I-TASSER results

I-TASSER results for job id Rv0628c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (383 residues)
MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHTDQAVDLLAAVQASVE
PAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVRTGSGALITGYRFDRTA
HDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRGDTRLFRDRDVLTSGLVG
VRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPLHRLREIVLGMAPDEQELV
SRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGEVVEVGATVQFQVRDAAAAD
KDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMFGVTDHDASTIEDLLGGIPLAGFFAAG
EIGPVAGHNALHGFTASMALFVD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHTDQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVRTGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRGDTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPLHRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGEVVEVGATVQFQVRDAAAADKDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMFGVTDHDASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD
Prediction	CCEEEEEHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCEEEHCCEEEHCCEEEEEEEEHCCCEEEEEHCCCCCCHHHHHHHHHCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCEEEEHCCEEHCCEEEEEEHCCCCEEEEEHCCCEEHCCEEEEEEHCCCEEEEHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEHCCCCCCCCCCCEEEEEEEHCCCCCCEEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCHHHHHHHCCCHHHHHHHHHHHHCCCCEEHCCCCCEEEEHCCCCCCCCEEEEEEEEHC
Conf.Score	96899985799999999999999999868899978999978875799999999999988999699856785997995886875899999867875899865666656788888765788887899995899998999999999986998698566589988887599989988778599999869965799976967758868999987969999689899999999997577556677664786545656665445788589997544678899799975799997999996899999999999999999977999868999965555577667656999999999699988966789856764897654564578999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHTDQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVRTGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRGDTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPLHRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGEVVEVGATVQFQVRDAAAADKDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMFGVTDHDASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD
Prediction	32000010225303400320053037505653010000000241263045005203730550300000000000333223210000000022351422314436436522331252455412000000001224043004102620430000000001233243010014440011000000012533111001102134451300204511021037420140034005514563352244201000013432334654210000013024730001001404331201000113420251024005402752744020000000000112036325400520361045110000000000022443220001000000028
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCEEEHCCEEEHCCEEEEEEEEHCCCEEEEEHCCCCCCHHHHHHHHHCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCEEEEHCCEEHCCEEEEEEHCCCCEEEEEHCCCEEHCCEEEEEEHCCCEEEEHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEHCCCCCCCCCCCEEEEEEEHCCCCCCEEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCHHHHHHHCCCHHHHHHHHHHHHCCCCEEHCCCCCEEEEHCCCCCCCCEEEEEEEEHC
MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHTDQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVRTGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRGDTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPLHRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGEVVEVGATVQFQVRDAAAADKDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMFGVTDHDASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD

4psnA2

0.20

0.06

0.30

1.27

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPEEEIAPIVEDFARAAPRLLEEEIRFTVEK---VGETDVGDVVYRIYRGSDLNGEALVRGAVVEPTLKRTRVQVEADRIDDFVRESVSRLFSEAQNVE---------------KREAVRVVNEILSLVKA---------------------------------

5kc9A

0.12

0.11

0.92

1.04

PPAS

IHIGAIFEENAADDRVFQLAVSDLSLNDDILQ-TYSIKVIEANNPFQAVQEACDLMTQ-GILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACH------------LNPSPDGEAYTLASRPPVRLNDVMLRLVTEL-RWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEERYRDTLRRAILLLSPQGAHSFINEAVETSDPEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLC----DPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASL--NCIRK----STKPWNGGRSMLDTIKKGHITGLT--GVME--DSSNPYVQFEILGTTYSE

2mu4A

0.11

0.03

0.29

1.13

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKGTQYKDGYYITTLNY-NFNTVYNATLQAIQNGQTFDYKSNPYDISVNK-----NNGTDAEIVSASDSDSTDSLQVAMKKLPNNTRISIKYGSNSIRSSALIGIIEGNIRYANTH------------------------------------------------------------------

