I-TASSER results

I-TASSER results for job id Rv0885

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (340 residues)
MDRTRIVRRWRRNMDVADDAEYVEMLATLSEGSVRRNFNPYTDIDWESPEFAVTDNDPRW
ILPATDPLGRHPWYQAQSRERQIEIGMWRQANVAKVGLHFESILIRGLMNYTFWMPNGSP
EYRYCLHESVEECNHTMMFQEMVNRVGADVPGLPRRLRWVSPLVPLVAGPLPVAFFIGVL
AGEEPIDHTQKNVLREGKSLHPIMERVMSIHVAEEARHISFAHEYLRKRLPRLTRMQRFW
ISLYFPLTMRSLCNAIVVPPKAFWEEFDIPREVKKELFFGSPESRKWLCDMFADARMLAH
DTGLMNPIARLVWRLCKIDGKPSRYRSEPQRQHLAAAPAA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDRTRIVRRWRRNMDVADDAEYVEMLATLSEGSVRRNFNPYTDIDWESPEFAVTDNDPRWILPATDPLGRHPWYQAQSRERQIEIGMWRQANVAKVGLHFESILIRGLMNYTFWMPNGSPEYRYCLHESVEECNHTMMFQEMVNRVGADVPGLPRRLRWVSPLVPLVAGPLPVAFFIGVLAGEEPIDHTQKNVLREGKSLHPIMERVMSIHVAEEARHISFAHEYLRKRLPRLTRMQRFWISLYFPLTMRSLCNAIVVPPKAFWEEFDIPREVKKELFFGSPESRKWLCDMFADARMLAHDTGLMNPIARLVWRLCKIDGKPSRYRSEPQRQHLAAAPAA
Prediction	CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
Conf.Score	9887765667887777666579999999999999986787656788898877889998888887677778678988999999999999999999999999999999999999985999889999999999999899999999999898889987689999988876557666799999999999999999999976898888999999999999999999999999999976887788999999999999999997578799999879999999999997989999999999999999999889887899999998999887655667654555455689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDRTRIVRRWRRNMDVADDAEYVEMLATLSEGSVRRNFNPYTDIDWESPEFAVTDNDPRWILPATDPLGRHPWYQAQSRERQIEIGMWRQANVAKVGLHFESILIRGLMNYTFWMPNGSPEYRYCLHESVEECNHTMMFQEMVNRVGADVPGLPRRLRWVSPLVPLVAGPLPVAFFIGVLAGEEPIDHTQKNVLREGKSLHPIMERVMSIHVAEEARHISFAHEYLRKRLPRLTRMQRFWISLYFPLTMRSLCNAIVVPPKAFWEEFDIPREVKKELFFGSPESRKWLCDMFADARMLAHDTGLMNPIARLVWRLCKIDGKPSRYRSEPQRQHLAAAPAA
Prediction	7542533443445242544540340043016303733131433020532625324742302044211021151056037622330011100010022010010002000110143352344020001001100200200020053241422424401420030042033332222000000000001210211045474031003200300130011013101510351057144130200020001000100200022243005516034620231036163124004300430041034020113202300320602354142444443533443568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
MDRTRIVRRWRRNMDVADDAEYVEMLATLSEGSVRRNFNPYTDIDWESPEFAVTDNDPRWILPATDPLGRHPWYQAQSRERQIEIGMWRQANVAKVGLHFESILIRGLMNYTFWMPNGSPEYRYCLHESVEECNHTMMFQEMVNRVGADVPGLPRRLRWVSPLVPLVAGPLPVAFFIGVLAGEEPIDHTQKNVLREGKSLHPIMERVMSIHVAEEARHISFAHEYLRKRLPRLTRMQRFWISLYFPLTMRSLCNAIVVPPKAFWEEFDIPREVKKELFFGSPESRKWLCDMFADARMLAHDTGLMNPIARLVWRLCKIDGKPSRYRSEPQRQHLAAAPAA

2jcdA

0.15

0.13

0.87

1.48

MUSTER

LATTWAARGWVEEEGIGS-----ATLGRLVRAWPRRA-NKADILDEWAD----YDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRTRRPPQPELVTYRRLRRVLADMPEQRDIAVLVWGAVAETCINALLALLARD-ATIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRAEEIVGDLRSTAGGTRLVRD-FSGARKMVEQLGLDDAVD-------------------------------

