I-TASSER results

I-TASSER results for job id Rv0725c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (301 residues)
MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEPLVRAVGLDFFTKLIDG
ELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVRQVVILAAGLDARAYRLPW
PAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDLRADWPAALQAAGLDSTAPTA
WLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSRALWISTQAGYEKWRIRFASTAW
TSTWRRWCIPANAATSSTTCAPRAGTLRAQCGPTYSGAMVCPFPPHTTTIRSAKSSSSAV
V

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEPLVRAVGLDFFTKLIDGELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVRQVVILAAGLDARAYRLPWPAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDLRADWPAALQAAGLDSTAPTAWLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSRALWISTQAGYEKWRIRFASTAWTSTWRRWCIPANAATSSTTCAPRAGTLRAQCGPTYSGAMVCPFPPHTTTIRSAKSSSSAVV
Prediction	CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCHHHHHHHHHCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHCCCCEEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEHCCCHHHHHHCCCCCCCCCCCCCCCCCCHCCC
Conf.Score	9988899766566689999999999999995999988996999999886657788776566665455555455566688999999999999999999989978999768876567766889996799956878999999999987998876479986666777999999989999998899995665589999999999978997899998656545555666778888898887656876546664678775689999998797899866857888878888988875556776543359
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEPLVRAVGLDFFTKLIDGELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVRQVVILAAGLDARAYRLPWPAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDLRADWPAALQAAGLDSTAPTAWLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSRALWISTQAGYEKWRIRFASTAWTSTWRRWCIPANAATSSTTCAPRAGTLRAQCGPTYSGAMVCPFPPHTTTIRSAKSSSSAVV
Prediction	7644573414246210200010000001115475210414003300441224103412445153443553444223211100000010003003300752031000000000000110643760200001224015203510572524133321100010243025204636245621000000000100456004302410340200011222323432444445225414431273413331331124342640351027220301142335122320111144144245344222016
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCHHHHHHHHHCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHCCCCEEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEHCCCHHHHHHCCCCCCCCCCCCCCCCCCHCCC
MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEPLVRAVGLDFFTKLIDGELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVRQVVILAAGLDARAYRLPWPAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDLRADWPAALQAAGLDSTAPTAWLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSRALWISTQAGYEKWRIRFASTAWTSTWRRWCIPANAATSSTTCAPRAGTLRAQCGPTYSGAMVCPFPPHTTTIRSAKSSSSAVV

2ckdA

0.37

0.36

0.97

2.53

MUSTER

--------WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETS-PLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRW-GDGVPMADDKDAFAEFVT

2ckdA

0.37

0.36

0.97

3.15

dPPAS

--------WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETS-PLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGR-WGDGVPMADDKDAFAEFVT

2ckdA

0.37

0.36

0.97

4.31

wdPPAS

--------WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETS-PLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVPMADDAFAEFVTAHL

2ckdA

0.37

0.36

0.96

3.00

wMUSTER

---------DIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETS-PLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRW-GDGVPMADDKDAFAEFVT

2ckdA

0.37

0.36

0.97

5.07

wPPAS

--------WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPSKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETS-PLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVPMADDKFAEFVTAHL

2ckdA

0.37

0.36

0.97

9.19

dPPAS2

--------WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETS-PLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGR-WGDGVPMADDKDAFAEFVT

2ckdA

0.37

0.36

0.97

4.10

PPAS

--------WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPSKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETS-PLHGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDG-VPMADDKDAFAEFVT

2ckdA

0.37

0.36

0.97

6.05

Env-PPAS

--------WDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMLDPAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQDGLFTEIVGSRIAVETSPL-HGDEWREQMQLRFRRVSDALGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDG-VPMADDKDAFAEFVT

1rjeC

0.12

0.11

0.92

1.28

MUSTER

-----------ERIIQQTDYDALSCKLAAISV--GYLPSSGLQRLSVDLSHRSYLITLKKFSAFGKVDKAMRSSFPVMNYGTYLRTVGIDAAILEFLVANEKQVVNLGCGSDLRMLPLQMFPHLAYVDIDYNESVELKNSILRESEIGLSKRYKLAACDLNDTETTRLLDVCTKREIPTIVISECLLCYMHNNESQLLINTIHGLWISYDPIGGS--QPNDRFGAIMQSNLKESRN-----LEMPTLMTYNSKEKYASRWS--AANVIVNDMWEIFNAQ---IPESERSLQFLDELEELKV

