I-TASSER results

I-TASSER results for job id Rv0823c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (389 residues)
MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQLEQSKVGTVSGLYVCEM
VTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAARMIAGEGLADHIDMNFGC
PVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRI
AEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRTIPVLGNGDIYDAGDALAMMSTT
GCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTLGEVADIIRRHGTLLAAHFGEDKGM
RDIRKHIAWYLHGFPAGSALRRALAMVKTFDELDCLLDRLDGTVPFPDSATGARGRQGSP
ARVALPDGWLTDPDDCRVPEGADAMGSGG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQLEQSKVGTVSGLYVCEMVTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAARMIAGEGLADHIDMNFGCPVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRTIPVLGNGDIYDAGDALAMMSTTGCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTLGEVADIIRRHGTLLAAHFGEDKGMRDIRKHIAWYLHGFPAGSALRRALAMVKTFDELDCLLDRLDGTVPFPDSATGARGRQGSPARVALPDGWLTDPDDCRVPEGADAMGSGG
Prediction	CCCCCCCCCCCCEEHCCEEHCCCEEEHCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHCCCCCCHHHHCCCHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCCEEEEHCCCHHHCCCCCCCHHHHHHHHHHCCCCCEEEHCCCCCHHHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	99887888999847856885897898668999998999999998898777776589865567867876885689885778999868999679999999999999999799988877579998644578864446799799999999999997578996899997666799867999999999989978998577777787788879999999998799988997799999999999999899888873566589689999999997799999999999999999999999999785567999999999999789888999999997999999999999999768776555666666788888888888888865444544566556889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQLEQSKVGTVSGLYVCEMVTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAARMIAGEGLADHIDMNFGCPVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRTIPVLGNGDIYDAGDALAMMSTTGCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTLGEVADIIRRHGTLLAAHFGEDKGMRDIRKHIAWYLHGFPAGSALRRALAMVKTFDELDCLLDRLDGTVPFPDSATGARGRQGSPARVALPDGWLTDPDDCRVPEGADAMGSGG
Prediction	75555545444304026160631000000010002000100111144433210000000000041013425502510621662200000000230420040042017343012020303000410163100000053162014005101500655701000000000147331023004101501030000001126142425021510330173057000000000221620240064040000000000111000030034115456324514162014003400520152226520022002000100211330450152036063163025005503752524752643544555553221161116346334314514254468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCEEHCCEEHCCCEEEHCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHCCCCCCHHHHCCCHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCCEEEEHCCCHHHCCCCCCCHHHHHHHHHHCCCCCEEEHCCCCCHHHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQLEQSKVGTVSGLYVCEMVTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAARMIAGEGLADHIDMNFGCPVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRTIPVLGNGDIYDAGDALAMMSTTGCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTLGEVADIIRRHGTLLAAHFGEDKGMRDIRKHIAWYLHGFPAGSALRRALAMVKTFDELDCLLDRLDGTVPFPDSATGARGRQGSPARVALPDGWLTDPDDCRVPEGADAMGSGG

3b0pA

0.27

0.21

0.78

2.83

MUSTER

-------------------LDPRLSVAPMVDRTDRHFRFLVRQVSLG------VRLYTEMTVDQAVLRGN--RERLLAFRPEEHPIALQLAGSDPKSLAEAARIGEAFG-YDEINLNLGCPSEKAQEGGYGACLLLDLARVREILKAMGEAV---RVPVTVKMRLGLEGKETGLAQSVEAMAEAGVKVFVVHARSA---LIPPLRHDWVHRLKGDFPQLTFVTNGGIRSLEEALFHLKR--VDGVMLGRAVYEDPFVLEEADRRVFGLP--RRPS---RLEVARRMRAYLEEEVLKGTPPWAVLRHMLNLFRGRPKGRLWRRLLSEGRSLQALDRALRLMEEEVGE-------------------------------------------

