I-TASSER results

I-TASSER results for job id Rv0811c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (368 residues)
MAAVPAPDPGPDAGAIWHYGDPLGEQRAGQADAVLVDRSHRAVLTLDGGDRQTWLHSIST
QHVSDLPEGASTQNLSLDGQGRVEDHWIQTELGGTTYLDTEPWRGEPLLAYLRKMVFWSM
VTPRAADMAVLSLLGPRLAEERVLDALGLDVLPAEWLAVPLAGGGIVRRMPDGLAGQIEL
DVVVKRGDRADWQRRLTQAGVRPAGIWAYEAHRVAHRVPARRPRLGVDTDERTIPHEVGW
IGGPGAGAVHLNKGCYRGQETVARVHNLGRPPRMLVLLHLDESVQRPSTGDAVLAGGRTV
GRLGTVVEHVELGPVALALLKRGLPGDTALVTGPEAEVAAVIDVDSLPPADDVGAGRRAV
ERLRGGIR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAVPAPDPGPDAGAIWHYGDPLGEQRAGQADAVLVDRSHRAVLTLDGGDRQTWLHSISTQHVSDLPEGASTQNLSLDGQGRVEDHWIQTELGGTTYLDTEPWRGEPLLAYLRKMVFWSMVTPRAADMAVLSLLGPRLAEERVLDALGLDVLPAEWLAVPLAGGGIVRRMPDGLAGQIELDVVVKRGDRADWQRRLTQAGVRPAGIWAYEAHRVAHRVPARRPRLGVDTDERTIPHEVGWIGGPGAGAVHLNKGCYRGQETVARVHNLGRPPRMLVLLHLDESVQRPSTGDAVLAGGRTVGRLGTVVEHVELGPVALALLKRGLPGDTALVTGPEAEVAAVIDVDSLPPADDVGAGRRAVERLRGGIR
Prediction	CCCCCCCCCCCCCCCHCCCCCHHHHHHHHHHCCEEEHCCCCEEEEEHCCHHHHHHHHHCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEEEHCCEEEEEHCCCHHHHHHHHHHHHCCCCEEEEEHCCCEEEEEHCCCHHHHHHHHCCCCCCCCCCCCCEEHCCCEEEEEHCCCCCCCCCEEEEHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCHHHHCCCCCCCCEEHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCEEEEHCCEEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCEEEEHCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHCCCCC
Conf.Score	99877899987667544448989999999977658978898699998785999999865556765899889998886899995689999997795999958987899999999977885889865674689986876788998767887655555444555487789996899999985799977889999999999989976566778888898575556877688899998855447654455545557778878899999999989998579999976877788898688769988899987556999884799987788898867899857765667888568899988874799998756889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAVPAPDPGPDAGAIWHYGDPLGEQRAGQADAVLVDRSHRAVLTLDGGDRQTWLHSISTQHVSDLPEGASTQNLSLDGQGRVEDHWIQTELGGTTYLDTEPWRGEPLLAYLRKMVFWSMVTPRAADMAVLSLLGPRLAEERVLDALGLDVLPAEWLAVPLAGGGIVRRMPDGLAGQIELDVVVKRGDRADWQRRLTQAGVRPAGIWAYEAHRVAHRVPARRPRLGVDTDERTIPHEVGWIGGPGAGAVHLNKGCYRGQETVARVHNLGRPPRMLVLLHLDESVQRPSTGDAVLAGGRTVGRLGTVVEHVELGPVALALLKRGLPGDTALVTGPEAEVAAVIDVDSLPPADDVGAGRRAVERLRGGIR
Prediction	75032013621001000101313400310063000000010010353162023003200001056054230100001136412000001121554111012101043015104411030403122432000000115014321452151432323222122122020000000001110000001262024005201614041000000100000020100111001003340000000002241311030624431232011003754514120001306552422442230246544023111001013011000000446155522212146552504052250212766632350054146568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCHCCCCCHHHHHHHHHHCCEEEHCCCCEEEEEHCCHHHHHHHHHCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEEEHCCEEEEEHCCCHHHHHHHHHHHHCCCCEEEEEHCCCEEEEEHCCCHHHHHHHHCCCCCCCCCCCCCEEHCCCEEEEEHCCCCCCCCCEEEEHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCHHHHCCCCCCCCEEHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCEEEEHCCEEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCEEEEHCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHCCCCC
MAAVPAPDPGPDAGAIWHYGDPLGEQRAGQADAVLVDRSHRAVLTLDGGDRQTWLHSISTQHVSDLPEGASTQNLSLDGQGRVEDHWIQTELGGTTYLDTEPWRGEPLLAYLRKMVFWSMVTPRAADMAVLSLLGPRLAEERVLDALGLDVLPAEWLAVPLAGGGIVRRMPDGLAGQIELDVVVKRGDRADWQRRLTQAGVRPAGIWAYEAHRVAHRVPARRPRLGVDTDERTIPHEVGWIGGPGAGAVHLNKGCYRGQETVARVHNLGRPPRMLVLLHLDESVQRPSTGDAVLAGGRTVGRLGTVVEHVELGPVALALLKRGLPGDTALVTGPEAEVAAVIDVDSLPPADDVGAGRRAVERLRGGIR

