I-TASSER results

I-TASSER results for job id Rv0837c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (342 residues)
MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSAT
AALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRR
SAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAK
ETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDG
LAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNL
PDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARL
Prediction	HHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCCCEEEEEEHCCEEEEEEEEEHCCHHHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHCCCEHCCCCEEEEEHCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEHCCCEEHCCHHHHHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHCCCHHHHCCHHHHHHCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCCCCCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
Conf.Score	689999999999998645675775565556788875899998898999999986445678899999875678988999778999999999998995665677599995897899985888877667777666666666544567678899999997945656769999999899899999999999998984775895898699999999999867655666556775677556666545444344456666556778579999867757899999998798557898799995567766667777767999999999769866699999999999987669
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARL
Prediction	554015400520462055231423641543547242202031464413020213431433422432444565210000022015401520473402000200001023531000103335444555454544444445434203430010000003237214300320063071022102300520474510463763340342640042016304641454142231444353242243221010001101311232220100024234521340264251352750402012211642627522000000000000134551033004302641351477
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

HHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCCCEEEEEEHCCEEEEEEEEEHCCHHHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHCCCEHCCCCEEEEEHCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEHCCCEEHCCHHHHHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHCCCHHHHCCHHHHHHCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCCCCCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARL

2fmyA2

0.17

0.04

0.21

1.01

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------FKDARLRLAEFLVQAAMDTGLNTEEIALMLGTTRQTVSVLLNDFKKMGILERVNQRTLLLKDLQKLKEFSS---------------------------------------------------------------------------------------------------------------------------------

5boxA

0.08

0.04

0.54

1.00

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------SKDRMVELLLNLYEARAYVALVAFG---VLTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLIE----------TEVPKYGVERVWVVRGIKNSTLKTKEMLE---EAQNEILLADD--------GFIAVNLEDDIIKAVDRGKNLLPRLKASKIIDYAKEGKL

5awhA

0.13

0.97

0.69

MUSTER

PWLLRARLDDALEEALPKYAAVKKRPFTFLAQKDELIDAAAGLSHRLLNSFKVIPRF-ALSPKIYEPVDGTTRVGVFVTIGMREASLRDLLEAGI---DLRGMYVVRRERGLLGRVRAISDDMQLFEETDLASVNVNDAKLEGSKENFTRCLSALLGYKKLLNALDDQEAGYRTGDDAVRRMGEFLAKKPIRLADNINAQVGDRIVFSNEGQARNVRLAPKVEYVFDRTGAKSAEYAWRGLSQF--GPFDRPSFANRSPRILVVYPSSTQGKVENFLSAFRDGMGSNYS-GFSKGFVDLMGLTKVEFVMCPVEVSS--ADRNGAHTKYNSAIEDKLAGAGEV

5kc9A

0.08

0.07

0.86

0.59

dPPAS

DDRVFQLAVSDLSLNDDILQ-----------------------SEKITYSIKVIEAFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHI--------------PHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELR---WQKFVMFYDSEYDIRGLQSFLDQASRLGLSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETN-------LASKDSHWVFVNEEISDPEILDLVHSALIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWH

5boxA

0.11

0.07

0.59

0.62

wdPPAS

-------------------------------------------------------------------------------------------------------------------------------------SKDRMVELLLNLYEARAYVALVAFG---VLTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLIEWVVRGIKNSTLKTKAQNEILLADDGIAVNLEDDIIKAVD-----RGKTKILLTKNLLPRLKASKIIDYAKLICDFALEDLAKDHRVVALFKEKFNEYWEV

5ghrA

0.12

0.11

0.86

0.65

wMUSTER

FLERVREGAELIKHIELGHTIRLI-------SHRDA--------------------ITAGAILAKAVAREGGTFQLSIVKQVSEELIDQLAREKREFSDL-GSGSIKLNFATVVVADHHPPEKDSFSTDS-PVPFGANSVRDLS--GSGVAYFVARENRKNRDAYVAIVGAVGTFHGLNLEIIEDGKELGILEVRKELRLFGRESRPLYQLAYATNPEIPEIT-----GDERKAIEWLRAKGFDPEKYWQLRE-------------EEKRKLHEALLVHIKHGAPKEAIDRLIGDVVISPLYPEGDVRHEAREFATLLNAGDEEAYKVARKLDDYKKEQIEA

