I-TASSER results

I-TASSER results for job id Rv0690c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (349 residues)
MTGTEHLVHTLRSQGRVCTSSGSPMYRELLELVAADVESGGVFASILADQKGAPEGQAVP
LRLLGGLHRMVLDGRAPVLRRWYPSTGGTWQAEAAWPDIVRTATDQPESLRAALDRPPQT
NEVGRSAALIGGLLIACLQFDLPIRLFEIGSSAGLNLRPDRYRYRYLGGEWGLADSPVRI
DNAWLGELPPTATVRIVERHGYDIAPIDVTSPDGELNALSYIWPDQTDRLERLRGAIAVA
RNIPADLHRQAAHAAVAGMTLTDDALTVLWHSITWQYLPADERAAIRAGIDALAAQADAH
CPFVHLTLEPAHQRPGAQIKYLVRMRSWPGGHARVLGECHPHGPPVTWQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGTEHLVHTLRSQGRVCTSSGSPMYRELLELVAADVESGGVFASILADQKGAPEGQAVPLRLLGGLHRMVLDGRAPVLRRWYPSTGGTWQAEAAWPDIVRTATDQPESLRAALDRPPQTNEVGRSAALIGGLLIACLQFDLPIRLFEIGSSAGLNLRPDRYRYRYLGGEWGLADSPVRIDNAWLGELPPTATVRIVERHGYDIAPIDVTSPDGELNALSYIWPDQTDRLERLRGAIAVARNIPADLHRQAAHAAVAGMTLTDDALTVLWHSITWQYLPADERAAIRAGIDALAAQADAHCPFVHLTLEPAHQRPGAQIKYLVRMRSWPGGHARVLGECHPHGPPVTWQ
Prediction	CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCEEEEEHCCCEHCCCCCCEEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHCCCHHHHHHHCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEHCCCCCCEEHC
Conf.Score	9879999999999999998679969999999998585545578999987678998876799999999999986999578887688899988657999999999999999999997899875788999999999999998799889998666767767875468997896557899985885666799999999745787678899899999999999998589998999999999999999879985446688999986789998577645788986999999999999999999788878656677658888887765578999985798658989977898755659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGTEHLVHTLRSQGRVCTSSGSPMYRELLELVAADVESGGVFASILADQKGAPEGQAVPLRLLGGLHRMVLDGRAPVLRRWYPSTGGTWQAEAAWPDIVRTATDQPESLRAALDRPPQTNEVGRSAALIGGLLIACLQFDLPIRLFEIGSSAGLNLRPDRYRYRYLGGEWGLADSPVRIDNAWLGELPPTATVRIVERHGYDIAPIDVTSPDGELNALSYIWPDQTDRLERLRGAIAVARNIPADLHRQAAHAAVAGMTLTDDALTVLWHSITWQYLPADERAAIRAGIDALAAQADAHCPFVHLTLEPAHQRPGAQIKYLVRMRSWPGGHARVLGECHPHGPPVTWQ
Prediction	7653540151035004302644010002003100523533420130033166244633200000000020035362440261034454545252004202400450252025006432111100000000000000044271100000000000000101200010443421345120302150525423634140020000112103163661221020001162650251043004104735141351201420461323770010000010010025721540251045104512141000000002444345231313020321454442200101211332518
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCEEEEEHCCCEHCCCCCCEEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHCCCHHHHHHHCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEHCCCCCCEEHC
MTGTEHLVHTLRSQGRVCTSSGSPMYRELLELVAADVESGGVFASILADQKGAPEGQAVPLRLLGGLHRMVLDGRAPVLRRWYPSTGGTWQAEAAWPDIVRTATDQPESLRAALDRPPQTNEVGRSAALIGGLLIACLQFDLPIRLFEIGSSAGLNLRPDRYRYRYLGGEWGLADSPVRIDNAWLGELPPTATVRIVERHGYDIAPIDVTSPDGELNALSYIWPDQTDRLERLRGAIAVARNIPADLHRQAAHAAVAGMTLTDDALTVLWHSITWQYLPADERAAIRAGIDALAAQADAHCPFVHLTLEPAHQRPGAQIKYLVRMRSWPGGHARVLGECHPHGPPVTWQ

