I-TASSER results

I-TASSER results for job id Rv0831c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (271 residues)
MLPETNQDEVQPNAPVALVTVEIRHPTTDSLTESANRELKHLLINDLPIERQAQDVSWGM
TAPGGAPTPVADRFVRYVNRDNTTAASLKNQAIVVETTAYRSFEAFTDVVMRVVDARAQV
SSIVGLERIGLRFVLEIRVPAGVDGRITWSNWIDEQLLGPQRFTPGGLVLTEWQGAAVYR
ELQPGKSLIVRYGPGMGQALDPNYHLRRITPAQTGPFFLLDIDSFWTPSGGSIPEYNRDA
LVSTFQDLYGPAQVVFQEMITSRLKDELLRQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLPETNQDEVQPNAPVALVTVEIRHPTTDSLTESANRELKHLLINDLPIERQAQDVSWGMTAPGGAPTPVADRFVRYVNRDNTTAASLKNQAIVVETTAYRSFEAFTDVVMRVVDARAQVSSIVGLERIGLRFVLEIRVPAGVDGRITWSNWIDEQLLGPQRFTPGGLVLTEWQGAAVYRELQPGKSLIVRYGPGMGQALDPNYHLRRITPAQTGPFFLLDIDSFWTPSGGSIPEYNRDALVSTFQDLYGPAQVVFQEMITSRLKDELLRQ
Prediction	CCCCCCCCCCCCCCCEEEEEEEEEHCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCCCCCCCCEEEEEEHCCCCEEEEEHCCEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEHCEEEEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
Conf.Score	9998886555689953789999985788778766589999999986987655556777766888766665446888886799789999799899999778998899999999999999985767668998788679976788776567899865654666667876544556554566775578967999986566766778877777777888776999754444566666666899999999999999999999998689999999859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLPETNQDEVQPNAPVALVTVEIRHPTTDSLTESANRELKHLLINDLPIERQAQDVSWGMTAPGGAPTPVADRFVRYVNRDNTTAASLKNQAIVVETTAYRSFEAFTDVVMRVVDARAQVSSIVGLERIGLRFVLEIRVPAGVDGRITWSNWIDEQLLGPQRFTPGGLVLTEWQGAAVYRELQPGKSLIVRYGPGMGQALDPNYHLRRITPAQTGPFFLLDIDSFWTPSGGSIPEYNRDALVSTFQDLYGPAQVVFQEMITSRLKDELLRQ
Prediction	7347355743154000110001021342451476214502520275034344454352415475445544354114022444421030354100020251641650251034004102520614401000010112032545455354025003540233234344333333334333244345622020222344433244445155244447230000000101424665145142640251044015202400230025502541268
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCEEEEEEEEEHCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCCCCCCCCEEEEEEHCCCCEEEEEHCCEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEHCEEEEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
MLPETNQDEVQPNAPVALVTVEIRHPTTDSLTESANRELKHLLINDLPIERQAQDVSWGMTAPGGAPTPVADRFVRYVNRDNTTAASLKNQAIVVETTAYRSFEAFTDVVMRVVDARAQVSSIVGLERIGLRFVLEIRVPAGVDGRITWSNWIDEQLLGPQRFTPGGLVLTEWQGAAVYRELQPGKSLIVRYGPGMGQALDPNYHLRRITPAQTGPFFLLDIDSFWTPSGGSIPEYNRDALVSTFQDLYGPAQVVFQEMITSRLKDELLRQ

4jmfB

0.11

0.04

0.40

1.33

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------MNPLYRAAIHQLFLALDLPTPNDEESVLSLQVGPHLCHLAEHPTDHLLMFTRLEGQGDATANEQNLFSQDPCKP---ILGRD---PESGEPLQLLDRAQIHHQLEQLVAAAEELR---------------

4ixjA

0.07

0.05

0.74

1.10

dPPAS2

----------------------------RNIEENIKTQIVIAMAEESSKDKNEVIKEVLENKDGKYFETEPK-------CKSGGIYSATFDKVYVTCTKHPDGIEMARDIHQSMKDLIASFAQDPSI-----------IPGASKGNDDFRKYLLDNKYKNGWPTIPGLSKDTLYIQPYAYNPTKSDATVVVFANNKTGGNWYTSLVYDYDEGRKGKNGISVAGRSWDVDTDSVKSVKTEIHSKELN-------------------------

4r04A4

0.10

0.93

0.69

MUSTER

NKIPSNNVEEAGSKNYVHYIIQLQ-------GDDISYEATCNLFSKNPKMNESAKSYFLSDDGESILELNKYRIPERLKNKEKVKVTFI-EFNTSEFARL-SVDSLSNEISSFLDTIKLDISPK-NVEVNLLGCNMFSYDFNVEETGKLLLSIMDKITSTLPDV-NKNSITIGANQYEVRINSEGRKELLA---HSGKWINKEEAIMSDLSSK----EYIFFDS--IDNKLKAKSKNIPGLASISEDIKTLLLSPDTKFILNNLKLNIESS

