I-TASSER results

I-TASSER results for job id Rv0826

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (351 residues)
MTQDTSATCPLTSTVQDSSPVAGQLGRPIGFRGLAGGCPVSPLGYESPPLPLGPDSLTWR
YFGDWRGMLQGPWAGSMQNMHPQLGAAVEDHSTFFRERWPRLLRSLYPIGGVVFDGDRAP
VTGVQVRDYHITIKGVDGAGRRYHALNPDVFYWAHATFFVGTLHVAERFCGGLTEAQRRQ
LFDEHVQWYRMYGMSMRPVPATWEEFQDYWDHMCRNVLENNFAARAVLDLTELPKPPFAQ
RVPDWLWAAPRKLLARFFVWLTVGLYDPPVRELMGYRWLRRDEWLHRRFGDIVRLVFALV
PFRFRKHPRARAGWDRATGRIPADAPLVQTPARNLPPPDERDNPTHYCPKV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTQDTSATCPLTSTVQDSSPVAGQLGRPIGFRGLAGGCPVSPLGYESPPLPLGPDSLTWRYFGDWRGMLQGPWAGSMQNMHPQLGAAVEDHSTFFRERWPRLLRSLYPIGGVVFDGDRAPVTGVQVRDYHITIKGVDGAGRRYHALNPDVFYWAHATFFVGTLHVAERFCGGLTEAQRRQLFDEHVQWYRMYGMSMRPVPATWEEFQDYWDHMCRNVLENNFAARAVLDLTELPKPPFAQRVPDWLWAAPRKLLARFFVWLTVGLYDPPVRELMGYRWLRRDEWLHRRFGDIVRLVFALVPFRFRKHPRARAGWDRATGRIPADAPLVQTPARNLPPPDERDNPTHYCPKV
Prediction	CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	988888888888888887765554466665566788888877788888888998757888875589999999999999978999999998655555489999999999999874999999999999999854678889998667899999999999999999999999889999999999999999999999999776998999999999999988747879999999999768888655554567788899999999999999799999999899999999999999999999998758888876754789999987567899987667777889876788988788899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTQDTSATCPLTSTVQDSSPVAGQLGRPIGFRGLAGGCPVSPLGYESPPLPLGPDSLTWRYFGDWRGMLQGPWAGSMQNMHPQLGAAVEDHSTFFRERWPRLLRSLYPIGGVVFDGDRAPVTGVQVRDYHITIKGVDGAGRRYHALNPDVFYWAHATFFVGTLHVAERFCGGLTEAQRRQLFDEHVQWYRMYGMSMRPVPATWEEFQDYWDHMCRNVLENNFAARAVLDLTELPKPPFAQRVPDWLWAAPRKLLARFFVWLTVGLYDPPVRELMGYRWLRRDEWLHRRFGDIVRLVFALVPFRFRKHPRARAGWDRATGRIPADAPLVQTPARNLPPPDERDNPTHYCPKV
Prediction	746446443434444454444454354344242344524244353743311021310001111010011012100000000010130023113025201400220030000000126504400430361155151447444402020120000000000100020021023303662132004001300310403473116115002400440156213345004102200422313214301320131023101200000000001420052060513442110020002002101210032003102032014204423457233162254514146554303210276
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MTQDTSATCPLTSTVQDSSPVAGQLGRPIGFRGLAGGCPVSPLGYESPPLPLGPDSLTWRYFGDWRGMLQGPWAGSMQNMHPQLGAAVEDHSTFFRERWPRLLRSLYPIGGVVFDGDRAPVTGVQVRDYHITIKGVDGAGRRYHALNPDVFYWAHATFFVGTLHVAERFCGGLTEAQRRQLFDEHVQWYRMYGMSMRPVPATWEEFQDYWDHMCRNVLENNFAARAVLDLTELPKPPFAQRVPDWLWAAPRKLLARFFVWLTVGLYDPPVRELMGYRWLRRDEWLHRRFGDIVRLVFALVPFRFRKHPRARAGWDRATGRIPADAPLVQTPARNLPPPDERDNPTHYCPKV

4ke2A

0.08

0.04

0.56

1.73

dPPAS2

------------------------------------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDT-----------AAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP------------------------------------------------------------------------------------

