I-TASSER results

Input Sequence in FASTA format

>protein (147 residues)
MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETGDDGRPSKVKMKVKTAG
ITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGDNTLVQFEITVDPQVPLPGFV
LKRAIKGTIDTATEALRSQVLKVKKGQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 \| \| \| \| \| \| \| MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETGDDGRPSKVKMKVKTAGITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGDNTLVQFEITVDPQVPLPGFVLKRAIKGTIDTATEALRSQVLKVKKGQ
Prediction	CCEEEEEEEEHCCCHHHHHHHHHCHHHHHHHCHCCEEEEEEHCCCCCCEEEEEEEEHCCCEEEEEEEEEEHCCCEEEEEEEHCCCEEEEEEEEEEEHCCCCEEEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	985777999986999999999986787566545465899998589996799999996565788999999995999999999778745677799999869986999999998588668999999999999999999999999987579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 \| \| \| \| \| \| \| MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETGDDGRPSKVKMKVKTAGITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGDNTLVQFEITVDPQVPLPGFVLKRAIKGTIDTATEALRSQVLKVKKGQ
Prediction	755535441406141630140033154025015315403212637724333030305334244431141314754020323547414535240303445741303030204251301330244124420440164025204735678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140

                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEEEEHCCCHHHHHHHHHCHHHHHHHCHCCEEEEEEHCCCCCCEEEEEEEEHCCCEEEEEEEEEEHCCCEEEEEEEHCCCEEEEEEEEEEEHCCCCEEEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETGDDGRPSKVKMKVKTAGITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGDNTLVQFEITVDPQVPLPGFVLKRAIKGTIDTATEALRSQVLKVKKGQ

2rezA

0.20

1.00

2.00

MUSTER

MAARTDNSIVVNAPFELVWDVTNDIEAWPELFSEYAEAEILRQDGDGFDFRLKTRPDANGRVWEWVSHRVPDSRTVRAHRVETGPFAYMNLHWTYRAVAGGTEMRWVQEFDMKAPFDNAHMTAHLNTTTRANMERIKKIIEDRHREG

2d4rA

0.15

0.97

3.37

dPPAS

--PEVRAERYIPAPPERVYRLAKDLEGLKPYLKEVESLEVVAREGA-RTRSRWVAVAGKKVRWLEEEEWDDENLRNRFFSPEGD-FDRYEGTWVFLPEGEGTRVVLTLTYELTIPIFGGLLRKLVQKLQENVESLLKGLEERVLAAS

2rezA

0.20

1.00

4.26

wdPPAS

MAARTDNSIVVNAPFELVWDVTNDIEAWPELFSEYAEAEILRQDGDGFDFRLKTRPDANGRVWEWVSHRVPDKRTVRAHRVETGPFAYMNLHWTYRAVAGGTEMRWVQEFDMKPPFDNAHMTAHLNTTTRANMERIKKIIEDRHREG

2rezA

0.20

1.00

3.93

wMUSTER

MAARTDNSIVVNAPFELVWDVTNDIEAWPELFSEYAEAEILRQDGDGFDFRLKTRPDANGRVWEWVSHRVPDSRTVRAHRVETGPFAYMNLHWTYRAVAGGTEMRWVQEFDMKAPFDNAHMTAHLNTTTRANMERIKKIIEDRHREG

1t17A

0.15

0.14

0.98

4.56

wPPAS

MH-RHVVTKVLPYTPDQLFELVGDVDAYPKFVPWITGMRTWNGRVDGATVDAEAQVGFSFLREKFATRVRRDARSIDVSLLYG-PFKRLNNGWRFMPEGDATRVEFVIEFAFKSALLDAMLAANVDRAAGKLIACFEARAQQLHGA-

1t17A

0.15

0.14

0.98

5.45

dPPAS2

MH-RHVVTKVLPYTPDQLFELVGDVDAYPKFVPWITGMRTWNGRVDGATVDAEAQVGFSFLREKFATRVRRDARSIDVSLLYGP-FKRLNNGWRFMPEGDATRVEFVIEFAFKSALLDAMLAANVDRAAGKLIACFEARAQQLHGA-

1t17A

0.15

0.14

0.98

4.06

PPAS

MH-RHVVTKVLPYTPDQLFELVGDVDAYPKFVPWITGMRTWNGRVDGATVDAEAQVGFSFLREKFATRVRRDKRSIDVSLLYG-PFKRLNNGWRFMPEGDATRVEFVIEFAFKSALLDAMLAANVDRAAGKLIACFEARAQQLHGA-

