I-TASSER results

I-TASSER results for job id Rv0754

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (584 residues)
MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAR
EYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGP
IHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAG
YTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALL
FGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHGQTPGNAAML
IDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLANLLGMAPQVL
PGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGA
VQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVV
QGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINA
VRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLPIGLPSLIP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLPIGLPSLIP
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHCCCEEEHCCCCEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
Conf.Score	96676447999999999999989999887666666554456667646899999999999999999999999999999999986888754554444556665566777656777776666656777776655456667777775678776888878888888888888887655578888888888888877788888887778888877777877788888877778888888887555677777777777887777667776545677777888888876589999987899775546766899998999899999999999999859976999877699999999999998998589588656647455699855788888789999988688777888999888878999999999999999986567765678878999985768999999996989998888866888857999998589987999978855787777765444566766555456788999987689999999999999999999987667899999998678766776667787789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLPIGLPSLIP
Prediction	31100000110100031033021002101000000000001022210000000000100320210021001013102311110020012321111220233243342323313222111211212331234313420120010002100000000123422443340110000000111013233333213213223223342322212013232232421222222232233333422332341224444444443323323221131221223324322100000000000211120101032331302530140033005202753200000001030012001100642704042231010000020132432430353124003102333242313202123241320240024003201640264313235120000000000000000002031032200221100000000012336310001103342144431233102202200300320012002104434143004003400230020014013300330041013121210112234227
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHCCCEEEHCCCCEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLPIGLPSLIP

1vw1A

0.11

0.10

0.99

0.93

MUSTER

YREARNSVYYLDTRRPDLKSM--ALSQQNMDIELSTLSLSLENYTKVMEMLSTFRPSGATPYHDAYENVREVIQLQDPGLEQLNASPAIAGLMHQASLLGINASISPELFNILTEEITEGNAEELYKKNFGNIEPASLAMPEYLKRYYLSDEELSQFIGKASNFGQQEYSNNQLITPVVNSSDGTVKVYRITREYTTNAYQMDVELFPFGGENYRLDYKFKNFYNASYLSIKLNDKRELVRTEGAPQVNIEYSANITLNTADISQPFEIGLTRVLPSGSWAYAAAKFTVEEYNQYSFLLKLNKAIRLSRATELSPTILEGIVRSVNLQLDINT----DVLGKVFLTKYYMQRYAIHAETALILCNAPISQRSYDNQPSQFDRLFNTPLLYFSTGDEEIDLNSGSTGDWRKTILKRAFDVSLFRLLKITDHDNKDGKKNNLKNL--SNLYIGKLLADIQLTIDEDLLLIAVGEGKTNLSITSWLHTQKWSLFIMTSTSYNKTLTPKNLLDTVYHGLADLLHVMAPYIAATLQLSSENVAHSVLLWADKLQPGDGAMTAEKFWDWLNTKYTPGSSEAVETQEHIVQ

4pz9A

0.19

0.07

0.35

1.17

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RARRLVMLRHGQTDYNVGSRMQGQL-DTELSELGRTQAVAAAEVLGKR-QPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLT-HAQIDADAPGARLAWREDAT---WAPHGGES--RVDVAARSRPLVAELVASEPEWGGADEPDR-PVVLVAHGGLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWGSDWRLDVWNAS----------------------------------------------------------------------------------------

4pz9A

0.20

0.07

0.35

2.30

wdPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RARRLVMLRHGQTDYNVGSRMQGQL-DTELSELGRTQAVAAAEVLGKR-QPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDAD--PGARLAWREDAT---WAPHGGES--RVDVAARSRPLVAELVASEPEGGADEPDRPVVLVAHGGLIAALSAALLKL--PVANWPALGGMGNASWTQLSGHWGSDWRLDVWNAS----------------------------------------------------------------------------------------