4k90B

0.15

0.07

0.46

1.12

dPPAS2

-------------------------------------------------------------------------------------------TVDLNAFRLKSLAKYVNATETVIEAPSPQSY------------VEVATQHVKMIAPDATFRVYVGDNGVAHVHFRQTANGLDIDNADFNVNVGKDGKVFSYGNSFYT------------------GQIPSSAALTKRDFSDPVTALKGTTNTLQLPITVDSASSESTKESYVFKGVSGTVSDDGTLALAWRVKSGEEIHGVVDYVAE-------------------------------------------------------------------------------------

5cukA

0.17

0.04

0.25

1.06

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPLPLADLARLLDAVQGRIQVASAAESHAARLQ---VRLPQLGAVEVQVLHG--HGQLQIEISAS----------PGSLALLQQARGELLERLQRLHPEQPVQLTFNQQ---------------------------------------------------------

4py5A1

0.07

0.01

0.19

1.06

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMKLSSSEKEKLLKKLKALGAKEEKPPEH---------AQYRLRLNDAILTVYKS---G-SVVYGGKGREKLKELVAETVLSDT------------------------------------------------------------------------

4gpaA

0.10

0.09

0.90

0.76

MUSTER

VQIGGLFIRNTDEYTAFRLAIFLHNTSPNASEAPFNLVPHVTANSFAVTNAFCSQYSR-GVFAIFGLYDKRSLTSFCSALHISLITPS-FPTEGESQFVLQLRPSLRGALLSLLD--HYEWNCFVFLYDTDRG--YSILQAIMEKANGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS-VGKH-----VKGYHYIIAN-----------LGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDR-WKKLDQRE-------YPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLA-----PAAPWGQGIDMERTLKQVRIQGLT--GNVQFDHYG-RRVNYTMDVFELKS

4gpaA

0.10

0.09

0.90

0.77

dPPAS

VQIGGLFIRNTDEYTAFRLAIFLHNTSPNASEAPVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHY---EWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNIVSVGKHVKGYHYIIA---------------------NLGFKDISLERFIHGGANV-TGFQLVDFNTPMVTKLMDRWKKLDQRE-------YPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDC----LANPAAPWGQGIDMERTLKQVRIQGLT---GNVQFDHYGRRVNYTMDVFELKS

4k3bA2

0.10

0.08

0.79

0.73

wdPPAS

LNIT----KMLQ-----NDAIKKNLESFGLAQ-------SQYFNQATLNQAVAGLKEEY---------GRGQITPKVTKLARVDIDITIDEGKSAKITDIENQVYSDRKLMRQMSLTEGGIWTWLTRSDRFDRQFAQDMEKVTDFYQNN---G-----DFRILDTDIQTNE---DKTRQTIKITVHE------------GGRFRWGKVS------IEGDTNEAELEKLLTMKPGKERQQMTAVL----EIQNRMGSAGYAYSEISVQPLPNAGTKTVDFVLHIEPGRKIYVNEIHITGNNKTRDEVVRRELRQMESA-----PYD------------TSKLQRSKERVELL---GYFD--QFDAVPLAGT--DKVDLNMSLTE

4gpaA

0.09

0.08

0.90

0.77

wMUSTER

VQIGGLFIRNTDEYTAFRLAIFLHNTSPNASEAPFNLVPHVTANSFAVTNAFCSQYSR-GVFAIFGLYDKRSLTSFCSALHISLITP-SFPTEGESQFVLQLRPSLRGALLSLLDHYEWN-CFVFLYDTDRGYSLQAIMEKAGQN--GWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS-VGKH-----VKGYHYIIAN-----------LGFKDISLERFIHGGANVTGFQLVDFNTPMVTKL-MDRWKKLDQRE-------YPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLA-----PAAPWGQGIDMERTLKQVRIQGLT--GNVQFDHYGRRV-NYTMDVFELKS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.59

