I-TASSER results

I-TASSER results for job id Rv0787

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (319 residues)
MHRPPWLAQLRRRLRIGVQLGSRVVLEQGRQPRDVYVIGVLVGDQDRGQTGDSLEAVRES
TGIEEQAGLTELSEEAGMAEMRELHVYDCALMGAFPMRLILATMLVAGRLLATLMAAPSA
QAEPETCPPICDQIPATAWISTHAVPLNSQYRWPAMAGAAVAVTRATPRFGFEQVCATPA
FPHDSRDWAVAGRVTVVHPDGQWQLQAQVLHWRGDTARGGQIAASVFGTAVAALRACQLG
APLQSPSVTDDEPTRMAAVISGPVIMYTYLVAHVSSSTISELTLWSSGPPQVPWPTVADS
AVLDALTAPLCEAYIGSCP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHRPPWLAQLRRRLRIGVQLGSRVVLEQGRQPRDVYVIGVLVGDQDRGQTGDSLEAVRESTGIEEQAGLTELSEEAGMAEMRELHVYDCALMGAFPMRLILATMLVAGRLLATLMAAPSAQAEPETCPPICDQIPATAWISTHAVPLNSQYRWPAMAGAAVAVTRATPRFGFEQVCATPAFPHDSRDWAVAGRVTVVHPDGQWQLQAQVLHWRGDTARGGQIAASVFGTAVAALRACQLGAPLQSPSVTDDEPTRMAAVISGPVIMYTYLVAHVSSSTISELTLWSSGPPQVPWPTVADSAVLDALTAPLCEAYIGSCP
Prediction	CCCCHHHHHHCCCEEEEEHCCEEEEEHCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCCCCCCEEEHCCCCCCEEEEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHCHHHHHHHHHHCCCCCCCEEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
Conf.Score	9987567765686688887464678653688888579999875788876546888987667875556534444554567788765555444677767799999999866554444677888898889988778998766785579987556888777876556788986434455557899999877766554787589986678899998678777788459999999999999785569988887556677765666646676556544478999779999985789988899898589999998777788876589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHRPPWLAQLRRRLRIGVQLGSRVVLEQGRQPRDVYVIGVLVGDQDRGQTGDSLEAVRESTGIEEQAGLTELSEEAGMAEMRELHVYDCALMGAFPMRLILATMLVAGRLLATLMAAPSAQAEPETCPPICDQIPATAWISTHAVPLNSQYRWPAMAGAAVAVTRATPRFGFEQVCATPAFPHDSRDWAVAGRVTVVHPDGQWQLQAQVLHWRGDTARGGQIAASVFGTAVAALRACQLGAPLQSPSVTDDEPTRMAAVISGPVIMYTYLVAHVSSSTISELTLWSSGPPQVPWPTVADSAVLDALTAPLCEAYIGSCP
Prediction	8542410140442010003221400043046343010000000245425435204302744416534212412662323304603221002223130200000000001211121332334244651323055125311143330302322304513433242435423020241022243675245232334141544623030211012032232433430230043025104404452444415144643441120020221001001231672311100021213352414425334004200210031125528
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHCCCEEEEEHCCEEEEEHCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCCCCCCEEEHCCCCCCEEEEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHCHHHHHHHHHHCCCCCCCEEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
MHRPPWLAQLRRRLRIGVQLGSRVVLEQGRQPRDVYVIGVLVGDQDRGQTGDSLEAVRESTGIEEQAGLTELSEEAGMAEMRELHVYDCALMGAFPMRLILATMLVAGRLLATLMAAPSAQAEPETCPPICDQIPATAWISTHAVPLNSQYRWPAMAGAAVAVTRATPRFGFEQVCATPAFPHDSRDWAVAGRVTVVHPDGQWQLQAQVLHWRGDTARGGQIAASVFGTAVAALRACQLGAPLQSPSVTDDEPTRMAAVISGPVIMYTYLVAHVSSSTISELTLWSSGPPQVPWPTVADSAVLDALTAPLCEAYIGSCP

