I-TASSER results

I-TASSER results for job id Rv0674

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (240 residues)
MPAMTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRMVGAGDLVRSADG
YRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDARTRAALRTCMHHKRFGELR
EGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLWDLSGWTEAGHRLLGDMAAAT
DMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRAAYHDFATAMAKRRDATQLLEVT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MPAMTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRMVGAGDLVRSADGYRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDARTRAALRTCMHHKRFGELREGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLWDLSGWTEAGHRLLGDMAAATDMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRAAYHDFATAMAKRRDATQLLEVT
Prediction	CCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEHCCCCCHCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCHHHHCHHHCEEEEHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	999997579999985899985459999999999899878999999999998996887454344589989999999887557889999689999958987789999999999998995457988985787755455555554567766898899999998998999999999999858756799999999999999997999997779999847999999999999998766888876479
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MPAMTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRMVGAGDLVRSADGYRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDARTRAALRTCMHHKRFGELREGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLWDLSGWTEAGHRLLGDMAAATDMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRAAYHDFATAMAKRRDATQLLEVT
Prediction	756140310000000134624020300140045161545100000210354420424541131144026304522441454455252400000012355455315402520443312312410000034264524450442032032446303400441150650163045006504736212210200220131025116005612377131540151034106403643514412547
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEHCCCCCHCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCHHHHCHHHCEEEEHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MPAMTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRMVGAGDLVRSADGYRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDARTRAALRTCMHHKRFGELREGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLWDLSGWTEAGHRLLGDMAAATDMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRAAYHDFATAMAKRRDATQLLEVT

3kfwX

0.75

0.69

0.92

2.38

MUSTER

--SLTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEA-RPRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRP-DNLDLDLESDVAARVRL-TARDEAPADLAGQLWDLSGWTEAGHRLLGDAADPGRFVVAAAVRH-----LLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3kfwX

0.77

0.71

0.93

3.24

dPPAS

--SLTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEAR-PRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRP-DNLDLDLESDVAARVRL-TARDEAPADLAGQLWDLSGWTEAGHRLLGDAAATD---PGRFVVAAAVRHLLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3kfwX

0.73

0.68

0.93

4.10

wdPPAS

--SLTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEA-RPRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRPDNLDLDLES-DVAARVRL-TARDEAPADLAGQLWDLSGWTEAGHRLLGDAAATD---PGRFVVAAAVRHLLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3kfwX

0.75

0.69

0.92

2.87

wMUSTER

L---TARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEA-RPRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRPD-NLDLDLESDVAARVRL-TARDEAPADLAGQLWDLSGWTEAGHRLLGDAADPGRFVVAAAVRH-----LLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3kfwX

0.75

0.69

0.92

4.13

wPPAS

--SLTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEA-RPRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRPD-NLDLDLESDVAARVRL-TARDEAPADLAGQLWDLSGWTEAGHRLLGDAADPGRFVVAAAVRH-----LLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3kfwX

0.75

0.69

0.92

10.50

dPPAS2

--SLTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEAR-PRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRP-DNLDLDLESDVAARVRL-TARDEAPADLAGQLWDLSGWTEAGHRLLGDAADPGRFVVAAAVRH-----LLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3kfwX

0.75

0.69

0.92

3.44

PPAS

--SLTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEA-RPRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRPD-NLDLDLESDVAARVRL-TARDEAPADLAGQLWDLSGWTEAGHRLLGDAADPGRFVVAAAVRH-----LLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3kfwX

0.74

0.68

0.92

5.33

Env-PPAS

--SLTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRVGAGDLVRSAD-GYRLSDRLLARQRRQDEA-RPRTRAWHGNWHLIVTSIGTD--ARTRAALRTCHHKRFGELREGVWRPD-NLDLDLESDVAARVRLT-ARDEAPADLAGQLWDLSGWTEAGHRLLGDAADPGRFVVAAAVRH-----LLTDP-LPAELLPADWPGAGLRAAYHDFATAAKRRDATQL-----

3l09C

0.15

0.14

0.92

1.71

MUSTER

EAPLKLWSVLVTCLGDDGVIEVSGVALSSFVER--LQPQ-ARVALHRLKRDGWVESRRLGRVGFHRLSDSALTQTRAVAGRPGAGPAPWHLAGP--PDAPDGLSLLPD----TLSATPISRRFALICGP-----LEDVPEDWLLTAPSGRGLPVWVQDVVVEAGCEAEFKALERTLARLERFTLRVLVLHAWRRLILRSSPAAEAALGGARAEISCRARVHQLLDQLGSVEPDW------

