I-TASSER results

I-TASSER results for job id Rv0633c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (279 residues)
MVDSMGWVLSSWHEVTGVDSGTWLAWAAWAALGLGVVALVVTKRQIQRNRRLAAEQTRPY
VAMFMEPHVADWHVIELVVRNFGRTAAYDVRFSFPNPPTVAQYENAANGYADVVELRLPQ
ELPMLAPGQEWRMVWDSALDRAEIGRGIESRFPGTVTYYDRPEQPRRWRFWRRGRRPLET
KVVLDWDALPPVARIELMTTHDLAKREKQKLELLRSLLTYFHYASKETRPDVFRSEIDRI
NRAAAETQDRWRARQVEVPTEVSQRSEGQGPQPTRIPAG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MVDSMGWVLSSWHEVTGVDSGTWLAWAAWAALGLGVVALVVTKRQIQRNRRLAAEQTRPYVAMFMEPHVADWHVIELVVRNFGRTAAYDVRFSFPNPPTVAQYENAANGYADVVELRLPQELPMLAPGQEWRMVWDSALDRAEIGRGIESRFPGTVTYYDRPEQPRRWRFWRRGRRPLETKVVLDWDALPPVARIELMTTHDLAKREKQKLELLRSLLTYFHYASKETRPDVFRSEIDRINRAAAETQDRWRARQVEVPTEVSQRSEGQGPQPTRIPAG
Prediction	CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCEEEEEEEHCCCCCEEEEEEEHCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCEEEEEHCCCCHHHHHCCCCCCEEEEEEEEHCCCCCCCHHHHHCCCCCCCCCEEEHCCCCCCCCEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	987556889998876578856788999999999999999999999999999999997897899997577777578999997798775789999779988766666667754444345666787678996789975566546665566655789999998477765444444457765455577666649874554445654578889999999998766554677777668889999999999999999998765567765667788889987677899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MVDSMGWVLSSWHEVTGVDSGTWLAWAAWAALGLGVVALVVTKRQIQRNRRLAAEQTRPYVAMFMEPHVADWHVIELVVRNFGRTAAYDVRFSFPNPPTVAQYENAANGYADVVELRLPQELPMLAPGQEWRMVWDSALDRAEIGRGIESRFPGTVTYYDRPEQPRRWRFWRRGRRPLETKVVLDWDALPPVARIELMTTHDLAKREKQKLELLRSLLTYFHYASKETRPDVFRSEIDRINRAAAETQDRWRARQVEVPTEVSQRSEGQGPQPTRIPAG
Prediction	744421302411341352424202000132013103201110221043145336334302000103334542301200040215120340304144134435354445433422414134503201234412121433253442476046414040423242465444434656444142412021451431431443433430443552053036204313232652446314641540443254145324565364156363566652353363468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCEEEEEEEHCCCCCEEEEEEEHCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCEEEEEHCCCCHHHHHCCCCCCEEEEEEEEHCCCCCCCHHHHHCCCCCCCCCEEEHCCCCCCCCEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
MVDSMGWVLSSWHEVTGVDSGTWLAWAAWAALGLGVVALVVTKRQIQRNRRLAAEQTRPYVAMFMEPHVADWHVIELVVRNFGRTAAYDVRFSFPNPPTVAQYENAANGYADVVELRLPQELPMLAPGQEWRMVWDSALDRAEIGRGIESRFPGTVTYYDRPEQPRRWRFWRRGRRPLETKVVLDWDALPPVARIELMTTHDLAKREKQKLELLRSLLTYFHYASKETRPDVFRSEIDRINRAAAETQDRWRARQVEVPTEVSQRSEGQGPQPTRIPAG

4yxzA

0.13

0.12

0.94

0.67

MUSTER

SVEELLKLAKAAYYSTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALK------LGISVEELLKLAKAAYYSGTTVALKLGISVEELLKLAKAAYYSGTTVEKLALKLGISVEELLKLAEAAYYSGTTVLALKLGISVEELLKLAAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEA--YKLALKLGISVEELLKLAEAAYY--SGTTVEEAYKLALKLGISVEELLKLAKAAYY-----SGTTVEEAYKLALKL---