Estimated TM-score = 0.52±0.15

Estimated RMSD = 10.4±4.6Å

Download Model 2

C-score=-3.30

Download Model 3

C-score=-4.72

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4gpaA	0.824	2.47	0.098	0.903
2	3kg2A	0.800	2.72	0.117	0.896
3	3o21A	0.792	2.77	0.103	0.890
4	3sajA	0.768	2.84	0.100	0.864
5	4uqqA	0.765	3.16	0.101	0.882
6	3h6gB	0.765	3.16	0.101	0.882
7	3om0A	0.748	3.33	0.104	0.877
8	5kcaA	0.743	3.66	0.085	0.898
9	5kc9A	0.742	3.54	0.095	0.885
10	3lkbA	0.725	3.33	0.082	0.856

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	2	2zt9G	III	Rep, Mult	138,146
2	0.03	1	4a5aA	MG	Rep, Mult	140,215
3	0.03	1	1s5lk	CLA	Rep, Mult	147,151
4	0.03	1	2ahiC	NUC	Rep, Mult	370,375
5	0.03	1	2al4C	CX6	Rep, Mult	247,248,377,378,380
6	0.03	1	2qbyA	MG	Rep, Mult	45,129,219
7	0.03	1	2ohjA	FE	Rep, Mult	371,372
8	0.03	1	3lsfE	PZI	Rep, Mult	126,139,143,144,147
9	0.03	1	1qiyF	III	Rep, Mult	381,382
10	0.03	1	3tdjA	3TJ	Rep, Mult	219,220,221,222,223
11	0.03	1	3h6tA	CYZ	Rep, Mult	126,136,139,143
12	0.03	1	3il1B	B5D	Rep, Mult	199,203,206
13	0.03	1	5c5cA	UNX	Rep, Mult	62,83,340,341,344
14	0.03	1	3lcmA	FAD	Rep, Mult	322,332
15	0.03	1	2xctS	CPF	Rep, Mult	329,330

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3bblA	0.526	4.01	0.107	0.661	5.1.1.1	211,213
2	0.060	3c3kB	0.530	3.93	0.079	0.661	5.1.1.1	249
3	0.060	1bgvA	0.439	5.30	0.046	0.619	1.4.1.2	NA
4	0.060	1aupA	0.427	5.06	0.050	0.585	1.4.1.2	NA
5	0.060	2fssA	0.408	5.33	0.066	0.577	1.2.1.2	NA
6	0.060	1hrdA	0.435	5.55	0.074	0.624	1.4.1.2	NA
7	0.060	2aw5B	0.457	5.75	0.067	0.676	1.1.1.40	NA
8	0.060	1b3bE	0.437	5.36	0.078	0.614	1.4.1.3	52
9	0.060	1t34A	0.696	4.26	0.115	0.882	4.6.1.2	71,79
10	0.060	2bmaA	0.441	5.19	0.047	0.611	1.4.1.4	NA
11	0.060	1gz3A	0.440	6.12	0.042	0.671	1.1.1.38	NA
12	0.060	1luaB	0.412	5.48	0.070	0.595	1.5.1.5	142
13	0.060	1b26A	0.435	5.53	0.069	0.619	1.4.1.3	NA
14	0.060	3c46B	0.426	6.89	0.070	0.708	2.7.7.6	NA
15	0.060	2rgyA	0.508	4.25	0.092	0.655	5.1.1.1	NA
16	0.060	1hwxA	0.438	5.74	0.066	0.634	1.4.1.3	NA
17	0.060	1lehA	0.412	5.52	0.083	0.588	1.4.1.9	NA
18	0.060	2o7qA	0.407	5.20	0.095	0.572	4.2.1.10,1.1.1.25	NA
19	0.060	1vjpA	0.407	5.66	0.078	0.572	5.5.1.4	101,218,296