3h3xR

0.10

0.96

0.66

MUSTER

KADPNKAAKLAASIAPARPGNSAKALKAVQDKLKAFVESGQLGIFTNAYFLGGHKAYPPEVDLIATAHYLEALHMQVKAASAMAILGGKNSNYQGLKDPLANYLALSKEVCQFVN-----ECYIPDLLAVAGFYKDWGGIGGTSNYLAFGEFATDDSSPEKHTSQFPSGVITGRDGAIYEDVKYSWYAPGGDGKHPYDGV-TDPKYTKLDDKDHYSWMKAPRYKGKAMEVGPLARTFIAYAKGQPDFKKV-VDMVLGKLSVPATALHSTLGRTAARGITAIVCANMEKWIKEMADSGAKDNTL-------CAKWEMPEESKGVGLADAPRGALSHWIRIK-GKKIDNFQ

5cwiA

0.10

0.06

0.65

0.63

dPPAS

KKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQE--HPNADIAKLCIKAASEAAEAASKAAELAQRHP-----DSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAA------------------------------------------------------------ELAQRHPDSQAARDAIKLA-----SQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER--------------------------------------------------

4a6dA

0.14

0.11

0.80

0.60

wdPPAS

MGSYRLLNDYANGFMVSQVLFAA-CELGVFDLLAEAPGPLD-VAAVAAGVRASAHGTELLLDICVSLKLLKVETRG-ELSSDYLTTVSPTSQCSMLKYMGRTSYRCWGHLADAVREGRNQRSEGERLQFMQALQEVWSVNGRSVLMCDLGGGAGALAK--ECMSLYPGCKI------TVFD------IPESFEEQIDFQEG-DFFKDPLPE-ADLYILARVLWAD-GKCSHLLERIYHTCKPG--GIL-------VIESLLDEDRLTQLYSLNMLVQTE--TPTHYHMLLSSAG--KKTGAIYDAILARKGT-------------------------------------

4m23A

0.11

0.09

0.85

0.65

wMUSTER

LTPASAVAELTLELAAAYGSFGDPVLLRDLPRLAARLP--EGVQDFLREFKLADRH--------GH---TVIRGDQRRIGP-TPDHWRGRVRPGPEFPEELLLMLYSALLGEPFGWATQQD-------LVHDIFPIRSHENDQLG---MGSKQLLTWHTEDAFHPYRSDYLI-----GALRNPDHV---------PTTVGELDLSSL---SAEDIDVLFEPRYHATEEEAARFATIQRMIDERPLPLLYGS-----------RLDPYMRLDPYFTSVPQDTDARRAYDALFKVVDSGMREDQVLFIDNHPFQARYDGTDRWLKRVCVTSDLRRSREMRATSATRLLG--

3lcrA

0.12

0.08

0.67

0.65

wPPAS

---SDYFGELFLQAMRTGELAQAQQLMAGAAQLRLKYGEAV--PEIVRLGRG---QLGPQLIL---VCPTVMTTGPSRLAEELDAPPGFHGGQALPATLTVLVRSLADVVQAEV--------------------------DGEFALAGH--SSGV-------AYEVA--ARGLAPRGVVLI----DSYSFDGDGG---------RPEELFRSALNERFVEYLGGNLSQRITAQVWCLELLRGWRPELVEQEKPEWRGDVLAAMGQVVEA-H---FTIIEGEHVASTAHIVGDWLREAHA--------------------------------------------------

2raeA

0.13

0.05

0.38

0.92

dPPAS2

WGDFDAHLAEMRAQLAAQPDDIPILTAALLQFNAFPASEEINHRKRMGLILRVPALQAYSVVMYEGWRNVIAE---YVASRL----GTSPTDHVPRTVGYLLLGVAMSAYEQWLDDDSLE----LNELLASGMQSLYDSLGEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.13

