I-TASSER results

I-TASSER results for job id Rv0774c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (303 residues)
MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPAAAIGTNVPLAPTPALD
PAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRPVIALHGLGGSASAVMDGG
VEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAMVLNELIPLLDTQRLDTSRVA
FLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAGSVAPGSFDGPDDWSANSVFGLP
ALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGFSPGGHNGGFWSAQLPAELTWFAPL
LTG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPAAAIGTNVPLAPTPALDPAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRPVIALHGLGGSASAVMDGGVEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAMVLNELIPLLDTQRLDTSRVAFLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAGSVAPGSFDGPDDWSANSVFGLPALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGFSPGGHNGGFWSAQLPAELTWFAPLLTG
Prediction	CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHCCC
Conf.Score	999888888567888887777666554456666788777777777777777778888777777777788589999997667998589999969999999868999589999989999987999999999988998799995899987778888875899999999999999899888858998787568999999997976444666547877888887777778998898879987788858998999956998678999999999899969998599887789999999999999998689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPAAAIGTNVPLAPTPALDPAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRPVIALHGLGGSASAVMDGGVEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAMVLNELIPLLDTQRLDTSRVAFLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAGSVAPGSFDGPDDWSANSVFGLPALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGFSPGGHNGGFWSAQLPAELTWFAPLLTG
Prediction	634424623110001100310011001122333132342322234334343333443424434434434413323122132463614032213442746120000000111214201432014102510454121000000002301012325123001010420041037314345310000001103000100032224100000000000113435334421523630472312224725612000000343301510340064073402010222134141035103400420173278
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHCCC
MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPAAAIGTNVPLAPTPALDPAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRPVIALHGLGGSASAVMDGGVEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAMVLNELIPLLDTQRLDTSRVAFLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAGSVAPGSFDGPDDWSANSVFGLPALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGFSPGGHNGGFWSAQLPAELTWFAPLLTG

4rgyA

0.25

0.18

0.73

2.16

MUSTER

--------------------------------------------------------------------HMALFQCDFFSDVLGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRT---SIERYVAE--MGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAERMVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWL---L--

4rgyA

0.23

0.17

0.73

3.30

dPPAS

--------------------------------------------------------------------HMALFQCDFFSDVLGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQLPGSDHDLFALAERMAQSDGPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWLPL----

4rgyA

0.26

0.19

0.73

3.67

wdPPAS

-------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRIFGDLAAGSDHDLFALAER-VPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWL---L--

4rgyA

0.26

0.19

0.72

2.63

wMUSTER

--------------------------------------------------------------------MALFQCDFFSDV-LGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAER-VPKLYQCCGTEDFLYEDNVRFRDHV-LDFMYEESPGEHEWGYWDAQIQRVLAWL---L--

4rgyA

0.26

0.19

0.73

3.64

wPPAS

-------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAER-VPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWL---L--

4rgyA

0.25

0.18

0.72

5.12

dPPAS2

--------------------------------------------------------------------HMALFQCDFFSDVLGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAERMVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAW-------

4rgyA

0.25

0.18

0.73

3.14

PPAS

--------------------------------------------------------------------HMALFQCDFFSDVLGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAERMVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWL---L--

4rgyA

0.25

0.18

0.73

4.11

Env-PPAS

--------------------------------------------------------------------HMALFQCDFFSDVLGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAERMVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWLP--L--

1jjfA

0.21

0.16

0.79

2.09

MUSTER

-------------------------------------------------SLPTMPPSGYDQVRNGVPRGQVVNISYFS-TATNSTRPARVYLPPGYDKKYSVLYLLHGIGGSENDWFEGGANVIADNLIAEGIKPLIIVTPNTNAAGPGIADGYENFTKDLLNSLIPYIESNYSDREHRAIAGLSMGGGQSFNIGLTN-LDKFAYIGPISAAPNTYPNERLFP--DGGKAAREKL---------KLLFIACGTNDSLIGFGQRVHEYCVINHVYWLIQGGHDFNVWKPGLWNFLQMADEA--G

1jjfA

0.18

0.14

0.79

3.22

dPPAS

--------------------------------------------------SLPTMPPSGYDQVRNGVPRGQVVNISYFSTATNSTRPARVYLPPGYDKKYSVLYLLHGIGGSENDWFEGGANVIADNLIAEGIKPLIIVTPNTNAAGPGIADGYENFTKDLLNSLIPYIESNYSDREHRAIAGLSMGGGQSFNIGLTN-LDKFAYIGPISAAPNTYPNERLFPDGG-----------KAAREKLKLLFIACGTNDSLIGFGQRVHEYCVINHVYWLIQGGHDFNVWKPGLWNFLQMADEA--G

