I-TASSER results

I-TASSER results for job id Rv0817c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (270 residues)
MPMRKVLVGVTGAAIVVAVLIVGAVGADFGASIYAEYRLSTTVRKAANLRSDPFVAILRF
PFIPQAMREHYAELEIKAFAVEHAGSGTATLEATMHSIDLSYASWLIRPDAKLPVGELES
RIIIDSMHLGRYLGISDLMVAAPRQESNDATGGTTESGISGSRGLVFSGTPISANFAHRV
SVLVDLSVASDDRATLVITPTAVVTGPDTADQPVPDDKRDAVLHAFASKLPNQKLPFGVV
PNTVGARGSDVIIEGITRGVTISLDEFKQS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MPMRKVLVGVTGAAIVVAVLIVGAVGADFGASIYAEYRLSTTVRKAANLRSDPFVAILRFPFIPQAMREHYAELEIKAFAVEHAGSGTATLEATMHSIDLSYASWLIRPDAKLPVGELESRIIIDSMHLGRYLGISDLMVAAPRQESNDATGGTTESGISGSRGLVFSGTPISANFAHRVSVLVDLSVASDDRATLVITPTAVVTGPDTADQPVPDDKRDAVLHAFASKLPNQKLPFGVVPNTVGARGSDVIIEGITRGVTISLDEFKQS
Prediction	CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCHHHHHHCCCCCEEEEEHCCEHCCCCEEEEEEEEEEEEEHCHHHCCCCCCCCEEEEEEEEEEEEEHHHHHHHHCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEEEEEEEHCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHCCEEHCCCCCCCCCEEEEEEEHCCEEEEEEEEHCEEHCHHHHHCC
Conf.Score	987646789999999999999999999999999999999999999859999986998577646777658678699998567668756889999999899757764458887568999999999868888999899765445688777778988766555678757999987479855589999999998578878999998998678777888898999999987685758999998757889999799799999985779878875549
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MPMRKVLVGVTGAAIVVAVLIVGAVGADFGASIYAEYRLSTTVRKAANLRSDPFVAILRFPFIPQAMREHYAELEIKAFAVEHAGSGTATLEATMHSIDLSYASWLIRPDAKLPVGELESRIIIDSMHLGRYLGISDLMVAAPRQESNDATGGTTESGISGSRGLVFSGTPISANFAHRVSVLVDLSVASDDRATLVITPTAVVTGPDTADQPVPDDKRDAVLHAFASKLPNQKLPFGVVPNTVGARGSDVIIEGITRGVTISLDEFKQS
Prediction	653331210010121110121111110020000201330053037447174414020101100210243405504030560527414414040204404032420243424413044040303032430232151540324424654554534444443444430203021634626440303030203457423020203302424654644126622540173043505376011403144041444303020435614032750468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCHHHHHHCCCCCEEEEEHCCEHCCCCEEEEEEEEEEEEEHCHHHCCCCCCCCEEEEEEEEEEEEEHHHHHHHHCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEEEEEEEHCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHCCEEHCCCCCCCCCEEEEEEEHCCEEEEEEEEHCEEHCHHHHHCC
MPMRKVLVGVTGAAIVVAVLIVGAVGADFGASIYAEYRLSTTVRKAANLRSDPFVAILRFPFIPQAMREHYAELEIKAFAVEHAGSGTATLEATMHSIDLSYASWLIRPDAKLPVGELESRIIIDSMHLGRYLGISDLMVAAPRQESNDATGGTTESGISGSRGLVFSGTPISANFAHRVSVLVDLSVASDDRATLVITPTAVVTGPDTADQPVPDDKRDAVLHAFASKLPNQKLPFGVVPNTVGARGSDVIIEGITRGVTISLDEFKQS

4ut1A

0.11

1.00

0.76

MUSTER

LPDVSLTGGALGGLLAFRSQTLDPAQAQLGALAVSFASQVNAQNALVDMSGNPGGSLFAVGAPAVYANQNNTTLSVSFVDGTQPTTSDYALSYDGAKYTLTDRATPSSTPPTMTIGGLKLSLSSTPNAGDSFTALDGFSLATANGSAIAAAGVATNSGTGVISQGSVSAGYQLPSGTTTLAYNAASKTLSGFPVGTTVTITSINITSATTPVPYDPSKGASMTISSTTQPAPSGVMNGVSVSLSGTPADGDQFTIGANKGTLALSQLVNS

