I-TASSER results

I-TASSER results for job id Rv0790c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (242 residues)
MTLANNGTGMDHFLTPTEYLDAGHPLVRTTAATLIRDAVSDTERVRRIYYYVRDVPYDVL
ASFRYLAQGHHRASDVIGHGVAFCMGKASSFVALCRAAGVPARIAFQTIDAPDKEFLSPQ
VRALWGGRTGRPFPWHSLGEAYLGRRWVKLDATIDAPTAARLGKPYRQEFDGATPIPTVE
GTILRENGSYADYPSAVAQWYERIAQSVLKALQSTEVHALVAADEELWTGPPVELADATH
RL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MTLANNGTGMDHFLTPTEYLDAGHPLVRTTAATLIRDAVSDTERVRRIYYYVRDVPYDVLASFRYLAQGHHRASDVIGHGVAFCMGKASSFVALCRAAGVPARIAFQTIDAPDKEFLSPQVRALWGGRTGRPFPWHSLGEAYLGRRWVKLDATIDAPTAARLGKPYRQEFDGATPIPTVEGTILRENGSYADYPSAVAQWYERIAQSVLKALQSTEVHALVAADEELWTGPPVELADATHRL
Prediction	CCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCEEHCCHHHHHHHHHHHHCCCEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCEEEEHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98877885789986557889999999999999999689999999999999999855445667788888877789999889577634689999999998998589999985677777776554567877778765678999998998899857899764554566666678888876667754334567655675665556489999999857858899885677655678887656777789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MTLANNGTGMDHFLTPTEYLDAGHPLVRTTAATLIRDAVSDTERVRRIYYYVRDVPYDVLASFRYLAQGHHRASDVIGHGVAFCMGKASSFVALCRAAGVPARIAFQTIDAPDKEFLSPQVRALWGGRTGRPFPWHSLGEAYLGRRWVKLDATIDAPTAARLGKPYRQEFDGATPIPTVEGTILRENGSYADYPSAVAQWYERIAQSVLKALQSTEVHALVAADEELWTGPPVELADATHRL
Prediction	45345457415521341522635364025004500663642240031003002302132333242446532202300453403022201000000211400011000203344453444434434434434432110000010444312020121341153143424451544432343545125644312411440352254015204624535403440364440243352423524565
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCEEHCCHHHHHHHHHHHHCCCEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCEEEEHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
MTLANNGTGMDHFLTPTEYLDAGHPLVRTTAATLIRDAVSDTERVRRIYYYVRDVPYDVLASFRYLAQGHHRASDVIGHGVAFCMGKASSFVALCRAAGVPARIAFQTIDAPDKEFLSPQVRALWGGRTGRPFPWHSLGEAYLGRRWVKLDATIDAPTAARLGKPYRQEFDGATPIPTVEGTILRENGSYADYPSAVAQWYERIAQSVLKALQSTEVHALVAADEELWTGPPVELADATHRL

3isrB

0.19

0.14

0.78

1.47

MUSTER

VPVVDLDGDIIPFLFPSRYCQS--DKLQKLAYKEFGKIENVYSKVLAITDWIYNNV----EYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFK------------------LNPPDFHACFEAYIGGNWIIFDATRLVPLNGLVKIATGRDAADAAVASIFGNASSTNHVECASL----------------------------DTDFTPFWYDKNSLKGLSFQ-

4xz7A2

0.11

0.09

0.81

1.83

dPPAS

--------------TKERFIANDDLIHKLIESSEAMKQSSERDKVKAFVQYVANHTTAVQNYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKNAEG---------------------VPHATARVYYDKKWHTIDGTGFITKYSEKHFSTIGEDSYDVVEAGQEPKAERNYMIIDSNYESWAMKQKTADLLLFN-------KEKSLVGLDYIAYVEPTYIT-----

4xz7A2

0.13

0.10

0.80

3.29

wdPPAS

--------------TKERFIANDDLIHKLIESSEAMKQSSERDKVKAFVQYVANHTTYDWNYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKNAEG---------------------VPHATARVYYDKKWHTIDGTGFITKSEKHFSTIGEDSYDVVEAG----QEPKAERNYMIIDSNYESWAMK--QKTADLLLFNKEKSLVGLDYIAYV--EPTYIT-----