4nx9A

0.06

0.05

0.88

0.74

dPPAS

STNILQRRDLSLQSANGNSDSERTALNGEVKQLQKELDRISNTTTFGGRKLLDGSFG----VASFQVGSAANEIISVGIDESAESLNGTYFKADGGGAVTAATASGTVDIAIDITGGSAVNVKVDKGNETAEQAAAKIAAAVNDANVGIGAFTDQISYVSKASADGTTSAVSGVAITDTGSTGAGTAAGTTTFTEANDTVAKIDISTAKGAQSAVLVIDEA-----IKQIDAQRADLGAVQNRFDNTINNLKNI-------------------------

5ck3B

0.14

0.10

0.70

0.59

wdPPAS

----------------------------------------------------------PSVLLI---------------SGAGKTA----PLLNPDGTSVGAADLKNPYRKPIVTSPVAQTHTSQVPTSVELAVGANEDGTPTSYKVDLDATARKFLLIDTPGHPKLQHLLNPSPSLTIIIFLLDAAAL-------ADSDGDYLSQTASYLYDVLLSLQKRFHSRKNRKQDLFTAPASLVKSRLEHELGRIRKTRQKGGWLGAVGSKEEFDMEVEVMGG

4xgtA1

0.12

0.10

0.85

0.67

wMUSTER

LERELISLQQERDAIIIPDESIVKDYYGVRQQLEEYNKDMVFVIQ-------------PQ---NCLGFFQEGRLIHIKSPS-GVDYGWGVLIKHIQRQTPKNGQPPYPEQESYVSGDFNPKTRGEGPMPEGIMPAGKDSKNARWENCLRALGQLRVFLPKRLESADEKDGVGKAVDEISRRFPDGIPILDPMENMGIND--DSFKKLLRKIEVLESRLVALHNSPLLVELWNQYSLKMQLGEQIKEKKKAIARAHS-----------------------

4wj1A

0.12

0.10

0.82

0.71

wPPAS

LQYELPGLERKAHECESTRPE--ATTASVYSKLASAAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAA----ELSRQNGSDA-------PPPAAEAVVPDSGIPGPLA---IPSEYPSAAAAA-----DEDWEAAARII-DTQALSKYFRDQWRD------QSTLEGHGRH-FAN----PAEGWAG----------AAAETCAEAQRRLSTWWADGAECGR-TLENVREFEEEWDRQNAWALQEQSEDALEAYANGSQIQE--RPGKP---PSG

4nx9A

0.06

0.05

0.88

0.94

dPPAS2

STNILQRRDLSLQSANGNSDSERTALNGEVKQLQKELDRISNTTTFGGRKLLDGSFG----VASFQVGSAANEIISVGIDESAESLNGTYFKADGGGAVTAATASGTVDIAIDITGGSAVNVKVDKGNETAEQAAAKIAAAVNDANVGIGAFTDQISYVSKASADGTTSAVSGVAITDTGSTGAGTAAGTTTFTEANDTVAKIDISTAKGAQSAVLVIDEA-----IKQIDAQRADLGAVQNRFDNTINNLKNI-------------------------

4wj1A

0.13

0.11

0.91

0.86

PPAS

LQYELPGLERKAHECESTKPDELATTASVYSKLASAAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAA----ELSRQNGSDA-------PPPAAEAVVPDSGIPGPLAIPSEYPS---AAAAAD---EDWEAAARIIHSGDTQALSKYFRDQWRD--YQSTLEGHGRHFANPAE-----GWAGAAAETCAEAQRRLRLAQEATTFVDAHDKLVANHPTLENVREFEETEWASEWDRQNAWALQEQSEDALEAYANGSQIQEIRPGKPPSILPI-