3b0pA

0.27

0.21

0.78

8.09

dPPAS

-------------------LDPRLSVAPMVDRTDRHFRFLVRQVSLGV------RLYTEMTVDQAVLRGN--RERLLAFRPEEHPIALQLAGSDPKSLAEAARIGEAFG-YDEINLNLGCPSEKAQEGGYGACLLLDLARVREILKAMGEAV---RVPVTVKMRLGLEGKETGLAQSVEAMAEAGVKVFVVHARSA---LIPPLRHDWVHRLKGDFPQLTFVTNGGIRSLEEALFHLKR--VDGVMLGRAVYEDPFVLEEADRRVFGLPRRPS-----RLEVARRMRAYLEEEVLKGTPPWAVLRHMLNLFRGRPKGRLWRRLLSEGRSLQALDRALRLMEEEVGE-------------------------------------------

3b0pA

0.27

0.21

0.78

6.17

wdPPAS

-------------------LDPRLSVAPMVDRTDRHFRFLVRQVSLGV------RLYTEMTVDQAVLRGN--RERLLAFRPEEHPIALQLAGSDPKSLAEAARIGEAFG-YDEINLNLGCPSEKAQEGGYGACLLLDLARVREILKAMGEAV---RVPVTVKMRLGLEGKETGLAQSVEAMAEAGVKVFVVHARSA---LIPPLRHDWVHRLKGDFPQLTFVTNGGIRSLEEALFHLKR--VDGVMLGRAVYEDPFVLEEADRRVFGLPRRPS-----RLEVARRMRAYLEEEVLKGTPPWAVLRHMLNLFRGRPKGRLWRRLLSEGRSLQALDRALRLMEEEVGE-------------------------------------------

3b0pA

0.27

0.21

0.78

3.32

wMUSTER

-------------------LDPRLSVAPMVDRTDRHFRFLVRQVSLG------VRLYTEMTVDQAVLRGN--RERLLAFRPEEHPIALQLAGSDPKSLAEAARIGEAFG-YDEINLNLGCPSEKAQEGGYGACLLLDLARVREILKAMGEAV---RVPVTVKMRLGLEGKETGLAQSVEAMAEAGVKVFVVHARSA---LIPPLRHDWVHRLKGDFPQLTFVTNGGIRSLEEALFHLKR--VDGVMLGRAVYEDPFVLEEADRRVFGLP--RRPS---RLEVARRMRAYLEEEVLKGTPPWAVLRHMLNLFRGRPKGRLWRRLLSEGRSLQALDRALRLMEEEVGE-------------------------------------------

1vhnA

0.29

0.22

0.76

3.95

wPPAS

---------------------VKVGLAP-AGYTDSAFRTLAFEWG-------ADFAFSEVSAKGFL----SQKTEELLPQPHERNVAVQIFGSEPNELSEAARILSEK--YKWIDLNAGCPVRKVVKEGAGGALLKDLRHFRYIVRELRKSV---SGKFSVKTRLGWEKNE--VEEIYRILVEEGVDEVFIHTRTVVQSFTGRAEWKALSVLEK---RIPTFVSGDIFTPEDAKRALEESGCDGLLVARGAIGRPWIFKQIKDFLRSGK-YSEPSREEILRTFERHLELLIKTKGERKAVVE--KFLAGYTKDLKGARRFREKVKIEEILKEFYNFIKEVE------------------------------------------------

3b0pA

0.27

0.21

0.78

11.34

dPPAS2

-------------------LDPRLSVAPMVDRTDRHFRFLVRQVSLGV------RLYTEMTVDQAVLRGN--RERLLAFRPEEHPIALQLAGSDPKSLAEAARIGEAFG-YDEINLNLGCPSEKAQEGGYGACLLLDLARVREILKAMGEAV---RVPVTVKMRLGLEGKETGLAQSVEAMAEAGVKVFVVHARSA---LIPPLRHDWVHRLKGDFPQLTFVTNGGIRSLEEALFHLKR--VDGVMLGRAVYEDPFVLEEADRRVFGLPRRPS-----RLEVARRMRAYLEEEVLKGTPPWAVLRHMLNLFRGRPKGRLWRRLLSEGRSLQALDRALRLMEEEVGE-------------------------------------------