1wopA

0.20

0.19

0.94

3.86

MUSTER

LGAKMVDFAGWE--MPLYYTSIFEEVMAVRKSVGMFDVSHMGEFLVKGPEAVSFIDFLITNDFSSLPDGKAIYSVMCNENGGIIDDLVVYKVSPEALMVVNAANIEKDFNWIKSHSFDVEVSNISDTTALIAFQGPKAQETLQELVDGLEEIAYYSFRKSIVAGVETLVSRTGYTGEDGFELMLEAKNAPKVWDALMNLLRKIDGRPAGLGARDVCRLEATYLLYGQDMDENTNPFEVGLSW-----VVKLNK-DFVGKEALLKAKEK--VERKLVALELSGK-RIARKGYEVLKNGERVGEITSGNFSPTLGSIALALVSKSVKIGDQLGVVFPGGKLVEALVVKKPFYR------------GSVRR

1wopA

0.19

0.18

0.94

7.73

dPPAS

LGAKMVDFAGWE--MPLYYTSIFEEVMAVRKSVGMFDVSHMGEFLVKGPEAVSFIDFLITNDFSSLPDGKAIYSVMCNENGGIIDDLVVYKVSPEALMVVNAANIEKDFNWIKSHSFDVEVSNISDTTALIAFQGPKAQETLQELEDGLEEIAYYSFRKSIVAGVETLVSRTGYTGEDGFELMLEAKNAPKVWDALMNLLRKIDGRPAGLGARDVCRLEATYLLYGQDMDENTNPFEVGLSWVVKL------NKDFVGKEALLKAKEK--VERKLVALELSGKRIA-RKGYEVLKNGERVGEITSGNFSPTLGSIALALVSKSVKIGDQLGVVFPGGKLVEALVVKKPFYRGSVRR------------

1wopA

0.19

0.18

0.93

7.60

wdPPAS

LGAKMVDFAGWE--MPLYYTSIFEEVMAVRKSVGMFDVSHMGEFLVKGPEAVSFIDFLITNDFSSLPDGKAIYSVMCNENGGIIDDLVVYKVSPEALMVVNAANIEKDFNWIKSHSFDVEVSNISDTTALIAFQGPKAQETLQELEDGLEEIAYYSFRKSIVAGVETLVSRTGYTGEDGFELMLEAKNAPKVWDALMNLLRKIDGRPAGLGARDVCRLEATYLLYGQDMDENTNPFEVGLSWVVKL------NKDFVGKEALLKAKE---VERKLVALELSGKRIAR-KGYEVLKNGERVGEITSGNFSPTLGSIALALVSKSVKIGDQLGVVFPGGKLVEALVVKKPFYRGSVRR------------