1rjeC

0.11

0.94

1.39

dPPAS

-----------ERIIQQTDYDALSCKLAAISVPSSRLSVDLSKKYTEWHRSYLITLKKFSRRAFGKVDKAMRSSFPVMNYGTYLRTVGIDAAILEFLVANEKQVVNLGCGSDLRMLPLQMFPHLAYVDIDYNESVELKNSILRESEILRIGRYKLAACDLNDTETTRLLDVCTKREIPTIVISECLLCYMHNNESQLLINTISHGLWISYDPIGGSQPNDRFGAIMQSNLKESRNLEMPT------LMTYNSKEKYASRWSAAPNVIVNDMWEIFNAQIPESERKRLRSLQFLDELEELKV

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.00

Estimated TM-score = 0.85±0.08

Estimated RMSD = 4.1±2.8Å

Download Model 2

C-score=-1.63

Download Model 3

C-score=-2.71

Download Model 4

C-score=-2.97

Download Model 5

C-score=-4.45

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ckdA	0.950	0.87	0.368	0.967
2	1rjeC	0.729	3.19	0.115	0.864
3	2zwaB	0.712	3.59	0.106	0.870
4	3mntA	0.650	3.05	0.160	0.748
5	2qe6A	0.598	4.33	0.128	0.777
6	3giwA	0.597	4.09	0.117	0.764
7	2vdwA	0.583	4.30	0.075	0.761
8	5hyzA	0.574	4.29	0.083	0.761
9	4ckbA	0.569	4.28	0.072	0.738
10	3ocjA	0.560	4.43	0.106	0.738

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.45	18	2zw9A	SAM	Rep, Mult	15,18,19,22,26,85,108,109,110,130,131,134,158,159,160,184,185,186,189,190
2	0.14	3	1d2hD	SAH	Rep, Mult	130,131,134,159,160,185,186,189