5boxA

0.11

0.07

0.59

0.80

wPPAS

----------------------------------------------------------------------------------SDRMVELLQEH--------E----------------------------------------LNLYEARAYVALVAFG---VLTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLIETEVRGIKNSTLKTLEEAQNEILL-FIAVNLEDDIIKAVD-----RGKTKILLTKNLLPRLKASKIIDYAKLICDFALEDLAKDHRVVALFKEKFNEYWEV

5boxA1

0.12

0.04

0.32

0.89

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------SKDRMVELLLNLYEARAYVALVAFG---VLTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKYRPVHPANVLEKFIQDWQERV------------KEELEAKKKAKEE---LLELMAPLIETE-----------------------------------------------------------------------------------

5gaoE

0.12

0.94

0.83

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK------------

2lkpA

0.17

0.05

0.32

0.82

Env-PPAS

---------------------------------------------------------------------------------------------------------------------GHGVEGRNRPSAPLDSQAAAQVASTLQPSRLMILTQLRNGP----LPVTDLAEAIGMEQSAVSHQLRVLRNLGLVVGDRAGYSLYDVAQLLDEAIYHSEHLHLGLSDRHPSAG----------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.90

Estimated TM-score = 0.29±0.09

Estimated RMSD = 16.2±3.1Å

Download Model 2

C-score=-4.52

Download Model 3

C-score=-3.78

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5kc9A	0.720	3.65	0.085	0.860
2	5kcaA	0.707	3.67	0.103	0.854
3	2e4zA	0.614	4.50	0.084	0.792
4	1ewtA	0.609	4.93	0.067	0.825
5	4uqqA	0.607	4.52	0.059	0.795
6	3h6gB	0.607	4.52	0.059	0.795
7	3o21A	0.604	4.43	0.081	0.789
8	3om0A	0.602	4.30	0.079	0.778
9	1dp4C	0.601	4.89	0.089	0.819
10	4gpaA	0.601	4.43	0.074	0.786

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	5d56D	78M	Rep, Mult	324,325,328
2	0.08	4	4n6sA	CYC	Rep, Mult	312,316
3	0.08	4	4u9dA	ZN	Rep, Mult	327,330
4	0.04	2	3ijoH	B4D	Rep, Mult	177,180,181,183,184,187
5	0.04	2	3jcuD	CLA	Rep, Mult	151,154
6	0.02	1	4dqdA	3PY	Rep, Mult	8,9,322,325,326,329
7	0.02	1	3m9gA	ZN	Rep, Mult	99,118
8	0.02	1	2wtfB	CA	Rep, Mult	26,322
9	0.02	1	1wuuB	MG	Rep, Mult	175,239
10	0.02	1	3pmvA	557	Rep, Mult	84,87,88,89
11	0.02	1	3ihiB	SO4	Rep, Mult	307,324
12	0.02	1	3lsfE	PZI	Rep, Mult	170,175,179,180,183
13	0.02	1	4asoB	NUC	Rep, Mult	175,199

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1b26A	0.429	5.63	0.072	0.640	1.4.1.3	336
2	0.060	1fw8A	0.417	6.12	0.085	0.670	2.7.2.3	308,310,317
3	0.060	1jqnA	0.421	5.48	0.043	0.620	4.1.1.31	NA
4	0.060	3c3kB	0.473	4.51	0.068	0.632	5.1.1.1	NA
5	0.060	3bblA	0.482	4.57	0.082	0.649	5.1.1.1	155,168,266
6	0.060	1aupA	0.410	5.63	0.070	0.617	1.4.1.2	231
7	0.060	1hwxA	0.422	5.69	0.039	0.632	1.4.1.3	NA
8	0.060	1bvuC	0.432	5.80	0.078	0.664	1.4.1.3	107
9	0.060	2axqA	0.420	5.77	0.084	0.640	1.5.1.10	NA
10	0.060	1gph1	0.447	6.52	0.059	0.740	2.4.2.14	190
11	0.060	1gq2A	0.454	6.07	0.062	0.714	1.1.1.40	NA
12	0.060	2ebsB	0.423	6.19	0.060	0.678	3.2.1.150	NA
13	0.060	1mioA	0.419	5.81	0.077	0.637	1.18.6.1	NA
14	0.060	1m34A	0.386	5.78	0.073	0.588	1.18.6.1	NA
15	0.060	1l5hA	0.288	6.19	0.051	0.459	1.18.6.1	NA
16	0.060	1qh8A	0.417	5.93	0.055	0.646	1.18.6.1	196,203
17	0.060	1kyzE	0.427	5.29	0.050	0.605	2.1.1.68	NA
18	0.060	1b3bE	0.431	5.67	0.072	0.649	1.4.1.3	50
19	0.060	1bvuA	0.431	5.72	0.073	0.655	1.4.1.3	336