4pypA1

0.07

0.05

0.69

0.68

Env-PPAS

VIEEFYTQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFRRNSMLMMNLLAFGFSKLGKSFEMLILGYCG--LTTGFVPMY---------------------------VGEVSPTAALGTLHQLGIVVGILIAQV-------FGLDSIMGNKDLWPLL------------LSIIFIPALLQCIVLPFCLLINR--NEENRAKSVLKKL-RGTADV-----THDLQEMKEESRQMMR------------------------------

5cwpA

0.11

0.09

0.81

0.67

MUSTER

MSSDEEEARELIERA----KEAAERAQEAAERTGDPRVRELARELKRLAQEAAEEVKRPS-------SSDVNEALKLIVEAIE--AAVRA---------LEAAERTGDPEVRELARELVRLAVEAA----------EEVQRNPSSSDVNEALKLIVEAIEAAVRALEAAERTGDPEVRELARELVRLAVEAAEEVQRNPSSEVNEALKKIVKAIQEAVESLREAEESGDPEKREKARERVREAVERAEEVQRD-----PSGWLE---------------

4xgtA1

0.08

0.07

0.89

0.70

dPPAS

VPQLERELISLQQERDAIIIPDESIVKDYYGVRQQLEEYNKDMVFVIQHPQNCLGFFQEGRLIHIKSPSGVDYGWGVLIKHIQRQTPKNGQPPYPEQESSGDFNPKTRGEGPMPEGIMPAGKDSKNARWEVVPCL---------LNCLRALGQLRVFLPKRLESADEKDGVGKAVDEISRRFPDGIPILDPME--NMGINDDSFKKLLRKIEVLESRLVANPLHNSPLLVELWNQYSLKMQLGEQIKEKKKAIARAHS---------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.24

Estimated TM-score = 0.27±0.08

Estimated RMSD = 16.6±2.9Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4nx9A	0.775	2.35	0.071	0.853
2	4cfiA	0.530	3.72	0.057	0.649
3	2zbiB	0.520	3.51	0.053	0.631
4	2j69A	0.467	4.76	0.067	0.659
5	3v47C	0.457	4.27	0.098	0.570
6	1ucuA	0.454	2.58	0.095	0.498
7	4ut1A	0.448	5.60	0.088	0.677
8	2d4xA	0.431	3.21	0.041	0.516
9	3pwxA	0.425	2.80	0.035	0.491
10	1f31A	0.420	6.14	0.039	0.710

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	5dirB	MLE	Rep, Mult	29,30,204,206,218
2	0.06	3	2ql2A	NUC	Rep, Mult	235,236,239
3	0.04	2	2r42A	MG	Rep, Mult	83,85,86,129,140
4	0.04	2	4wb7B	ZN	Rep, Mult	248,249
5	0.04	2	1cc1L	SF4	Rep, Mult	50,55
6	0.04	2	1f31A	UUU	Rep, Mult	93,159,161,171
7	0.02	1	1vykA	ZN	Rep, Mult	12,17,212
8	0.02	1	3j47V	III	Rep, Mult	34,38,41
9	0.02	1	3o8nA	ADP	Rep, Mult	110,135,136,137,138,141
10	0.02	1	1zavA	III	Rep, Mult	36,43
11	0.02	1	2wse1	CLA	Rep, Mult	40,44
12	0.02	1	4jolB	III	Rep, Mult	207,210,211,213,214
13	0.02	1	3o8oB	F6P	Rep, Mult	56,57,58,80
14	0.02	1	1r4pA	FMT	Rep, Mult	47,48,51
15	0.02	1	1vltA	ASP	Rep, Mult	250,254
16	0.02	1	3o8lB	PO4	Rep, Mult	41,51,82,83
17	0.02	1	3ojaB	MAN	Rep, Mult	215,218
18	0.02	1	1i6qA	CO3	Rep, Mult	84,85

