I-TASSER results

I-TASSER results for job id Rv0862c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (756 residues)
MTEHTPDIPLGSWLAALPDERLTQLLELRPDLAQPPPGSIAALAARAQARQSVKAATDEL
DFLRLAVFDALLVLQADTAPVPIVRLLAVIGDRAAQADVLGALADLKQRALAWGETAVRV
ATDAGTALPWHPGQVTLEGSSRSGDQLADLIAGLDPAQRDVLDKLLQGSPVGRTRDAAPG
APSDRPVPRLLAMGLLRRIDAETVILPRHVGQVLRGEQPGPMELTAPDPVVSTTTPDDAD
AAAAGAVIDLLREVDVLLENLGATPVAELRSGGLGVREFKRLAKATGIDEPRLGLILEIA
AAAGLIASGMPDPEPPHSDGPFWAPTVAADRFATMSPAERWHLLASAWLDLPGRPALIGT
RGPDAKPYGALSDSLFSTAAPLDRRLLLGMLAELPAGAGVDASRASATLIWRRPRWARRL
QPAPIADLLTEGHALGLVGRGAISTPARALLDEALEPATAPAAAVGVMARALPKPIDHFL
VQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFF
ANRSKTPVPQGLTYLIDDVARRHGQLRIGMAASFVRCEDPTLLAQVVAAPEADGLALRAL
APTVAVSPAPISEVLVTLRGAGFAPAAEDSTGAVVDVRTRGARVPTPQRRRPYRPPPRPN
SEALKAVVAVLREVTAAPFANVRVDPAVTMSLLQRAAKDQATLVISYLDAAGVATQRVVA
PITLRGGQLVAFDSSSGRLRDFAIHRITLVVSAHDR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTEHTPDIPLGSWLAALPDERLTQLLELRPDLAQPPPGSIAALAARAQARQSVKAATDELDFLRLAVFDALLVLQADTAPVPIVRLLAVIGDRAAQADVLGALADLKQRALAWGETAVRVATDAGTALPWHPGQVTLEGSSRSGDQLADLIAGLDPAQRDVLDKLLQGSPVGRTRDAAPGAPSDRPVPRLLAMGLLRRIDAETVILPRHVGQVLRGEQPGPMELTAPDPVVSTTTPDDADAAAAGAVIDLLREVDVLLENLGATPVAELRSGGLGVREFKRLAKATGIDEPRLGLILEIAAAAGLIASGMPDPEPPHSDGPFWAPTVAADRFATMSPAERWHLLASAWLDLPGRPALIGTRGPDAKPYGALSDSLFSTAAPLDRRLLLGMLAELPAGAGVDASRASATLIWRRPRWARRLQPAPIADLLTEGHALGLVGRGAISTPARALLDEALEPATAPAAAVGVMARALPKPIDHFLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDDVARRHGQLRIGMAASFVRCEDPTLLAQVVAAPEADGLALRALAPTVAVSPAPISEVLVTLRGAGFAPAAEDSTGAVVDVRTRGARVPTPQRRRPYRPPPRPNSEALKAVVAVLREVTAAPFANVRVDPAVTMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITLRGGQLVAFDSSSGRLRDFAIHRITLVVSAHDR
Prediction	CCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEHCCCCCEHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEHCCCEEEHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHCCCEEEHCCCCCHHHHHHHHHHHHHHCCCCEEEEEHCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEHCCEEEEEEHCCHHHHHHHHHCCHHHHHHCEHCCCCEEEHCCCHHHHHHHHHHHCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEEEEEEHCCEEEEEHCCCCCEEEEEEEEEEEEEHCCCC
Conf.Score	998889875999998799999999999887678999999999999997688999999869979999999999968999886599999986788878899999999999854337987455555555688887667888888999999999987999999999999988998657877888997579999999899656589879957988888747888998889998888888888888888999999999999999999978965546788667999999999899989999999999998976678888788888897687689999998899999999999999868787554678888898666778455677669999999999998889989999999999999788777767768999999999998854468776788888667777777757889998876898888599967978997899999999999998753447976999868999999999899999999999999589999769999999999878668745579999889999999998656777654344885998678899999999999998876789997554577777888888888888888888688999999875577787777778879999999999998997999998699987999999999968689999878996899997688998985799