1vhnA

0.29

0.22

0.76

3.73

PPAS

---------------------VKVGLAP-AGYTDSAFRTLAFEWG-------ADFAFSEVSAK-GFLNS--QKTEELLPQPHERNVAVQIFGSEPNELSEAARILSEK--YKWIDLNAGCPVRKVVKEGAGGALLKDLRHFRYIVRELRKSV---SGKFSVKTRLGWEKNE--VEEIYRILVEEGVDEVFIHTRTVVQSFTGRAEWKALSVLEK---RIPTFVSGDIFTPEDAKRALEESGCDGLLVARGAIGRPWIFKQIKDFLRSGK-YSEPSREEILRTFERHLELLIKTKGERKAVVE--KFLAGYTKDLKGARRFREKVKIEEILKEFYNFIKEVE------------------------------------------------

1vhnA

0.29

0.22

0.76

6.21

Env-PPAS

---------------------VKVGLAP-AGYTDSAFRTLAFEWG-------ADFAFSEVS-AKGFLNS--QKTEELLPQPHERNVAVQIFGSEPNELSEAARILSEK--YKWIDLNAGCPVRKVVKEGAGGALLKDLRHFRYIVRELRKSV---SGKFSVKTRLGWEKNE--VEEIYRILVEEGVDEVFIHTRTVVQSFTGRAEWKALSVLEK---RIPTFVSGDIFTPEDAKRALEESGCDGLLVARGAIGRPWIFKQIKDFLRSGKY-SEPSREEILRTFERHLELLIKTKGERKAVVER-KFLAGYTKDLKGARRFREKVKIEEILKEFYNFIKEVE------------------------------------------------

1vhnA

0.30

0.23

0.76

2.79

MUSTER

---------------------VKVGLAP-AGYTDSAFRTLAFEWG-------ADFAFSEVS-AKGFLN-SQKTEELL-PQPHERNVAVQIFGSEPNELSEAARILSEK--YKWIDLNAGCPVRKVVKEGAGGALLKDLRHFRYIVRELRKSV---SGKFSVKTRLGWEKNE--VEEIYRILVEEGVDEVFIHTRTVVQSFTGRAEWKALSVLEK---RIPTFVSGDIFTPEDAKRALEESGCDGLLVARGAIGRPWIFKQIKDFLRSGK-YSEPSREEILRTFERHLELLIKTKGERKAVVE--KFLAGYTKDLKGARRFREKVKIVQILKEFYNFIKEVE------------------------------------------------

1vhnA

0.29

0.22

0.76

7.98

dPPAS

---------------------VKVGLAP-AGYTDSAFRTLAFEWG-------ADFAFSEVSAKGFLN---SQKTEELLPQPHERNVAVQIFGSEPNELSEAARILSEK--YKWIDLNAGCPVRKVVKEGAGGALLKDLRHFRYIVRELRKSV---SGKFSVKTRLGWEKNE--VEEIYRILVEEGVDEVFIHTRTVVQSFTGRAEWKALSVLE---KRIPTFVSGDIFTPEDAKRALEESGCDGLLVARGAIGRPWIFKQIKDFLRSGKY-SEPSREEILRTFERHLELLIKTKGERKAVVER-KFLAGYTKDLKGARRFREKVKIEEILKEFYNFIKEVE------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.08

Estimated TM-score = 0.58±0.14

Estimated RMSD = 9.2±4.6Å

Download Model 2

C-score=-1.30

Download Model 3

C-score=-1.57

Download Model 4

C-score=-1.80

Download Model 5

C-score=-2.24

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3b0pA	0.742	1.83	0.272	0.784
2	1vhnA	0.679	2.75	0.294	0.766
3	3w9zA	0.650	2.64	0.241	0.725
4	4xp7A	0.637	2.84	0.191	0.720
5	1djnA	0.624	4.27	0.118	0.761
6	1ps9A	0.623	4.15	0.139	0.756
7	3k30A	0.621	4.32	0.106	0.761
8	4xwhA	0.574	5.23	0.063	0.807
9	4qnwA	0.572	3.65	0.135	0.671
10	3hf3A	0.570	3.39	0.141	0.658