2nn6E

0.09

0.08

0.89

0.71

dPPAS

-----------------------------TLSEAEKVYIVHGVQEDLRVCEDYRCVEVETDVVSNTSKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGP

2nn6E

0.09

0.08

0.85

0.68

wdPPAS

-----------------------------TLSEAEKVYIVHGVQEDL-GCEDYRCVEVETDV-----VSNTSGSARVKLGHTDILVGVKEGYLEFFVDEFEGGDDLGTEIANTLYRIFNNKSSVDLKTLCILYVDVLLLECGGNLFDAISIAVKAALF------NTRIPRVRVLEDIELSDDPYDCICIVTLCKIGYRHVV-DATLQEEACSLASLLVSVTSKGVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSKEESLGPKRQ

5dfzC

0.10

0.96

0.72

wMUSTER

SRLDKKSRNILND--LINVLRECCETRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTHLMFKVGDDLRQDQLVVQIISLMNELLKNLTPYKILATG-PQEGAIEFIPNDTLASILSKYILGYLKLHYPDENATLGVQGWVLDNFVKSCAG-------YCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKFPPLMKPPQIIEAFGGAESSNYDKFRSYC-FVAYSILRRN

4r04A4

0.11

0.10

0.90

0.71

wPPAS

NKIPSNNVEEAGSKNYVHYIIQLQ-------GDDISYEATCNLFSKNP--KNSIIIQRNMNESLSDDGESILELNKYLKNKEKVKVTFI-NTSEFA--RL-SVDSLSNEISSFLDTIKLDISPK-NVEVNLL--NMFSYDFNVEETGKLLLSIMDKITSTLP-DVNKNSITIGANQYEVRINSEGRKELLA---HSGKWINKEEAIMSDLSSKEYIFF--SID-----NKLKAKSKNIPGLASISEDIKTLLLDPDTKFILNNLKLNIESS

2yn3A1

0.11

0.03

0.28

1.04

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------TPPNAPVVTYSDIVNDLIIQGTAEAKSQLIITDSEGNTYVPDNGKWSAIPYPSEGKFTITSVDAIGNRSDDVPLDI-----------------------------------

4r04A4

0.09

0.08

0.93

PPAS

NKIPSNNVEEAGSKNYVHYIIQLQ-------GDDISYEATCNLFSKNPKMNESAKSYFLSDDGESILELNKYRIPERLKNKEKVKVTFIGDEFNTSEFARLSVDSLSNEISSFLDTIKLDISPK-NVEVNLLNMFSYDFNVEETYPGKLLLSIMDKITSTLP-DVNKNSITIGANQYEVRINSEGRKELLA---------HSGKWINKEEAIMSDLSSKEYIFFDSIDNKLKAKSKNIPGLASISEDIKTLLLDASVSPDTKFILNNLKLN

2wamA

0.08

0.07

0.96

0.72

Env-PPAS

MYELEFPAPQLSSSDGRGPVLVHALEGFSDAGH-AIRLAAAHLKAALDLDYRSRRPLMTFKTDHFTHSDDPELSLYALRDSIG------TPFLLLAGLEPDKWERFITAVRLLAERLG----VRQTIGLGTVPMAVPHTPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGH-EVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDSAEVAQVVAALERQYDAFIDAQENRSLGAEFERF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.94

Estimated TM-score = 0.48±0.15

Estimated RMSD = 10.4±4.6Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4r04A4	0.796	2.68	0.100	0.904
2	3ho6A	0.603	3.90	0.065	0.756
3	3pa8A	0.589	4.06	0.057	0.745
4	5cg0A	0.511	5.41	0.052	0.782
5	1wcgA	0.505	5.36	0.044	0.775
6	5dt5A	0.504	5.43	0.044	0.779
7	3ahzA	0.504	5.26	0.039	0.767
8	2jieA	0.504	5.42	0.035	0.775
9	3ahxA	0.503	5.22	0.076	0.756
10	2e9mA	0.501	5.38	0.070	0.775