2jcdA

0.14

0.13

0.89

2.19

dPPAS

HLATTWAARGWVEEEGIGSATLGRLVRAWPRRAAVVNKADILD------EWADYDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRTRRPPQPELVTYRRLRRVLADMPEQRDIAVLVWGAVAETCINALLALLARDA-TIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRGAEEIVGDLRSTAGGTRLVRDFSGARKMVEQLGLDDAVD-------------------------------

2jcdA

0.15

0.13

0.87

4.17

wdPPAS

LATTWAARGWVEEEGIGS-----ATLGRLVRAWPRRA-NKADILDEWAD----YDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRT-RPPQPELVTYRRLRRVLADMPEQRDIAVLVWGAVAETCINALLALLARDA-TIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRGAEEIVGDLRSTAGGTRLVRDFSGARKMVEQLGLDDAVD-------------------------------

2jcdA

0.15

0.13

0.88

1.98

wMUSTER

LATTWAARGWVEEEGIGS-----ATLGRLVRAWPRRA-NKADILDEWAD----YDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRTRRPPQPELVTYRRLRRVLADMPEQRDIAVLVWGAVAETCINALLALLARD-ATIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRGAEEIVGDLRSTAGGTRLVRDFSGARKMVEQLGLDDAVD-------------------------------

2jcdA

0.16

0.14

0.87

3.07

wPPAS

LATTWAARGWVEEEGIGS-----ATLGRLVRAWPRRA-NKADILDEWAD----YDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRT-ISERPPQPELVTYRRLRRVLADMRDIAVLVWGAVAETCINALLALLARDA-TIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRGAEEIVGDLRSTAGGTRLVRDFSGARKMVEQLGLDDAVD-------------------------------

2jcdA

0.14

0.12

0.89

5.97

dPPAS2

HLATTWAARGWVEEEGIGSATLGRLVRAWPRRAAVVN--KADILDEWAD----YDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRTRRPPQPELVTYRRLRRVLADMPEQRDIAVLVWGAVAETCINALLALLARDA-TIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRGAEEIVGDLRSTAGGTRLVRDFSGARKMVEQLGLDDAVD-------------------------------

2jcdA

0.16

0.14

0.87

2.06

PPAS

LATTWAARGWVEEEGIGS-----ATLGRLVRAWPRRA-NKADILDEWAD----YDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRT-ISERPPQPELVTYRRLRRVLADMRDIAVLVWGAVAETCINALLALLARDA-TIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRGAEEIVGDLRSTAGGTRLVRDFSGARKMVEQLGLDDAVD-------------------------------

2jcdA

0.16

0.14

0.88

3.26

Env-PPAS

LATTWAARGWVEEEGIGS-----ATLGRLVRAWPRRAANKADILDEWAD----YDTLVPDYPLEIVPFAEHPLFLAAEPHQRQRVLTGMWIGYNERVIATEQLIAEPAFDLVMHGSDDPLIRKSVQQAIVDESFHTYMHMLAIDRTRISERPPQPELVTYRRLRRVLADMRDIAVLVWGAVAETCINALLALLARDA-TIQPMHSLITTLHLRDETAHGSIVVEVVRELYARMNEQQRRALVRCLPIALEAFAEQDLSALLLELNAAGIRGAEEIVGDLRSTAGGTRLVRDFSGARKMVEQLGLDDAVD-------------------------------

5hygA

0.12

0.09

0.79

1.38

MUSTER

----------------------NAVINRLVGNWHRRA-----AVKFD--------PGRPDFREDMIPFRGHPIWERLSDETRSRLLSWGWVAYNRNTVLIEQRIANPAFELVIGGLGGQQLELAVAQAMVDEQYHTLMHINGSAVT-SDFSPDSHITTIHQEHLDRCEEPWRSLTTLGFATVAEISINAYLDLLADDQEIQVVNSTTVKLHNRDEYCHASISGEMMKQVYEALPADRRRFLLEKVVAGLEAFVAPDFTTWESIVAFEGVPWEKAAAEVREAQGGTHLVQD-HSGIHTLLTEMDV------------------------------------

5hygA

0.12

0.10

0.79

2.04

dPPAS

----------------------NAVINRLVGNWHRRA-------------AVKFDPGRPDFREDMIPFRGHPIWERLSDETRSRLLSWGWVAYNRNTVLIEQRIANPAFELVIGGLGGQQLELAVAQAMVDEQYHTLMHINGSAVTRRVLPDSHITTIHQEHLDRCEEPWQRSLTTLGFATVAEISINAYLDLLADDQEIQVVNSTTVKLHNRDEYCHASISGEMMKQVYEALPADRRRFLLEKVVAGLEAFVAPDFTTWESIVAFEGVPGWEKAAAEVREAQGGTHLVQDHSGIHTLLTEMDV------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.57