1wopA

0.20

0.19

0.94

4.67

wMUSTER

LGAKMVDFAGWEM--PLYYTSIFEEVMAVRKSVGMFDVSHMGEFLVKGPEAVSFIDFLITNDFSSLPDGKAIYSVMCNENGGIIDDLVVYKVSDEALMVVNAANIEKDFNWIKSHSFDVEVSNISDTTALIAFQGPKAQETLQELVDGLEEIAYYSFRKSIVAGVETLVSRTGYTGEDGFELMLEAKNAPKVWDALMNLLRKIDGRPAGLGARDVCRLEATYLLYGQDMDENTNPFEVGLSW-----VVKLNK-DFVGKEALLKAKEK--VERKLVALELSGKR-IARKGYEVLKNGERVGEITSGNFSPTLGSIALALVSKSVKIGDQLGVVFPGGKLVEALVVKKPFYRGSVR-R-----------

1wopA

0.20

0.19

0.93

5.12

wPPAS

LGAKMVDFAGWE--MPLYYTSIFEEVMAVRKSVGMFDVSHMGEFLVKGPEAVSFIDFLITNDFSSLPDGKAIYSVMCNENGGIIDDLVVYKVSDEALMVVNAANIEKDFNWIKSHSFDVEVSNISDTTALIAFQGPKAQETLQELVDGLEEIAYYSFRKSIVAGVETLVSRTGYTGEDGFELMLEAKNAPKVWDALMNLLRKIDGRPAGLGARDVCRLEATYLLYGQDMDENTNPFEVGLSW-----VVKLNK-DFVGKEALLKAKE---VERKLVALELSGKRIAR-KGYEVLKNGERVGEITSGNFSPTLGSIALALVSKSVKIGDQLGVVFPGGKLVEALVVKKPFYRGSVR--------R----

3girA

0.19

0.18

0.93

7.40

dPPAS2

AGAKFGAFAGWR--MPLTYPGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYALPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAERFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQAAAVLADAGLPGNELLFMQGFEPQQD---WFITRSGYTGEDGFEIALPIGCARALAEKLLGDSVEWVG----LAARDSLRLEAGLCLHGNDITPDTTPIDAALTWAVPKNV--REKAQFYGAKAFLESLQKG-PSRCRVGLKPQTRQPIRAGAVLFDNEGNRIGVVTSGGFGPSFDPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQRYFK------------

3girA

0.19

0.18

0.93

4.81

PPAS

AGAKFGAFAGWR--MPLTYPGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYALPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAERFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQAAAVLADAGLPGNELLFM---QGFEPQQDWFITRSGYTGEDGFEIALPIGCARALAEKLLGDRVEWVG----LAARDSLRLEAGLCLHGNDITPDTTPIDAALTWAVPKNV--REKAQFYGAKAFLESLQKG-PSRCRVGLKPQTRQPIRAGAVLFDNEGNRIGVVTSGGFGPSFDPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQ-RYFK-----------

3girA

0.19

0.18

0.93

7.11

Env-PPAS

AGAKFGAFAGWR--MPLTYPGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYALPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAERFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQAAAVLADAGLPGNELLFMQGFEPQQ---DWFITRSGYTGEDGFEIALPIGCARALAEKLLGDRVEWVG----LAARDSLRLEAGLCLHGNDITPDTTPIDAALTWAVPK--NVREKAQFYGAKAFLESLQKG-PSRCRVGLKPQTRQPIRAGAVLFDNEGNRIGVVTSGGFGPSFDPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQRYF-K-----------

3girA

0.20

0.18

0.93

3.78

MUSTER

AGAKFGAFAGWRM--PLTYPGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYALPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAERFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQAAAVLADAGLPGNELLFMQGFEPQQD---WFITRSGYTGEDGFEIALPIGCARALAEKLLGDRVEWVG----LAARDSLRLEAGLCLHGNDITPDTTPIDAALTWAVPKNV--REKAQFYGAKAFLESLQKG-PSRCRVGLKPQTRQ-PIRAGAVLFNEGNRIGVVTSGGFGPSFDPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQRYF-K-----------

