I-TASSER results

I-TASSER results for job id Rv0686

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (265 residues)
MLARYIKMQLLVLLCGGLVGPIFLVVYFTLGLGSLMSWMFYVGLIITVADVLVALALTNY
GAKTAAKTAALERSGVLALAQITGLSETGTRINDQPLVKVHLHISGPGITPFDTEDRVIA
SVTRLGNLTARKLVVLVNPATQQYLIDWERSALVNGLVPAQFTVAEDNKTYDLSGQTGPL
MEILQILKANNVPLNRMVDIRSNPALRQQVQAVVRRAAERQAPAAEPASQGSIAERLAEL
ESLRASGAVNAAEYESKRAQIISEI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLARYIKMQLLVLLCGGLVGPIFLVVYFTLGLGSLMSWMFYVGLIITVADVLVALALTNYGAKTAAKTAALERSGVLALAQITGLSETGTRINDQPLVKVHLHISGPGITPFDTEDRVIASVTRLGNLTARKLVVLVNPATQQYLIDWERSALVNGLVPAQFTVAEDNKTYDLSGQTGPLMEILQILKANNVPLNRMVDIRSNPALRQQVQAVVRRAAERQAPAAEPASQGSIAERLAELESLRASGAVNAAEYESKRAQIISEI
Prediction	CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEEEEEHCCEEHCCCEEEEEEEEEHCCCCCCCEEEEEEEHCHHHCCCCCCCEEEEEHCCCCCEEEEEHCHHHHCCCCCCCEEEEHCCCCEEEHCCCCCHHHHHHHHHHHHCCCCCCCHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
Conf.Score	8688999999999987655567766664358868999999999999999999999876645665578999999897578899887654678878668999999985898876567888864544456789879999879987699975545444577665688745896886557765678999999987898887654567988999999998865678888889988899899999999999987899899999999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLARYIKMQLLVLLCGGLVGPIFLVVYFTLGLGSLMSWMFYVGLIITVADVLVALALTNYGAKTAAKTAALERSGVLALAQITGLSETGTRINDQPLVKVHLHISGPGITPFDTEDRVIASVTRLGNLTARKLVVLVNPATQQYLIDWERSALVNGLVPAQFTVAEDNKTYDLSGQTGPLMEILQILKANNVPLNRMVDIRSNPALRQQVQAVVRRAAERQAPAAEPASQGSIAERLAELESLRASGAVNAAEYESKRAQIISEI
Prediction	5323203000111031233112111000012342102001220033132310100002223454454344144340301030330342323036303030402043542541423242303223134045420000002334513021434111423321312244564324044434211401410453604353114134445235413521552455444446456645336115505503642304464045314502677
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEEEEEHCCEEHCCCEEEEEEEEEHCCCCCCCEEEEEEEHCHHHCCCCCCCEEEEEHCCCCCEEEEEHCHHHHCCCCCCCEEEEHCCCCEEEHCCCCCHHHHHHHHHHHHCCCCCCCHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
MLARYIKMQLLVLLCGGLVGPIFLVVYFTLGLGSLMSWMFYVGLIITVADVLVALALTNYGAKTAAKTAALERSGVLALAQITGLSETGTRINDQPLVKVHLHISGPGITPFDTEDRVIASVTRLGNLTARKLVVLVNPATQQYLIDWERSALVNGLVPAQFTVAEDNKTYDLSGQTGPLMEILQILKANNVPLNRMVDIRSNPALRQQVQAVVRRAAERQAPAAEPASQGSIAERLAELESLRASGAVNAAEYESKRAQIISEI

4yxzA

0.12

0.98

0.72

MUSTER

SVEELLKLAKAAYYSGTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTALKLGISVEELLKLAEAAYYSGTTVEEAY-KLALKLGISVELLKLAKAAYYSGTTVEEAYKALKLGISVEELLKLAKAAYYSGTTVEEAYKLGISVEELLKLAEAAYYSGTTVEEAYKLALGISVEELLKLAKAAYYSGT-TVEEAYKLALKL----

4ut1A3

0.11

0.10

0.95

0.65

dPPAS

ATAITNYFTGLQTVANNAADPSARQTAMSNAQTLASQLVAAGQQYSQLRGGALGGLLAFRSQTLDPAQAQLGALAVSFASQVNAQNALGVDMSGNPFAVGAPAVYANQNNTGSATLSVSFV--DGTQPTTSDYALSYDGAKYTLTDRATGSVVTATPSSTPPTMTIGGLKLSLSSTPNAGDSFT--VLPTRGALDGFSLATAN----------GSAIAAASPVANKGTNDGRNALALSQLVNSKNNGTTTLTGAYAGYVNAIGNA