Estimated TM-score = 0.64±0.13

Estimated RMSD = 7.7±4.3Å

Download Model 2

C-score=-0.87

Download Model 3

C-score=-1.73

Download Model 4

C-score=-0.68

Download Model 5

C-score=-1.88

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2jcdA	0.818	1.75	0.147	0.862
2	5hygA	0.732	2.00	0.112	0.788
3	1mhzD	0.644	4.34	0.078	0.829
4	1t0rA	0.634	4.53	0.067	0.835
5	3dhiA	0.633	4.50	0.071	0.835
6	2innA	0.617	4.43	0.074	0.815
7	1mhyB	0.604	4.72	0.060	0.815
8	1xmgC	0.604	4.79	0.053	0.821
9	1rsrB	0.590	4.39	0.081	0.759
10	1syyA	0.582	4.33	0.088	0.744

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.39	51	4n83B	MN	Rep, Mult	101,132,135,183,215
2	0.22	34	5k53A	FE	Rep, Mult	132,183,215,218
3	0.01	2	3chtA	4NB	Rep, Mult	93,97,100,101,132,183,190,211,215
4	0.01	1	1xvgA	BRJ	Rep, Mult	40,41,43,134,137,138
5	0.01	1	2jcd0	III	Rep, Mult	10,11,33,34,41,42,45,95,98,99,102,103,107,113,119,123,126,127,130,133,134,136,137,140,141,143,144,147,157
6	0.01	2	1xvbA	BHL	Rep, Mult	100,101,104,132,179,182,183,186,187,189,190,215