5cwdA

0.11

0.05

0.48

1.57

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------TKEDARSTCEKAARKAAESNDEEVAKQAAKDCLEVAKQAGMPTKEAARSFCEAAARAAAESNDEEVAKIAAKACLEVAKQAGMPTKEAARSFCEAAARAAAESEEVAKIAAKACLEVAKQAGMPTKEAARSFCEAAKRAAKESND--EEVEKIAKKACKEVAKQAGMPWLE---------------------------

4fxgB

0.11

0.10

0.94

0.83

MUSTER

GSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLGEQTMIYLAPTLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMQQFRKADG-SYAALSRDSSTWLTAFVLKVLSLAQEQVG--GSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLG-----------------AHAAAITAYALSLTKAPVDLLG--VAHNNLMAMAQETGDNGSVTGSQSNAVSPTPAPRNPSDPMPQA

5cwiA

0.07

0.05

0.66

0.80

dPPAS

------------------------------------------------------DIEKLCKKAESEAREARSKAEELRQRHPQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAE----AVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHP------------DSQKARDEIKEASQKAEEVKERCER--------------------------------------------------

5i1uA

0.14

0.10

0.72

0.62

wdPPAS

MSDDTSLELPFTHRRNPQTEAADRHLE----------------------RELAAVV-------SGSTYTGWDITELASLVYPES-------------SAEDLALAADLMGFYFL-GRRPEQVALICERLSAIAHGTLTAVTS--------------PSERAFADLWRRITLGMTDRWRARAACNWEYYFACHPAEAAGPPD----REGYLTLRRGTAAM--ESIFDMIERLGHFEVP----MHHPLFRQLRQLAADIPSFTNDVR--MIVRRDRCCS--AVVWDEAQRMADRFCDLRDQLPDACRSMSLDPAQRLAAER--------SHT---------------------

4fxgB1

0.11

0.10

0.93

0.83

wMUSTER

GSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLD-PPETKDHAVDLIQKGYMRIQFRKADG-SYAALSRDSSTWLTAFVLKVLSLAQEQVG--GSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLG-----------------AHAAAITAYALSLTKAPVDLLGV-AHNNLMAMAQETGDN-GSVTGSQSNAVSPTPAPRNPSDPMPQA

5i1uA

0.14

0.10

0.71

0.72

wPPAS

MSDDTSLELPFTHRR--QTEAADRHLE----------------------RELAAVV-------SGSTYTGWDITELASLVYPES-------------SAEDLALAADLMGFYFLLGRRPEQVALICERLSAIAHGTLTAVTS--------------PSERAFADLWRRITLGMTDRWRARAACNWEYYFACHPAEAAGPPD----REGYLTLRRGTAAM--ESIFDMIERLGHFEVP------HPLFRQLRQLAADIPSFTNDVR--MIVRRDRCCSTAAVVWDEAQRMADRFCDLRDQLPDACRSMSLDPAQRLAAER---------------------------Y---A

5cwbA

0.08

0.04

0.53

1.51

dPPAS2

---------------------------------------------------------------DECEEKARRVAEKVERLKDEIAEEVAREISEVIRTLKESGSSYEVICECV--ARIVAEIVEALKRSG---------------TSEDEIAEIVARVISEVIRTLKESGSSVICECVARIVAEIVEALKRSGTSEDEIAEIVARVISEVIRTLKESGSSYEVIKECVQRIVEEIVEALGTSEDEINEIVRRVKSEVERTLKESGS-------------------------------------------------------------------------------------

4ozvA

0.09

0.08

0.87

0.90

PPAS

--------------ADLVPPPGYYAAVGERKAGSCPAVPPPYTGSLVFTSKYGSDS-----------------------ARATLNVKAEKTFRSQIKDITDMERGATKLVTQYMRDGDLACALNWMSAWARA---GALQSDDFNHTGKSMRKWALGSLSGAYMRLKFSSSRPAHAEQSREIEDWFARLGTQVVRDWSGLPLKKINNHSYWAAWSVMSTNRRDLFDWAVSEFKVAANQVDEFLPNELKRRQRALAYHNYALPPLAMI-AAFAQVNGVDLRQENHGALQRLAERVMKGVD--EETFEEKTGEDQDMTDLKVDNKYA--ALYRCEPKMLEAKKDREPFNS-FRL