4kc5A

0.12

0.97

0.66

MUSTER

PERIINGRKQVFPRRAGLT-GAHMIVEEYPEPADSQLVFVFSVKLALAQNLTSFRDWLASSEAP----LAQIAYT--LQVGKNNLRNRLAIRCRTRQALSRALNACIDGHYQSSADSKIFYRFQESDAVQPLESDLNDPLAPLLTQWDSQVDWASLYAPPVRISLPAYRFEKTRCWYTEEGYESSIVNPPLVAKNCSTPQPGAIFRTDFVEDELLDYRGGRRAFNFADVALAMPALASRFDGRTHYIADWTTVTGLEYRLFEIDQLELEFDFRRSGEQPTHLGFAVINPLTSDEPPLP--QQWLDDARELLNRQALQAG

5gaoE

0.13

1.00

0.86

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK

2bv9A

0.14

0.11

0.79

0.51

wdPPAS

-----------SGLKIGAWVGTQPSESAGRKLD---IVHQFINSTDFSWVRPYADAVYN-NG-----SILMIT-EYNTVDIKN--KADAY------ITRMAQDMKAYGKIWLRPLHEANGDWYPAIGYSSRVNTNEAAFFRANGAT-NVKWVFNVNCDNVGNGTSYLGHY--------P---GD--NY-------VD------YTSIDGYNWGTTQSWGSQSFDQVFSRAYQALAS--INKPIIIAEFASAEIGG-----NKARWITEAYNSIRTSYNKVIAAVWFHENKETDWRINSSPEALAAYREAIGAL---EHH

3eo7A

0.15

0.14

0.94

0.58

wMUSTER

DTNGQWWQRLSRLLFYGLTAGNTVYLRAGLYPAEVYVVSRGTPLLSPGQCRTSLIHYWESQSLQEACFWHPALESTQSAWRYEDRAYRRICLD---TGHLLGNIELSAAITPHLIGGFIDEADPLQEGAIA--VLPLADLLDIQQNISPGCTALPSATETNYPQVPDGELLKYFHHHTQISASDKYNFPFCLKISTVSAPIYWGEDLEITHKRRST-NGEELTFDELKALLDFTYQ---------PQNYIDQSLDNSPDYFDLNLIETFIAVCG----VQGLGCYYYAPKAQELRQIRFKNFRRELHFLCLQELGRDAA

4a37A2

0.14

0.10

0.73

0.48

wPPAS

-FEPERHARL---V---ALGIEGVERLAGTSVQGRDIELLRVRRHPDSH------KL-IA-QQ--HPG--HMAEWFMEGLIERLRPDDTE------MQRLLEKADL-----YLV--------------PNMN--PDGNL-NAAGQDLN---AWLE------PSAERSP-WFVQQEM---------KRHGVDLFLDI----GDEEIPHVFAAGCEGNPGYTPRLERLEQRFREELMARGEF--QIRHGYPRSAPGQANLALACNFVGQTY-LA------TIEMP--DDNPPGTGW----SGARSKRLGQDVLSTLAVLVD

5gaoE

0.18

0.12

0.68

dPPAS2

---------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAA--AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

5gaoE

0.13

0.96

0.77

PPAS

AAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSN

4kyxA

0.15

0.06

0.43

0.78

Env-PPAS

INHP----RIGIGILIFNNRN-EILLGKRISSHGESSYAPAGGHLEFGET---FEECAI----------REVLEETNLINPQFIAVTNDIFEKEQKHYVSI-----------FLKAHCLNEHELQNLPHKVENW---QWFALDNLP--SNLFLP----LKRLIEKKCYLYK-EII------------------------------------------------------------------------------------------------------------------------------------------------