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.43

Estimated TM-score = 0.54±0.15

Estimated RMSD = 9.4±4.6Å

Download Model 2

C-score=-1.95

Download Model 3

C-score=-2.44

Download Model 4

C-score=-1.98

Download Model 5

C-score=-3.08

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cxuA	0.697	2.59	0.155	0.785
2	3ls2A	0.696	2.11	0.203	0.756
3	1jjfA	0.694	2.65	0.190	0.772
4	4rotA	0.692	2.48	0.188	0.762
5	4b6gA	0.691	2.19	0.192	0.756
6	1h2xA	0.686	4.18	0.114	0.878
7	3fcxB	0.685	2.17	0.183	0.749
8	3i6yA	0.684	2.22	0.203	0.749
9	1pv1A	0.684	2.39	0.202	0.759
10	4rgyA	0.681	1.96	0.239	0.733

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.27	9	1jt2A	FER	Rep, Mult	108,109,185,186,212,213,282
2	0.11	6	1wb4A	SXX	Rep, Mult	185,186,189,211,212,256,257,260
3	0.04	2	3hrhB	GOL	Rep, Mult	147,148,149,158,193,194,226,234
4	0.04	2	3hrhB	GOL	Rep, Mult	147,186,189,190,212,234
5	0.03	2	1u8eA	UUU	Rep, Mult	89,91,138,139,140
6	0.03	2	1f0pA	TRE	Rep, Mult	108,109,110,185,281,283,286
7	0.02	1	3i6yB	CL	Rep, Mult	109,185,186,220
8	0.02	1	3fcxA	CA	Rep, Mult	254,255,256,280,281
9	0.02	1	2bgrB	UUU	Rep, Mult	106,111,112,115
10	0.02	1	3c8dA	CIT	Rep, Mult	185,186,212,214
11	0.02	1	3mgaB	NA	Rep, Mult	92,129,133,134,136,137
12	0.02	1	4flmA	CU	Rep, Mult	59,172
13	0.02	1	3hrhB	GOL	Rep, Mult	84,85,86,87,141

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.341	3cn7A	0.524	2.88	0.197	0.604	3.1.1.1	109,185,255,281
2	0.337	1auoA	0.541	2.91	0.239	0.621	3.1.1.1	109,185,255,281
3	0.286	1i6wB	0.466	3.30	0.147	0.554	3.1.1.3	185,186,281
4	0.275	1jjfA	0.694	2.65	0.190	0.772	3.2.1.8	111,119,147,186
5	0.274	1dinA	0.538	2.98	0.136	0.627	3.1.1.45	255,281
6	0.242	1vkhA	0.592	3.15	0.099	0.696	3.5.1.9	166
7	0.217	2ocgA	0.571	3.09	0.183	0.667	3.1.-.-	106,185,187,191,255,281
8	0.208	2h1iA	0.506	3.44	0.140	0.611	3.1.1.1	111,185,211
9	0.067	1fj2A	0.550	3.06	0.191	0.640	3.1.4.39	109
10	0.067	3fakA	0.598	3.37	0.124	0.720	3.1.1.-	NA
11	0.066	1j1iA	0.550	3.50	0.180	0.660	3.7.1.8	185
12	0.060	1aknA	0.618	3.80	0.103	0.766	3.1.1.13,3.1.1.3	NA
13	0.060	2ecfA	0.661	3.62	0.159	0.802	3.4.14.5	185,255,281
14	0.060	1cleA	0.629	3.52	0.130	0.756	3.1.1.3	NA
15	0.060	1qo9A	0.629	3.51	0.120	0.756	3.1.1.7	NA
16	0.060	1f6wA	0.627	3.77	0.115	0.772	3.1.1.13,3.1.1.3	NA
17	0.060	2veoB	0.604	3.45	0.115	0.743	3.1.1.3	198
18	0.060	2ogsA	0.616	3.47	0.119	0.743	3.1.1.1	185
19	0.060	1thgA	0.621	3.56	0.093	0.756	3.1.1.3	NA
20	0.060	3fcxB	0.685	2.17	0.183	0.749	3.1.2.12	185
21	0.060	2fj0A	0.629	3.58	0.100	0.759	3.1.1.1	NA
22	0.060	1b41A	0.633	3.45	0.100	0.759	3.1.1.7	NA
23	0.060	1gz7C	0.627	3.53	0.129	0.756	3.1.1.3	NA
24	0.060	1k4yA	0.617	3.49	0.126	0.746	3.1.1.1	NA
25	0.060	2pm8A	0.627	3.47	0.097	0.756	3.1.1.8	NA
26	0.060	3c6bA	0.682	2.36	0.198	0.756	3.1.2.12	109,186,281,287
27	0.060	1c7jA	0.610	3.56	0.118	0.743	3.1.1.-	185
28	0.060	1mx9D	0.624	3.41	0.112	0.749	3.1.1.1	NA
29	0.060	1jjiA	0.605	3.65	0.118	0.743	3.1.1.1	255,281
30	0.060	3n2zB	0.605	3.34	0.121	0.723	3.4.16.2	273,281