2d4aD

0.09

0.07

0.76

0.68

Env-PPAS

MMRGYDTPGKPQGEALDLAHAAAELGVDIRISGSNSYEDMRGSDTAGIGR--KPGMTREQLLEANANTMADLAEKIKAYAKDAMTYVMYKKTGF---PRERVIGFSGILDSARMAYYISQKLGVSFKSVNAIVLGM--HG------QKMFPVPRLSSVGGVPLEHL------MSKEEIEEVVSETVNAGAKI-TELRGY-SSNYGPAAGLVLTVEAIKRDSKRI-----------------YPYSLYLQGEYGYNDIVAEVPAVIGKSGIERIIELPLTEDEKRKFDEAVQAVKKLVETLPPQLRE---------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.23

Estimated TM-score = 0.45±0.15

Estimated RMSD = 11.8±4.5Å

Download Model 2

C-score=-3.53

Download Model 3

C-score=-4.76

Download Model 4

C-score=-4.98

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4fxgB1	0.880	2.02	0.109	0.940
2	3cu7A	0.749	3.55	0.063	0.886
3	2b39A	0.740	3.32	0.069	0.866
4	2pn5A	0.681	3.66	0.045	0.818
5	2cqtA	0.604	4.97	0.070	0.823
6	1w6jA	0.597	4.80	0.049	0.795
7	4zleA	0.590	4.77	0.050	0.798
8	3c68A	0.586	5.09	0.063	0.801
9	3wkfA	0.586	3.99	0.077	0.727
10	3vw5A	0.586	4.30	0.066	0.744

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	2y02A	2CV	Rep, Mult	224,227,246,250,253
2	0.08	4	1ji5A	FE	Rep, Mult	130,155
3	0.04	2	1n95B	HFP	Rep, Mult	99,102,151,153,154,157,197,222,286
4	0.02	1	2okxB	GOL	Rep, Mult	156,159,160,222,225,226,229
5	0.02	1	1bk5B	CO	Rep, Mult	67,115
6	0.02	1	3cz3B	NUC	Rep, Mult	82,84
7	0.02	1	1g6iA	UUU	Rep, Mult	136,137,140,174,180
8	0.02	1	3c68A	BMA	Rep, Mult	94,145,147,154
9	0.02	1	2wy2A	PO3	Rep, Mult	218,286
10	0.02	1	3o0rC	CA	Rep, Mult	140,143
11	0.02	1	5jreD	ADE	Rep, Mult	194,256
12	0.02	1	2q6qA	CO	Rep, Mult	204,208
13	0.02	1	1dogA	NOJ	Rep, Mult	203,204,205,341,347
14	0.02	1	1dl2A	UUU	Rep, Mult	133,136,139,170,174,178
15	0.02	1	3c72B	CX1	Rep, Mult	99,100,102,153,156,216,218,219,221,222,287,290
16	0.02	1	3c67B	GLC	Rep, Mult	218,221,222,225
17	0.02	1	1g6iA	DMJ	Rep, Mult	98,99,100,157,161
18	0.02	1	1rcsB	TRP	Rep, Mult	173,174