4ij5A

0.16

0.06

0.36

1.15

wMUSTER

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKLILVRHAESEWNPVGRYQGLL-DPDLSERGKKQAKLLAQELSR-EHLDVIYSSPLKRTYLTALEIAEAKNLEVIKEDRIIEIDHGMWSGML-VEEVMEKYPEDFRRWVEEPHKVEF--QGGES--LASVYNRVKGFLEEVRKRHWNQ-------TVVVVSHTVPMRAMYCALLGV---DLSKFWSFGCDNASYSVIHME-ERRNVILKLNITCHLGEFYVEAH----KAI----------------------------------------------------------------------

4pz9A

0.20

0.07

0.35

2.36

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RARRLVMLRHGQTDYNVGSRMQGQL-DTELSELGRTQAVAAAEVLGKR-QPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLT-HAQIDADAPGARLAWREDAT---WAPHGGES--RVDVAARSRPLVAELVASEPEGGADEPDRPVVLVAHGGLIAALSAALLKL--PVANWPALGGMGNASWTQLSGHWGSDWRLDVWNAS----------------------------------------------------------------------------------------

4pz9A

0.19

0.07

0.35

1.96

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RARRLVMLRHGQTDYNVGSRMQGQL-DTELSELGRTQAVAAAEVLGKR-QPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLT-HAQIDADAPGARLAWREDAT---WAPHGGES--RVDVAARSRPLVAELVASEPEWGGADEPDR-PVVLVAHGGLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWGSDWRLDVWNAS----------------------------------------------------------------------------------------

4pz9A

0.20

0.07

0.35

1.86

PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RARRLVMLRHGQTDYNVGSRMQGQL-DTELSELGRTQAVAAAEVLGKR-QPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLT-HAQIDADAPGARLAWREDATWAP---HGGES--RVDVAARSRPLVAELVASEPEWGGADEPDR-PVVLVAHGGLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWGSDWRLDVWNAS----------------------------------------------------------------------------------------

4ij5A

0.16

0.06

0.35

3.42

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVKLILVRHAESEWNPVGRYQGLL-DPDLSERGKKQAKLLAQELSRE-HLDVIYSSPLKRTYLTALEIAEAKNLEVIKEDRIIEIDHGMWSGML-VEEVMEKYPEDFRRWVEEPHKVEF--QGGES--LASVYNRVKGFLEEVRKRHWNQ---------TVVVVSHTVPMRAMYCALLGV-DLSKFWSFGCDNASYSVIHME-ERRNVILKLNITCFYVEAHKAI------------------------------------------------------------------------------

4ij5A

0.16

0.06

0.36

0.86

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVKLILVRHAESEWNPVGRYQGLL-DPDLSERGKKQAKLLAQELSR-EHLDVIYSSPLKRTYLTALEIAEAKNLEVIKEDRIIEIDHGMWSGML-VEEVMEKYPEDFRRWVEEPHKVEF--QGGES--LASVYNRVKGFLEEVRKRHWNQ---------TVVVVSHTVPMRAMYCALLGV-DLSKFWSFGCDNASYSVIHME-ERRNVILKLNITCLGEFYVEAHKAI---------------------------------------------------------------------------

4ij5A

0.16

0.06

0.35

1.10

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVKLILVRHAESEWNPVGRYQGLL-DPDLSERGKKQAKLLAQELSR-EHLDVIYSSPLKRTYLTALEIAEAKNLEVIKEDRIIEIDHGMWSGML-VEEVMEKYPEDFRRWVEEPHKVE--FQGGES--LASVYNRVKGFLEEVRKRHWNQ---------TVVVVSHTVPMRAMYCALLGV-DLSKFWSFGCDNASYSVIHME-ERRNVILKLNITCFYVEAHKAI------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 3 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.42