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.82	48	3atyA	FMN	Rep, Mult	27,28,29,30,60,89,117,120,162,192,224,225,226,247,248,249,387,388
2	0.02	2	3b0vD	NUC	Rep, Mult	30,31,32,60,62,64,72,75,117,120,122,124,127,128,130,199,301,308,312,313,314,316,317,318,321,322,325,326,328
3	0.01	1	3b0uX	NUC	Rep, Mult	60,61,62,65,69,70,75,76,117,120,122,124,130,202,203
4	0.01	1	1eepB	SO4	Rep, Mult	29,225,226,248,249
5	0.01	1	3l5lA	BU3	Rep, Mult	238,241,243
6	0.01	1	1o94B	SF4	Rep, Mult	103,105,153,154,155,156,157,158

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.186	1mzhA	0.466	3.39	0.117	0.545	4.1.2.4	162
2	0.156	3f4wA	0.453	3.29	0.141	0.527	4.1.2.-	27,225
3	0.095	1n7kA	0.453	3.38	0.128	0.530	4.1.2.4	NA
4	0.067	3exrA	0.451	3.37	0.130	0.530	4.1.1.85	94
5	0.067	1w0mA	0.450	3.05	0.144	0.517	5.3.1.1	NA
6	0.066	1hg3A	0.450	3.23	0.113	0.522	5.3.1.1	NA
7	0.060	1gthA	0.558	3.73	0.114	0.650	1.3.1.2	120
8	0.060	3kruA	0.566	3.35	0.119	0.645	1.6.99.1	NA
9	0.060	2djxA	0.524	3.62	0.123	0.622	1.3.3.1	120
10	0.060	1bwlA	0.569	4.03	0.145	0.689	1.6.99.1	28,225,248
11	0.060	2c8nA	0.529	4.91	0.055	0.692	3.2.1.55	NA
12	0.060	2epoA	0.545	5.39	0.047	0.769	3.2.1.52	NA
13	0.060	1q45B	0.553	3.60	0.143	0.653	1.3.1.42	NA
14	0.060	3bg3A	0.532	5.10	0.074	0.717	6.4.1.1	NA
15	0.060	2qf7B	0.523	5.17	0.088	0.715	6.4.1.1	NA
16	0.060	2j62A	0.534	4.84	0.033	0.702	3.2.1.52	130
17	0.060	3figB	0.537	5.05	0.065	0.712	2.3.3.13	133,160
18	0.060	2bs9E	0.548	5.11	0.076	0.748	3.2.1.37	NA
19	0.060	2ashA	0.534	5.07	0.073	0.728	2.4.2.29	NA
20	0.060	2ashD	0.529	5.19	0.057	0.733	2.4.2.29	120,254
21	0.060	1icpA	0.553	3.57	0.154	0.650	1.3.1.42	NA
22	0.060	3c61A	0.526	3.55	0.111	0.622	1.3.99.11	120
23	0.060	1y5xD	0.508	4.97	0.073	0.684	2.4.2.29	NA
24	0.060	2zxqA	0.522	5.48	0.061	0.730	3.2.1.97	118,132
25	0.060	1ps9A	0.623	4.15	0.139	0.756	1.3.1.34	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.41	0.691	2.76	0.29	0.78	1vhnA	GO:0000166 GO:0002943 GO:0003824 GO:0005829 GO:0008033 GO:0016491 GO:0017150 GO:0050660 GO:0055114
1	0.35	0.650	2.64	0.24	0.72	3w9zA	GO:0000049 GO:0002943 GO:0003723 GO:0003824 GO:0005829 GO:0008033 GO:0010181 GO:0016491 GO:0017150 GO:0050660 GO:0055114
2	0.34	0.698	2.90	0.26	0.79	4bf9A	GO:0000049 GO:0002943 GO:0003723 GO:0003824 GO:0005829 GO:0008033 GO:0010181 GO:0016491 GO:0017150 GO:0050660 GO:0055114
3	0.30	0.743	1.83	0.27	0.79	3b0vC	GO:0000049 GO:0000166 GO:0002943 GO:0003723 GO:0003824 GO:0008033 GO:0010181 GO:0016491 GO:0017150 GO:0050660 GO:0055114