0.12

0.93

0.84

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQK-FHGT

1af7A

0.12

0.09

0.75

0.86

Env-PPAS

----------------------SVLLQ-MTQRLALSDAHFRRICQLIYQRAGIVLADHKRDMVYNRLVRRLRALGLDDFGRYLSMLEANQNSAEWQAFINALT----------------TNLTAREAHHFPILAEHARRRHGEYRVWSAAASTGIAITLADA--------LGMAPGRWKVFADID--------TEVLERSGI--YRLSELKTLSPQQLQRYFGTGPHEGLVRVRQELANY----VEFSSVNLLE---KQYNVPGPFDAIFCRNVMIYFDKTTQEDILRRFVPLLK------PDGLLFAGHSENFSNLVREFSLRGQ-----TVYALS------------

5l4kN

0.10

0.09

0.96

0.64

MUSTER

MQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPTLKMIKGEMAIELHLQFLIRNNNMILKNTKDAVRNSVCHTATVIANSFMHCGQFLRDNLEWLKFTATASLGVIHK-----------GHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHAHGGDIIDYLLNQL--NASNDIVRHGGSLGLGLAAMGTARQ-DVYDLLKTNLYQDDAVTGEAAGLALGLVLGSKNAQAIEDMVGYAQETQHEKILRGLAVMYGRMEEADALIESLCILRRSGMYTVAMAYCGS-GNNKAIR

5gaoE

0.13

0.12

0.93

0.62

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAFHGTKSNKK---------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.59

Estimated TM-score = 0.24±0.07

Estimated RMSD = 18.3±2.3Å

Download Model 2

C-score=-4.60

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4a6dA	0.613	4.50	0.096	0.817
2	5iccA	0.586	4.83	0.083	0.814
3	5cvuB	0.585	4.91	0.113	0.822
4	4e70A	0.583	5.08	0.093	0.822
5	1kyzE	0.575	5.15	0.093	0.825
6	3gwzA	0.573	4.89	0.092	0.794
7	1tw2B	0.556	5.31	0.101	0.802
8	5f8cA	0.556	5.18	0.093	0.805
9	3i5uA	0.553	5.21	0.119	0.785
10	4d7kA	0.552	5.16	0.109	0.791

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.16	8	1zq9B	SAM	Rep, Mult	126,129,150,152,180,181,182,185,201,203,204,220,221,228
2	0.06	3	4xriA	SO4	Rep, Mult	120,121,122,125
3	0.04	2	3p9kA	CIY	Rep, Mult	102,103,133,220,223,224,276,277
4	0.04	2	1h2aL	F3S	Rep, Mult	116,119
5	0.02	1	3urqA	IMD	Rep, Mult	160,189,190
6	0.02	1	4asoB	NUC	Rep, Mult	121,199
7	0.02	1	4dcaA	MG	Rep, Mult	156,175
8	0.02	1	5dhfC	ZN	Rep, Mult	103,272,277
9	0.02	1	8iciA	MG	Rep, Mult	23,199
10	0.02	1	3vmmA	MG	Rep, Mult	122,148
11	0.02	1	2qjmA	CS2	Rep, Mult	221,223
12	0.02	1	1y10C	CA	Rep, Mult	201,203
13	0.02	1	2g9zA	MG	Rep, Mult	203,208
14	0.02	1	2g9zA	PO4	Rep, Mult	203,208,226