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.362	3ee4A	0.574	4.21	0.101	0.727	1.17.4.1	139
2	0.177	1uzrB	0.574	4.22	0.091	0.732	1.17.4.1	NA
3	0.067	1h0nA	0.567	4.20	0.083	0.718	1.17.4.1	NA
4	0.067	1smsA	0.570	4.05	0.072	0.721	1.17.4.1	NA
5	0.067	1syyA	0.582	4.33	0.088	0.744	1.17.4.1	139
6	0.060	2rccA	0.559	4.42	0.059	0.727	1.17.4.1	30
7	0.060	1rsrB	0.590	4.39	0.081	0.759	1.17.4.1	29,216,296
8	0.060	2bq1I	0.567	4.37	0.089	0.735	1.17.4.1	NA
9	0.060	1jk0A	0.576	4.10	0.073	0.729	1.17.4.1	NA
10	0.060	3fg3A	0.487	5.76	0.036	0.727	4.2.1.92,1.13.11.40	NA
11	0.060	1fziA	0.646	4.30	0.092	0.829	1.14.13.25	NA
12	0.060	1iw1A	0.403	3.97	0.074	0.509	1.14.99.3	NA
13	0.060	2qcxB	0.445	4.11	0.046	0.559	3.5.99.2	NA
14	0.060	1biqB	0.589	4.32	0.078	0.756	1.17.4.1	139
15	0.060	3no6A	0.405	4.37	0.033	0.529	3.5.99.2	177
16	0.060	1no3A	0.505	5.62	0.041	0.750	1.13.11.12	NA
17	0.060	2vuxB	0.533	3.95	0.076	0.665	1.17.4.1	NA
18	0.060	2p0mB	0.443	5.85	0.042	0.659	1.13.11.33	210
19	0.060	1mhyB	0.604	4.72	0.060	0.815	1.14.13.25	98,138
20	0.060	3hf1B	0.573	4.07	0.070	0.721	1.17.4.1	NA
21	0.060	2rgzB	0.410	4.51	0.075	0.550	1.14.99.3	128
22	0.060	2iukB	0.512	5.70	0.041	0.759	1.13.11.12	NA
23	0.060	1xvgC	0.603	4.79	0.053	0.821	1.14.13.25	98,138,219
24	0.060	3dy5A	0.466	5.58	0.033	0.676	1.13.11.40,4.2.1.92	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.646	4.30	0.09	0.83	1fziA	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0015050 GO:0015947 GO:0016491 GO:0046872 GO:0055114
1	0.24	0.571	4.28	0.06	0.72	4dr0B	GO:0004748 GO:0005971 GO:0006260 GO:0009186 GO:0009263 GO:0016491 GO:0046872 GO:0055114
2	0.22	0.633	4.50	0.07	0.84	3dhiA	GO:0004497 GO:0006725 GO:0016491 GO:0019439 GO:0042203 GO:0046872 GO:0055114
3	0.21	0.218	5.75	0.04	0.34	3k32B
4	0.16	0.818	1.75	0.15	0.86	2jcdA	GO:0046872
5	0.12	0.646	4.42	0.07	0.84	1mhyD	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0016491 GO:0046872 GO:0055114
6	0.08	0.528	4.12	0.10	0.67	3dhiB	GO:0004497 GO:0006725 GO:0016491 GO:0016709 GO:0019439 GO:0042203 GO:0055114
7	0.08	0.633	4.54	0.07	0.84	2innA	GO:0006725 GO:0016491 GO:0046872 GO:0055114
8	0.07	0.635	4.50	0.07	0.84	2incA	GO:0004497 GO:0006725 GO:0016491 GO:0046872 GO:0055114
9	0.07	0.604	4.72	0.06	0.81	1mhyB	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0016491 GO:0016709 GO:0055114
10	0.06	0.283	6.97	0.04	0.51	3eddA	GO:0003824 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046872 GO:0047798
11	0.06	0.303	6.95	0.04	0.53	2y27B	GO:0000166 GO:0003824 GO:0005524 GO:0008152 GO:0010124 GO:0016874 GO:0046872 GO:0047475
12	0.06	0.271	6.58	0.02	0.46	3eiwA
13	0.06	0.293	6.52	0.08	0.48	3gw3A	GO:0001889 GO:0004853 GO:0005654 GO:0005737 GO:0005829 GO:0006779 GO:0006782 GO:0006783 GO:0008198 GO:0010039 GO:0014070 GO:0014075 GO:0016829 GO:0016831 GO:0032355 GO:0042168 GO:0045471 GO:0046502 GO:0046689 GO:0051597 GO:0060992 GO:0071243
14	0.06	0.222	6.12	0.04	0.35	1q7fB	GO:0005622 GO:0005737 GO:0006417 GO:0006909 GO:0007400 GO:0007402 GO:0007405 GO:0007406 GO:0007411 GO:0007419 GO:0007420 GO:0008270 GO:0008285 GO:0008356 GO:0008582 GO:0009303 GO:0017148 GO:0022008 GO:0030182 GO:0030371 GO:0035282 GO:0043025 GO:0045179 GO:0045180 GO:0045182 GO:0046872 GO:0048477 GO:0050767 GO:0051726 GO:0055060 GO:1900242
15	0.06	0.211	5.50	0.04	0.31	1k4nA	GO:0005829
16	0.06	0.186	5.42	0.01	0.27	3wx8A	GO:0000166 GO:0000287 GO:0004550 GO:0005524 GO:0005525 GO:0005737 GO:0005856 GO:0005874 GO:0005875 GO:0005880 GO:0005886 GO:0006163 GO:0006165 GO:0006183 GO:0006220 GO:0006228 GO:0006241 GO:0006468 GO:0007017 GO:0007067 GO:0007424 GO:0007427 GO:0008017 GO:0009117 GO:0009142 GO:0016301 GO:0016310 GO:0016334 GO:0016740 GO:0018105 GO:0034332 GO:0035152 GO:0046777 GO:0046872
17	0.06	0.208	4.30	0.03	0.27	2lznA	GO:0000287 GO:0003677 GO:0003678 GO:0003896 GO:0003899 GO:0005524 GO:0006260 GO:0006269 GO:0008270 GO:0016740 GO:0016779 GO:0032508 GO:0046872 GO:1990077
18	0.06	0.181	5.90	0.03	0.28	3tfmA	GO:0000166 GO:0001726 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005547 GO:0005730 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005938 GO:0006810 GO:0008360 GO:0016020 GO:0016459 GO:0022409 GO:0030027 GO:0030175 GO:0030507 GO:0030705 GO:0030898 GO:0031527 GO:0032433 GO:0042995 GO:0043005 GO:0043025 GO:0051015 GO:0051489 GO:0060002

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0016709	GO:0061731
GO-Score	0.64	0.54	0.48
Biological Processes	GO:0055114	GO:0043446	GO:0009262	GO:0006259	GO:1901137	GO:0009165	GO:0034645	GO:0009132	GO:0042178	GO:0018970	GO:0072491
GO-Score	0.56	0.54	0.48	0.48	0.48	0.48	0.48	0.48	0.44	0.44	0.44
Cellular Component	GO:1990204	GO:0044445
GO-Score	0.54	0.48

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.