3l09C

0.15

0.14

0.92

2.17

dPPAS

EAPLKLWSVLVTCLGDDGVIEVSGVALSSFVERGL--QPQARVALHRLKRDGWVESRRLGRVGFHRLSDSALTQTRAVAGGPGAGPAPWHLAGPPDAPD------GLSLLPDTLSATPISRRFALICGP-----LEDVPEDWLLTAPSGRGLPVWVQDVVVEAGCEAEFKALERTLARLERFTLRVLVLHAWRRLILRSSPAAEAALGGARAEISCRARVHQLLDQLGSVEPDW------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.10

Estimated TM-score = 0.86±0.07

Estimated RMSD = 3.5±2.4Å

Download Model 2

C-score=-1.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3kfwX	0.876	1.54	0.861	0.929
2	3l09C	0.665	3.97	0.160	0.879
3	4f4cA	0.445	5.81	0.063	0.742
4	4kf7A	0.437	5.62	0.060	0.738
5	4f9iA	0.429	6.17	0.046	0.767
6	3ebgA	0.423	5.26	0.056	0.675
7	3c68A	0.422	5.88	0.037	0.733
8	1urjB1	0.422	5.23	0.077	0.650
9	1it7A	0.419	6.10	0.051	0.733
10	2xdtA	0.417	5.52	0.038	0.679

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	4hfdA	MBR	Rep, Mult	193,196,197,199,220
2	0.04	2	3l26B	MG	Rep, Mult	202,203,213
3	0.04	2	1a9x1	III	Rep, Mult	5,7,8,44,45,46
4	0.04	2	1fx4A	MG	Rep, Mult	161,199
5	0.04	2	3ffzA	NA	Rep, Mult	28,29,31,32,36,37
6	0.02	1	2zkrp	NUC	Rep, Mult	101,104
7	0.02	1	1m3xL	BPH	Rep, Mult	223,226,227
8	0.02	1	3c67B	GLC	Rep, Mult	172,187,190,191,194
9	0.02	1	1izlB	CLA	Rep, Mult	30,233
10	0.02	1	1ay5A	MAE	Rep, Mult	61,194
11	0.02	1	5hxcA	MYC	Rep, Mult	188,192,216
12	0.02	1	3qnfA	UUU	Rep, Mult	91,119,124,125
13	0.02	1	1m34A	SF4	Rep, Mult	27,28
14	0.02	1	4r7cA	GLY	Rep, Mult	186,190,223
15	0.02	1	1jdbH	GLN	Rep, Mult	9,31,40,41
16	0.02	1	1rwtF	CLA	Rep, Mult	195,196,200,211
17	0.02	1	2zxeB	CLR	Rep, Mult	216,220
18	0.02	1	1ystL	BCL	Rep, Mult	170,223
19	0.02	1	2zh0L	HIS	Rep, Mult	220,221
20	0.02	1	2p1rC	CA	Rep, Mult	115,117