4dlqA2

0.12

0.09

0.73

dPPAS

-----------NATEQVHTATMLLDVLEEGAFLLADN-----------VREPARFLAA--------KQNVVLEVTVLSTEGQVQELVFPQEYASESSIQLSANTIKQNSRNG-----VVKVVFILYNNLGLFLSTENATVKLAGEAGTGGPGGAS--LVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQG-----------------------CRLVESNKTHTTCACSHL------------

5eq2A

0.10

0.07

0.64

0.82

wdPPAS

--------------------------------------------RRATDTTPPTITV---P----------SDIIAYRGE--------FEFYFEITD-----------DSGQVKNIELSTF--------------GKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQDRLSSLSPSEKNAVEAAVRAA---PQIPAA---ARITVSANGVTIT-DSSTDTITANRVVKD

5eq2A

0.14

0.09

0.64

0.72

wMUSTER

--------------------------------------------RRATDTTPPTITV---P----------SDIIAYRGE--------FEFYFEITD-------------DSGQVKNIELSTF------------GKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPIPADKNRAQFTRTIRAWDAAGNTFVIKYRAQTADPTDRLSSLSPSEKNAVEAAVRAA--NPQIPAAA---RITVSANGVTIT--SSTDTITANRVDLA

5eq2A

0.11

0.07

0.63

0.88

wPPAS

-------------------------------------------RRATD-TTPPTITV---P----------SDIIAYRGE--------FEFYFEITD---------SGQ-----VKNIELSTF------------GKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQDRLSSLSPSEKNAVEAAVRAA---PQIPAA---ARITVSANGVTIT--SSTDTITANRVDLA

5eq2A

0.09

0.06

0.64

1.01

dPPAS2

-------------------------------------------------------------------RRATDTTTITVSDIIAYRGEEFEFYFEITD-----------DSGQVKNIELSTF--------------GKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQDRLSSLSPSEKNAVEAAVRAA--NPQIPAAA---RITVSANG-TVTITYPDDTITANRVVKD

5gaoE

0.13

0.12

0.97

0.96

PPAS

------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAA---AAAAAAAAAAAAAAAAA

4qpjA

0.12

0.09

0.74

0.68

Env-PPAS

VTLSGALLCSRICHDIISPIGAINNGLELLEEGGADEDAMALIKSSARNA---SARLQ---FARIAFG----------------AAGSAGVQIDTGDAQNVATEYFRN--EKPEFTWEGARVLLP-KNKVKLL----LNM------------------------LLIGNGAIPRGGSLAVRLEGS-----DTDPRFVITVKGR-------MLRVPPKFLELHSAAPEEPIDAHSVQPYYTLLLAEEAGMKISIHATAEDIVFSAE-----

4hmcA

0.08

0.99

0.72

MUSTER

QNNDALKEEFIYYIADSLINGTRNYHKIPHDKLVFGLPSNIDAAATGYIQDPQDLYKA--FDRLKAQGQPLRGVMTWSVNWDMGTDAANNSYNQQFIKDYGNFIHNQLPPVTDMTPTLSGIVDTR-VELDSHFDPLIGITAKDYQGNDITADVTVSGSVNTNQVGDYLLTYSVSSDDETTNQPRKITVYEILPAFTGITDTTVVIDSPMQGVSASHPTQGDLTANITVTGEVDTNVVGVYELTYQLFYGQDNQQNMTDKRIVTVVTDAVS

3wprA

0.08

0.07

0.83

0.72

dPPAS

---KQIEDKIEEILSKIYHIENEIARIKKLIKAVGNQVVTTQTTLVNSLGGNAKVN----------ADGTITGPTYNVAQGNQTNVGDALTALDNAINTAATTSKSTVSNGQNIVVSKSKN------------ADGSDNYEVSTAKDLTVDSVKAGDTVLNNAGITINNAVVLNNTGLTISGGPSVTLAGIDAGNKTIQNVA---NAVNATDAVNKGQMKQIEDK---------------IEEILSKIYHIENEIARIKKLIKLHHH---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.67