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.673	2.59	0.19	0.75	1dqyA	GO:0004144 GO:0005576 GO:0005618 GO:0006869 GO:0009247 GO:0016740 GO:0016746 GO:0016747 GO:0046677 GO:0050348 GO:0071769
1	0.30	0.694	2.65	0.19	0.77	1jjfA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0031176 GO:0033905 GO:0045493
2	0.29	0.545	2.85	0.18	0.62	3u0vA	GO:0002084 GO:0004622 GO:0005737 GO:0005829 GO:0008474 GO:0016787 GO:0052689 GO:0070062
3	0.28	0.596	3.44	0.17	0.71	3visA	GO:0003847 GO:0015996 GO:0016042 GO:0046872 GO:0047746
4	0.27	0.524	2.88	0.20	0.60	3cn7A	GO:0002084 GO:0005737 GO:0008474 GO:0016787 GO:0052689
5	0.27	0.705	2.73	0.15	0.80	5cxxB	GO:0016787 GO:0030600
6	0.26	0.657	2.44	0.20	0.73	2uz0A
7	0.24	0.592	2.95	0.15	0.69	1ufoA	GO:0016020 GO:0016021
8	0.23	0.681	2.76	0.15	0.77	1gklA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0043263 GO:0045493
9	0.23	0.495	3.81	0.17	0.63	4h0cA	GO:0016787
10	0.23	0.596	3.36	0.18	0.70	4cg3A	GO:0003847 GO:0015996 GO:0016042 GO:0016787 GO:0047746 GO:0050525
11	0.22	0.691	2.19	0.19	0.76	4b6gA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
12	0.21	0.696	2.11	0.20	0.76	3ls2A	GO:0016787 GO:0018738 GO:0046294 GO:0052689
13	0.21	0.527	3.38	0.14	0.64	4ke6E	GO:0016787 GO:0047372 GO:0052689
14	0.21	0.536	2.97	0.14	0.63	3trdA	GO:0016787
15	0.21	0.593	3.23	0.18	0.70	4eb0A	GO:0003847 GO:0016042 GO:0016787 GO:0050525
16	0.20	0.595	2.88	0.12	0.69	3pf8A	GO:0016787
17	0.20	0.697	2.14	0.21	0.76	3i6yA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
18	0.20	0.653	3.15	0.15	0.76	3mgaA	GO:0005506 GO:0005737 GO:0006826 GO:0008849
19	0.19	0.670	2.34	0.18	0.75	1sfrA	GO:0004144 GO:0005576 GO:0005618 GO:0005737 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0044119 GO:0044121 GO:0050348
20	0.19	0.684	2.39	0.20	0.76	1pv1A	GO:0005737 GO:0005829 GO:0016787 GO:0018738 GO:0046294 GO:0052689
21	0.18	0.496	3.64	0.17	0.61	2r8bA	GO:0016787
22	0.17	0.584	3.43	0.19	0.70	4wfiA	GO:0003847 GO:0016042 GO:0046872
23	0.16	0.611	3.49	0.18	0.72	3dohA	GO:0002084 GO:0005737 GO:0008474 GO:0016787 GO:0052689
24	0.14	0.685	2.17	0.18	0.75	3fcxB	GO:0005737 GO:0005788 GO:0016023 GO:0016787 GO:0016788 GO:0018738 GO:0031410 GO:0046294 GO:0047374 GO:0052689 GO:0070062 GO:1901687
25	0.13	0.588	3.04	0.15	0.69	3hjuA	GO:0004622 GO:0005654 GO:0005737 GO:0005789 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0006954 GO:0009966 GO:0016020 GO:0016042 GO:0016787 GO:0019369 GO:0019433 GO:0019898 GO:0036155 GO:0042803 GO:0046464 GO:0047372 GO:0050727 GO:0051930 GO:0052689 GO:2000124
26	0.10	0.547	2.83	0.11	0.63	2i3dB	GO:0016787
27	0.10	0.694	2.15	0.21	0.76	3e4dA	GO:0016787 GO:0018738 GO:0046294 GO:0046872 GO:0052689