2csbA1

0.19

0.15

0.82

0.50

wdPPAS

V-EREFEEERETFLKGVKAYDGVLATRYLERSSSAKN---EELLELHQNFILLTGSYACSIDPTEDRYQNVIVRGVNFDERVQRLS-TG----GSP-ARYAI-VYRRG---WRAIAKALIDEEDVPAIEVR--AVKRNPLQPAL-----RILVRYGRVDLPVTVDE------VPPEAG---EFERLIERYDVPID---------EKEERILEILRENP---------TPHDEIARRL-SVSEVESSGIITAKRHVKRRDRLLEEL

4ml9A

0.13

0.12

0.93

0.67

wMUSTER

ISEQKRRKALKKVLDAVEEHTTILSTGITGDDARIARAAVAGGALLEPNHPAVALARGHKGVITHAAEQVRHEIPLDELKVTQGVRNV---VGED----IYITVGVPGG--FTEILPLELKEEDFFKIASGADGVHIHKSTEDLKDVVKYAHKYGLLVDAYIGHPDDLHTFGISART--PEEVAEAAKEEKIGVDIGLTGAGEPVIKERLSALVSSVKVPTLAEGGINDT--------NYVAFKDTGVGTDNVVSEAATNVVKKF

4w4iA

0.17

0.14

0.78

0.60

wPPAS

V----LTVDNAWFIAETIAGPWVLAI--MPYSD-----------------------AAQRGAFVDRQRDELTRMGL--------LSPQG-VINPFPDRWLDLRYVGPASADGACELLRGIVALRTGTGKKTGNGVVA--NAQLVTFTA-VPILGVGRPPARFSLPTRV---RADERLRSGVPLGEVVDYLGIP----------ASARPVVESVFSGPAGCNRDGRHTTTEVGLS-RV--LVSPSRAGTFTPFAIAVAIQTLTACL

4ut1A3

0.15

0.13

0.88

0.63

dPPAS2

PSARQTAMSNAQTLASQLVAAGQQYSQLRGG--ALGGLLAFRSQTLDPAQAQLGALAVSF----ASQVNAQNALG---------VDMSGNPGGSLFAVGAPAVYANQNNTGSAT---LSVSFVDGTQPTTSDYALSYDGAK--YTLTDRATGSVVGPSSTPPTMTIGGLKLSLSSTPNAGDSFT--VLPTRGALDGFSLATANGSAI----------AAASPVANKGTNDGRNALALSQLVNSKNNGTTTLTGAYAGYVNAIGNA

4ut1A3

0.11

0.92

0.76

PPAS

ATAITNYFTGLQTVANNAADPSARQTAMS---NAQTLASQLVAAGQQYSQLRGGALGGLLAFRSQTLDPAQAQLGALAVSQVNAQNALGVDMSGNPFAVGAPAVYANQNNTGSATLSVSFV--DGTQPTTSDYALSYDGAKYTLTDRATGSVVGTATPSSTPTMTIGGLKLSLSSTPNA----SFTVLPTRGALDGFSLATANGSA-----------AAASPVANKGTNDGRNALALSQLVNSKNNGTTTLTGAYAGYVNAIGNA

3orgA1

0.18

0.13

0.72

0.68

Env-PPAS

SLMYLLRLVCFLTLLGVTAALFIFAVDLAVHAGRFAGYILYVVSGVALCLLSTFWCAVLS----------TEAEG------------SG--L---PQMKSILS----GF------------YDKMRSALELRVLF--------AKALGLICAIGGGLP---------------VGWEGPNVHIACIIAHQFYRLGVFKELCTDRALRLQTLAAACAVSSFGAP---------LGGVLYSIETIALVQAFWKGVLSALSGAIVYEL

4ut1A3

0.10

0.99

0.69

MUSTER

QLNNYVGSPTAGIATAITNYFTGLQTVANNAADPSARQTAMSNAQTLASQLVAAGQQYSQLRGGALGGLLAFRSQTVSFASVNAQNALGVDMSGNPGGSLFAVPAVYANQNNTGSATLSVSFVDGTQPTTSDYALSYDGAK--YTLTDRATGSVVGTATPPPTMTIGGLKLSLSSTPNAVLPTRGALDGFSLATANGSAINKGTNDGRNALALSQLVNSKTMNNGTTTLTGAYAGYVNAIGNAASQLKASSAAQTALVGQITQAQ

4ml9A

0.13

0.97

0.61

dPPAS

SEQKRRKALKKVLDAVEEHGGTTILSTGITGDDARIARAAVAGRLLEPNHPAVALARGHKGVITHAAEQVRHEIPLDELKVTQGVRNV---VGED----IYITVGVPGG--FTEILPLELKEEDFFKIASGADGVHIHKSTEDLKDVVKYAHKYGLLVDAYIGHPDDLHTFGISARTPEEVAEAAKEEKIGVDIGLTGAGEIHPVIKERLSALVSSVKVPTLAEGGINDTNYVAFKDTGVNILVIGTSIDNVVSEAATNVVKKFL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.58