3isrB

0.18

0.14

0.75

1.98

wMUSTER

VPVVDLDGDIIPFLFPSRYCQS--DKLQKLAYKEFGKIENVYSKVLAITDWIYNNV----EYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFK------------------LNPPDFHACFEAYIGGNWIIFDATRLVPLNGLVKIATGRDAADAAVASIFGNECASLDTDFTPFWYDKNSLKGLSFQ------------------------------------

4xz7A2

0.14

0.11

0.79

3.29

wPPAS

----------------TRFIANDDLIHKLIESSEAMKQSSERDKVKAFVQYVANHTKAVQNYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKNAEG---------------------VPHATARVYYDKKWHTIDGTGFIKYSEKHFSTIGEDSYDVVEAG----QEPKAERNYMIIDSNYESWAMK--QKTADLLLFNKEKSLVGLDYIAYV--EPTYIT-----

3isrB

0.20

0.14

0.71

5.23

dPPAS2

VPVVDLDGDIIPFLFPSRYCQS--DKLQKLAYKEFGKIENVYSKVLAITDWIYNNV----EYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFK------------------LNPPDFHACFEAYIGGNWIIFDATRLVPLNGLVKIATGRDAADAAVLDTDFTPFWYDKNSLKGLSFQ----------------------------------------------

4xz7A2

0.15

0.12

0.80

2.39

PPAS

--------TKERFIA-------NDDLIHKLIESSAMKQSSERDKVKAFVQYVANHTKAVQNYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKNAEG---------------------VPHATARVYYDKKWHTIDGTGFIT------KYSEKHFSTIGEDSYDVVEAGQEPKAERNYMIIDSNYESWAMQKTADLLLFNKEKSLVGLDYIAYV--EPTYIT-----

4xz7A2

0.14

0.11

0.80

2.81

Env-PPAS

--------TKERFIA-------NDDLIHKLIESSAMKQSSERDKVKAFVQYVANHTKAVQNYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKNAE---------------------GVPHATARVYYDKKWHTIDGTGFIKYSEKHFSTIGEDSYDVVEA----GQEPKAERNYMIIDSNYESWAMKQ--KTADLLLFNKEKSLVGLDYIAYV--EPTYIT-----

4xz7A

0.12

0.10

0.86

1.19

MUSTER

KYYEDYSKYTHNSVKNINVTKANDDLIHKLIESSAMKQSSERDKVKAFVQYVANHTKAVQNYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKN---------------------AEGVPHATARVYYDKKWHTIDGTGFIKYSEKHFSTIGEDSYDVVEA----GQEPKAERNYMIIDSNYESWAMKQKTADLLLFNKEKS---LVGLDYIAYVEPTYIT------

3isrB

0.20

0.14

0.71

1.63

dPPAS

VPVVDLDGDIIPFLFPSRYCQS--DKLQKLAYKEFGKIENVYSKVLAITDWIYNNV----EYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFK------------------LNPPDFHACFEAYIGGNWIIFDATRLVPLNGLVKIATGRDAADAAVLDTDFTPFWYDKNSLKGLSFQ----------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.88

Estimated TM-score = 0.60±0.14

Estimated RMSD = 7.6±4.3Å

Download Model 2

C-score=-2.36

Download Model 3

C-score=-3.70

Download Model 4

C-score=-2.06

Download Model 5

C-score=-2.25

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4xz7A	0.675	2.96	0.121	0.789
2	1l9mB	0.520	4.65	0.080	0.723
3	2q3zA4	0.520	4.73	0.088	0.723
4	1g0dA	0.516	4.78	0.088	0.719
5	1f13A	0.513	4.67	0.092	0.715
6	2qshA1	0.487	5.03	0.088	0.723
7	2f4mA	0.487	4.59	0.138	0.669
8	3d9wA	0.478	4.09	0.063	0.640
9	3eswA	0.474	5.14	0.106	0.690
10	3isrB	0.474	4.29	0.173	0.624