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	6	3pa8A	IHP	Rep, Mult	14,16,43,46,85,217,236
2	0.04	2	2axtM	CLA	Rep, Mult	256,260
3	0.04	2	1q9xA	CA	Rep, Mult	223,224
4	0.04	2	1ps9A	SF4	Rep, Mult	248,250,251,252,258,259,263,264
5	0.04	2	3gcdB	AZ0	Rep, Mult	35,38,39,42,90,132,134,176,177,178,206
6	0.04	2	4h13D	TDS	Rep, Mult	106,109
7	0.04	2	1s5ld	CLA	Rep, Mult	220,241
8	0.02	1	4ntlA	ZN	Rep, Mult	104,108
9	0.02	1	3ihkA	MG	Rep, Mult	221,223
10	0.02	1	2qdgC	PO4	Rep, Mult	20,86,88,173,175
11	0.02	1	3uomD	CA	Rep, Mult	136,137
12	0.02	1	1yxmB	ADE	Rep, Mult	87,88,110,153
13	0.02	1	2x9xA	IMD	Rep, Mult	67,69
14	0.02	1	3c5iA	MG	Rep, Mult	203,221
15	0.02	1	2wscJ	CLA	Rep, Mult	15,19

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1qoxA	0.495	5.40	0.076	0.760	3.2.1.21	NA
2	0.060	2et6A	0.473	5.40	0.059	0.738	1.1.1.-	NA
3	0.060	3gnrA	0.496	5.56	0.069	0.779	3.2.1.21	148,156,159
4	0.060	2jf6B	0.499	5.47	0.048	0.775	3.2.1.105	172
5	0.060	1rkxC	0.481	5.66	0.064	0.749	4.2.1.45	NA
6	0.060	1ujmA	0.473	5.56	0.053	0.749	1.1.1.2	210
7	0.060	2jieA	0.504	5.42	0.035	0.775	3.2.1.21	NA
8	0.060	1gonA	0.494	5.36	0.067	0.756	3.2.1.21	NA
9	0.060	2c8nA	0.480	5.93	0.068	0.779	3.2.1.55	NA
10	0.060	1wvgA	0.478	5.71	0.064	0.749	4.2.1.45	NA
11	0.060	1np2A	0.492	5.31	0.079	0.749	3.2.1.21	NA
12	0.060	2c59A	0.470	5.51	0.051	0.742	5.1.3.18	87
13	0.060	1y1pA	0.476	5.50	0.063	0.753	1.1.1.2	87,126
14	0.060	2pbgA	0.499	5.25	0.059	0.756	3.2.1.85	NA
15	0.060	1bgaA	0.500	5.32	0.080	0.764	3.2.1.21	NA
16	0.060	3gnoA	0.495	5.57	0.069	0.779	3.2.1.21	172
17	0.060	1z45A	0.473	5.28	0.034	0.727	5.1.3.2,5.1.3.3	97,100
18	0.060	1wcgA	0.505	5.36	0.044	0.775	3.2.1.147	NA
19	0.060	3cmjA	0.494	5.33	0.077	0.760	3.2.1.21	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.603	3.90	0.07	0.76	3ho6A	GO:0006508 GO:0008233 GO:0008234 GO:0009405 GO:0016757 GO:0016787
1	0.07	0.589	4.06	0.06	0.75	3pa8A	GO:0009405 GO:0016740 GO:0016757
2	0.07	0.471	3.91	0.10	0.60	3fzyA	GO:0000166 GO:0000287 GO:0000822 GO:0003824 GO:0004197 GO:0005509 GO:0005524 GO:0005576 GO:0006508 GO:0008152 GO:0008233 GO:0008234 GO:0008289 GO:0009405 GO:0016020 GO:0016540 GO:0016787 GO:0016874 GO:0016881 GO:0018153 GO:0018262 GO:0019836 GO:0020002 GO:0030042 GO:0030430 GO:0031640 GO:0033644 GO:0044164 GO:0046872 GO:0090527
3	0.06	0.404	5.40	0.06	0.61	2x5fA	GO:0003824 GO:0009058 GO:0030170
4	0.06	0.399	6.28	0.04	0.68	1qhoA	GO:0003824 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0043169 GO:0043897 GO:0046872 GO:2001070
5	0.06	0.400	5.01	0.07	0.58	2hk0A	GO:0016853 GO:0016857 GO:0030145 GO:0046872 GO:0050897
6	0.06	0.353	6.54	0.06	0.61	2au3A	GO:0000287 GO:0003677 GO:0003896 GO:0003899 GO:0006260 GO:0006269 GO:0008270 GO:0016740 GO:0016779 GO:0046872 GO:1990077
7	0.06	0.395	4.91	0.06	0.57	2xtzB	GO:0000166 GO:0001789 GO:0003924 GO:0004871 GO:0005095 GO:0005525 GO:0005789 GO:0005834 GO:0005886 GO:0006571 GO:0007165 GO:0007186 GO:0008219 GO:0009094 GO:0009506 GO:0009738 GO:0009740 GO:0009749 GO:0009785 GO:0009788 GO:0009789 GO:0009845 GO:0010027 GO:0010119 GO:0010244 GO:0016020 GO:0016247 GO:0019001 GO:0031683 GO:0034260 GO:0042127 GO:0046872 GO:0071215 GO:0072593
