0.416	5.96	0.056	0.677	1.2.7.1	NA
7	0.060	2rnpC	0.309	6.57	0.008	0.537	2.7.7.6	NA
8	0.060	1qd1B	0.323	5.47	0.032	0.477	2.1.2.5,4.3.1.4	NA
9	0.060	1azsA	0.499	2.55	0.139	0.561	4.6.1.1	NA
10	0.060	3c46B	0.379	5.97	0.034	0.604	2.7.7.6	NA
11	0.060	1yk9A	0.492	2.51	0.185	0.558	4.6.1.1	197
12	0.060	1ub2A	0.402	6.23	0.056	0.677	1.11.1.7	NA
13	0.060	2w01A	0.532	2.15	0.214	0.579	4.6.1.2	197
14	0.060	2ow6A	0.401	6.49	0.046	0.681	3.2.1.114	NA
15	0.060	1i8qA	0.428	5.98	0.044	0.691	4.2.2.1	151
16	0.060	1b0pA	0.414	6.42	0.050	0.716	1.2.7.1	107
17	0.060	1mswD	0.381	4.77	0.026	0.533	2.7.7.6	NA
18	0.060	1rw9A	0.457	5.92	0.044	0.730	4.2.2.5	NA
19	0.060	3ciaA	0.400	5.68	0.049	0.621	3.4.11.-	NA
20	0.060	2cfmA	0.402	6.56	0.051	0.702	6.5.1.1	NA
21	0.060	1z1wA	0.448	5.78	0.064	0.709	3.4.11.-	NA
22	0.060	2pfdB	0.417	5.89	0.062	0.670	2.1.2.5,4.3.1.4	178
23	0.060	2g49A	0.310	6.12	0.045	0.516	3.4.24.56	NA
24	0.060	1hn0A	0.415	6.26	0.049	0.709	4.2.2.20	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.41	0.554	3.58	0.13	0.66	1y11A	GO:0000166 GO:0004016 GO:0005524 GO:0005622 GO:0005886 GO:0006171 GO:0007165 GO:0008289 GO:0009190 GO:0009268 GO:0009405 GO:0016829 GO:0016849 GO:0030145 GO:0035556 GO:0046872
1	0.31	0.499	2.55	0.14	0.56	1azsA	GO:0000166 GO:0004016 GO:0005524 GO:0005622 GO:0005886 GO:0005929 GO:0006171 GO:0007189 GO:0007193 GO:0007204 GO:0009190 GO:0016020 GO:0016021 GO:0016829 GO:0016849 GO:0019933 GO:0035556 GO:0042995 GO:0046872 GO:0061178 GO:0072372 GO:1904322
2	0.31	0.531	2.05	0.28	0.58	1ybtB	GO:0004016 GO:0004383 GO:0004601 GO:0005622 GO:0006171 GO:0006182 GO:0009190 GO:0016787 GO:0016849 GO:0030145 GO:0035556 GO:0042803 GO:0046872 GO:0098869
3	0.31	0.555	2.80	0.29	0.62	1fx2A	GO:0000166 GO:0004016 GO:0005524 GO:0005622 GO:0006171 GO:0009190 GO:0016020 GO:0016021 GO:0016829 GO:0016849 GO:0035556 GO:0046872
4	0.29	0.709	3.10	0.14	0.83	4yutA	GO:0005622 GO:0009190 GO:0009785 GO:0009882 GO:0016849 GO:0035556 GO:0071949
5	0.27	0.504	2.86	0.19	0.58	1wc4A	GO:0000155 GO:0000160 GO:0004016 GO:0005622 GO:0006171 GO:0007165 GO:0009190 GO:0016310 GO:0016772 GO:0016829 GO:0016849 GO:0018298 GO:0023014 GO:0035556 GO:0046872
6	0.26	0.553	2.87	0.31	0.62	1fx4A	GO:0000166 GO:0004016 GO:0005524 GO:0005622 GO:0006171 GO:0009190 GO:0016020 GO:0016021 GO:0016829 GO:0016849 GO:0035556 GO:0046872
7	0.26	0.507	2.50	0.12	0.57	1cjkB	GO:0000166 GO:0000287 GO:0004016 GO:0005524 GO:0005622 GO:0005737 GO:0005886 GO:0005887 GO:0006171 GO:0007188 GO:0007189 GO:0007193 GO:0008179 GO:0009190 GO:0016020 GO:0016021 GO:0016829 GO:0016849 GO:0019933 GO:0030145 GO:0030425 GO:0031683 GO:0035556 GO:0043234 GO:0045121 GO:0046872 GO:0046982 GO:1904322