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.28	0.800	2.72	0.12	0.90	4uq6B	GO:0001919 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005246 GO:0005783 GO:0005789 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0007268 GO:0008328 GO:0009986 GO:0010226 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0019901 GO:0030054 GO:0030165 GO:0030425 GO:0030426 GO:0030672 GO:0031623 GO:0032279 GO:0032281 GO:0032839 GO:0034220 GO:0035235 GO:0042734 GO:0042802 GO:0043025 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043234 GO:0045184 GO:0045202 GO:0045211 GO:0050806 GO:0051262 GO:0051966 GO:0060992
1	0.25	0.824	2.47	0.10	0.90	4gpaA	GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007268 GO:0008328 GO:0014069 GO:0016020 GO:0016021 GO:0030054 GO:0030425 GO:0032281 GO:0032983 GO:0034220 GO:0035235 GO:0042995 GO:0043025 GO:0043195 GO:0045202 GO:0045211 GO:0050803 GO:0050804 GO:0051968 GO:0060992
2	0.23	0.803	2.73	0.11	0.90	5idfB	GO:0001919 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0008328 GO:0010226 GO:0014069 GO:0016020 GO:0016021 GO:0030054 GO:0030165 GO:0030425 GO:0032279 GO:0032281 GO:0034220 GO:0035235 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043234 GO:0045202 GO:0045211 GO:0060992
3	0.22	0.748	3.47	0.10	0.89	3qluB	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005783 GO:0005886 GO:0006621 GO:0006810 GO:0006811 GO:0007268 GO:0008066 GO:0008328 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0017124 GO:0030054 GO:0030165 GO:0030424 GO:0030425 GO:0031630 GO:0032983 GO:0034220 GO:0035235 GO:0035249 GO:0042391 GO:0042734 GO:0042802 GO:0043005 GO:0043025 GO:0043113 GO:0043195 GO:0043204 GO:0043525 GO:0045202 GO:0045211 GO:0051649 GO:0060079 GO:0071333
4	0.17	0.800	2.72	0.12	0.90	3kg2A	GO:0001919 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005246 GO:0005783 GO:0005789 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0007268 GO:0008328 GO:0009986 GO:0010226 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0019901 GO:0030054 GO:0030165 GO:0030425 GO:0030426 GO:0030672 GO:0031623 GO:0032279 GO:0032281 GO:0032839 GO:0034220 GO:0035235 GO:0042734 GO:0042802 GO:0043025 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043234 GO:0045184 GO:0045202 GO:0045211 GO:0050806 GO:0051262 GO:0051966 GO:0060992
5	0.16	0.800	2.70	0.12	0.89	4u1xC	GO:0001919 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005246 GO:0005783 GO:0005789 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0007268 GO:0008328 GO:0009986 GO:0010226 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0019901 GO:0030054 GO:0030165 GO:0030425 GO:0030426 GO:0030672 GO:0031623 GO:0032279 GO:0032281 GO:0032839 GO:0034220 GO:0035235 GO:0042734 GO:0042802 GO:0043025 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043234 GO:0045184 GO:0045202 GO:0045211 GO:0050806 GO:0051262 GO:0051966 GO:0060992
6	0.15	0.807	2.76	0.11	0.91	5fwyB	GO:0001919 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0008328 GO:0010226 GO:0014069 GO:0016020 GO:0016021 GO:0030054 GO:0030165 GO:0030425 GO:0032279 GO:0032281 GO:0034220 GO:0035235 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043234 GO:0045202 GO:0045211 GO:0060992
7	0.15	0.765	3.37	0.10	0.89	5ideC	GO:0001919 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005246 GO:0005783 GO:0005789 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0007268 GO:0008328 GO:0009986 GO:0010226 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0019901 GO:0030054 GO:0030165 GO:0030425 GO:0030426 GO:0030672 GO:0031623 GO:0032279 GO:0032281 GO:0032839 GO:0034220 GO:0035235 GO:0042734 GO:0042802 GO:0043025 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043234 GO:0045184 GO:0045202 GO:0045211 GO:0050806 GO:0051262 GO:0051966 GO:0060992
8	0.15	0.756	2.85	0.11	0.85	4u1wA	GO:0001919 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005246 GO:0005783 GO:0005789 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0007268 GO:0008328 GO:0009986 GO:0010226 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0019901 GO:0030054 GO:0030165 GO:0030425 GO:0030426 GO:0030672 GO:0031623 GO:0032279 GO:0032281 GO:0032839 GO:0034220 GO:0035235 GO:0042734 GO:0042802 GO:0043025 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043234 GO:0045184 GO:0045202 GO:0045211 GO:0050806 GO:0051262 GO:0051966 GO:0060992
9	0.15	0.762	2.95	0.10	0.87	3olzA	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007165 GO:0007268 GO:0008066 GO:0016020 GO:0016021 GO:0030054 GO:0030424 GO:0030425 GO:0032839 GO:0034220 GO:0035235 GO:0042391 GO:0043195 GO:0043204 GO:0045202 GO:0045211 GO:0051967