Estimated TM-score = 0.77±0.10

Estimated RMSD = 6.7±4.0Å

Download Model 2

C-score=-3.05

Download Model 3

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1vw1A	0.917	2.46	0.095	0.969
2	3ecqB	0.393	7.79	0.059	0.645
3	2zxqA	0.380	8.01	0.069	0.640
4	3cmuA	0.365	7.49	0.046	0.574
5	5cskA	0.358	7.87	0.042	0.591
6	3jb9A	0.358	7.70	0.039	0.577
7	3javA	0.357	7.93	0.051	0.593
8	5a22A	0.352	8.39	0.041	0.613
9	5d06A	0.351	7.61	0.030	0.565
10	5t8vA	0.348	7.48	0.031	0.553

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.19	9	3my9A	MG	Rep, Mult	322,325
2	0.11	5	1h9sB	MOO	Rep, Mult	293,296
3	0.07	3	4jcbT	BCL	Rep, Mult	300,304
4	0.04	2	3cc9C	GRG	Rep, Mult	296,299
5	0.02	1	3nwyA	GTP	Rep, Mult	340,341
6	0.02	1	2muwB	3LW	Rep, Mult	298,301
7	0.02	1	4r6cA	6BP	Rep, Mult	343,346,347
8	0.02	1	3db1A	PO4	Rep, Mult	289,290,293,365,446