1t17A

0.15

0.14

0.98

3.94

Env-PPAS

MH-RHVVTKVLPYTPDQLFELVGDVDAYPKFVPWITGMRTWNGRVDGATVDAEAQVGFSFLREKFATRVRRDKRSIDVSLLYG-PFKRLNNGWRFMPEGDATRVEFVIEFAFKSALLDAMLAANVDRAAGKLIACFEARAQQLHGA-

2kf2A

0.18

1.00

1.98

MUSTER

MAGHTDNEITIAAPMELVWTMTNDIEKWPGLFSEYASVEVLGRDDDKVTFRLTMHPDADGKVWSWVSERVADPRTVRAQRVETGPFQYMNIVWEYAETAEGTVMRWTQDFAMKAPVDDAWMTDNINRNSRTQMALIRDRIEQAAGER

2rezA

0.20

1.00

3.32

dPPAS

MAARTDNSIVVNAPFELVWDVTNDIEAWPELFSEYAEAEILRQDGDGFDFRLKTRPDANGRVWEWVSHRVPDKRTVRAHRVETGPFAYMNLHWTYRAVAGGTEMRWVQEFDMKAPFDNAHMTAHLNTTTRANMERIKKIIEDRHREG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 4 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.98

Estimated TM-score = 0.85±0.08

Estimated RMSD = 2.8±2.1Å

Download Model 2

C-score=0.07

Download Model 3

C-score=-0.25

Download Model 4

C-score=-1.83

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2rezA	0.919	1.56	0.204	1.000
2	3tfzA	0.875	1.77	0.131	0.986
3	1em2A	0.838	2.18	0.099	0.966
4	3p0lA	0.828	2.23	0.143	0.952
5	2d4rA	0.825	1.82	0.174	0.939
6	2mouA	0.820	2.48	0.082	0.993
7	2r55A	0.819	2.45	0.138	0.986
8	4xrwA2	0.818	2.08	0.120	0.966
9	1t17A	0.813	2.24	0.120	0.966
10	2kf2A	0.811	2.33	0.170	0.959

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	12	3c0vD	ZEA	Rep, Mult	22,25,52,65,67,78,89,91,129,132
2	0.14	12	4n3eM	2AN	Rep, Mult	7,9,11,18,22,93,95,104,106,133
3	0.05	4	4q0kA	GA3	Rep, Mult	22,28,32,52,54,65,93,128,129,132
4	0.04	3	3tl1A	JRO	Rep, Mult	54,57,63,65,80,86,89,108,120,121,124,125,128
5	0.04	3	4a81A	2AN	Rep, Mult	7,9,22,78,93,106,108,125,128,129,132,133
6	0.03	3	3nmnA	PYV	Rep, Mult	32,52,62,65,67,78,80,89,124,128,129
7	0.02	2	2qimA	ZEA	Rep, Mult	5,7,9,78,91,106,108,125
8	0.02	2	4a8gA	DMX	Rep, Mult	22,25,28,51,76,78,93,106,132
9	0.02	2	4ryvA	ZEA	Rep, Mult	5,7,108,110,122,123,126
10	0.01	1	2qimA	ZEA	Rep, Mult	6,8,126,129,130
11	0.01	1	1bv10	III	Rep, Mult	20,23,24,25,26,29,30,38,39,40,41,43,72,74

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.202	2vq5A	0.718	3.04	0.131	0.932	4.2.1.78	39,47
2	0.060	1yaaA	0.498	4.12	0.080	0.714	2.6.1.1	NA
3	0.060	2fy3A	0.518	4.86	0.022	0.871	2.3.1.6	NA
4	0.060	1ndoA	0.632	3.85	0.071	0.952	1.14.12.12	NA
5	0.060	3b8kA	0.499	4.65	0.066	0.844	2.3.1.12	NA
6	0.060	1b5sE	0.502	4.92	0.058	0.871	2.3.1.12	70
7	0.060	2pmgB	0.357	5.52	0.065	0.714	5.4.2.2	NA
8	0.060	1q6xA	0.534	4.25	0.076	0.816	2.3.1.6	NA
9	0.060	1wnlA	0.521	3.41	0.091	0.701	6.3.4.15	NA
10	0.060	3efsA	0.507	3.83	0.080	0.728	6.3.4.15	NA
11	0.060	1yaaB	0.500	4.15	0.081	0.721	2.6.1.1	NA
12	0.060	1b5sA	0.502	4.92	0.058	0.871	2.3.1.12	NA
13	0.060	2ii4A	0.553	4.24	0.037	0.837	2.3.1.168	NA
14	0.060	1eadA	0.536	4.38	0.074	0.830	2.3.1.12	46
15	0.060	1i1iP	0.503	4.87	0.057	0.857	3.4.24.16	NA
16	0.060	2ewnA	0.539	3.56	0.140	0.721	6.3.4.15	NA
17	0.060	2b1xA	0.625	3.79	0.075	0.912	1.14.12.12	NA
18	0.060	1wqlA	0.642	3.74	0.094	0.939	1.14.12.-	NA
19	0.060	1dpbA	0.534	4.41	0.074	0.830	2.3.1.12	NA
20	0.060	3en1A	0.651	3.64	0.079	0.946	1.14.12.11	35