3girA

0.19

0.18

0.93

7.63

dPPAS

AGAKFGAFAGWR--MPLTYPGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYALPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAERFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQAAAVLADAGLPGNELLFMQGFEPQQD---WFITRSGYTGEDGFEIALPIGCARALAEKLLGDSVEWVG----LAARDSLRLEAGLCLHGNDITPDTTPIDAALTWAVPKNV--REKAQFYGAKAFLESLQKG-PSRCRVGLKPQTRQPIRAGAVLFDNEGNRIGVVTSGGFGPSFDPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQRYFK------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.26

Estimated TM-score = 0.89±0.07

Estimated RMSD = 4.0±2.7Å

Download Model 2

C-score=1.03

Download Model 3

C-score=-2.18

Download Model 4

C-score=-0.35

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1wopA	0.895	1.62	0.197	0.938
2	4p9sA2	0.893	2.22	0.153	0.962
3	1pj6A2	0.873	2.28	0.175	0.948
4	1v5vA	0.870	2.38	0.163	0.946
5	1wsrA	0.869	2.15	0.191	0.938
6	3girA	0.868	2.07	0.192	0.932
7	1yx2B	0.850	2.10	0.186	0.918
8	2gahA	0.843	2.64	0.169	0.932
9	3tfhA	0.832	2.42	0.128	0.910
10	1vloA	0.807	2.38	0.195	0.878

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.66	23	1wooA	THG	Rep, Mult	41,73,86,87,88,90,99,101,154,155,173,174,181,213,242,360
2	0.14	5	1worA	RED	Rep, Mult	210,213,214,217,225
3	0.04	2	2gagA	FOA	Rep, Mult	56,62,63,64,253,254
4	0.02	1	1v5v0	III	Rep, Mult	50,53,54,57,79,80,84,103,106,107,110,111,114,115,231,256,257,258,259,260
5	0.02	1	1wopA	FFO	Rep, Mult	45,95,97,124,159,160,161,166,167,168,183

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.327	3girA	0.868	2.07	0.192	0.932	2.1.2.10	211,213
2	0.313	1wsvA	0.869	2.14	0.191	0.938	2.1.2.10	37,40,88,213
3	0.289	1wopA	0.895	1.62	0.197	0.938	2.1.2.10	213,220
4	0.060	3gtgB	0.379	6.86	0.066	0.639	2.7.7.6	NA
5	0.060	1aorB	0.360	6.61	0.048	0.582	1.2.7.5	153,175,178
6	0.060	1pj6A	0.873	2.28	0.175	0.948	1.5.3.10	NA
7	0.060	1w36D	0.367	6.57	0.085	0.598	3.1.11.5	NA
8	0.060	2wk5A	0.374	7.32	0.042	0.663	2.4.2.4	NA
9	0.060	3gpbA	0.338	6.81	0.048	0.571	2.4.1.1	224
10	0.060	2wqdA	0.353	6.76	0.035	0.590	2.7.3.9	211
11	0.060	1vlbA	0.364	6.90	0.056	0.614	1.2.99.7	NA
12	0.060	2r7oA	0.359	5.84	0.059	0.535	2.7.7.48	32,218,222
13	0.060	1vloA	0.807	2.38	0.195	0.878	2.1.2.10	40,88,176,220
14	0.060	1zj9B	0.364	5.85	0.070	0.546	1.8.7.1	NA
15	0.060	2qllA	0.354	6.83	0.025	0.584	2.4.1.1	NA
16	0.060	3l76A	0.405	5.47	0.072	0.565	2.7.2.4	76,229
17	0.060	1yx2B	0.850	2.10	0.186	0.918	2.1.2.10	40,176,220
18	0.060	1yq2A	0.389	6.86	0.052	0.652	3.2.1.23	NA
19	0.060	1fa9A	0.390	6.40	0.045	0.614	2.4.1.1	NA
20	0.060	1v5vA	0.870	2.38	0.163	0.946	2.1.2.10	213
21	0.060	1e1yA	0.397	6.56	0.030	0.636	2.4.1.1	224
22	0.060	1ygpA	0.381	6.77	0.033	0.630	2.4.1.1	230,237