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	6	4f8hC	LMD	Rep, Mult	89,92
2	0.06	3	3ltwA	HLZ	Rep, Mult	98,100,101,142,145,227
3	0.04	2	1so2D	MG	Rep, Mult	136,151
4	0.04	2	2f4oA	III	Rep, Mult	69,83,84,85,136,137
5	0.04	2	1j95A	TBA	Rep, Mult	30,52
6	0.02	1	1ea4J	NUC	Rep, Mult	14,15,17
7	0.02	1	3d5d7	MG	Rep, Mult	103,119
8	0.02	1	1g0dA	SO4	Rep, Mult	103,147
9	0.02	1	3nteB	FE	Rep, Mult	46,150
10	0.02	1	4rku4	CLA	Rep, Mult	45,48
11	0.02	1	4ej7A	CA	Rep, Mult	187,192
12	0.02	1	3zweA	FUC	Rep, Mult	142,147
13	0.02	1	4l9sA	CA	Rep, Mult	52,54
14	0.02	1	1h1lB	MG	Rep, Mult	54,58
15	0.02	1	2o01G	CLA	Rep, Mult	194,195

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1t9gC	0.408	5.92	0.068	0.682	1.3.99.3	NA
2	0.060	2qnoA	0.401	6.64	0.074	0.777	3.2.1.4	35
3	0.060	1is2A	0.415	5.15	0.045	0.624	1.3.3.6	NA
4	0.060	2q3zA	0.518	4.56	0.098	0.719	2.3.2.13	NA
5	0.060	1g0dA	0.516	4.78	0.088	0.719	2.3.2.13	84,136,151
6	0.060	1xc6A	0.411	6.27	0.054	0.723	3.2.1.23	86
7	0.060	1f13A	0.513	4.67	0.092	0.715	2.3.2.13	84,136,151
8	0.060	3mddA	0.407	5.83	0.068	0.678	1.3.99.3	14,216,219
9	0.060	2bszA	0.453	4.08	0.054	0.595	2.3.1.5	84,136,151
10	0.060	1kv3A	0.518	4.69	0.076	0.719	2.3.2.13	84,136,151
11	0.060	1ivhA	0.411	5.94	0.046	0.711	1.3.99.10	98
12	0.060	2ebaA	0.414	5.76	0.047	0.694	1.3.99.7	NA
13	0.060	3d9wA	0.478	4.09	0.063	0.640	2.3.1.5	84,136,151
14	0.060	1ukwA	0.413	5.85	0.058	0.690	1.3.99.3	NA
15	0.060	1bucA	0.424	5.80	0.026	0.707	1.3.99.2	NA
16	0.060	1l2aE	0.407	6.20	0.048	0.723	3.2.1.4	NA
17	0.060	1bucB	0.416	5.70	0.052	0.694	1.3.99.2	NA
18	0.060	2pg0A	0.406	5.65	0.057	0.678	1.3.99.3	98
19	0.060	1e2tA	0.452	4.02	0.064	0.591	2.3.1.118	84,136,151