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTEHTPDIPLGSWLAALPDERLTQLLELRPDLAQPPPGSIAALAARAQARQSVKAATDELDFLRLAVFDALLVLQADTAPVPIVRLLAVIGDRAAQADVLGALADLKQRALAWGETAVRVATDAGTALPWHPGQVTLEGSSRSGDQLADLIAGLDPAQRDVLDKLLQGSPVGRTRDAAPGAPSDRPVPRLLAMGLLRRIDAETVILPRHVGQVLRGEQPGPMELTAPDPVVSTTTPDDADAAAAGAVIDLLREVDVLLENLGATPVAELRSGGLGVREFKRLAKATGIDEPRLGLILEIAAAAGLIASGMPDPEPPHSDGPFWAPTVAADRFATMSPAERWHLLASAWLDLPGRPALIGTRGPDAKPYGALSDSLFSTAAPLDRRLLLGMLAELPAGAGVDASRASATLIWRRPRWARRLQPAPIADLLTEGHALGLVGRGAISTPARALLDEALEPATAPAAAVGVMARALPKPIDHFLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDDVARRHGQLRIGMAASFVRCEDPTLLAQVVAAPEADGLALRALAPTVAVSPAPISEVLVTLRGAGFAPAAEDSTGAVVDVRTRGARVPTPQRRRPYRPPPRPNSEALKAVVAVLREVTAAPFANVRVDPAVTMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITLRGGQLVAFDSSSGRLRDFAIHRITLVVSAHDR
Prediction	646644443014103614262013004101200202244021003103124002200430220000000000203362422203301410455144440340043013100001120000012011001110010113244242630340055035602400320171202020342245242540022001200011035300100120010011331232414215254452435302220010002002101300410373304103110000100220054170535200000000100000032234242464533100004103401624113001100100010011001013333543313100320222200300210030021024132131420131010000110320232003100300000000001110100000023234334244411520452025223100000200000124124401400220021114200000100340022004102405301400361073200220230032002211101023020000041340043014234044001320110000021415401510372310001022513224243432214434434344443424452032003102334434444444423200310130043423000000054343231202011031020000034463312000000000341568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEHCCCCCEHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEHCCCEEEHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHCCCEEEHCCCCCHHHHHHHHHHHHHHCCCCEEEEEHCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEHCCEEEEEEHCCHHHHHHHHHCCHHHHHHCEHCCCCEEEHCCCHHHHHHHHHHHCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEEEEEEHCCEEEEEHCCCCCEEEEEEEEEEEEEHCCCC
MTEHTPDIPLGSWLAALPDERLTQLLELRPDLAQPPPGSIAALAARAQARQSVKAATDELDFLRLAVFDALLVLQADTAPVPIVRLLAVIGDRAAQADVLGALADLKQRALAWGETAVRVATDAGTALPWHPGQVTLEGSSRSGDQLADLIAGLDPAQRDVLDKLLQGSPVGRTRDAAPGAPSDRPVPRLLAMGLLRRIDAETVILPRHVGQVLRGEQPGPMELTAPDPVVSTTTPDDADAAAAGAVIDLLREVDVLLENLGATPVAELRSGGLGVREFKRLAKATGIDEPRLGLILEIAAAAGLIASGMPDPEPPHSDGPFWAPTVAADRFATMSPAERWHLLASAWLDLPGRPALIGTRGPDAKPYGALSDSLFSTAAPLDRRLLLGMLAELPAGAGVDASRASATLIWRRPRWARRLQPAPIADLLTEGHALGLVGRGAISTPARALLDEALEPATAPAAAVGVMARALPKPIDHFLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDDVARRHGQLRIGMAASFVRCEDPTLLAQVVAAPEADGLALRALAPTVAVSPAPISEVLVTLRGAGFAPAAEDSTGAVVDVRTRGARVPTPQRRRPYRPPPRPNSEALKAVVAVLREVTAAPFANVRVDPAVTMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITLRGGQLVAFDSSSGRLRDFAIHRITLVVSAHDR