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.39	0.896	1.81	0.20	1.00	2rerA	GO:0003824 GO:0008152 GO:0008168 GO:0008171 GO:0016740 GO:0017000 GO:0032259
1	0.31	0.857	2.17	0.11	0.99	1em2A	GO:0005737 GO:0005739 GO:0005765 GO:0005768 GO:0006629 GO:0006694 GO:0006701 GO:0006810 GO:0006839 GO:0006869 GO:0008202 GO:0008203 GO:0008289 GO:0015485 GO:0016020 GO:0016021 GO:0031902
2	0.27	0.828	2.23	0.14	0.95	3p0lA	GO:0005739 GO:0005758 GO:0005829 GO:0006082 GO:0006694 GO:0006699 GO:0006700 GO:0006701 GO:0006703 GO:0006810 GO:0006869 GO:0007420 GO:0007584 GO:0007623 GO:0008203 GO:0008211 GO:0008289 GO:0008584 GO:0009635 GO:0009636 GO:0010033 GO:0010212 GO:0010288 GO:0010628 GO:0014070 GO:0014823 GO:0015485 GO:0016101 GO:0017085 GO:0017127 GO:0017143 GO:0018879 GO:0018894 GO:0018958 GO:0018963 GO:0030061 GO:0031667 GO:0032367 GO:0032869 GO:0034698 GO:0035094 GO:0035457 GO:0042493 GO:0042542 GO:0042747 GO:0043005 GO:0043025 GO:0043434 GO:0043524 GO:0043627 GO:0044255 GO:0044321 GO:0044344 GO:0045471 GO:0046677 GO:0048168 GO:0048545 GO:0050769 GO:0050810 GO:0051412 GO:0060992 GO:0061370 GO:0071222 GO:0071236 GO:0071248 GO:0071276 GO:0071312 GO:0071320 GO:0071333 GO:0071346 GO:0071371 GO:0071372 GO:0071373 GO:0071378 GO:0071407 GO:0071549 GO:0071560 GO:0071872
3	0.24	0.806	2.42	0.14	0.96	5brlA	GO:0005739 GO:0005783 GO:0005829 GO:0006810 GO:0006869 GO:0008289 GO:0015485 GO:0016023 GO:0034435
4	0.23	0.762	2.74	0.15	0.93	1z94B	GO:0006950
5	0.18	0.820	2.48	0.08	0.99	2mouA	GO:0006810 GO:0006869 GO:0008289
6	0.18	0.819	2.45	0.14	0.99	2r55A	GO:0005829 GO:0006700 GO:0006810 GO:0006869 GO:0008289 GO:0032052
7	0.16	0.772	2.73	0.12	0.95	2psoB	GO:0005096 GO:0005737 GO:0005739 GO:0005811 GO:0005829 GO:0007165 GO:0008289 GO:0016020 GO:0031966 GO:0043542 GO:0043547 GO:0051056 GO:0090051 GO:0097498
8	0.16	0.783	2.43	0.13	0.95	4n0gC	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0042803 GO:0043086 GO:0080163
9	0.16	0.771	2.68	0.16	0.95	3fo5A	GO:0005737 GO:0005829 GO:0006631 GO:0008289 GO:0009266 GO:0009409 GO:0016787 GO:0035338 GO:0035556 GO:0047617 GO:0052689 GO:0070062
10	0.14	0.753	2.69	0.14	0.93	3cnwA	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0009738 GO:0010427 GO:0043086 GO:0080163
11	0.14	0.804	2.53	0.10	0.98	3w9rA	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0042803 GO:0043086 GO:0080163
12	0.13	0.752	2.78	0.12	0.95	2flhB	GO:0006952 GO:0009607
13	0.13	0.747	3.04	0.12	0.97	2qimA	GO:0006952 GO:0009607 GO:0046872
14	0.13	0.794	2.56	0.10	0.97	3ojiB	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0042803 GO:0043086 GO:0080163
15	0.12	0.797	2.83	0.10	1.00	3rt0C	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0042803 GO:0043086 GO:0080163
16	0.12	0.807	2.59	0.10	0.98	3k3kA	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0042802 GO:0042803 GO:0043086 GO:0080163
17	0.12	0.703	3.40	0.13	0.97	4m9bA	GO:0006952 GO:0009607
18	0.12	0.797	2.45	0.08	0.97	4oicA	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0009738 GO:0010427 GO:0043086 GO:0080163
19	0.12	0.750	2.95	0.10	0.97	4a80A	GO:0005737 GO:0006952 GO:0009607
20	0.11	0.788	2.62	0.13	0.97	3nefA	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0042803 GO:0043086 GO:0080163
21	0.11	0.729	2.44	0.12	0.88	4jdlB	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0043086 GO:0080163
22	0.11	0.780	2.69	0.12	0.97	3kdhA	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0042803 GO:0043086 GO:0080163
23	0.08	0.631	3.24	0.11	0.84	2kewA	GO:0006950
24	0.07	0.598	2.40	0.12	0.71	4jdlC	GO:0004864 GO:0004872 GO:0005634 GO:0005737 GO:0005886 GO:0009738 GO:0010427 GO:0016020 GO:0043086 GO:0080163
25	0.07	0.433	4.65	0.02	0.69	3frkA	GO:0003824
26	0.06	0.388	5.61	0.07	0.76	3l2nA	GO:0004180 GO:0004181 GO:0006508 GO:0008270 GO:0046872
27	0.06	0.360	5.43	0.04	0.70	3tovA	GO:0008152 GO:0016740 GO:0016757
28	0.06	0.363	5.33	0.05	0.65	2qk4B	GO:0000166 GO:0003360 GO:0003824 GO:0004637 GO:0004641 GO:0004644 GO:0005524 GO:0005737 GO:0005829 GO:0006164 GO:0006189 GO:0006544 GO:0008152 GO:0009058 GO:0009113 GO:0009156 GO:0009168 GO:0010033 GO:0010035 GO:0016740 GO:0016742 GO:0016874 GO:0021549 GO:0021987 GO:0046654 GO:0046872 GO:0070062
29	0.06	0.318	5.72	0.09	0.64	3hlyC	GO:0010181 GO:0016491 GO:0055114
30	0.06	0.283	5.60	0.03	0.55	4v6wAI	GO:0000462 GO:0003735 GO:0005622 GO:0005840 GO:0006412 GO:0022008 GO:0022627 GO:0030529 GO:0035167
31	0.06	0.237	4.65	0.08	0.39	1ihjB	GO:0005198 GO:0005516 GO:0005886 GO:0007601 GO:0007602 GO:0007605 GO:0008104 GO:0009881 GO:0016020 GO:0016027 GO:0016028 GO:0016059 GO:0017022 GO:0030159 GO:0031473 GO:0050896 GO:0050962 GO:0071482
32	0.06	0.813	2.24	0.12	0.97	1t17A
33	0.06	0.875	1.77	0.13	0.99	3tfzA