Estimated TM-score = 0.32±0.11

Estimated RMSD = 14.6±3.7Å

Download Model 2

C-score=-4.17

Download Model 3

C-score=-4.62

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.62

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ml9A	0.715	3.66	0.133	0.909
2	1dquA2	0.642	4.53	0.068	0.898
3	1f8mA	0.635	4.62	0.077	0.902
4	3e5bC	0.633	4.73	0.072	0.906
5	3i4eA	0.632	4.64	0.069	0.902
6	3lg3A	0.625	4.66	0.093	0.894
7	3czkA	0.605	4.64	0.078	0.860
8	2hsaA	0.600	4.29	0.074	0.811
9	3tjlA	0.599	4.55	0.056	0.838
10	4u33A	0.596	4.81	0.077	0.853

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.20	11	1m3uC	KPL	Rep, Mult	26,47,49,50,51,105,136,161,199
2	0.02	1	1y10D	CA	Rep, Mult	166,167
3	0.02	1	3mioA	PO4	Rep, Mult	113,121,124
4	0.02	1	2x7qA	CA	Rep, Mult	59,199
5	0.02	1	3o8oB	F6P	Rep, Mult	131,236
6	0.02	1	2oejB	PO4	Rep, Mult	26,237,251,252
7	0.02	1	2zunB	CBI	Rep, Mult	54,55,59,73,75
8	0.02	1	2v8vD	URP	Rep, Mult	156,195
9	0.02	1	1hgwB	MAN	Rep, Mult	88,90
10	0.02	1	3iibA	ZN	Rep, Mult	103,113,167
11	0.02	1	1ajsB	PLA	Rep, Mult	27,215
12	0.02	1	1qhoA	MAL	Rep, Mult	78,79,80,105,106
13	0.02	1	4dcaA	MG	Rep, Mult	93,147
14	0.02	1	3zstA	ACX	Rep, Mult	202,203,204,227
15	0.02	1	3kftA	NAD	Rep, Mult	21,22,24
16	0.02	1	2xz4A	CU	Rep, Mult	82,87
17	0.02	1	1b57A	PGH	Rep, Mult	102,103,105,134,135,136,137