4bs9A

0.12

0.09

0.77

0.96

wPPAS

----------------------PTALQIKPHFVEIIEPKQVYLNHALTG-QLYCQILPFLN-------------GE-----TREQIVEKLDGQVPEEYIDFVLSRLVEKGYLTEVA---------PELS---------------LEVAAFWSELGIAPSVVAEGLKQPVTVTTAGKGIREGIVANLAAALEEAGIQVSDPTAQLQV------VLTDDYLQP-------------ELAAINKEALERQQPWLVGSILWL------PL--FVPGETGWHCLAQRLQGNREVEASVLQQKRALQERPTARATLPSTLQT-------GLQWAATEIAKWMVKRHLNAIAPGTARFPTLAGKI-QTTLELKAHPLSRRPQCPTCGDRETLQRRGFEPLKLESRPKHPEQTVQKYQHLIGPITGVVTELVRSRASGLCEAI-PRKRATLAELGDLAIHPEQCLHFSDRQYDNRESSNERATVHDWIPQRSLHKYLP--------TALCYYRYPFPPEHRFCRSDS-----NGNAAGNTLQGFMELVERDS-VSRPEPYFLQLQQFYQTQNDLWV--FVGVSNRKAGS-------------------SERIILGFGPTVAILRALTEV-LELDATDWLVNATLAASPYLVADASQPLKTAKDYPRRW----------------------SDDIYTDVMTCVEIAKQ-ETLVLDQTRPDGLNVVKVIVP-----G-MRFW-------SRFGSGRLYDVQPLAEA

5gaoE

0.16

0.07

0.41

1.17

dPPAS2

---------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAA----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4bs9A

0.11

0.09

0.81

1.13

PPAS

----------------------PTALQIKPHFVEIIEPKLGEQGNHALTGQLYCQILPFLN------------------EYTREQIVEKLDGQVPEEYIDFVLSRLVEKGYLTEVAP------------------------ELSLEVAAFWSELGIAPSVVAEGLKQPVTVTTAGKGIREGIVANLAAALEEAGIQVSDPTAQVVLQPELAAINKEALERQQPWLLVKPVGSIVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTARATLPSTLQTGLQWA---ATEIAKWMVKRHLNAIAPGTARFPTLAGKIFTFNQTTLELKAH--------------PLSRRPQCPTCGDRETLQRRGFEPLKLESRPKH-PEQTVQKYQHLIGPITGVVTELVRSRASGLCE-FQGDEPRKRATLAELGDLPEQCLHFSDRQYDNRESSNERATVTHDWIP-------QRFDASKAHDWTPVWSLHKYLP--------TALCYYRYPFPPEHRFCRSDS-NTLEEAILQG--VERDSVCLWWYNRVSRPEPYFLQLQQFYQTQNDLWV--FVGVSNRKAGS-------------------SERIILGFGAHLDPTVAILRA----LTEVNQIGLELDATDWLVNATLAASPYLVADASQP----------LKTAKDYPRRWSDDIYTDVMTCVEIAKQAGLETLVLDQTRPGLNVVKVIVP-----GMRFWSRFGSGRLYDVPVKLGWREQPLAEA