10	0.14	0.773	3.06	0.11	0.88	3sajC	GO:0001919 GO:0001965 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005769 GO:0005783 GO:0005789 GO:0005829 GO:0005886 GO:0006810 GO:0006811 GO:0007616 GO:0008179 GO:0008328 GO:0009636 GO:0009986 GO:0010226 GO:0014069 GO:0014070 GO:0016020 GO:0016021 GO:0019228 GO:0019901 GO:0019904 GO:0021510 GO:0030054 GO:0030165 GO:0030425 GO:0031267 GO:0031489 GO:0031594 GO:0031623 GO:0031681 GO:0031698 GO:0032279 GO:0032281 GO:0032355 GO:0034220 GO:0035235 GO:0035249 GO:0042220 GO:0042493 GO:0042802 GO:0042803 GO:0042995 GO:0043005 GO:0043025 GO:0043197 GO:0043198 GO:0043234 GO:0043434 GO:0044309 GO:0045202 GO:0045211 GO:0045838 GO:0046685 GO:0048167 GO:0050804 GO:0050806 GO:0051018 GO:0051602 GO:0060076 GO:0060992 GO:0071230 GO:0071359 GO:0071363 GO:0071375 GO:0071407 GO:0071418
11	0.14	0.765	3.16	0.10	0.88	4uqqA	GO:0001662 GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006874 GO:0006886 GO:0007268 GO:0008066 GO:0008328 GO:0014069 GO:0015277 GO:0016020 GO:0016021 GO:0019228 GO:0030054 GO:0030165 GO:0030424 GO:0030425 GO:0031624 GO:0031625 GO:0032839 GO:0032983 GO:0034220 GO:0035235 GO:0035249 GO:0042391 GO:0042734 GO:0042802 GO:0042803 GO:0043025 GO:0043113 GO:0043195 GO:0043204 GO:0043524 GO:0043525 GO:0045202 GO:0045211 GO:0046328 GO:0048169 GO:0048172 GO:0050804 GO:0050806 GO:0051402 GO:0051967 GO:0060079 GO:0060080
12	0.10	0.689	4.22	0.08	0.88	4mqeA	GO:0001649 GO:0004871 GO:0004930 GO:0004965 GO:0005576 GO:0005615 GO:0005737 GO:0005789 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007193 GO:0007194 GO:0007214 GO:0008021 GO:0008134 GO:0008285 GO:0014048 GO:0014049 GO:0014053 GO:0016020 GO:0016021 GO:0030054 GO:0030425 GO:0030673 GO:0030817 GO:0031966 GO:0032811 GO:0033602 GO:0035094 GO:0038037 GO:0038039 GO:0042734 GO:0042995 GO:0043005 GO:0043025 GO:0043197 GO:0043198 GO:0043231 GO:0045121 GO:0045202 GO:0045211 GO:0045471 GO:0050805 GO:0060124
13	0.07	0.594	4.68	0.11	0.80	5fxkA	GO:0004872 GO:0004970 GO:0004972 GO:0005102 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007611 GO:0010942 GO:0014069 GO:0014070 GO:0014075 GO:0016020 GO:0016021 GO:0016594 GO:0016595 GO:0017146 GO:0019899 GO:0022843 GO:0030054 GO:0032590 GO:0034220 GO:0034765 GO:0035235 GO:0035254 GO:0042165 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0044307 GO:0045202 GO:0045211 GO:0046982 GO:0046983 GO:0048511 GO:0051262 GO:0051592 GO:0060076 GO:0060992 GO:0071287 GO:2000463
14	0.07	0.595	4.46	0.12	0.78	4pe5C	GO:0004872 GO:0004970 GO:0004972 GO:0005102 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007611 GO:0010942 GO:0014069 GO:0014070 GO:0014075 GO:0016020 GO:0016021 GO:0016594 GO:0016595 GO:0017146 GO:0019899 GO:0022843 GO:0030054 GO:0032590 GO:0034220 GO:0034765 GO:0035235 GO:0035254 GO:0042165 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0044307 GO:0045202 GO:0045211 GO:0046982 GO:0046983 GO:0048511 GO:0051262 GO:0051592 GO:0060076 GO:0060992 GO:0071287 GO:2000463
15	0.07	0.580	5.00	0.07	0.81	4pe5D	GO:0001508 GO:0001975 GO:0004872 GO:0004970 GO:0004972 GO:0005102 GO:0005149 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007611 GO:0007613 GO:0007616 GO:0008013 GO:0008144 GO:0008270 GO:0008306 GO:0009612 GO:0009636 GO:0009743 GO:0010042 GO:0010350 GO:0010942 GO:0014049 GO:0014069 GO:0014070 GO:0014075 GO:0016020 GO:0016021 GO:0017146 GO:0021766 GO:0021987 GO:0030018 GO:0030054 GO:0031749 GO:0032026 GO:0033555 GO:0034097 GO:0034220 GO:0035235 GO:0035255 GO:0042165 GO:0042220 GO:0042734 GO:0043005 GO:0043083 GO:0043113 GO:0043195 GO:0043197 GO:0043408 GO:0045202 GO:0045211 GO:0045471 GO:0046872 GO:0046982 GO:0048169 GO:0048511 GO:0050806 GO:0050839 GO:0051592 GO:0051597 GO:0051602 GO:0051707 GO:0060416 GO:0060992 GO:0071230 GO:0071287 GO:0071359 GO:0071363 GO:0071396 GO:0071407
16	0.07	0.591	4.53	0.11	0.78	4tllA	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0035235 GO:0045202 GO:0045211
17	0.07	0.581	4.76	0.10	0.79	5fxgA	GO:0004872 GO:0004970 GO:0004972 GO:0005102 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007611 GO:0010942 GO:0014069 GO:0014070 GO:0014075 GO:0016020 GO:0016021 GO:0016594 GO:0016595 GO:0017146 GO:0019899 GO:0022843 GO:0030054 GO:0032590 GO:0034220 GO:0034765 GO:0035235 GO:0035254 GO:0042165 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0044307 GO:0045202 GO:0045211 GO:0046982 GO:0046983 GO:0048511 GO:0051262 GO:0051592 GO:0060076 GO:0060992 GO:0071287 GO:2000463
18	0.07	0.592	4.48	0.11	0.78	5ipqA	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0035235 GO:0045202 GO:0045211