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	2cl5A	0.492	4.23	0.097	0.621	2.1.1.6	NA
2	0.066	3e05B	0.451	3.79	0.063	0.558	2.1.1.132	NA
3	0.066	3c3yA	0.495	4.05	0.067	0.628	2.1.1.104	NA
4	0.066	2ex4A	0.495	3.96	0.075	0.631	2.1.1.-	NA
5	0.066	3hnrA	0.462	3.70	0.091	0.581	2.1.1.-	NA
6	0.060	1bxsA	0.489	5.52	0.057	0.734	1.2.1.36	NA
7	0.060	2avdA	0.486	4.15	0.077	0.628	2.1.1.-	NA
8	0.060	3bwmA	0.494	4.31	0.092	0.625	2.1.1.6	NA
9	0.060	3fg0C	0.492	5.69	0.064	0.748	1.2.1.8	NA
10	0.060	3k2wB	0.488	5.49	0.050	0.724	1.2.1.8	NA
11	0.060	1suiA	0.495	4.17	0.052	0.635	2.1.1.104	NA
12	0.060	3bt7A	0.491	4.36	0.077	0.644	2.1.1.35	204
13	0.060	2opbB	0.534	4.14	0.081	0.691	2.1.1.28	110,130,158
14	0.060	3cbgA	0.490	3.95	0.063	0.618	2.1.1.-	NA
15	0.060	2iipA	0.531	3.90	0.089	0.664	2.1.1.1	110,159
16	0.060	1ej6A	0.532	4.79	0.064	0.728	2.7.7.50	110
17	0.060	1kphC	0.522	4.50	0.056	0.701	2.1.1.79	15,17
18	0.060	2a14A	0.538	3.98	0.088	0.681	2.1.1.49	110
19	0.060	1tpyA	0.523	4.58	0.097	0.698	2.1.1.79	NA
20	0.060	1susD	0.494	4.13	0.042	0.631	2.1.1.104	NA
21	0.060	1ri1A	0.523	3.77	0.071	0.658	2.1.1.56	130
22	0.060	1wznA	0.502	4.11	0.091	0.638	2.1.1.-	NA
23	0.060	3bt7B	0.491	4.37	0.077	0.644	2.1.1.35	49
24	0.060	1o9jA	0.486	5.50	0.068	0.731	1.2.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.63	0.950	0.87	0.37	0.97	2ckdA	GO:0008168 GO:0016740 GO:0032259
1	0.56	0.860	1.12	0.39	0.88	2uyoA	GO:0008168 GO:0016740 GO:0032259
2	0.31	0.716	3.09	0.16	0.83	3p71T	GO:0003880 GO:0005829 GO:0006464 GO:0006479 GO:0006481 GO:0008168 GO:0008276 GO:0008757 GO:0010906 GO:0016740 GO:0018423 GO:0031333 GO:0032259 GO:0042981 GO:0090266
3	0.30	0.731	3.14	0.12	0.86	1rjdC	GO:0005829 GO:0006481 GO:0008168 GO:0010506 GO:0016740 GO:0018423 GO:0032259 GO:0043623
4	0.28	0.712	3.59	0.11	0.87	2zwaB	GO:0005737 GO:0005739 GO:0005829 GO:0006400 GO:0008033 GO:0008168 GO:0008175 GO:0008757 GO:0016740 GO:0030488 GO:0031591 GO:0032259
5	0.28	0.650	3.09	0.16	0.75	3o7wA	GO:0003880 GO:0005829 GO:0006464 GO:0006479 GO:0006481 GO:0008168 GO:0008276 GO:0008757 GO:0010906 GO:0016740 GO:0018423 GO:0031333 GO:0032259 GO:0042981 GO:0090266
6	0.26	0.665	2.80	0.13	0.76	1rjgA	GO:0005829 GO:0006481 GO:0008168 GO:0010506 GO:0016740 GO:0018423 GO:0032259 GO:0043623
7	0.07	0.509	4.26	0.07	0.66	3ggdA
8	0.06	0.349	5.64	0.07	0.53	3ingA	GO:0000166 GO:0004412 GO:0006520 GO:0016491 GO:0050661 GO:0055114
9	0.06	0.302	6.15	0.05	0.49	2zi8A	GO:0003824 GO:0005506 GO:0006629 GO:0006707 GO:0006725 GO:0008198 GO:0008202 GO:0008203 GO:0009405 GO:0016042 GO:0016491 GO:0019439 GO:0046872 GO:0047071 GO:0051213 GO:0055114 GO:0070723
10	0.06	0.304	6.62	0.02	0.54	2vpjA	GO:0000139 GO:0004842 GO:0005815 GO:0005829 GO:0006513 GO:0006810 GO:0006888 GO:0016055 GO:0016192 GO:0016567 GO:0030134 GO:0031410 GO:0031463 GO:0043231 GO:0048208 GO:0090090
11	0.06	0.306	6.68	0.02	0.54	2wozA	GO:0001726 GO:0004842 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0005856 GO:0005886 GO:0016020 GO:0016529 GO:0016567 GO:0030239 GO:0031143 GO:0031275 GO:0031430 GO:0031463 GO:0033017 GO:0035914 GO:0042995 GO:0045214 GO:0045661 GO:0048741 GO:2000291 GO:2001014
12	0.06	0.450	4.59	0.06	0.61	4dcmA	GO:0003676 GO:0005737 GO:0006364 GO:0008168 GO:0008990 GO:0016740 GO:0031167 GO:0032259 GO:0052916 GO:0070475
13	0.06	0.307	6.76	0.04	0.55	4ascA	GO:0004842 GO:0005737 GO:0007275 GO:0016567 GO:0031397 GO:0031463 GO:0031672 GO:0031674 GO:0032435 GO:0048741
14	0.06	0.286	5.11	0.02	0.41	2yc3A	GO:0003824 GO:0008299 GO:0009507 GO:0009536 GO:0009570 GO:0016740 GO:0016779 GO:0019288 GO:0050518
15	0.06	0.241	6.21	0.04	0.40	4f4wA	GO:0000287 GO:0003677 GO:0003684 GO:0003887 GO:0005737 GO:0006260 GO:0006261 GO:0006281 GO:0006974 GO:0016740 GO:0016779 GO:0046872 GO:0071897
16	0.06	0.300	5.39	0.06	0.46	1j1zA	GO:0000166 GO:0004055 GO:0005524 GO:0005737 GO:0006526 GO:0008652 GO:0016874
17	0.06	0.252	6.45	0.04	0.43	3fdsA	GO:0000287 GO:0003677 GO:0003684 GO:0003887 GO:0005737 GO:0006260 GO:0006261 GO:0006281 GO:0006974 GO:0016740 GO:0016779 GO:0046872 GO:0071897
18	0.06	0.200	7.56	0.03	0.40	3e1yC	GO:0000184 GO:0003723 GO:0003747 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0006449 GO:0006479 GO:0008079 GO:0016149 GO:0043022 GO:0044822

Consensus prediction of GO terms

Molecular Function	GO:0008173	GO:0018423
GO-Score	0.56	0.52
Biological Processes	GO:0006914	GO:0034622	GO:1901659	GO:1901566	GO:0008033	GO:0001510	GO:0031590	GO:0006481	GO:0042981	GO:0090266	GO:0010906	GO:0031333
GO-Score	0.60	0.60	0.56	0.56	0.56	0.56	0.56	0.52	0.31	0.31	0.31	0.31
Cellular Component	GO:0005829	GO:0043231
GO-Score	0.65	0.56

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.