1dlcA

0.10

0.08

0.75

1.05

Env-PPAS

--------TTKDVIQK-GISVVGDLLGV---VGFPF------GGALVSFYTNFLNTIWPSEDPWKAFMEQVEALMDQKIADYAKNKALAE-----LQGLQNNVEDYVSALSSWQKNPVSSRNPHS------------------QGRIRELFSQAESHFRNSMPSFA-------------ISGYEVLFLTTYAQAA-------NTHLFLLKDAQIYGEEWG-------------YEKEDIAEFYKRQLKLTQEYTDHCVKWYNVG-LDKLR--GSSYESWVNFNRYR---REMTLTVLDLIALFPLYDVRLPKEVKTELTRDVLDPIVGVNNL------RGYGTTFSNIENYIRKPHLFD----------------------YLHRIQFHTRFQPGYYGNDSFNYWSGNYVSTRPSIGSND--------IITSPFYGNKSSEPVQNL-------EFNGEKVYRAVANTNLAVWPSAVYSGVTKVEFSQYNDQT----------------DEASTQTYDSKRNV-------GAVSWDSIDQLPPET-TDEPLEKGYSVMCFLMQGSRGTIPVLTWTHKSVDF--FNMIDSKKITQLVKAYKLQSGASVVAGP-----------RFT------GGDIIQCTENGSAATIYVTPDVSYSQ---------KYRARIHYASTSQITF----------TLSLDGAPFNQYYFDKTINKGDTLTNLASPFELSGNNLQIGVTGLSAGDKVYIDKIEFIPVN---

4wd9A1

0.11

0.08

0.73

0.95

wPPAS

LNDKRSFTEYTQVIETVKNKVFLEQLLL-PKLAGLLKKSIYKYYKRSYLRSTT--SIGVFSK------SSQYKLMGKTTKGILIRLVHKM-----EVDFSKKL-SFTRNNANY-GDRVFQVY-------TINSSELEEVNIKYTNVYQIISEFCENKYEDICETVTLCYG------DEYRELSEQYLGSLIVNHYLIS-----LQKDNTFLTKVEA----------DEDK---------------KYIIPLKKVQKFIQEYSEIEI------GEGIEKLKEIYQEMSLENDNVKQKQQLEHLAEFLGN------------TKSVRRTYLDDYKDK-FIEKY--ITELF------STFIGAPYNYNHPRNDFYESEPSTYSEEEREKYLSMYVEAVKNHNV-DDLESHYQKMDLEKKSELQGLELFLNLAKEYEILGDINNNLGGASGRFS-ALSPELTSYHRTIVDSVERENENK-EITSCE-RKVLPFFTSTSHN---EVL-LTNIIDEKE----KF----YARDISTQELFSNELRFLYEISLDDGNLPWELIYRDFDRVFDEIVISPAKWKIWGRDVNSKMTIRE-IQSKEI------PKFYIVNGDMEILESAIKKSSKRKDQEYFEDENIINKGEKIRAFIREKRTKDFNLDLVSVSK---------------------------------------------------------------------------------------------

4qqxA

0.15

0.13

0.92

1.11

PPAS

RGLRGKTYPLVCHSLD--AAAALVLWNEYLS---------------PGLRDTIASSMETDEEHAGHCIAFWAGLHDIDLSAYPGEELSGEQRSHAAATGKWLPFALPSLGY---PNGGLVTGLVAQMLGGHHGTFHPHPSFQSRNPLAEFGFSSPKQRHALLHAVFD-----ATGRPTPPDMLDGPTASVVCGLVSLPADGSASALRAHFETSLRRIPSLLDAAGLRPITVPPATFTESFP-HLSKPNGLQASLAKHLPCLCTGPGLVL--GEAAYHVADLLGKATGRPDQMHTRLKEYARYRVENTDLPRSSTLALLHSMAWLNPDYAPAHRDPFAATDWLMGRKRGLL---APWAVGTIDQ-------ALMAVLRAKHNALRLFGLAGAHAVDPYMQVLLEQLLRWLGTLDVPVV---LHHSIANSLVKAYLEGARGRRWNRSEPQPVSEVSARIGKVTRSSDVDPLPIATTPRKPLEVRLVDVPVKEGALNRSTVLAKELTPLVKQGGCAAIICTT---VAEAQGV---YDLLSQWFATLAPSRFPTEITATIVDLFGKEGAQSGRRPTAVLVAT------------QVVEQSLDLDVDLMISDLAPVSLLLQRAGRCWINRPQWAKQPELVVLTPEQNRAPWFPR----SWTSVYPLALLQRTYTLLRRRNGAPAEDLEADMERMGEELAQRGLARNAVIPDPDDAEDNLNSVRVLCYYVDTAGNRWLDPECTVERTIPVRMGPWASQLTED