8	0.25	0.515	2.68	0.20	0.58	4ni2A	GO:0000166 GO:0004016 GO:0004383 GO:0004872 GO:0005525 GO:0005737 GO:0005886 GO:0006182 GO:0007263 GO:0008015 GO:0008074 GO:0008217 GO:0009190 GO:0009635 GO:0014070 GO:0016829 GO:0016849 GO:0020037 GO:0030828 GO:0035556 GO:0043167 GO:0043234 GO:0046982 GO:0052565 GO:0060087
9	0.23	0.513	2.42	0.24	0.57	3mr7A	GO:0005622 GO:0009190 GO:0016787 GO:0016849 GO:0035556
10	0.23	0.533	2.53	0.26	0.59	4wp3C	GO:0004016 GO:0005622 GO:0006171 GO:0009190 GO:0016829 GO:0016849 GO:0035556
11	0.22	0.532	2.15	0.21	0.58	2w01A	GO:0004016 GO:0005622 GO:0005886 GO:0006171 GO:0007165 GO:0009190 GO:0016020 GO:0016021 GO:0016849 GO:0035556
12	0.20	0.516	2.42	0.19	0.58	3et6A	GO:0000166 GO:0004016 GO:0004383 GO:0005886 GO:0006182 GO:0007165 GO:0008074 GO:0009190 GO:0016829 GO:0016849 GO:0020037 GO:0035556
13	0.19	0.526	2.09	0.18	0.57	3r5gB	GO:0004016 GO:0005622 GO:0005886 GO:0006171 GO:0007165 GO:0009190 GO:0009405 GO:0016020 GO:0016021 GO:0016849 GO:0035556
14	0.15	0.532	2.40	0.18	0.59	4ni2B	GO:0000166 GO:0004016 GO:0004383 GO:0004872 GO:0005525 GO:0005737 GO:0005886 GO:0006182 GO:0007263 GO:0008015 GO:0008074 GO:0009190 GO:0016829 GO:0016849 GO:0020037 GO:0035556 GO:0038060 GO:0043231 GO:0046872 GO:0071732
15	0.14	0.504	2.84	0.20	0.58	4p2fA	GO:0000166 GO:0000287 GO:0004016 GO:0005524 GO:0005622 GO:0005886 GO:0006171 GO:0007165 GO:0009190 GO:0016020 GO:0016021 GO:0016829 GO:0016849 GO:0030145 GO:0035556 GO:0046872
16	0.07	0.538	3.85	0.12	0.66	4oyzA	GO:0000166 GO:0000287 GO:0003351 GO:0004016 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0005856 GO:0005886 GO:0005929 GO:0006171 GO:0007283 GO:0009190 GO:0015630 GO:0016020 GO:0016829 GO:0016849 GO:0030145 GO:0030424 GO:0030425 GO:0030426 GO:0031514 GO:0035556 GO:0042995 GO:0043025 GO:0043065 GO:0045177 GO:0045178 GO:0046872 GO:0048471 GO:0051117 GO:0071241 GO:0071890
17	0.06	0.295	6.94	0.01	0.57	4b52A	GO:0004222 GO:0006508 GO:0046872
18	0.06	0.300	6.28	0.04	0.51	3dwlA	GO:0000147 GO:0000166 GO:0003779 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005885 GO:0006897 GO:0030041 GO:0030479 GO:0032153 GO:0034314 GO:0044396 GO:0051285 GO:0051666 GO:1903475
19	0.06	0.231	6.12	0.04	0.39	1y44A	GO:0004518 GO:0004519 GO:0008033 GO:0008270 GO:0016787 GO:0016891 GO:0034414 GO:0042779 GO:0042781 GO:0046872 GO:0090502

Consensus prediction of GO terms

Molecular Function	GO:0004016	GO:0005524	GO:0030145	GO:0009881	GO:0050660	GO:0008289	GO:0016787	GO:0004601	GO:0004383	GO:0042803
GO-Score	0.81	0.72	0.59	0.57	0.57	0.41	0.31	0.31	0.31	0.31
Biological Processes	GO:0006171	GO:0071483	GO:0030522	GO:0009268	GO:0009405	GO:0007204	GO:0061178	GO:0007189	GO:1904322	GO:0019933	GO:0007193	GO:0098869	GO:0006182
GO-Score	0.81	0.57	0.57	0.41	0.41	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31
Cellular Component	GO:0005622	GO:0005886	GO:0016021	GO:0072372
GO-Score	0.86	0.59	0.52	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.