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1js4A	0.510	4.68	0.095	0.681	3.2.1.4	NA
2	0.060	1lf6A	0.562	5.06	0.071	0.781	3.2.1.3	NA
3	0.060	1f1sA	0.517	5.19	0.042	0.712	4.2.2.1	NA
4	0.060	1hcuB	0.555	5.18	0.044	0.761	3.2.1.113	NA
5	0.060	1j0mA	0.527	4.44	0.078	0.690	4.2.2.12	199
6	0.060	2qnoA	0.546	4.41	0.049	0.704	3.2.1.4	228
7	0.060	1fo2A	0.508	5.09	0.048	0.707	3.2.1.113	NA
8	0.060	1i8qA	0.517	5.06	0.038	0.707	4.2.2.1	139,147
9	0.060	1ksdA	0.505	5.17	0.049	0.692	3.2.1.4	94,104
10	0.060	2vn7A	0.520	5.28	0.084	0.755	3.2.1.3	NA
11	0.060	2ri9B	0.538	4.86	0.054	0.724	3.2.1.113	272
12	0.060	1ft1B	0.518	4.68	0.081	0.695	2.5.1.58,2.5.1.-	NA
13	0.060	1l2aE	0.546	4.88	0.042	0.746	3.2.1.4	152,203
14	0.060	1fp3A	0.547	4.76	0.059	0.721	5.1.3.8	99,186
15	0.060	1ia7A	0.512	4.96	0.041	0.690	3.2.1.4	NA
16	0.060	1ut9A	0.549	5.26	0.048	0.778	3.2.1.4	NA
17	0.060	1hzfA	0.565	3.47	0.105	0.655	3.4.21.43	NA
18	0.060	1clcA	0.531	4.90	0.037	0.718	3.2.1.4	NA
19	0.060	2sqcA	0.536	4.12	0.057	0.669	5.4.99.17	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.880	2.02	0.11	0.94	4fxgB	GO:0001849 GO:0002376 GO:0004252 GO:0004866 GO:0005576 GO:0005615 GO:0005886 GO:0006508 GO:0006954 GO:0006956 GO:0006958 GO:0010951 GO:0030449 GO:0045087 GO:0070062 GO:0072562 GO:2000427
1	0.13	0.749	3.55	0.06	0.89	3cu7B	GO:0000187 GO:0001701 GO:0002376 GO:0004866 GO:0005102 GO:0005576 GO:0005579 GO:0005615 GO:0006935 GO:0006950 GO:0006954 GO:0006956 GO:0006957 GO:0006958 GO:0007166 GO:0007186 GO:0008009 GO:0010575 GO:0010760 GO:0010951 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0060326 GO:0070062 GO:0090197 GO:0098779
2	0.12	0.737	3.45	0.06	0.87	5hccA	GO:0000187 GO:0001701 GO:0002376 GO:0004866 GO:0005102 GO:0005576 GO:0005579 GO:0005615 GO:0006935 GO:0006950 GO:0006954 GO:0006956 GO:0006957 GO:0006958 GO:0007166 GO:0007186 GO:0008009 GO:0010575 GO:0010760 GO:0010951 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0060326 GO:0070062 GO:0090197 GO:0098779
3	0.12	0.740	3.04	0.06	0.85	2a73B	GO:0001798 GO:0001934 GO:0001970 GO:0002376 GO:0002507 GO:0004252 GO:0004866 GO:0005102 GO:0005576 GO:0005615 GO:0005886 GO:0006508 GO:0006629 GO:0006631 GO:0006954 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0007165 GO:0007186 GO:0007596 GO:0008289 GO:0010575 GO:0010828 GO:0010866 GO:0010884 GO:0010951 GO:0030449 GO:0031715 GO:0032026 GO:0032355 GO:0032570 GO:0043627 GO:0045087 GO:0045745 GO:0045766 GO:0048037 GO:0048639 GO:0050766 GO:0050776 GO:0051384 GO:0070062 GO:0070374 GO:0072562 GO:2000427
4	0.09	0.681	3.66	0.04	0.82	2pn5A	GO:0004866 GO:0005576 GO:0005615 GO:0010951
5	0.09	0.665	3.59	0.05	0.79	4lnvB	GO:0004866 GO:0005576 GO:0005615 GO:0010951
6	0.07	0.589	4.26	0.06	0.73	4acqC	GO:0001869 GO:0002020 GO:0002576 GO:0004866 GO:0004867 GO:0005096 GO:0005102 GO:0005576 GO:0005615 GO:0005829 GO:0007597 GO:0010466 GO:0010951 GO:0019838 GO:0019899 GO:0019959 GO:0019966 GO:0022617 GO:0030414 GO:0031093 GO:0043120 GO:0043547 GO:0048306 GO:0048863 GO:0051056 GO:0070062 GO:0072562