4q2cA

0.12

0.11

0.92

1.07

PPAS

VWGSGPDLGW---LLCLDVAAVTLQWRRVLP-----AAWKARISGVLGVGQEDAERWLAFEQGRELVARRLRDAGLPLFNARAP-----------GTISANVLETVLADVFGLSGRSARWVAFAVGGHHGFVPSYDEVRRDLDQQAVG---WGWDAAREVLLCRLADALGL----PGSSRPTVESTPDAFLAG--------------LVSVADWIGSNEEYFPYAAQSALQVPQLDAEAYLERARQAERAASLGWVGWRPASGSRLTELFPYIRQPTTVQAAAEELAGEKTEAALLADTFSTAH--GSGCYFALPTATSNQFGRVTDYLRHRYPEDVVVVNLVHGHSDLSALLQELRQKGEEIFQLQGVYDEALGDEQLGAVVAGQWFTRGKRALLPQVKHVFVRLFALSTKTVIVDEVVYTTLLHRLLEWLGALSVVLSATLPSARRRELVGWQAERDLPPAGYPRITYAAAEDVRGIHFAPSEKVALRWVSAPEHEALGQLLAEALSQG-GCAAIICN-TVPRAQAL---YSALREVFPGLAEDGPYEEREVREARTLGRFSRNGRRPHRAILVA-DLAPVDLVLQ-VHDPLRPERLRSPELWVVSPQVGDVPIFDRGSAYDEHTRDRDTLQLDGRVPQGASEELRSLWERTFKAQQKVLREDSLQAKYRSIWGIVTASVEEDAPELHPALQALTRLAESAVCLVAGSGG--------PCLPDGTPVDLDTPPDAAAESVAITDARVLDPLLDV

4wd9A1

0.09

0.07

0.78

1.03

PPAS

PNDKRSFTEYTQVIETVNKVFLEQLLLANPKLY----DVMQKYNAGLLKKKRVKKLFESIYKYYKRSY-SIGVFSKSSQYKLMGKTTKGI--RLDTQWLIRLVHKMEVD-LSFTRNNANYKFGDRVFQVYTINSSELEEYTNVYQIISEFCENDYQKYEDICETVTLCYG------DEYRELSEQYLGSLIVNHYLIS--DLLSDFSNTFLTKVEAIDEDK------------------------KYIIPLKKVQKFIQEYSEIEI------GEGIEKLKEIYQEMSLENDNVKQKQQLEHLAEFLGN------------TKSVRRTYLDDYKDK-FIEKY--ITELF--STFGIGAPYNYNHPRNDFYESEPSTLYYSEEEREKYLSMYVEAVKNHNVINLDDLESHYQKMDLEKKSELQGLELFLNLAKEYILGDINNNLGGASGRFS-ALSPELTSYHRTIVDSVERENENK-EITSCE-RRKVLPFFTSTSHNEVLLTNIYGIDEKEKFYARDISTQEVLKFYITSTLFSNELRFLYEISLDDGNLPWELIYRDFD-VFDEIVISPAKWKIWGRDVNSKMTIRE--LIQSKEI----PKFYIVNGDMEILESAIKKSSKRKDFEYFEDENIINKGEKIRAFIREKRTKDFNLDLVSVSK---------------------------------------------------------------------------------------------