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.614	4.50	0.08	0.79	2e4zA	GO:0001640 GO:0001642 GO:0004871 GO:0004930 GO:0005246 GO:0005516 GO:0005791 GO:0005794 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007196 GO:0007608 GO:0007611 GO:0009986 GO:0014050 GO:0016020 GO:0016021 GO:0016595 GO:0030165 GO:0030424 GO:0030425 GO:0032279 GO:0042734 GO:0042803 GO:0043025 GO:0043195 GO:0043198 GO:0043234 GO:0043679 GO:0045202 GO:0045211 GO:0048306 GO:0048786 GO:0050896 GO:0051966
1	0.07	0.608	4.33	0.08	0.78	3olzA	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007165 GO:0007268 GO:0008066 GO:0016020 GO:0016021 GO:0030054 GO:0030424 GO:0030425 GO:0032839 GO:0034220 GO:0035235 GO:0042391 GO:0043195 GO:0043204 GO:0045202 GO:0045211 GO:0051967
2	0.07	0.609	4.93	0.07	0.82	1ewtA	GO:0001639 GO:0004871 GO:0004930 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007205 GO:0007206 GO:0007216 GO:0007268 GO:0008066 GO:0014048 GO:0014069 GO:0016020 GO:0016021 GO:0019233 GO:0019722 GO:0030331 GO:0030424 GO:0038042 GO:0042734 GO:0042802 GO:0043197 GO:0051482 GO:0051899 GO:0051932 GO:0051966
3	0.07	0.583	4.91	0.08	0.80	5cnjA	GO:0001641 GO:0004871 GO:0004930 GO:0005246 GO:0005622 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007194 GO:0007196 GO:0007268 GO:0008066 GO:0014047 GO:0016020 GO:0016021 GO:0030054 GO:0030424 GO:0030425 GO:0042734 GO:0042995 GO:0043005 GO:0045202 GO:0051966
4	0.07	0.607	4.52	0.06	0.80	4uqqA	GO:0001662 GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006874 GO:0006886 GO:0007268 GO:0008066 GO:0008328 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0019228 GO:0030054 GO:0030165 GO:0030424 GO:0030425 GO:0031624 GO:0031625 GO:0032839 GO:0032983 GO:0034220 GO:0035235 GO:0035249 GO:0042391 GO:0042734 GO:0042802 GO:0042803 GO:0043025 GO:0043113 GO:0043195 GO:0043204 GO:0043524 GO:0043525 GO:0045202 GO:0045211 GO:0046328 GO:0048169 GO:0048172 GO:0050804 GO:0050806 GO:0051402 GO:0051967 GO:0060079 GO:0060080
5	0.07	0.593	4.92	0.07	0.81	4mqeA	GO:0001649 GO:0004871 GO:0004930 GO:0004965 GO:0005576 GO:0005615 GO:0005737 GO:0005789 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007193 GO:0007194 GO:0007214 GO:0008021 GO:0008134 GO:0008285 GO:0014048 GO:0014049 GO:0014053 GO:0016020 GO:0016021 GO:0030054 GO:0030425 GO:0030673 GO:0030817 GO:0031966 GO:0032811 GO:0033602 GO:0035094 GO:0038037 GO:0038039 GO:0042734 GO:0042995 GO:0043005 GO:0043025 GO:0043197 GO:0043198 GO:0043231 GO:0045121 GO:0045202 GO:0045211 GO:0045471 GO:0050805 GO:0060124