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2e1qA	0.373	6.03	0.047	0.617	1.17.3.2,1.17.1.4	NA
2	0.060	3ixzA	0.388	6.24	0.020	0.645	3.6.3.10	89
3	0.060	1gaxA	0.370	6.08	0.080	0.602	6.1.1.9	NA
4	0.060	1z0hB	0.249	6.18	0.062	0.430	3.4.24.69	209
5	0.060	2gewA	0.399	5.56	0.050	0.631	1.1.3.6	NA
6	0.060	3b9jJ	0.246	6.12	0.022	0.409	1.17.1.4,1.17.3.2	138,154
7	0.060	2hkjA	0.291	6.64	0.033	0.520	5.99.1.3	61
8	0.060	1tt0A	0.403	6.04	0.059	0.674	1.1.3.10	NA
9	0.060	1pj6A	0.371	6.86	0.044	0.695	1.5.3.10	NA
10	0.060	2iveA	0.369	6.52	0.074	0.659	1.3.3.4	NA
11	0.060	1cf3A	0.380	6.42	0.053	0.656	1.1.3.4	196
12	0.060	1kdgB	0.411	5.53	0.042	0.642	1.1.99.18,	158
13	0.060	1e3xA	0.341	6.53	0.038	0.620	3.2.1.1	44,55
14	0.060	3b9jI	0.184	4.97	0.039	0.269	1.17.1.4,1.17.3.2	NA
15	0.060	1bliA	0.311	6.54	0.053	0.548	3.2.1.1	51
16	0.060	1fo4A	0.411	5.89	0.033	0.667	1.17.1.4	NA
17	0.060	2jbvB	0.406	5.95	0.063	0.659	1.1.3.17	NA
18	0.060	3g61A	0.367	5.78	0.053	0.591	3.6.3.44	NA
19	0.060	2c6fA	0.381	5.74	0.039	0.591	3.4.15.1	38