8	0.06	0.286	6.13	0.05	0.49	4dmvA	GO:0006508 GO:0008233 GO:0008234 GO:0009405 GO:0016757 GO:0016787
9	0.06	0.312	4.61	0.06	0.45	2wteA	GO:0003677 GO:0051607
10	0.06	0.305	6.68	0.03	0.56	2bvlA	GO:0006508 GO:0008233 GO:0008234 GO:0009405 GO:0016757 GO:0016787 GO:0020002 GO:0046527
11	0.06	0.302	6.22	0.07	0.53	4xk1A	GO:0003824 GO:0004648 GO:0005737 GO:0006564 GO:0008483 GO:0008615 GO:0008652 GO:0016740 GO:0030170
12	0.06	0.322	6.44	0.03	0.57	3gdeA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
13	0.06	0.259	6.36	0.03	0.46	4mboA	GO:0005576 GO:0005618 GO:0007155 GO:0009986 GO:0030260 GO:1990254
14	0.06	0.317	5.65	0.03	0.50	2vk9A	GO:0009405 GO:0016757
15	0.06	0.258	6.40	0.03	0.45	5bugA	GO:0000079 GO:0000287 GO:0001525 GO:0001933 GO:0002902 GO:0004438 GO:0004721 GO:0004722 GO:0004725 GO:0005161 GO:0005576 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006470 GO:0006629 GO:0006661 GO:0006915 GO:0007270 GO:0007399 GO:0007416 GO:0007417 GO:0007507 GO:0007568 GO:0007584 GO:0007611 GO:0007613 GO:0007626 GO:0008138 GO:0008283 GO:0008284 GO:0008285 GO:0008289 GO:0009749 GO:0009898 GO:0010033 GO:0010035 GO:0010043 GO:0010975 GO:0010997 GO:0014067 GO:0014070 GO:0016311 GO:0016314 GO:0016324 GO:0016477 GO:0016605 GO:0016787 GO:0016791 GO:0019899 GO:0019901 GO:0021542 GO:0021955 GO:0030165 GO:0030336 GO:0030534 GO:0031175 GO:0031642 GO:0031647 GO:0031658 GO:0032228 GO:0032286 GO:0032355 GO:0032535 GO:0033032 GO:0033198 GO:0033555 GO:0035176 GO:0035335 GO:0035749 GO:0036294 GO:0042493 GO:0042711 GO:0042802 GO:0042995 GO:0043005 GO:0043065 GO:0043066 GO:0043197 GO:0043220 GO:0043491 GO:0043542 GO:0043647 GO:0045211 GO:0045471 GO:0045475 GO:0045792 GO:0046621 GO:0046685 GO:0046855 GO:0046856 GO:0048008 GO:0048015 GO:0048679 GO:0048738 GO:0048853 GO:0048854 GO:0050680 GO:0050765 GO:0050771 GO:0050821 GO:0050852 GO:0051091 GO:0051717 GO:0051726 GO:0051800 GO:0051895 GO:0051898 GO:0060024 GO:0060070 GO:0060074 GO:0060134 GO:0060179 GO:0060291 GO:0060292 GO:0060341 GO:0060736 GO:0060997 GO:0061002 GO:0070373 GO:0070374 GO:0071456 GO:0090071 GO:0090344 GO:0090394 GO:0097105 GO:0097107 GO:1903984 GO:1904668 GO:2000060 GO:2000134 GO:2000463 GO:2000808 GO:2001235
16	0.06	0.253	6.02	0.07	0.41	1f5xA	GO:0005085 GO:0005089 GO:0005829 GO:0005911 GO:0006909 GO:0006955 GO:0007186 GO:0007229 GO:0007264 GO:0008361 GO:0030168 GO:0030217 GO:0030593 GO:0030676 GO:0035023 GO:0035556 GO:0042110 GO:0043087 GO:0043547 GO:0045785 GO:0045954 GO:0046872 GO:0048010 GO:0072593
17	0.06	0.302	6.60	0.05	0.55	4mixB	GO:0003824 GO:0005509 GO:0005576 GO:0008152 GO:0009405 GO:0016020 GO:0016262 GO:0016740 GO:0016757 GO:0016787 GO:0020002 GO:0033644 GO:0036210 GO:0043087 GO:0046872 GO:0050568
18	0.06	0.270	6.61	0.04	0.48	2vkdA	GO:0000166 GO:0009405 GO:0016757 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0016757	GO:0008289	GO:0000287	GO:0016881	GO:0005524	GO:0005509	GO:0004197	GO:0000822	GO:0030170	GO:2001070	GO:0043897
GO-Score	0.13	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.06	0.06	0.06
Biological Processes	GO:0051704
GO-Score	0.37
Cellular Component	GO:0016020	GO:0044164	GO:0005576	GO:0020002
GO-Score	0.07	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.