4	0.30	0.637	2.84	0.19	0.72	4xp7A	GO:0002943 GO:0003723 GO:0003725 GO:0003824 GO:0004860 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0006469 GO:0008033 GO:0016491 GO:0017150 GO:0050660 GO:0055114 GO:0060548
5	0.13	0.442	4.26	0.06	0.56	3q45A	GO:0000287 GO:0003824 GO:0006518 GO:0008152 GO:0016853 GO:0016854 GO:0046872
6	0.07	0.531	3.83	0.15	0.64	1ep3A	GO:0003824 GO:0004152 GO:0004589 GO:0005737 GO:0006207 GO:0006221 GO:0006222 GO:0016491 GO:0016627 GO:0044205 GO:0055114
7	0.07	0.513	3.96	0.12	0.62	3oixA	GO:0000166 GO:0003824 GO:0004152 GO:0005737 GO:0006207 GO:0006221 GO:0006222 GO:0016491 GO:0016627 GO:0044205 GO:0055114
8	0.07	0.490	4.59	0.12	0.62	4qj1D	GO:0003824 GO:0003938 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
9	0.07	0.487	3.64	0.13	0.58	3iivB
10	0.07	0.459	3.74	0.11	0.55	4tx9A	GO:0000105 GO:0000162 GO:0003824 GO:0003949 GO:0004640 GO:0005737 GO:0008152 GO:0008652 GO:0009073 GO:0016853
11	0.07	0.468	3.69	0.14	0.56	3femA	GO:0003824 GO:0004359 GO:0008152 GO:0008615 GO:0009228 GO:0016829 GO:0036381 GO:0042819 GO:0042823 GO:1903600
12	0.07	0.465	4.42	0.10	0.58	3bo9A	GO:0003824 GO:0004318 GO:0016491 GO:0018580 GO:0055114
13	0.07	0.458	3.63	0.10	0.54	4x9sA	GO:0000105 GO:0000162 GO:0003824 GO:0003949 GO:0004640 GO:0005737 GO:0008152 GO:0008652 GO:0009073 GO:0016853
14	0.07	0.467	3.99	0.15	0.57	2issB	GO:0003824 GO:0008152 GO:0016829 GO:0036381 GO:0042819 GO:0042823
15	0.07	0.454	3.63	0.10	0.54	5dn1A	GO:0000105 GO:0000162 GO:0003824 GO:0003949 GO:0004640 GO:0005622 GO:0005737 GO:0008152 GO:0008652 GO:0009073 GO:0016853
16	0.07	0.457	3.48	0.12	0.54	4axkB	GO:0000105 GO:0000162 GO:0003824 GO:0003949 GO:0004640 GO:0005737 GO:0008152 GO:0008652 GO:0016853
17	0.06	0.429	3.98	0.12	0.54	3vzxB	GO:0000287 GO:0002094 GO:0006629 GO:0006650 GO:0008654 GO:0016740 GO:0016765 GO:0046474 GO:0046872
18	0.06	0.429	3.96	0.14	0.52	4uttA	GO:0003824 GO:0005975 GO:0006051 GO:0008152 GO:0016853 GO:0016857 GO:0019262 GO:0047465

Consensus prediction of GO terms

Molecular Function	GO:0050660	GO:0017150	GO:0010181	GO:0000049	GO:0019210	GO:0019887
GO-Score	0.88	0.88	0.70	0.70	0.59	0.59
Biological Processes	GO:0055114	GO:0002943	GO:0010941	GO:0045859	GO:0001933	GO:0033673
GO-Score	0.88	0.88	0.59	0.59	0.59	0.59
Cellular Component	GO:0005829	GO:0012505	GO:0043231
GO-Score	0.82	0.59	0.59

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.