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.15	0.780	2.37	0.07	0.86	4nx9A	GO:0005198 GO:0005576 GO:0009288 GO:0009420 GO:0071973
1	0.09	0.467	4.79	0.07	0.66	2j68A	GO:0000166 GO:0003924 GO:0005525 GO:0005886 GO:0008289 GO:0016020 GO:0016021 GO:0016787
2	0.07	0.534	3.64	0.05	0.64	3k8vA	GO:0005198 GO:0005576 GO:0009288 GO:0009420 GO:0044781 GO:0071973
3	0.07	0.530	3.72	0.06	0.65	4cfiA	GO:0005198 GO:0005576 GO:0009288 GO:0009420 GO:0071973
4	0.06	0.457	4.27	0.10	0.57	3v47C	GO:0005198 GO:0005576 GO:0009288 GO:0009420 GO:0071973
5	0.06	0.351	5.53	0.03	0.55	4aurA	GO:0005525
6	0.06	0.447	2.69	0.03	0.51	3pwxA	GO:0005198 GO:0009288 GO:0009424 GO:0071973
7	0.06	0.295	6.23	0.02	0.49	3w6nB	GO:0000166 GO:0000266 GO:0001836 GO:0003374 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005741 GO:0005777 GO:0005794 GO:0005829 GO:0005874 GO:0005903 GO:0005905 GO:0006897 GO:0006921 GO:0008289 GO:0010821 GO:0012501 GO:0012505 GO:0015630 GO:0016020 GO:0016559 GO:0016787 GO:0030054 GO:0030672 GO:0031410 GO:0031625 GO:0032459 GO:0042802 GO:0042803 GO:0043065 GO:0043231 GO:0043234 GO:0043653 GO:0045202 GO:0048471 GO:0050714 GO:0051289 GO:0060047 GO:0061025 GO:0070266 GO:0070584 GO:0070585 GO:0090141 GO:0090149 GO:0090200 GO:1900063 GO:1903146 GO:1903578 GO:2001244
8	0.06	0.255	6.00	0.04	0.42	3tviE	GO:0004072 GO:0008152 GO:0008652 GO:0009088 GO:0009089 GO:0016301 GO:0016310 GO:0016597 GO:0016740
9	0.06	0.280	5.98	0.06	0.46	4ryeA	GO:0004175 GO:0004180 GO:0005887 GO:0006508 GO:0009002 GO:0009252 GO:0016787
10	0.06	0.247	5.80	0.05	0.38	5ady6	GO:0000166 GO:0000287 GO:0003924 GO:0005524 GO:0005525 GO:0005737 GO:0005829 GO:0009408 GO:0019042 GO:0019843 GO:0043022 GO:0046872
11	0.06	0.267	6.96	0.04	0.50	4h1uA	GO:0000166 GO:0000266 GO:0001836 GO:0003374 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005741 GO:0005777 GO:0005794 GO:0005829 GO:0005874 GO:0005903 GO:0005905 GO:0006897 GO:0006921 GO:0008289 GO:0010821 GO:0012501 GO:0012505 GO:0015630 GO:0016020 GO:0016559 GO:0016787 GO:0030054 GO:0030672 GO:0031410 GO:0031625 GO:0032459 GO:0042802 GO:0042803 GO:0043065 GO:0043231 GO:0043234 GO:0043653 GO:0045202 GO:0048471 GO:0050714 GO:0051289 GO:0060047 GO:0061025 GO:0070266 GO:0070584 GO:0070585 GO:0090141 GO:0090149 GO:0090200 GO:1900063 GO:1903146 GO:1903578 GO:2001244
12	0.06	0.235	6.73	0.06	0.43	2aa4A	GO:0000166 GO:0005524 GO:0005975 GO:0006051 GO:0006974 GO:0008270 GO:0009384 GO:0016301 GO:0016310 GO:0016740 GO:0019262 GO:0046835 GO:0046872
13	0.06	0.434	3.05	0.06	0.49	3a5xA	GO:0002755 GO:0005198 GO:0005576 GO:0005886 GO:0009288 GO:0009420 GO:0034146 GO:0071973
14	0.06	0.296	6.83	0.03	0.55	5c8sB	GO:0000166 GO:0000175 GO:0001172 GO:0003676 GO:0003723 GO:0003725 GO:0003727 GO:0003968 GO:0004197 GO:0004386 GO:0004482 GO:0004483 GO:0004518 GO:0004519 GO:0004527 GO:0005524 GO:0006351 GO:0006370 GO:0006508 GO:0008168 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016788 GO:0016817 GO:0016896 GO:0019079 GO:0019082 GO:0019083 GO:0030430 GO:0030683 GO:0032259 GO:0033644 GO:0036265 GO:0036459 GO:0039502 GO:0039503 GO:0039519 GO:0039520 GO:0039549 GO:0039579 GO:0039595 GO:0039604 GO:0039644 GO:0039648 GO:0039657 GO:0039690 GO:0039694 GO:0039714 GO:0044172 GO:0044220 GO:0046872 GO:0071108 GO:0080009 GO:0090305 GO:0090503 GO:1990380 GO:2000158
15	0.06	0.222	5.65	0.03	0.34	1x33C	GO:0005198 GO:0019028 GO:0046872
16	0.06	0.431	3.21	0.04	0.52	2d4xA	GO:0005198 GO:0005576 GO:0009288 GO:0009424 GO:0071973
17	0.06	0.216	6.43	0.04	0.38	1dlpC
18	0.06	0.226	6.55	0.03	0.39	3wi5A	GO:0002755 GO:0005576 GO:0006810 GO:0006811 GO:0009279 GO:0015288 GO:0016020 GO:0016021 GO:0038123 GO:0046930 GO:0055085

Consensus prediction of GO terms

Molecular Function	GO:0005198
GO-Score	0.31
Biological Processes	GO:0071973
GO-Score	0.31
Cellular Component	GO:0009420	GO:0005576
GO-Score	0.31	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.