5ifeC

0.12

0.11

0.94

1.00

MUSTER

LKPDDIQDKLLVDVDESEEQKERKIMKLLLKIKNGTPPQITDKAREFGAGPLFNQILPLL-HLLVKVIDRILYKLDDLVRPYVHKILVVIEPIDEDYYARVEGREIISN-LAKAAGLATMISTMRPDI--------DNMDEYVRNTTARAFAVVIPSLLPFLKAVCKSKKSWQARHTGMGCAILPHLRSLVEI-IEHGLVDEQQKVRTISALAIAAAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYY------TREVMLILIRESPDEEMKKIVLKVVKQC----------CGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEA-EQYRKMVMETIEKIMGNLGAAEEQLIDGILYAF-QEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRNNKSAKVRQQAADLISRTAV-------------VMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVGMPIKDLLPRLTPILKNRVQENCIDLVGRIADRGAEYVCFELLELLKAHKKAIRRATVNTYIAKAIGPTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYA--MDRDLVHRQTASAVVQHSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRD-VYWKISIYIGSQDA

5frpA

0.10

0.08

0.82

0.85

dPPAS

ISTSDQLISTNELLDR--LKALHEELAS-LDQDNTDLTGLDKYRDALVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKENGYHIQQTYLITKLLEYRSIVLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEVISEFDEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCD-------TYSNRMSRHLTKYYS-----------------EIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELI------NAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHS--------DTFKAWISISPDVRVEWTESIPQIIATRE------DISKELNQALAKTFIDSD-PRVRRTSVMIFNKVPWKNITNKAIYTSLLHLAREKHKEVRELCINTMAKFYSNSLNEIERTYQNKEIWEIIDTINDLNINEQVDSVIFEYLLPFEPD-------------------NDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSQGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFN-DERIFYLLNACVTNDIPFLTF-KNCYNELVSKLQTPSIMPRDIAKVIQIFRASPIIYNVSNISVLLNLSNNSDAKQLDLKRRILDDISKVNPTLFKDQIRTLK-----------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 4 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.66

Estimated TM-score = 0.51±0.15

Estimated RMSD = 12.3±4.4Å

Download Model 2

C-score=-1.36

Download Model 3

C-score=-1.61

Download Model 4

C-score=-3.21

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4bs9A	0.681	4.55	0.087	0.802
2	1hn0A	0.369	8.02	0.039	0.573
3	4bxsV	0.354	8.39	0.043	0.571
4	2q1fA	0.348	8.44	0.044	0.568
5	4o9xA	0.342	8.56	0.041	0.559
6	4zhjA	0.339	8.32	0.041	0.540
7	3jb9A	0.338	8.38	0.042	0.541
8	4bgdA	0.338	8.31	0.062	0.536
9	3cmuA	0.338	8.69	0.047	0.557
10	5d06A	0.334	8.57	0.030	0.540

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3jcuH	CLA	Rep, Mult	329,336
2	0.02	1	2z6iB	CA	Rep, Mult	285,288
3	0.02	1	1s5lk	CLA	Rep, Mult	321,327
4	0.02	1	1s0bA	CA	Rep, Mult	583,586,593
5	0.02	1	3aalA	ZN	Rep, Mult	525,558,563
6	0.02	1	1f31A	UUU	Rep, Mult	538,611,613,614
7	0.02	1	1dj5A	HGU	Rep, Mult	341,342
8	0.02	1	1h65B	GDP	Rep, Mult	516,517,549
9	0.02	1	1y10D	CA	Rep, Mult	431,575
10	0.02	1	2bsqH	NUC	Rep, Mult	515,517
11	0.02	1	3cmvB	ANP	Rep, Mult	520,521,525,526,527,528
12	0.02	1	2ehtA	ZN	Rep, Mult	557,558
13	0.02	1	4q1qB	289	Rep, Mult	606,607
14	0.02	1	3e5sB	CA	Rep, Mult	484,517,528
15	0.02	1	3wmoP	BCL	Rep, Mult	344,345
16	0.02	1	2fhfA	CA	Rep, Mult	563,577,579,582,585
17	0.02	1	3c6hB	MG	Rep, Mult	484,579
18	0.02	1	1i1eA	DM2	Rep, Mult	538,573,607,608,614
19	0.02	1	3lotA	UNL	Rep, Mult	516,567,578,579
20	0.02	1	1r3nF	BIB	Rep, Mult	412,530