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2d0vA	0.396	6.55	0.050	0.750	1.1.99.8	NA
2	0.060	1ut9A	0.393	5.61	0.047	0.637	3.2.1.4	NA
3	0.060	2cqsA	0.389	6.35	0.054	0.729	2.4.1.20	NA
4	0.060	1w6sC	0.391	6.36	0.046	0.721	1.1.99.8	NA
5	0.060	3b8aX	0.389	6.35	0.050	0.704	2.7.1.1	210
6	0.060	2ihvA	0.390	5.83	0.040	0.671	2.5.1.66	NA
7	0.060	1h54B	0.406	6.32	0.052	0.746	2.4.1.8	118
8	0.060	2e0wB	0.390	5.70	0.022	0.658	2.3.2.2	NA
9	0.060	1lrwC	0.375	6.54	0.040	0.708	1.1.99.8	112
10	0.060	1l2aE	0.397	4.91	0.033	0.596	3.2.1.4	NA
11	0.060	3ebgA	0.423	5.26	0.056	0.675	3.4.11.-	NA
12	0.060	1y8bA	0.418	6.31	0.032	0.746	2.3.3.9	NA
13	0.060	2zufA	0.394	4.74	0.039	0.567	6.1.1.19	NA
14	0.060	2e7zA	0.392	6.21	0.033	0.683	4.2.1.71	NA
15	0.060	1aozA	0.395	6.19	0.039	0.692	1.10.3.3	NA
16	0.060	3fnrA	0.401	4.53	0.041	0.571	6.1.1.19	NA
17	0.060	3fvyA	0.409	5.96	0.056	0.721	3.4.14.4	NA
18	0.060	2dqmA	0.399	5.90	0.050	0.679	3.4.11.2	NA
19	0.060	2z8kC	0.276	5.56	0.045	0.438	2.3.2.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.68	0.913	1.51	0.92	0.97	3kfwX	GO:0005576 GO:0040007
1	0.07	0.442	5.67	0.05	0.72	4m1mA	GO:0000086 GO:0000166 GO:0002481 GO:0002485 GO:0002489 GO:0002591 GO:0005524 GO:0005886 GO:0006810 GO:0006855 GO:0008559 GO:0009986 GO:0015893 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0042623 GO:0042626 GO:0042908 GO:0046581 GO:0055085 GO:0070062 GO:0072089
2	0.06	0.363	6.33	0.07	0.67	5do7A	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0007584 GO:0007588 GO:0010212 GO:0010949 GO:0015918 GO:0016020 GO:0016021 GO:0016324 GO:0016887 GO:0017127 GO:0030299 GO:0033344 GO:0042493 GO:0042626 GO:0042632 GO:0043190 GO:0043235 GO:0045177 GO:0045796 GO:0046982 GO:0055085
3	0.06	0.323	6.66	0.05	0.61	5da9A	GO:0000723 GO:0005089 GO:0005524 GO:0005634 GO:0006281 GO:0016887 GO:0030870 GO:0035023 GO:0043547
4	0.06	0.352	5.38	0.04	0.55	5b0oB	GO:0000166 GO:0005524 GO:0005737 GO:0006754 GO:0006810 GO:0006811 GO:0009058 GO:0015031 GO:0015992 GO:0016787 GO:0016887 GO:0030254 GO:0030257 GO:0044780 GO:0044781 GO:0071973
5	0.06	0.307	6.42	0.05	0.57	3pihA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
6	0.06	0.324	6.55	0.05	0.60	3ozxB	GO:0000054 GO:0000166 GO:0005506 GO:0005524 GO:0005623 GO:0005852 GO:0006413 GO:0006415 GO:0016887 GO:0043024
7	0.06	0.302	6.52	0.05	0.57	1oxuA	GO:0000166 GO:0005524 GO:0016887
8	0.06	0.327	6.18	0.04	0.58	2iw3B	GO:0000166 GO:0001933 GO:0003723 GO:0003746 GO:0005524 GO:0005737 GO:0005840 GO:0006412 GO:0006414 GO:0006415 GO:0006469 GO:0010494 GO:0016887 GO:0019843 GO:0022626 GO:0042788
9	0.06	0.328	6.15	0.05	0.57	5da9B	GO:0000723 GO:0005089 GO:0005524 GO:0005634 GO:0006281 GO:0016887 GO:0030870 GO:0035023 GO:0043547
10	0.06	0.319	6.26	0.03	0.56	4crmP	GO:0000054 GO:0000166 GO:0003743 GO:0005506 GO:0005524 GO:0005634 GO:0005737 GO:0005852 GO:0006364 GO:0006412 GO:0006413 GO:0006415 GO:0006810 GO:0016887 GO:0022626 GO:0032790 GO:0042254 GO:0042273 GO:0043024 GO:0045727
11	0.06	0.319	6.05	0.05	0.56	2d62A	GO:0000166 GO:0005215 GO:0005524 GO:0006810 GO:0016820 GO:0016887 GO:0043190 GO:0055085
12	0.06	0.323	6.53	0.07	0.62	3auyA	GO:0000166 GO:0005524 GO:0006281 GO:0006302 GO:0006974 GO:0008270 GO:0016787 GO:0016887 GO:0046872
13	0.06	0.303	6.39	0.05	0.56	3zqjA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0060543 GO:0090305
14	0.06	0.306	6.06	0.05	0.52	4ry2A	GO:0005524 GO:0006508 GO:0006810 GO:0008233 GO:0008234 GO:0016020 GO:0016021 GO:0016887 GO:0022885 GO:0042626 GO:0043213 GO:0055085
15	0.06	0.313	6.18	0.05	0.56	3jagjj	GO:0000166 GO:0005524 GO:0005737 GO:0005739 GO:0016020 GO:0016887
16	0.06	0.353	6.47	0.03	0.65	4hvtA	GO:0004252 GO:0006508 GO:0008236 GO:0016787 GO:0070008
17	0.06	0.260	6.30	0.02	0.47	1kzhB	GO:0003872 GO:0005524 GO:0005737 GO:0006002 GO:0006096 GO:0016301 GO:0016310 GO:0016740 GO:0046835 GO:0046872 GO:0047334 GO:0061615
18	0.06	0.294	6.64	0.06	0.56	2vf8B	GO:0000166 GO:0003677 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009380 GO:0009381 GO:0016887 GO:0046872 GO:0090305

Consensus prediction of GO terms

Molecular Function	GO:0035639	GO:0032559	GO:0017111	GO:0032550
GO-Score	0.47	0.47	0.47	0.47
Biological Processes	GO:0040007	GO:0051234
GO-Score	0.68	0.36
Cellular Component	GO:0005576
GO-Score	0.68

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.