28	0.09	0.589	2.69	0.15	0.67	3f67A	GO:0016787
29	0.09	0.661	3.62	0.16	0.80	2ecfA	GO:0006508 GO:0008236
30	0.09	0.675	2.48	0.18	0.76	1f0nA	GO:0004144 GO:0005576 GO:0005618 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0040007 GO:0044119 GO:0046677 GO:0050348 GO:0052572
31	0.08	0.601	2.65	0.15	0.69	2wtmA
32	0.07	0.541	2.91	0.24	0.62	1auoA	GO:0016787 GO:0052689
33	0.07	0.570	3.54	0.13	0.69	1u2eA	GO:0003824 GO:0005737 GO:0016787 GO:0018771 GO:0019380 GO:0019439 GO:0019622 GO:0042803 GO:0052823
34	0.07	0.611	3.61	0.13	0.75	1qz3A	GO:0008152 GO:0016787
35	0.07	0.566	3.71	0.13	0.69	4i3fA	GO:0016787
36	0.07	0.564	3.59	0.13	0.70	3b12A	GO:0003824 GO:0016787 GO:0018785
37	0.07	0.537	3.20	0.16	0.64	4lheA	GO:0016787 GO:0047372 GO:0052689
38	0.07	0.548	3.10	0.17	0.64	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
39	0.07	0.521	3.11	0.18	0.61	1m33A	GO:0005737 GO:0009102 GO:0016787 GO:0052689 GO:0090499
40	0.07	0.592	3.72	0.09	0.73	4e15B	GO:0004061 GO:0006569 GO:0008152 GO:0016272 GO:0016787 GO:0019441
41	0.07	0.515	2.94	0.18	0.60	4nmwA	GO:0005737 GO:0009102 GO:0016787 GO:0052689
42	0.07	0.548	4.00	0.11	0.70	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
43	0.07	0.560	3.14	0.17	0.66	3p2mA	GO:0052689
44	0.07	0.585	3.17	0.13	0.69	4opmA	GO:0004806 GO:0016787
45	0.07	0.654	3.16	0.16	0.76	2b20A	GO:0005506 GO:0005737 GO:0006826 GO:0008849 GO:0016787
46	0.07	0.546	3.23	0.18	0.64	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
47	0.07	0.547	3.05	0.18	0.64	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
48	0.07	0.554	2.90	0.17	0.64	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
49	0.07	0.557	3.31	0.15	0.66	4dgqA	GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
50	0.07	0.584	3.46	0.11	0.70	3wlaA	GO:0016787 GO:0042597 GO:0047699
51	0.07	0.635	3.32	0.09	0.77	4eziA	GO:0004806 GO:0016042
52	0.07	0.576	3.03	0.14	0.67	4ufoA	GO:0003824 GO:0016787
53	0.07	0.498	4.10	0.09	0.64	1ex9A	GO:0004806 GO:0005576 GO:0005615 GO:0006629 GO:0009986 GO:0016042 GO:0016298 GO:0016787 GO:0046872
54	0.07	0.497	2.91	0.10	0.57	5f2hB	GO:0016787
55	0.06	0.420	5.11	0.10	0.60	1tglA	GO:0004806 GO:0006629 GO:0016042 GO:0016787 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0004620	GO:0043169	GO:0008474	GO:0052689	GO:0004144	GO:0050348	GO:0033905	GO:0030246	GO:0031176
GO-Score	0.58	0.56	0.48	0.48	0.34	0.34	0.30	0.30	0.30
Biological Processes	GO:0046149	GO:0044712	GO:0006787	GO:0015994	GO:0002084	GO:0009247	GO:0046677	GO:0006869	GO:0071769	GO:0045493
GO-Score	0.56	0.56	0.56	0.56	0.48	0.34	0.34	0.34	0.34	0.30
Cellular Component	GO:0044444	GO:0031988	GO:1903561	GO:0005618
GO-Score	0.58	0.58	0.58	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.