7	0.07	0.572	3.89	0.10	0.68	4xamC	GO:0001849 GO:0002376 GO:0004252 GO:0004866 GO:0005576 GO:0005615 GO:0005886 GO:0006508 GO:0006954 GO:0006956 GO:0006958 GO:0010951 GO:0030449 GO:0045087 GO:0070062 GO:0072562 GO:2000427
8	0.07	0.497	5.42	0.10	0.70	4ziqA	GO:0004866 GO:0005886 GO:0010951 GO:0016020 GO:0031362
9	0.07	0.511	3.26	0.08	0.59	1qqfA	GO:0001934 GO:0002376 GO:0002507 GO:0004866 GO:0005576 GO:0005615 GO:0006629 GO:0006631 GO:0006935 GO:0006954 GO:0006956 GO:0006957 GO:0006958 GO:0007596 GO:0008289 GO:0010828 GO:0010866 GO:0010884 GO:0010951 GO:0031715 GO:0032026 GO:0032355 GO:0032570 GO:0043627 GO:0045087 GO:0045745 GO:0048037 GO:0048639 GO:0051384 GO:0070374
10	0.07	0.467	5.43	0.07	0.68	4rtdA	GO:0004866 GO:0005886 GO:0010951 GO:0016020 GO:0031362
11	0.06	0.500	4.13	0.10	0.63	5bp8A	GO:0003824
12	0.06	0.289	7.19	0.06	0.51	3pvmB	GO:0004866 GO:0005576 GO:0005615 GO:0006954 GO:0006956 GO:0010951 GO:0046872
13	0.06	0.301	4.01	0.04	0.38	2c2lA	GO:0000151 GO:0000209 GO:0001664 GO:0004842 GO:0005634 GO:0005654 GO:0005737 GO:0005783 GO:0005886 GO:0006281 GO:0006457 GO:0006511 GO:0006515 GO:0006974 GO:0016567 GO:0016874 GO:0019899 GO:0019900 GO:0030018 GO:0030544 GO:0030579 GO:0030674 GO:0030911 GO:0030968 GO:0031072 GO:0031371 GO:0031398 GO:0031625 GO:0031647 GO:0031943 GO:0032091 GO:0032436 GO:0034450 GO:0036503 GO:0042405 GO:0042787 GO:0042803 GO:0043161 GO:0045111 GO:0046332 GO:0051443 GO:0051604 GO:0051787 GO:0051865 GO:0051879 GO:0061630 GO:0070062 GO:0070534 GO:0071218 GO:0090035 GO:1904264
14	0.06	0.277	5.96	0.06	0.43	3ugvF	GO:0003824 GO:0008152 GO:0009063 GO:0046872
15	0.06	0.266	7.27	0.03	0.47	2e4zA	GO:0001640 GO:0001642 GO:0004871 GO:0004930 GO:0005246 GO:0005516 GO:0005791 GO:0005794 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007196 GO:0007608 GO:0007611 GO:0009986 GO:0014050 GO:0016020 GO:0016021 GO:0016595 GO:0030165 GO:0030424 GO:0030425 GO:0032279 GO:0042734 GO:0042803 GO:0043025 GO:0043195 GO:0043198 GO:0043234 GO:0043679 GO:0045202 GO:0045211 GO:0048306 GO:0048786 GO:0050896 GO:0051966
16	0.06	0.271	6.54	0.04	0.45	5cerA	GO:0004180 GO:0004185 GO:0006508 GO:0009002 GO:0016787
17	0.06	0.159	4.45	0.04	0.21	2o03A	GO:0003677 GO:0003700 GO:0005737 GO:0005886 GO:0006351 GO:0006355 GO:0008270 GO:0010043 GO:0042803 GO:0045893 GO:0046872
18	0.06	0.161	4.77	0.02	0.22	4v6wCT	GO:0000022 GO:0003735 GO:0005622 GO:0005840 GO:0006412 GO:0007052 GO:0022625 GO:0051298

Consensus prediction of GO terms

Molecular Function	GO:0008236	GO:0004175	GO:0004866	GO:0042379	GO:0005125	GO:0001848	GO:0001846
GO-Score	0.59	0.59	0.51	0.47	0.47	0.40	0.40
Biological Processes	GO:2000425	GO:0050766	GO:0010951	GO:0043009	GO:0043406	GO:0002689	GO:0010758	GO:0098780	GO:0090196	GO:0032147	GO:0000423	GO:0032722	GO:0050715	GO:0006958	GO:0030449	GO:0006957	GO:0010575	GO:0045766	GO:0007186
GO-Score	0.59	0.59	0.51	0.47	0.47	0.47	0.47	0.47	0.47	0.47	0.47	0.47	0.47	0.46	0.46	0.33	0.33	0.33	0.33
Cellular Component	GO:0005615	GO:0005887	GO:0046930	GO:0098797	GO:0070062
GO-Score	0.51	0.47	0.47	0.47	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.