4bxsV

0.10

0.09

0.95

0.64

MUSTER

STGGEYEKHLGGPI-IRAEVDIEIQFKLASRPYSLHAHGLLYEKSSEGRSYDDKSPELFKKDDAIMPNGTQVPPRSGPTDNTESWAYYSGVN--------PEKDIHSG-LIGPILICQKGMIDKYNRTIDIREFFMVFDEEKSWYFPCSLHTFPAINGIPYQLQGKDENVHWHLLNMGGPKDIHVVNFHGQTFTEEGREDNQLPLLPGTFASIKMKPSKIGTWLLETEVGENQERGMQDKDCKLPMGLASGIIQDSQISASGHVGYWEPKLARLNNTGKYNAWSIIKKEHEHPWIQI-----LQRQVVITGIQTQGTVQ

4wj1A

0.13

0.10

0.80

0.57

dPPAS

-------------------------------------------EELQYELPERKAHECESTRPEGPGDATKATTASVYSKLASAAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAAELSRQNGSDAPPPAAEAVVPDSGIPGPLA---IPSEYPSAAAAADEDWEAAARIIHSGDTQALSKYFRDQWRDYQS------TLEGHGRHFANPAEGWGAAAETCAEAQRRLSTWWADGA----------ECGRLAQEATTFVDAHDKLVA--NHPTLENVREFEETEWASEW-DRQNAWALQEQSEDALEAYANGSQ

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-5.00

Estimated TM-score = 0.21±0.05

Estimated RMSD = 19.2±2.0Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3eo7A	0.623	5.04	0.063	0.884
2	4krgA	0.415	6.23	0.051	0.680
3	4ineA	0.411	6.13	0.023	0.671
4	4krhA	0.408	6.22	0.072	0.658
5	1hmwA	0.405	6.42	0.051	0.680
6	3t5tA	0.405	5.99	0.059	0.636
7	1gz5A	0.401	6.15	0.048	0.646
8	3rkoL	0.399	6.51	0.067	0.674
9	4j5tA	0.399	6.25	0.067	0.652
10	4cu6A	0.398	6.68	0.054	0.693

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1iw7P	MG	Rep, Mult	306,310
2	0.04	2	1jb0J	CLA	Rep, Mult	226,229,230
3	0.04	2	4f8hB	LMD	Rep, Mult	229,230,233
4	0.02	1	2cixA	MAN	Rep, Mult	283,284
5	0.02	1	2e75G	OPC	Rep, Mult	302,306
6	0.02	1	2dkiA	XE	Rep, Mult	205,234,242,243,267
7	0.02	1	1js4B	BGC	Rep, Mult	211,213,230,234
8	0.02	1	1hxxA	C8E	Rep, Mult	269,270,284
9	0.02	1	2b0qA	MG	Rep, Mult	215,250
10	0.02	1	3a8eA	CE5	Rep, Mult	233,236,237
11	0.02	1	3fefA	MG	Rep, Mult	176,198
12	0.02	1	3rf6A	MG	Rep, Mult	46,299
13	0.02	1	3kc2B	MG	Rep, Mult	44,46,299
14	0.02	1	3rkoL	LFA	Rep, Mult	227,230,231,269
15	0.02	1	3dtbA	BCT	Rep, Mult	195,289,290,291,292
16	0.02	1	2boqA	ZN	Rep, Mult	273,299
17	0.02	1	1ia6A	CA	Rep, Mult	247,250,251
18	0.02	1	2hzyA	DHJ	Rep, Mult	242,243
19	0.02	1	3cskA	MG	Rep, Mult	280,282,294