6	0.07	0.588	4.75	0.08	0.80	1jdnA	GO:0001501 GO:0002158 GO:0004016 GO:0005622 GO:0005886 GO:0005887 GO:0006171 GO:0007189 GO:0007193 GO:0007200 GO:0008217 GO:0008528 GO:0009190 GO:0016020 GO:0016021 GO:0016941 GO:0017046 GO:0019933 GO:0030157 GO:0033688 GO:0035810 GO:0042562 GO:0042803 GO:0048015 GO:0048662 GO:0051000 GO:0070062
7	0.07	0.575	5.28	0.08	0.81	4f11A	GO:0004871 GO:0004930 GO:0004965 GO:0005737 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007194 GO:0007214 GO:0007268 GO:0016020 GO:0016021 GO:0030054 GO:0038039 GO:0043005 GO:0045202 GO:0045211
8	0.07	0.554	5.07	0.08	0.77	3ip5A	GO:0006865 GO:0046872
9	0.07	0.561	5.01	0.06	0.79	2lbpA	GO:0006810 GO:0006865 GO:0015190 GO:0015807 GO:0015820 GO:0030288 GO:0042597 GO:0098655 GO:1902475
10	0.07	0.571	4.79	0.07	0.78	3hutA	GO:0006865
11	0.07	0.573	4.87	0.06	0.79	3lmkB	GO:0004871 GO:0004930 GO:0005737 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007205 GO:0007206 GO:0007216 GO:0007268 GO:0007612 GO:0007626 GO:0008066 GO:0014069 GO:0016020 GO:0016021 GO:0043005 GO:0048169 GO:0050890 GO:0051966 GO:0070062
12	0.07	0.573	4.49	0.10	0.75	4mlcA	GO:0006865
13	0.07	0.547	4.93	0.07	0.76	4n0qB	GO:0006810 GO:0006865
14	0.07	0.565	5.17	0.06	0.79	5fbkA	GO:0001503 GO:0004435 GO:0004871 GO:0004930 GO:0005513 GO:0005886 GO:0005887 GO:0006874 GO:0007165 GO:0007186 GO:0007635 GO:0009653 GO:0016020 GO:0016021 GO:0070509
15	0.07	0.545	5.21	0.07	0.78	2livA	GO:0006810 GO:0006865 GO:0015658 GO:0015803 GO:0030288 GO:0042597
16	0.07	0.565	4.77	0.06	0.77	2e4vB	GO:0001641 GO:0004871 GO:0004930 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007196 GO:0016020 GO:0016021 GO:0019233 GO:0042734 GO:0050804 GO:0051966 GO:0097449
17	0.07	0.539	5.14	0.12	0.76	3td9A	GO:0006865
18	0.07	0.535	4.61	0.07	0.70	3mq4A	GO:0001642 GO:0001661 GO:0001662 GO:0004871 GO:0004930 GO:0005245 GO:0005246 GO:0005509 GO:0005886 GO:0005887 GO:0005938 GO:0007165 GO:0007186 GO:0007194 GO:0007196 GO:0007268 GO:0007605 GO:0007608 GO:0007613 GO:0007614 GO:0008066 GO:0008306 GO:0010855 GO:0014050 GO:0016020 GO:0016021 GO:0016595 GO:0019226 GO:0030165 GO:0030424 GO:0030425 GO:0030534 GO:0030818 GO:0031279 GO:0032279 GO:0033555 GO:0042734 GO:0043198 GO:0043235 GO:0045211 GO:0048786 GO:0050877 GO:0050896 GO:0051966 GO:0070588 GO:0070905
19	0.07	0.510	5.44	0.09	0.75	5ipqA	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0035235 GO:0045202 GO:0045211
20	0.07	0.512	5.46	0.09	0.75	4tllA	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0035235 GO:0045202 GO:0045211

Consensus prediction of GO terms

Molecular Function	GO:0004888
GO-Score	0.48
Biological Processes	GO:0051716	GO:0035249	GO:0050804
GO-Score	0.49	0.38	0.38
Cellular Component	GO:0036477	GO:0031226	GO:0097060	GO:0098793	GO:0043679	GO:0098794
GO-Score	0.49	0.49	0.49	0.49	0.38	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.