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	3ez4H	0.550	4.30	0.101	0.732	2.1.2.11	50,68
2	0.067	2qiwA	0.581	4.48	0.082	0.807	2.7.8.23	80,124,130
3	0.067	1oy0D	0.571	4.29	0.067	0.766	2.1.2.11	24
4	0.067	2ekcB	0.578	4.39	0.041	0.800	4.2.1.20	NA
5	0.066	1wx0A	0.492	4.47	0.121	0.679	2.2.1.2	NA
6	0.066	2fliC	0.499	4.23	0.059	0.675	5.1.3.1	NA
7	0.066	1xi3B	0.485	4.08	0.080	0.645	2.5.1.3	NA
8	0.066	1xi3A	0.485	4.01	0.080	0.641	2.5.1.3	NA
9	0.066	1vlwB	0.489	4.18	0.055	0.668	4.1.3.16	NA
10	0.066	1mxsA	0.495	4.49	0.054	0.698	4.1.2.14	NA
11	0.066	2yswC	0.503	4.44	0.063	0.698	4.2.1.10	193
12	0.060	3e5bC	0.633	4.73	0.072	0.906	4.1.3.1	103
13	0.060	1igwA	0.612	4.67	0.059	0.875	4.1.3.1	NA
14	0.060	3i68A	0.583	4.59	0.074	0.819	1.3.5.2	NA
15	0.060	1eceB	0.581	4.74	0.097	0.838	3.2.1.4	NA
16	0.060	2hsaA	0.600	4.29	0.074	0.811	1.3.1.42	144
17	0.060	1oqfA	0.590	4.31	0.086	0.819	4.1.3.30	NA
18	0.060	3a47A	0.585	4.93	0.043	0.864	3.2.1.10	NA
19	0.060	2oykB	0.585	4.72	0.065	0.830	3.2.1.123	103
20	0.060	2duaA	0.588	4.22	0.084	0.804	3.11.1.3	NA
21	0.060	2q3rA	0.585	4.37	0.085	0.800	1.3.1.42	109,118
22	0.060	3czkA	0.605	4.64	0.078	0.860	3.2.1.48	NA
23	0.060	1q45B	0.597	4.31	0.066	0.807	1.3.1.42	NA
24	0.060	1uokA	0.585	4.86	0.048	0.860	3.2.1.10	NA
25	0.060	3i4eA	0.632	4.64	0.069	0.902	4.1.3.1	103
26	0.060	1cygA	0.588	4.75	0.034	0.845	2.4.1.19	NA
27	0.060	3fa3B	0.592	4.38	0.059	0.823	4.1.3.32	103
28	0.060	2zunB	0.594	4.74	0.068	0.845	3.2.1.4	NA
29	0.060	1icpA	0.589	4.45	0.070	0.811	1.3.1.42	139
30	0.060	3eooA	0.586	4.39	0.073	0.819	4.1.3.30	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.18	0.725	3.62	0.13	0.92	4ml9A	GO:0000105 GO:0003824 GO:0008152 GO:0008652 GO:0046872
1	0.09	0.639	4.65	0.07	0.91	3oq8A	GO:0003824 GO:0004451 GO:0008152 GO:0016829 GO:0019752
2	0.09	0.638	4.75	0.09	0.92	3lg3A	GO:0003824 GO:0004451 GO:0005737 GO:0006097 GO:0008152 GO:0016829 GO:0019752 GO:0046912
3	0.09	0.635	4.61	0.08	0.90	1f8iA	GO:0001101 GO:0003824 GO:0004451 GO:0005829 GO:0005886 GO:0006097 GO:0006099 GO:0006102 GO:0008152 GO:0009405 GO:0010034 GO:0016829 GO:0019752 GO:0046421 GO:0046872 GO:0046912 GO:0052572 GO:0070542 GO:0071456 GO:0075141
4	0.09	0.647	4.60	0.08	0.91	5e9hB	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
5	0.09	0.641	4.58	0.07	0.90	5e9fB	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
6	0.09	0.644	4.49	0.07	0.90	5e9fD	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
7	0.08	0.635	4.59	0.07	0.90	1igwC	GO:0003824 GO:0004451 GO:0005829 GO:0006097 GO:0006099 GO:0008152 GO:0016829 GO:0019752 GO:0043169 GO:0046872 GO:0046912
8	0.08	0.632	4.64	0.07	0.90	3i4eA	GO:0003824 GO:0004451 GO:0008152 GO:0016829 GO:0019752
9	0.08	0.592	4.38	0.06	0.82	3fa3B	GO:0003824 GO:0008152 GO:0016787
10	0.08	0.642	4.53	0.07	0.90	1dquA	GO:0003824 GO:0004451 GO:0005777 GO:0005782 GO:0006097 GO:0006099 GO:0008152 GO:0009062 GO:0009514 GO:0015976 GO:0016829 GO:0019752 GO:0045733 GO:0046421 GO:0046872 GO:0046912
11	0.07	0.644	4.50	0.07	0.90	5e9gD	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
12	0.07	0.612	4.67	0.06	0.88	1igwA	GO:0003824 GO:0004451 GO:0005829 GO:0006097 GO:0006099 GO:0008152 GO:0016829 GO:0019752 GO:0043169 GO:0046872 GO:0046912
13	0.07	0.595	4.26	0.07	0.82	3m0jA
14	0.07	0.590	4.31	0.09	0.82	1oqfA	GO:0000287 GO:0003824 GO:0005737 GO:0006097 GO:0008152 GO:0016829 GO:0019629 GO:0046421 GO:0046872 GO:0046912
15	0.07	0.574	4.80	0.07	0.83	3eolA	GO:0003824 GO:0004451 GO:0008152 GO:0016829 GO:0019752
16	0.07	0.586	4.39	0.07	0.82	3eooA	GO:0000287 GO:0003824 GO:0008152 GO:0016829 GO:0019629 GO:0046421 GO:0046872
17	0.07	0.583	4.28	0.09	0.81	1m1bA	GO:0003824 GO:0016853 GO:0032923 GO:0046872 GO:0050188
18	0.07	0.572	4.56	0.06	0.81	3b8iA	GO:0000287 GO:0003824 GO:0005737 GO:0006097 GO:0006107 GO:0008948 GO:0016829 GO:0016831 GO:0019629 GO:0042866 GO:0046421 GO:0046872 GO:0046912
19	0.07	0.589	4.36	0.07	0.82	4iqdA	GO:0000287 GO:0003824 GO:0008152 GO:0008807 GO:0016829 GO:0019629 GO:0046421 GO:0046872
20	0.07	0.481	4.16	0.06	0.65	3ktsA	GO:0003723 GO:0006071 GO:0006351 GO:0006355 GO:0009607

Consensus prediction of GO terms

Molecular Function	GO:0016746	GO:0046872	GO:0004451
GO-Score	0.35	0.32	0.32
Biological Processes	GO:0044262	GO:0044723	GO:0046487	GO:0008652	GO:0006547	GO:0009060
GO-Score	0.50	0.50	0.50	0.36	0.36	0.35
Cellular Component	GO:0005829	GO:0005886	GO:0009514
GO-Score	0.09	0.09	0.09

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.