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3btaA	0.307	7.80	0.038	0.500	3.4.24.69	NA
2	0.060	1z0hB	0.214	6.55	0.032	0.310	3.4.24.69	NA
3	0.060	1kc7A	0.338	7.94	0.070	0.553	2.7.9.1	361
4	0.060	3gtgB	0.307	7.99	0.026	0.503	2.7.7.6	343,444
5	0.060	1b0pA	0.315	8.07	0.054	0.529	1.2.7.1	NA
6	0.060	3h0gA	0.309	7.68	0.028	0.495	2.7.7.6	NA
7	0.060	1bglA	0.307	8.28	0.053	0.522	3.2.1.23	365
8	0.060	2uv8G	0.313	7.64	0.033	0.505	2.3.1.86	NA
9	0.060	2pffD	0.304	7.88	0.028	0.498	2.3.1.86	NA
10	0.060	1ob2A	0.208	7.23	0.027	0.324	3.6.1.48	NA
11	0.060	2vumB	0.252	8.23	0.037	0.428	2.7.7.6	155,176,309
12	0.060	3eqlM	0.298	8.34	0.047	0.514	2.7.7.6	192
13	0.060	3gm8A	0.308	7.68	0.028	0.497	3.2.1.-	NA
14	0.060	1hn0A	0.317	8.00	0.034	0.527	4.2.2.20	NA
15	0.060	3iayA	0.309	8.12	0.040	0.524	2.7.7.7	NA
16	0.060	2pffB	0.328	8.13	0.046	0.550	2.3.1.86	369
17	0.060	2vuaA	0.205	6.66	0.034	0.301	3.4.24.69	301,325
18	0.060	2j5wA	0.314	8.06	0.034	0.520	1.16.3.1	NA
19	0.060	1ahpA	0.320	7.61	0.049	0.515	2.4.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.288	8.04	0.05	0.48	3cfoA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
1	0.06	0.382	7.53	0.06	0.61	3ecqB	GO:0005576 GO:0005618 GO:0008152 GO:0009405 GO:0016020 GO:0016787 GO:0016798 GO:0033926 GO:0046872 GO:0050110
2	0.06	0.278	8.15	0.06	0.47	5d0uA	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0008026 GO:0016787
3	0.06	0.380	8.01	0.07	0.64	2zxqA	GO:0008152 GO:0016020 GO:0016021 GO:0016787 GO:0016798 GO:0033926 GO:0046872 GO:0050110
4	0.06	0.280	8.00	0.02	0.47	3wsyA	GO:0000042 GO:0001540 GO:0004888 GO:0005576 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005802 GO:0005887 GO:0006605 GO:0006622 GO:0006629 GO:0006810 GO:0006869 GO:0006892 GO:0006897 GO:0006898 GO:0007165 GO:0008202 GO:0008203 GO:0014910 GO:0016020 GO:0016021 GO:0030169 GO:0030306 GO:0031985 GO:0032091 GO:0032460 GO:0034362 GO:0043407 GO:0045053 GO:0045732 GO:0050768 GO:0051604 GO:0055037 GO:0070062 GO:0070863 GO:1901215 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:2001137
5	0.06	0.256	7.60	0.03	0.41	4lxfA	GO:0003824 GO:0005975 GO:0046872
6	0.06	0.260	7.79	0.02	0.42	3zo9B	GO:0000023 GO:0000272 GO:0003824 GO:0004556 GO:0005509 GO:0005975 GO:0005977 GO:0005978 GO:0005991 GO:0008152 GO:0016787 GO:0016798 GO:0016853 GO:0046872 GO:0047471
7	0.06	0.228	7.51	0.03	0.36	2y51A	GO:0000166 GO:0008152 GO:0016491 GO:0016620 GO:0055114
8	0.06	0.238	7.72	0.04	0.39	3wy1A	GO:0000023 GO:0003824 GO:0004558 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0032450 GO:0046872
9	0.06	0.245	7.10	0.04	0.37	5brpA	GO:0003824 GO:0005737 GO:0005975 GO:0005993 GO:0008788 GO:0016787
10	0.06	0.226	7.36	0.03	0.35	1m53A	GO:0003824 GO:0005975
11	0.06	0.245	7.85	0.04	0.40	1m1cA	GO:0019012 GO:0019028
12	0.06	0.255	7.70	0.04	0.41	4lxfB	GO:0003824 GO:0005975 GO:0046872
13	0.06	0.224	7.84	0.04	0.36	4aieA	GO:0003824 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0043896 GO:0046872
14	0.06	0.202	6.29	0.05	0.29	3ftbA	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
15	0.06	0.217	7.16	0.04	0.34	1kywC	GO:0008168 GO:0008171 GO:0009699 GO:0009809 GO:0016740 GO:0032259 GO:0046983 GO:0047763
16	0.06	0.203	6.27	0.04	0.29	3hf2A	GO:0003824 GO:0003958 GO:0004497 GO:0005506 GO:0005737 GO:0008152 GO:0010181 GO:0016491 GO:0016705 GO:0016712 GO:0020037 GO:0042802 GO:0046872 GO:0055114 GO:0070330
17	0.06	0.193	6.81	0.03	0.29	4ijpB	GO:0000166 GO:0000398 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005654 GO:0005681 GO:0005694 GO:0006397 GO:0006468 GO:0008380 GO:0016301 GO:0016310 GO:0016740 GO:0044822 GO:0071013
18	0.06	0.190	6.63	0.06	0.28	4ojjC	GO:0000290 GO:0000776 GO:0000932 GO:0001731 GO:0003682 GO:0003723 GO:0003729 GO:0005634 GO:0005737 GO:0006397 GO:0006417 GO:0006446 GO:0007049 GO:0007059 GO:0010494 GO:0022627 GO:0033962 GO:0045947 GO:0051301 GO:0061641 GO:1990726

Consensus prediction of GO terms

Molecular Function	GO:0003824
GO-Score	0.32
Biological Processes	GO:0070863	GO:1901215	GO:1902960	GO:0039693	GO:1902953	GO:0045053	GO:0006892	GO:0008203	GO:0045732	GO:0006622	GO:0050768	GO:0006869	GO:0043407	GO:2001137	GO:0051604	GO:1902771	GO:1902955	GO:0006898	GO:0071897	GO:0032460	GO:0090305	GO:1902997	GO:0032091	GO:0000042	GO:0009405	GO:1902948	GO:1902430	GO:1902966	GO:1902963	GO:0014910
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0005802	GO:0055037	GO:0005887	GO:0034362	GO:0005618	GO:0005769	GO:0005783	GO:0005641	GO:0070062	GO:0031985
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.