Estimated TM-score = 0.23±0.07

Estimated RMSD = 17.8±2.5Å

Download Model 2

C-score=-4.60

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4dlqA	0.707	2.35	0.115	0.767
2	4dloA	0.592	3.48	0.080	0.707
3	5kvmA2	0.521	3.73	0.056	0.659
4	1wygA	0.470	5.88	0.052	0.759
5	3fahA2	0.463	5.90	0.062	0.748
6	1t3qB	0.460	6.07	0.062	0.763
7	1ffvB	0.459	5.96	0.075	0.752
8	1sb3D	0.459	6.02	0.079	0.752
9	1dgjA2	0.458	6.20	0.047	0.778
10	1jroB	0.456	5.96	0.057	0.733

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	4	1qiyF	III	Rep, Mult	62,63
2	0.09	3	1fo4A	FES	Rep, Mult	94,95,96,125,126,127,165
3	0.06	2	2e7fA	CA	Rep, Mult	26,28
4	0.04	1	4dlqA	III	Rep, Mult	24,135,138,142,145,146,147,148,149,157,158,159,161,162,164,165,166,167,168,182,184,186,188,193,194,195,197,198,200,201,202,213,253,255,258
5	0.03	1	3ee6A	ZN	Rep, Mult	73,96
6	0.03	1	2ckjD	PO4	Rep, Mult	32,72,125,262
7	0.03	1	2vl1B	III	Rep, Mult	190,191
8	0.03	1	3ddrA	HEM	Rep, Mult	70,72,152,153
9	0.03	1	2hdqB	C21	Rep, Mult	234,236
10	0.03	1	1fiqA	FAD	Rep, Mult	36,39,40,76

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1zyzA	0.386	6.42	0.072	0.689	1.17.4.1	NA
2	0.060	2ewbA	0.385	6.16	0.050	0.659	3.4.11.1,3.4.11.5	121
3	0.060	2e1qA	0.450	5.69	0.076	0.719	1.17.3.2,1.17.1.4	108
4	0.060	1hdhA	0.385	5.87	0.031	0.619	3.1.6.1	32,74
5	0.060	3b9jI	0.246	5.59	0.061	0.389	1.17.1.4,1.17.3.2	59
6	0.060	2ckjA	0.465	5.57	0.072	0.730	1.17.1.4,1.17.3.2	108
7	0.060	1t3qB	0.460	6.07	0.062	0.763	1.3.99.17	NA
8	0.060	1ffuB	0.457	5.93	0.079	0.748	1.2.99.2	NA
9	0.060	1bglA	0.334	6.30	0.047	0.582	3.2.1.23	71
10	0.060	2qvrA	0.385	5.74	0.039	0.626	3.1.3.11	254
11	0.060	1jroB	0.456	5.96	0.057	0.733	1.1.1.204	NA
12	0.060	1bdgA	0.392	6.14	0.070	0.663	2.7.1.1	50
13	0.060	1ig8A	0.398	6.14	0.050	0.670	2.7.1.1	NA
14	0.060	1spiA	0.340	5.92	0.057	0.574	3.1.3.11	156
15	0.060	3b9jJ	0.292	6.13	0.030	0.496	1.17.1.4,1.17.3.2	20,22,72,126
16	0.060	1gytJ	0.391	6.39	0.047	0.681	3.4.11.1	188
17	0.060	2hb6B	0.387	6.15	0.040	0.656	3.4.11.1	71
18	0.060	1gytA	0.385	6.36	0.053	0.681	3.4.11.1	131
19	0.060	2pflA	0.348	6.89	0.069	0.652	2.3.1.54	53