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.893	2.50	0.15	0.97	4pabB	GO:0005542 GO:0005739 GO:0006579 GO:0016491 GO:0019695 GO:0035999 GO:0042426 GO:0047865 GO:0050660 GO:0055114
1	0.33	0.832	2.42	0.13	0.91	3tfhA	GO:0008168 GO:0016740 GO:0032259
2	0.32	0.834	2.37	0.19	0.91	1vloA	GO:0004047 GO:0005829 GO:0006546 GO:0008483 GO:0016740 GO:0019464 GO:0032259
3	0.31	0.866	2.05	0.19	0.93	1yx2B	GO:0004047 GO:0006546 GO:0008483 GO:0016740 GO:0019464 GO:0032259
4	0.30	0.869	2.15	0.19	0.94	1wsrA	GO:0004047 GO:0005739 GO:0005759 GO:0006546 GO:0008483 GO:0016740 GO:0019464 GO:0032259 GO:0046487
5	0.30	0.894	1.65	0.19	0.94	1wooA	GO:0004047 GO:0006546 GO:0008483 GO:0016740 GO:0019464 GO:0032259
6	0.26	0.860	2.70	0.17	0.95	2gagA	GO:0000166 GO:0008115 GO:0016491 GO:0046653 GO:0055114
7	0.25	0.873	2.28	0.17	0.95	1pj6A	GO:0000166 GO:0016491 GO:0047866 GO:0055114
8	0.25	0.860	2.69	0.16	0.95	3ad7A	GO:0000166 GO:0008115 GO:0016491 GO:0046653 GO:0055114
9	0.21	0.868	2.07	0.19	0.93	3girA	GO:0004047 GO:0006546 GO:0008483 GO:0016740 GO:0032259
10	0.19	0.870	2.38	0.16	0.95	1v5vA	GO:0004047 GO:0006546 GO:0008483 GO:0016740 GO:0019464 GO:0032259
11	0.06	0.323	6.69	0.03	0.53	2z67A	GO:0000049 GO:0003723 GO:0003824 GO:0006412 GO:0016740 GO:0016785 GO:0097056
12	0.06	0.302	5.92	0.05	0.46	2iveA	GO:0004729 GO:0005737 GO:0006779 GO:0006782 GO:0006783 GO:0016020 GO:0016491 GO:0055114
13	0.06	0.287	6.69	0.07	0.48	3nksA	GO:0004729 GO:0005739 GO:0005743 GO:0005758 GO:0006779 GO:0006782 GO:0006783 GO:0016020 GO:0016491 GO:0031304 GO:0031305 GO:0031966 GO:0042493 GO:0046501 GO:0050660 GO:0055114
14	0.06	0.306	6.85	0.05	0.51	4ow6B	GO:0005576 GO:0009405 GO:0016740 GO:0016757 GO:0047286
15	0.06	0.272	7.14	0.01	0.48	3ldfA	GO:0005737 GO:0006364 GO:0008168 GO:0016740 GO:0032259
16	0.06	0.298	5.96	0.06	0.46	4wctA	GO:0016491 GO:0055114
17	0.06	0.292	6.54	0.04	0.46	5dbjC	GO:0016491 GO:0016787 GO:0047651 GO:0055114
18	0.06	0.279	6.24	0.06	0.43	4yshA	GO:0016491 GO:0050660 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0004047	GO:0008483	GO:0005542	GO:0047865	GO:0050660
GO-Score	0.67	0.67	0.34	0.34	0.34
Biological Processes	GO:0032259	GO:0019464	GO:0006579	GO:0055114	GO:0035999	GO:0042426	GO:0046487
GO-Score	0.78	0.67	0.34	0.34	0.34	0.34	0.30
Cellular Component	GO:0005829	GO:0005759
GO-Score	0.32	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.