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	1tw2B	0.556	5.31	0.101	0.802	2.1.1.-	NA
2	0.066	1kyzE	0.575	5.15	0.093	0.825	2.1.1.68	NA
3	0.060	2o06A	0.430	4.98	0.078	0.596	2.5.1.16	150,201,220,230
4	0.060	2e5wA	0.430	5.14	0.093	0.599	2.5.1.16	150,201,220
5	0.060	3bq5A	0.435	6.42	0.064	0.708	2.1.1.14	NA
6	0.060	2aw5B	0.433	5.47	0.046	0.636	1.1.1.40	NA
7	0.060	2ip2A	0.551	5.13	0.092	0.794	2.1.1.-	NA
8	0.060	2dqmA	0.409	6.84	0.053	0.714	3.4.11.2	NA
9	0.060	2b3tA	0.404	5.11	0.067	0.565	2.1.1.-	NA
10	0.060	3drwA	0.412	5.89	0.061	0.622	2.7.1.146	NA
11	0.060	3lccA	0.402	4.26	0.065	0.524	2.1.1.-	150,185
12	0.060	2zuwC	0.406	6.31	0.064	0.653	2.4.1.211	125,127
13	0.060	3ebgA	0.410	6.78	0.028	0.705	3.4.11.-	NA
14	0.060	1ej6A	0.430	5.81	0.057	0.656	2.7.7.50	NA
15	0.060	3bwbA	0.432	5.02	0.083	0.602	2.5.1.16	149,181
16	0.060	1mjfA	0.426	5.00	0.117	0.587	2.5.1.16	NA
17	0.060	1fp1D	0.543	5.48	0.093	0.814	2.1.1.-	NA
18	0.060	1fp2A	0.553	5.41	0.080	0.814	2.1.1.150	NA
19	0.060	1iy9D	0.420	4.82	0.056	0.576	2.5.1.16	181
20	0.060	1kywC	0.558	5.33	0.117	0.820	2.1.1.68	NA
21	0.060	3i58A	0.554	5.26	0.115	0.791	2.1.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.16	0.564	5.08	0.11	0.80	3lstA	GO:0008168 GO:0008171 GO:0032259
1	0.16	0.553	5.20	0.10	0.79	4d7kF	GO:0008168 GO:0008171 GO:0016740 GO:0032259
2	0.14	0.511	6.03	0.08	0.80	2qyoA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
3	0.07	0.613	4.50	0.10	0.82	4a6dA	GO:0005829 GO:0006412 GO:0008168 GO:0008171 GO:0008172 GO:0008757 GO:0016740 GO:0017096 GO:0030187 GO:0032259 GO:0042802 GO:0042803 GO:0046219
4	0.07	0.586	4.83	0.08	0.81	5iccA	GO:0008168 GO:0008171 GO:0016740 GO:0030786 GO:0032259 GO:0046983
5	0.07	0.587	4.95	0.11	0.83	5cvjA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983 GO:0050630
6	0.07	0.576	4.93	0.09	0.80	3gwzA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:1901663
7	0.07	0.587	5.00	0.09	0.82	4eviA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
8	0.07	0.579	5.02	0.11	0.82	3p9iA	GO:0008168 GO:0008171 GO:0016206 GO:0016740 GO:0032259 GO:0046983
9	0.07	0.545	5.45	0.14	0.81	4pggA	GO:0005829 GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259 GO:0046872 GO:0046983 GO:0047763 GO:0051536 GO:0051539
10	0.07	0.543	5.48	0.09	0.81	1fp1D	GO:0008168 GO:0008171 GO:0016740 GO:0030751 GO:0032259 GO:0033802 GO:0046983
11	0.07	0.554	5.26	0.12	0.79	3i58A	GO:0008168 GO:0008171 GO:0016740 GO:0017000 GO:0032259
12	0.07	0.553	5.41	0.08	0.81	1fp2A	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0033800 GO:0046983
13	0.07	0.556	5.31	0.10	0.80	1tw2B	GO:0008168 GO:0008171 GO:0016740 GO:0017000 GO:0032259 GO:1901771
14	0.07	0.551	5.13	0.09	0.79	2ip2A	GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259
15	0.07	0.561	5.33	0.10	0.81	3mczA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
16	0.07	0.558	5.33	0.12	0.82	1kywC	GO:0008168 GO:0008171 GO:0009699 GO:0009809 GO:0016740 GO:0032259 GO:0046983 GO:0047763
17	0.07	0.550	5.37	0.07	0.81	2r3sA
18	0.07	0.540	5.43	0.10	0.81	4qvgC	GO:0008168 GO:0008171 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0008171	GO:0005515
GO-Score	0.47	0.39
Biological Processes	GO:0032259
GO-Score	0.47
Cellular Component	GO:0005829
GO-Score	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.