Consensus prediction of GO terms

Molecular Function	GO:0005234	GO:0004971	GO:0030165	GO:0042802	GO:0015277	GO:0019901	GO:0005246
GO-Score	0.73	0.65	0.64	0.54	0.54	0.40	0.40
Biological Processes	GO:0035235	GO:0034220	GO:0060992	GO:0010226	GO:0001919	GO:0071331	GO:0043065	GO:0031338	GO:2000300	GO:0072657	GO:1901216	GO:0051668	GO:0035437	GO:0060078	GO:0001678	GO:0043523	GO:0099565	GO:0009749	GO:0031629	GO:0045184	GO:0031623	GO:0050806	GO:0051966	GO:0051262
GO-Score	0.73	0.73	0.65	0.54	0.54	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.40	0.40	0.40	0.40	0.40
Cellular Component	GO:0043195	GO:0014069	GO:0030054	GO:0045211	GO:0032281	GO:0043204	GO:0032279	GO:0043198	GO:0043197	GO:0042734	GO:0005576	GO:0032983	GO:0030426	GO:0030672	GO:0032839	GO:0009986	GO:0005789
GO-Score	0.73	0.73	0.73	0.73	0.65	0.64	0.54	0.54	0.54	0.54	0.46	0.42	0.40	0.40	0.40	0.40	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.