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1od2A	0.318	6.57	0.038	0.542	6.3.4.14,6.4.1.2	228
2	0.060	2pdaA	0.353	7.14	0.038	0.649	1.2.7.1	NA
3	0.060	1js4A	0.389	5.93	0.050	0.621	3.2.1.4	NA
4	0.060	2zciA	0.375	6.31	0.035	0.611	4.1.1.32	NA
5	0.060	2a3lA	0.380	5.88	0.038	0.589	3.5.4.6	234,263,264
6	0.060	3eifA	0.380	6.63	0.042	0.655	3.4.21.110	NA
7	0.060	1ks8A	0.390	5.97	0.064	0.621	3.2.1.4	NA
8	0.060	1yq2A	0.388	6.47	0.062	0.652	3.2.1.23	NA
9	0.060	1oqzB	0.386	6.23	0.039	0.636	3.5.1.93	NA
10	0.060	1uyrA	0.377	6.43	0.044	0.633	6.4.1.2,6.3.4.14	NA
11	0.060	1ojnA	0.384	6.45	0.047	0.652	4.2.2.1	NA
12	0.060	3h6oC	0.374	6.46	0.051	0.618	2.7.1.40	261
13	0.060	1i8qA	0.377	6.51	0.042	0.636	4.2.2.1	193
14	0.060	3gm8A	0.377	6.75	0.029	0.668	3.2.1.-	NA
15	0.060	3hqqX	0.381	6.41	0.042	0.624	2.7.1.40	222,224,230
16	0.060	3dt7A	0.387	6.41	0.022	0.639	4.1.1.32	NA
17	0.060	1f1sA	0.376	6.44	0.044	0.636	4.2.2.1	NA
18	0.060	1ksdA	0.391	5.92	0.055	0.618	3.2.1.4	NA
19	0.060	1cb8A	0.406	6.48	0.042	0.690	4.2.2.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.623	5.03	0.07	0.88	3eo7A	GO:0000166 GO:0016491 GO:0055114
1	0.06	0.419	6.21	0.05	0.69	4krgA	GO:0008152 GO:0008168 GO:0032259
2	0.06	0.411	6.13	0.02	0.67	4ineA	GO:0000773 GO:0005737 GO:0006656 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0080101
3	0.06	0.304	6.83	0.05	0.53	1ox0A	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817 GO:0046872
4	0.06	0.308	7.17	0.06	0.57	4nyuA	GO:0003824 GO:0004099 GO:0004553 GO:0005576 GO:0005975 GO:0016787 GO:0016810 GO:0030246
5	0.06	0.318	6.32	0.06	0.52	2bh2A	GO:0003723 GO:0005506 GO:0006364 GO:0006396 GO:0008168 GO:0008173 GO:0016740 GO:0031167 GO:0032259 GO:0046872 GO:0051536 GO:0051539 GO:0070041 GO:0070475
6	0.06	0.277	5.39	0.02	0.41	3ge6A	GO:0000166 GO:0016491 GO:0055114
7	0.06	0.278	5.13	0.07	0.40	1bkjA	GO:0008218 GO:0016491 GO:0052873 GO:0055114
8	0.06	0.270	5.93	0.04	0.42	4eviA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
9	0.06	0.296	6.23	0.05	0.48	4mwzB	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
10	0.06	0.246	5.93	0.03	0.40	3bkwA	GO:0008152 GO:0008168 GO:0032259
11	0.06	0.283	5.18	0.09	0.41	4dn2A	GO:0000166 GO:0016491 GO:0055114
12	0.06	0.283	5.31	0.06	0.42	2freA	GO:0000166 GO:0016491 GO:0055114
13	0.06	0.242	5.79	0.06	0.38	3kkzA	GO:0046872 GO:0051536 GO:0051539
14	0.06	0.255	5.99	0.06	0.41	2h1rB	GO:0000154 GO:0000179 GO:0005737 GO:0006364 GO:0008168 GO:0008649 GO:0016740 GO:0031167 GO:0032259
15	0.06	0.284	5.84	0.08	0.44	3d2lC	GO:0008168 GO:0016740 GO:0032259
16	0.06	0.270	5.70	0.08	0.41	2r01A	GO:0000166 GO:0016491 GO:0046872 GO:0055114
17	0.06	0.273	5.61	0.05	0.43	3l8dA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
18	0.06	0.272	5.17	0.06	0.39	3ek3A	GO:0000166 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0000166	GO:0016491	GO:0080101	GO:0000773	GO:0046872	GO:0033817	GO:0030246	GO:0004099	GO:0004553
GO-Score	0.07	0.07	0.07	0.07	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0032259	GO:0055114	GO:0006656	GO:0006633	GO:0005975
GO-Score	0.12	0.07	0.07	0.06	0.06
Cellular Component	GO:0005737	GO:0005576
GO-Score	0.07	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.