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3cmmC	0.300	8.50	0.046	0.484	6.3.2.19	NA
2	0.060	2np0A	0.312	8.58	0.038	0.508	3.4.24.69	NA
3	0.060	2vz8A	0.306	8.50	0.050	0.500	2.3.1.85	NA
4	0.060	2vz8B	0.278	8.43	0.053	0.447	2.3.1.85	NA
5	0.060	1ffyA	0.293	8.84	0.053	0.492	6.1.1.5	NA
6	0.060	2vkzG	0.260	8.54	0.033	0.419	2.3.1.38,3.1.2.14	NA
7	0.060	2jgdA	0.299	8.39	0.053	0.485	1.2.4.2	NA
8	0.060	2vumA	0.288	8.49	0.029	0.463	2.7.7.6	NA
9	0.060	2fhbA	0.328	8.51	0.039	0.529	3.2.1.41	NA
10	0.060	1ej6A	0.287	8.83	0.050	0.477	2.7.7.50	NA
11	0.060	2fhcA	0.315	8.81	0.064	0.528	3.2.1.41	242
12	0.060	2vdcF	0.295	9.00	0.027	0.508	1.4.1.13	265
13	0.060	1ug9A	0.308	8.66	0.045	0.504	3.2.1.70	NA
14	0.060	2uv8G	0.260	8.56	0.028	0.421	2.3.1.86	NA
15	0.060	2e9bA	0.284	8.56	0.043	0.468	3.2.1.41	NA
16	0.060	2vz9B	0.297	8.53	0.037	0.483	2.3.1.85	NA
17	0.060	3k1dA	0.280	8.23	0.046	0.441	2.4.1.18	484
18	0.060	2wanA	0.282	8.99	0.042	0.480	3.2.1.41	433
19	0.060	1jqnA	0.286	7.70	0.075	0.432	4.1.1.31	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.11	0.681	4.55	0.09	0.80	4bs9A	GO:0046872
1	0.08	0.658	4.98	0.10	0.80	4v1tB	GO:0000166 GO:0046872
2	0.06	0.369	8.02	0.04	0.57	1hn0A	GO:0003824 GO:0005576 GO:0005975 GO:0016829 GO:0016837 GO:0030246 GO:0034000 GO:0042597 GO:0046872
3	0.06	0.358	8.48	0.05	0.58	2q1fA	GO:0000287 GO:0003824 GO:0005509 GO:0005576 GO:0005975 GO:0006027 GO:0016829 GO:0016837 GO:0030200 GO:0030209 GO:0030246 GO:0034000 GO:0034001 GO:0042597 GO:0046872 GO:0047488 GO:0052809
4	0.06	0.259	8.85	0.04	0.43	4ejxA	GO:0001889 GO:0004322 GO:0005507 GO:0005576 GO:0005615 GO:0005765 GO:0006810 GO:0006811 GO:0006825 GO:0006879 GO:0007568 GO:0007584 GO:0016491 GO:0030324 GO:0046658 GO:0046688 GO:0046872 GO:0051087 GO:0055114 GO:0070062 GO:0072562
5	0.06	0.269	8.23	0.06	0.42	1rw9A	GO:0003824 GO:0005576 GO:0005975 GO:0016829 GO:0016837 GO:0030246
6	0.06	0.282	8.23	0.04	0.45	1f1sA	GO:0003824 GO:0005576 GO:0005975 GO:0016829 GO:0016837 GO:0030246 GO:0030340
7	0.06	0.354	8.39	0.04	0.57	4bxsV	GO:0004252 GO:0005507 GO:0005576 GO:0006508 GO:0007596 GO:0010952 GO:0016504 GO:0035807 GO:0044469 GO:0046872
8	0.06	0.262	5.62	0.10	0.34	3h5aC	GO:0000166 GO:0005524 GO:0008641 GO:0046872
9	0.06	0.252	8.24	0.05	0.40	3cdzA	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
10	0.06	0.259	7.84	0.04	0.40	1cb8A	GO:0003824 GO:0005576 GO:0005975 GO:0016829 GO:0016837 GO:0030246 GO:0030341 GO:0046872