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.18	0.707	2.35	0.12	0.77	4dlqA	GO:0004871 GO:0004888 GO:0004930 GO:0005622 GO:0005829 GO:0005886 GO:0007157 GO:0007165 GO:0007166 GO:0007186 GO:0007420 GO:0014069 GO:0015643 GO:0016020 GO:0016021 GO:0016079 GO:0016524 GO:0030054 GO:0030246 GO:0030424 GO:0030426 GO:0035584 GO:0042734 GO:0042995 GO:0043005 GO:0045202 GO:0050839 GO:0090129
1	0.07	0.592	3.48	0.08	0.71	4dloA	GO:0004871 GO:0004888 GO:0004930 GO:0005096 GO:0005886 GO:0007165 GO:0007166 GO:0007186 GO:0007520 GO:0016020 GO:0016021 GO:0016525 GO:0043547 GO:0048814 GO:0051965
2	0.06	0.460	6.07	0.06	0.76	1t3qB	GO:0016491 GO:0055114
3	0.06	0.456	5.93	0.09	0.73	3ax7A	GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0009055 GO:0009115 GO:0016491 GO:0016614 GO:0016903 GO:0043546 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0055114
4	0.06	0.354	6.31	0.04	0.61	4ikvA	GO:0005215 GO:0006810 GO:0006857 GO:0015197 GO:0015833 GO:0016020 GO:0016021
5	0.06	0.465	5.57	0.07	0.73	2ckjA	GO:0001933 GO:0001937 GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0006195 GO:0006919 GO:0007595 GO:0009055 GO:0009115 GO:0010629 GO:0016491 GO:0016529 GO:0016614 GO:0016903 GO:0030856 GO:0042803 GO:0043546 GO:0045602 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0051898 GO:0055114 GO:1900745 GO:1900747 GO:2000379 GO:2001213
6	0.06	0.317	6.46	0.05	0.56	2qdeA	GO:0003824 GO:0008152 GO:0009063
7	0.06	0.355	6.09	0.03	0.60	2yk0A	GO:0004872 GO:0009405 GO:0016020 GO:0016021 GO:0046872
8	0.06	0.470	5.51	0.07	0.73	1fo4A	GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0009055 GO:0009115 GO:0016491 GO:0016614 GO:0016903 GO:0043546 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0055114
9	0.06	0.331	5.96	0.07	0.55	1ffuC	GO:0003824 GO:0016491 GO:0016614 GO:0018492 GO:0050660 GO:0055114
10	0.06	0.321	5.96	0.07	0.54	1t3qC	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0050660 GO:0055114
11	0.06	0.457	6.04	0.07	0.75	1rm6A	GO:0016491 GO:0018525 GO:0055114
12	0.06	0.436	6.07	0.06	0.71	4zohA	GO:0016491 GO:0055114
13	0.06	0.288	6.27	0.05	0.50	3hrdG	GO:0003824 GO:0016491 GO:0016614 GO:0050138 GO:0050660 GO:0051187 GO:0055114
14	0.06	0.373	6.23	0.05	0.64	3fahA	GO:0009055 GO:0016491 GO:0033727 GO:0046872 GO:0051536 GO:0051537 GO:0055114
15	0.06	0.318	6.90	0.05	0.61	3o04A	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
16	0.06	0.368	6.30	0.05	0.64	1dgjA	GO:0009055 GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114
17	0.06	0.450	5.69	0.08	0.72	2e1qA	GO:0001933 GO:0001937 GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0006195 GO:0006919 GO:0007595 GO:0009055 GO:0009115 GO:0010629 GO:0016491 GO:0016529 GO:0016614 GO:0016903 GO:0030856 GO:0042803 GO:0043546 GO:0045602 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0051898 GO:0055114 GO:1900745 GO:1900747 GO:2000379 GO:2001213
18	0.06	0.306	6.66	0.02	0.57	3wqoA	GO:0003677 GO:0006281 GO:0008270

Consensus prediction of GO terms

Molecular Function	GO:0004888	GO:0005515
GO-Score	0.48	0.37
Biological Processes	GO:0019722	GO:0007417	GO:0060322	GO:0048513	GO:0048489	GO:0051962	GO:0099504	GO:0051130	GO:0099003	GO:0090128	GO:0017156	GO:0007269	GO:0098742
GO-Score	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.37
Cellular Component	GO:0044444	GO:0031224	GO:0098793	GO:0099572	GO:0060076	GO:0097060	GO:0030427	GO:0043005	GO:0044463
GO-Score	0.47	0.46	0.37	0.37	0.37	0.37	0.37	0.37	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.