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.18	0.513	4.67	0.09	0.71	1f13A	GO:0002576 GO:0003810 GO:0005576 GO:0005737 GO:0007596 GO:0007599 GO:0016740 GO:0016746 GO:0018149 GO:0031093 GO:0042060 GO:0046872 GO:0072562
1	0.07	0.518	4.56	0.10	0.72	2q3zA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
2	0.07	0.520	4.65	0.08	0.72	1l9mB	GO:0003810 GO:0003824 GO:0005509 GO:0005737 GO:0006464 GO:0016740 GO:0016746 GO:0018149 GO:0030216 GO:0031069 GO:0031234 GO:0031424 GO:0043163 GO:0046872 GO:0051262 GO:0070062
3	0.07	0.513	4.55	0.08	0.71	4pygA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
4	0.07	0.516	4.78	0.09	0.72	1g0dA	GO:0003810 GO:0016740 GO:0016746 GO:0018149 GO:0046872
5	0.07	0.469	4.66	0.10	0.65	3s3sA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
6	0.06	0.322	6.28	0.02	0.58	5a63A	GO:0002262 GO:0004175 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0005887 GO:0005925 GO:0006508 GO:0006509 GO:0007219 GO:0007220 GO:0008233 GO:0016020 GO:0016021 GO:0016485 GO:0031293 GO:0042098 GO:0042470 GO:0042987 GO:0043065 GO:0043085 GO:0048013 GO:0050435 GO:0050673 GO:0070062
7	0.06	0.327	6.57	0.03	0.62	3ucpA	GO:0046872 GO:0055114
8	0.06	0.319	6.49	0.08	0.59	4uisA	GO:0002262 GO:0004175 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0005887 GO:0005925 GO:0006508 GO:0006509 GO:0007219 GO:0007220 GO:0008233 GO:0016020 GO:0016021 GO:0016485 GO:0031293 GO:0042098 GO:0042470 GO:0042987 GO:0043065 GO:0043085 GO:0048013 GO:0050435 GO:0050673 GO:0070062
9	0.06	0.278	6.34	0.03	0.51	3czmB	GO:0003824 GO:0004459 GO:0005975 GO:0016491 GO:0016616 GO:0019752 GO:0055114
10	0.06	0.293	6.08	0.04	0.51	2aryA	GO:0004198 GO:0005509 GO:0005622 GO:0005737 GO:0005739 GO:0005764 GO:0005829 GO:0005886 GO:0005925 GO:0006508 GO:0008092 GO:0008233 GO:0008234 GO:0008284 GO:0016020 GO:0016241 GO:0016540 GO:0016787 GO:0022617 GO:0032801 GO:0046872 GO:0060056 GO:0070062
11	0.06	0.281	6.31	0.03	0.50	4mwaF	GO:0003824 GO:0005506 GO:0008299 GO:0016114 GO:0016491 GO:0019288 GO:0044237 GO:0046429 GO:0046872 GO:0051536 GO:0051539 GO:0055114
12	0.06	0.280	6.59	0.06	0.54	4q9nA	GO:0004319 GO:0016491 GO:0055114
13	0.06	0.252	6.71	0.04	0.50	4upcA	GO:0002262 GO:0004175 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0005887 GO:0005925 GO:0006508 GO:0006509 GO:0007219 GO:0007220 GO:0008233 GO:0016020 GO:0016021 GO:0016485 GO:0031293 GO:0042098 GO:0042470 GO:0042987 GO:0043065 GO:0043085 GO:0048013 GO:0050435 GO:0050673 GO:0070062
14	0.06	0.315	5.85	0.04	0.53	4aw6A	GO:0004222 GO:0005634 GO:0005637 GO:0005783 GO:0005789 GO:0006508 GO:0006998 GO:0008233 GO:0008235 GO:0008237 GO:0016020 GO:0016021 GO:0016787 GO:0030327 GO:0046872 GO:0070062 GO:0071586
15	0.06	0.324	5.96	0.03	0.55	4r2bA	GO:0005215 GO:0006810
16	0.06	0.249	5.51	0.08	0.41	3ibxA	GO:0006772 GO:0009228 GO:0009229 GO:0016787 GO:0050334
17	0.06	0.305	5.70	0.04	0.50	2p0rA	GO:0004198 GO:0005509 GO:0005622 GO:0005737 GO:0006508 GO:0007586 GO:0008233 GO:0008234 GO:0016787 GO:0046872
18	0.06	0.257	4.45	0.07	0.36	3a0bV	GO:0005506 GO:0009055 GO:0009523 GO:0009579 GO:0015979 GO:0016020 GO:0018063 GO:0019684 GO:0020037 GO:0022904 GO:0042651 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0003810	GO:0046872
GO-Score	0.37	0.37
Biological Processes	GO:0018149	GO:0045055	GO:0007599	GO:0042060	GO:0050817
GO-Score	0.37	0.36	0.36	0.36	0.36
Cellular Component	GO:1903561	GO:0005615	GO:0034774	GO:0031091
GO-Score	0.37	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.