11	0.06	0.275	8.30	0.03	0.44	2e22A	GO:0003824 GO:0005509 GO:0005537 GO:0005576 GO:0005615 GO:0005975 GO:0005976 GO:0016829 GO:0016837 GO:0030246 GO:0046872 GO:0047492
12	0.06	0.245	8.13	0.04	0.38	2r7eB	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
13	0.06	0.205	8.12	0.04	0.32	1sddB	GO:0005507 GO:0005576 GO:0007596 GO:0007599 GO:0030168 GO:0046872
14	0.06	0.261	8.50	0.05	0.43	2r7eA	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
15	0.06	0.210	8.30	0.05	0.34	2qqlA	GO:0001525 GO:0001938 GO:0002116 GO:0004872 GO:0005021 GO:0005576 GO:0005886 GO:0007155 GO:0007275 GO:0007399 GO:0007411 GO:0008201 GO:0010595 GO:0016020 GO:0016021 GO:0017154 GO:0019838 GO:0019955 GO:0021675 GO:0030154 GO:0038084 GO:0046872 GO:0048010 GO:0048846 GO:0061549 GO:0097490 GO:0097491 GO:1902285
16	0.06	0.232	7.74	0.05	0.36	4gz9A	GO:0001525 GO:0001569 GO:0001764 GO:0002040 GO:0002042 GO:0005021 GO:0005615 GO:0005769 GO:0005829 GO:0005883 GO:0005886 GO:0005925 GO:0007275 GO:0007399 GO:0007411 GO:0007413 GO:0007507 GO:0008045 GO:0008201 GO:0009611 GO:0009887 GO:0009986 GO:0016020 GO:0016021 GO:0016358 GO:0016477 GO:0017154 GO:0019838 GO:0021612 GO:0021636 GO:0021637 GO:0021649 GO:0021675 GO:0021785 GO:0021828 GO:0030154 GO:0030424 GO:0030426 GO:0030517 GO:0031290 GO:0035729 GO:0035767 GO:0035924 GO:0036486 GO:0038084 GO:0038085 GO:0038190 GO:0043025 GO:0043524 GO:0046872 GO:0048008 GO:0048010 GO:0048012 GO:0048485 GO:0048666 GO:0048841 GO:0048842 GO:0048843 GO:0048844 GO:0048846 GO:0050731 GO:0050918 GO:0060385 GO:0060666 GO:0060978 GO:0060980 GO:0060982 GO:0061299 GO:0061441 GO:0061549 GO:0061551 GO:0070374 GO:0071526 GO:0071679 GO:0090259 GO:0097374 GO:0097443 GO:0097490 GO:0097491 GO:1901166 GO:1901998 GO:1902285 GO:1902287 GO:1902336 GO:1902378 GO:1902946 GO:1903375 GO:1904835 GO:1905040 GO:2001237
17	0.06	0.244	7.78	0.03	0.38	4bdvB	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
18	0.06	0.268	5.95	0.07	0.35	4q86B	GO:0000287 GO:0005829 GO:0018339 GO:0047693

Consensus prediction of GO terms

Molecular Function	GO:0046872
GO-Score	0.33
Biological Processes	GO:0005975	GO:0030200	GO:0030209	GO:0006879	GO:0007584	GO:0055114	GO:0030324	GO:0007568	GO:0006825	GO:0046688	GO:0001889
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0042597	GO:0005765	GO:0072562	GO:0070062	GO:0046658
GO-Score	0.12	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.