Consensus prediction of GO terms

Molecular Function	GO:0015485	GO:0015248	GO:0008171
GO-Score	0.61	0.54	0.39
Biological Processes	GO:0050767	GO:0046546	GO:0071331	GO:0043279	GO:1901655	GO:0046686	GO:0000302	GO:0043523	GO:0071363	GO:0031667	GO:0009404	GO:0097305	GO:0008406	GO:0035455	GO:0010720	GO:0001678	GO:0071871	GO:0050802	GO:0071219	GO:0034699	GO:0060416	GO:0071345	GO:0043066	GO:0051385	GO:0051591	GO:0046677	GO:0019218	GO:0071870	GO:0032366	GO:0009314	GO:0071559	GO:0051962	GO:0072330	GO:0006721	GO:0046483	GO:0008206	GO:0042537	GO:0010468	GO:0009749	GO:0048167	GO:0032868	GO:0007417	GO:0046890	GO:0060322	GO:0071385	GO:0032496	GO:0008210	GO:0034341	GO:0010604	GO:0071375	GO:0071248	GO:0071548	GO:0009636	GO:0071774	GO:0043648	GO:1901617	GO:0032354	GO:0006805	GO:0030301	GO:1901215	GO:0006701	GO:0008203	GO:0034434	GO:0017000	GO:0032259	GO:0006839
GO-Score	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.54	0.49	0.49	0.48	0.39	0.39	0.31
Cellular Component	GO:0044455	GO:0031970	GO:0044297	GO:0042995	GO:0036477	GO:0005743	GO:0031410	GO:0031988	GO:0005829	GO:0016021	GO:0005765	GO:0031902
GO-Score	0.54	0.54	0.54	0.54	0.54	0.54	0.48	0.48	0.44	0.31	0.31	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv0854

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]